Best TWAS P=2.05e-09 · Best GWAS P=5.87e-10 conditioned to 4.33e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | ARHGEF40 | 0.34 | 0.32 | enet | 17 | 0.31 | 1.5e-17 | -5.9 | -5.4 | 5.4e-08 | 0.06 | 0.01 | 0.99 | TRUE |
| 2 | GTEx | Testis | TOX4 | 0.31 | 0.00 | enet | 24 | 0.04 | 6.8e-03 | -5.8 | -6.0 | 2.1e-09 | -0.49 | 0.03 | 0.67 | TRUE |
| 3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | METTL3 | 0.03 | 0.04 | lasso | 1 | 0.04 | 3.1e-08 | -5.7 | -5.7 | 1.1e-08 | -0.19 | 0.02 | 0.98 | FALSE |
| 4 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | METTL3 | 0.04 | 0.04 | lasso | 2 | 0.04 | 2.5e-05 | -5.8 | -5.8 | 6.4e-09 | -0.20 | 0.02 | 0.97 | FALSE |
| 5 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | METTL3 | 0.17 | 0.03 | lasso | 2 | 0.04 | 1.5e-02 | -5.8 | -6.0 | 2.2e-09 | -0.29 | 0.01 | 0.66 | FALSE |