TWAS hub - MAP2K5

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1050	0.0340	2.2e-08	0.069	0.075	0.062	0.077	0.071	8.7e-09	2.1e-09	4.4e-08	1.2e-09	4.6e-09
2	GTEx	Adipose Subcutaneous	0.1400	0.0430	5.5e-09	0.183	NA	0.166	NA	0.181	7.1e-15	NA	1.6e-13	NA	1.0e-14
3	GTEx	Adipose Visceral Omentum	0.0730	0.0350	3.5e-03	0.079	NA	0.031	NA	0.052	6.3e-05	NA	1.0e-02	NA	1.0e-03
4	GTEx	Artery Aorta	0.0640	0.0320	6.4e-03	0.052	NA	0.052	NA	0.044	7.5e-04	NA	7.7e-04	NA	1.8e-03
5	GTEx	Artery Coronary	0.1100	0.0550	7.9e-03	0.005	NA	0.026	NA	0.019	2.1e-01	NA	4.5e-02	NA	7.2e-02
6	GTEx	Artery Tibial	0.1537	0.0419	4.2e-10	0.184	NA	0.171	NA	0.178	2.2e-14	NA	2.1e-13	NA	6.4e-14
7	GTEx	Brain Cerebellum	0.2690	0.0860	5.5e-05	0.122	NA	0.116	NA	0.136	1.9e-04	NA	2.7e-04	NA	7.9e-05
8	GTEx	Breast Mammary Tissue	0.1410	0.0490	4.4e-06	0.072	NA	0.075	NA	0.088	1.5e-04	NA	1.1e-04	NA	2.8e-05
9	GTEx	Esophagus Muscularis	0.2370	0.0690	2.7e-07	0.144	NA	0.103	NA	0.132	4.6e-09	NA	7.8e-07	NA	2.1e-08
10	GTEx	Heart Atrial Appendage	0.1640	0.0540	3.4e-06	0.079	NA	0.152	NA	0.159	2.0e-04	NA	2.4e-07	NA	1.3e-07
11	GTEx	Heart Left Ventricle	0.1025	0.0419	5.6e-04	0.101	NA	0.084	NA	0.095	5.1e-06	NA	3.2e-05	NA	9.4e-06
12	GTEx	Lung	0.1232	0.0513	1.7e-04	0.085	NA	0.072	NA	0.072	4.7e-07	NA	3.6e-06	NA	3.6e-06
13	GTEx	Muscle Skeletal	0.0777	0.0291	3.9e-06	0.033	NA	0.037	NA	0.047	3.0e-04	NA	1.3e-04	NA	1.9e-05
14	GTEx	Nerve Tibial	0.1886	0.0505	1.6e-09	0.214	NA	0.176	NA	0.201	3.9e-15	NA	1.6e-12	NA	3.3e-14
15	GTEx	Ovary	0.1910	0.0700	1.1e-03	0.244	NA	0.131	NA	0.207	1.1e-06	NA	4.3e-04	NA	8.3e-06
16	GTEx	Skin Sun Exposed Lower leg	0.1290	0.0410	2.4e-07	0.060	NA	0.089	NA	0.092	9.6e-06	NA	8.4e-08	NA	4.4e-08
17	GTEx	Spleen	0.2450	0.0830	1.5e-04	0.189	NA	0.157	NA	0.181	1.4e-05	NA	7.7e-05	NA	2.1e-05
18	GTEx	Thyroid	0.1090	0.0360	2.6e-07	0.161	NA	0.144	NA	0.152	2.4e-12	NA	4.1e-11	NA	9.6e-12
19	GTEx	Whole Blood	0.0880	0.0360	2.2e-04	0.063	NA	0.051	NA	0.055	2.0e-06	NA	1.6e-05	NA	8.1e-06
20	METSIM	Adipose	0.0711	0.0263	2.3e-06	0.053	0.055	0.059	0.059	0.056	2.2e-08	1.0e-08	2.8e-09	2.8e-09	8.0e-09
21	NTR	Blood	0.0154	0.0069	3.2e-04	0.005	0.007	0.009	0.007	0.008	7.9e-03	1.7e-03	5.7e-04	2.4e-03	7.3e-04
