TWAS
hub
About
Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Leg fat-free mass (left)
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chr14:20,843,889-22,662,856
Best TWAS P=2.05e-09 · Best GWAS P=5.87e-10 conditioned to 4.33e-05
21M
21.5M
22M
22.5M
0
2
4
6
8
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Testis
TOX4
0.31
0.00
enet
24
0.04
6.8e-03
-5.8
-6.0
2.1e-09
-0.49
0.03
0.67
TRUE
1
GTEx
Artery Aorta
ARHGEF40
0.34
0.32
enet
17
0.31
1.5e-17
-5.9
-5.4
5.4e-08
0.06
0.01
0.99
TRUE
5
The Cancer Genome Atlas
Testicular Germ Cell Tumors
METTL3
0.17
0.03
lasso
2
0.04
1.5e-02
-5.8
-6.0
2.2e-09
-0.29
0.01
0.66
FALSE
4
The Cancer Genome Atlas
Head and Neck Squamous Cell Carcinoma
METTL3
0.04
0.04
lasso
2
0.04
2.5e-05
-5.8
-5.8
6.4e-09
-0.20
0.02
0.97
FALSE
3
The Cancer Genome Atlas
Breast Invasive Carcinoma
METTL3
0.03
0.04
lasso
1
0.04
3.1e-08
-5.7
-5.7
1.1e-08
-0.19
0.02
0.98
FALSE