Best TWAS P=8.36e-09 · Best GWAS P=1.64e-12 conditioned to 1e-04
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | RPL9P25 | 0.26 | 0.02 | enet | 27 | 0.07 | 1.3e-04 | -2.3 | -5.5 | 3.1e-08 | 0.05 | 0.72 | 0.02 | TRUE |
| 2 | GTEx | Breast Mammary Tissue | MAP2K5 | 0.14 | 0.07 | lasso | 5 | 0.09 | 2.8e-05 | -5.7 | 5.6 | 1.8e-08 | -0.87 | 0.03 | 0.97 | FALSE |
| 3 | GTEx | Heart Atrial Appendage | MAP2K5 | 0.16 | 0.08 | lasso | 5 | 0.16 | 1.3e-07 | -4.4 | 5.3 | 1.3e-07 | -0.76 | 0.38 | 0.61 | FALSE |
| 4 | GTEx | Muscle Skeletal | MAP2K5 | 0.08 | 0.03 | lasso | 6 | 0.05 | 1.9e-05 | 4.5 | 5.8 | 8.4e-09 | -0.69 | 0.21 | 0.79 | TRUE |
| 5 | METSIM | Adipose | MAP2K5 | 0.07 | 0.05 | enet | 19 | 0.06 | 2.8e-09 | -5.6 | 5.3 | 1.3e-07 | -0.84 | 0.12 | 0.88 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | MAP2K5 | 0.03 | 0.03 | blup | 142 | 0.02 | 1.6e-03 | -4.5 | 5.2 | 2.2e-07 | -0.90 | 0.05 | 0.93 | FALSE |