22	YFS	Blood	0.0494	0.0144	1.9e-12	0.070	0.042	0.068	0.068	0.069	6.2e-22	1.2e-13	2.3e-21	2.0e-21	1.2e-21
23	TCGA	Kidney Renal Clear Cell Carcinoma	0.0344	0.0189	7.0e-04	0.028	0.021	0.018	NA	0.019	3.7e-04	1.6e-03	3.5e-03	NA	3.1e-03
24	TCGA	Lung Adenocarcinoma	0.0360	0.0199	1.3e-03	0.042	0.021	0.029	NA	0.033	1.0e-05	1.3e-03	2.3e-04	NA	8.7e-05
25	TCGA	Thyroid Carcinoma	0.1040	0.0630	9.8e-05	0.056	0.034	0.036	NA	0.042	3.9e-06	2.6e-04	2.0e-04	NA	6.1e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25
Comparative body size at age 10	21.9	60.4	95.5	7.9	7.6	7.8	7.2	3.9	7.5	5.9	9.3	7.5	9.3	8.0	6.6	9.3	7.6	7.6	7.8	6.8	7.5	6.2	9.8	8.1	7.5	9.3	7.8	8.2
Body Mass Index (BMI) (2010)	21.3	29.2	44.4	5.6	5.6	5.6	5.6	2.3	5.6	3.9	5.7	5.5	5.7	5.7	4.6	5.2	5.7	5.5	5.3	5.2	5.6	5.2	6.7	5.0	5.6	5.6	5.8	5.8
BMI	15.8	91.5	125.7	8.7	9.8	10.4	9.6	5.4	9.8	7.4	10.8	9.6	10.7	10.0	8.4	11.1	9.8	9.5	9.3	8.3	9.8	8.8	11.2	8.4	9.6	10.6	10.0	10.1
Arm fat percentage (right)	15.7	62.1	79.2	7.2	8.1	8.6	8.2	7.0	8.3	7.5	7.8	8.2	8.2	8.1	7.4	8.7	8.1	8.2	6.7	6.7	8.2	8.9	8.0	6.7	7.9	7.6	8.2	8.0
Arm fat percentage (left)	15.6	62.3	78.9	7.3	8.1	8.6	8.3	7.0	8.3	7.5	7.7	8.2	8.1	8.1	7.4	8.5	8.1	8.2	6.7	6.9	8.3	8.9	8.2	6.7	7.9	7.6	8.3	8.0
Body fat percentage	15.5	61.2	88.7	7.1	8.1	8.4	8.4	7.4	8.2	8.1	7.3	8.3	7.7	8.0	7.4	8.2	8.1	8.2	6.4	6.8	8.3	9.4	7.6	6.5	7.9	7.1	8.2	7.9
Trunk fat percentage	14.5	58.0	88.7	6.9	7.8	8.2	8.2	7.9	8.0	8.2	7.0	8.0	7.3	7.7	7.2	7.6	7.8	8.0	5.9	6.7	8.0	9.4	7.3	6.4	7.6	6.9	7.9	7.6
Leg fat mass (right)	14.4	55.9	73.7	6.8	7.8	8.1	8.0	6.2	7.8	7.1	7.3	7.8	7.8	7.7	7.1	8.6	7.7	7.7	6.5	6.1	7.9	8.3	7.6	6.3	7.6	6.8	7.9	7.6
Whole body fat mass	13.8	57.8	76.5	6.6	7.8	8.2	8.1	7.1	7.9	7.6	7.5	7.9	7.8	7.7	7.1	8.5	7.7	7.9	6.5	6.3	8.0	8.7	7.6	6.6	7.5	7.1	7.9	7.6
Leg fat mass (left)	13.8	54.0	74.8	6.6	7.6	7.9	7.8	6.0	7.7	6.9	7.1	7.7	7.8	7.6	6.9	8.7	7.6	7.6	6.5	6.0	7.8	8.1	7.5	6.2	7.4	6.8	7.7	7.5
Leg fat percentage (right)	13.5	49.1	64.5	6.3	7.4	7.5	7.5	5.6	7.4	6.9	6.5	7.4	7.1	7.3	6.7	7.8	7.4	7.3	6.0	5.9	7.5	8.0	7.0	5.5	7.2	6.2	7.5	7.2
Trunk fat mass	13.4	57.6	81.9	6.7	7.7	8.1	8.1	7.6	7.9	8.0	7.3	7.9	7.6	7.7	7.1	8.2	7.7	7.9	6.3	6.4	8.0	9.1	7.5	6.5	7.5	7.0	7.8	7.5
Arm fat mass (left)	13.4	55.0	73.4	6.7	7.6	8.1	7.7	6.4	7.7	6.8	7.7	7.6	7.9	7.6	6.8	8.6	7.5	7.6	6.5	6.1	7.7	8.0	7.9	6.4	7.3	7.3	7.7	7.5
Leg fat percentage (left)	13.4	48.6	62.9	6.3	7.3	7.4	7.5	5.4	7.4	6.7	6.5	7.4	7.2	7.3	6.6	7.9	7.3	7.2	6.2	5.9	7.4	7.9	7.1	5.5	7.1	6.3	7.4	7.2
Body mass index (BMI)	13.3	56.6	77.8	7.0	7.8	8.2	7.7	4.8	7.8	5.7	8.1	7.6	8.3	7.9	6.8	8.8	7.8	7.6	7.1	6.5	7.7	7.2	8.7	6.2	7.6	8.0	7.9	7.9
Arm fat mass (right)	13.2	54.3	74.3	6.7	7.5	8.0	7.7	6.4	7.6	6.8	7.6	7.5	7.9	7.5	6.7	8.6	7.5	7.6	6.6	6.0	7.7	7.9	7.8	6.4	7.3	7.2	7.6	7.4
Townsend deprivation index at recruitment	12.8	18.0	21.3	3.2	4.5	4.5	4.4	2.6	4.5	3.9	4.2	4.5	4.5	4.5	4.0	4.5	4.5	4.3	4.5	4.1	4.5	4.6	3.9	3.9	4.4	4.1	4.5	4.5
Waist circumference	12.8	46.9	64.3	6.1	7.0	7.3	7.1	5.7	7.1	7.2	7.0	7.1	7.3	6.9	6.2	8.0	6.9	7.1	6.3	5.7	7.2	7.3	7.0	6.3	6.7	6.6	7.0	6.8
Past tobacco smoking	11.5	21.2	33.2	-3.6	-4.7	-4.6	-4.6	-2.2	-4.8	-5.3	-4.7	-4.8	-5.3	-4.6	-4.3	-5.8	-4.7	-4.9	-5.7	-3.5	-4.8	-4.2	-3.8	-5.3	-4.5	-3.7	-4.6	-4.5
Age when periods started (menarche)	10.8	26.0	36.9	-4.0	-5.2	-5.4	-4.9	-1.7	-5.2	-4.8	-5.8	-5.2	-6.1	-5.4	-4.6	-5.9	-5.1	-5.2	-5.4	-4.4	-5.3	-5.0	-5.0	-4.9	-5.1	-5.7	-5.2	-5.4
Neuroticism	10.6	25.5	31.7	-4.1	-5.2	-5.6	-5.3	-3.7	-5.4	-5.2	-5.5	-5.2	-5.3	-5.1	-4.9	-4.7	-5.2	-5.3	-5.2	-4.8	-5.1	-5.1	-4.0	-5.3	-5.0	-4.9	-5.1	-5.3
Vascular/heart problems diagnosed by doctor	9.4	25.6	32.8	-5.1	-5.2	-5.4	-4.8	-2.6	-5.3	-5.4	-5.0	-5.3	-5.7	-5.3	-5.2	-5.7	-5.2	-5.4	-5.4	-4.1	-5.3	-4.7	-4.3	-4.9	-5.2	-4.4	-5.2	-5.2
Weight	8.9	43.8	61.6	5.7	6.7	7.1	7.0	5.8	6.7	6.0	7.1	6.7	7.0	6.7	6.1	7.8	6.6	6.7	6.0	5.3	6.8	7.0	7.2	6.0	6.5	6.7	6.8	6.7
Seen doctor (GP) for nerves, anxiety, tension or depression	8.8	13.4	16.8	3.8	3.9	3.7	3.7	2.4	3.7	3.1	3.5	3.8	3.4	4.0	4.1	3.2	3.8	3.8	2.7	3.6	3.9	3.6	4.1	3.4	3.9	3.8	3.9	4.0
Worry too long after embarrassment	8.4	14.1	17.6	-2.5	-3.8	-4.1	-4.2	-3.0	-3.9	-4.1	-4.0	-3.9	-4.2	-3.8	-3.8	-3.8	-3.7	-3.9	-4.0	-3.1	-4.0	-3.9	-3.2	-4.0	-3.7	-3.4	-3.7	-3.7
Number of self-reported non-cancer illnesses	8.2	14.3	31.7	2.9	3.8	3.9	3.5	3.0	4.0	5.6	3.5	4.1	4.0	3.7	3.4	4.0	3.7	4.3	4.7	3.0	4.0	3.9	2.7	3.7	3.7	2.6	3.7	3.5
Fractured/broken bones in last 5 years	8.1	10.5	19.2	1.4	3.7	3.6	3.8	2.9	3.6	4.4	2.1	3.8	2.4	3.4	3.5	2.4	3.5	3.7	3.0	3.1	3.9	4.1	2.0	2.2	3.6	2.0	3.6	2.9
Smoking status: Previous	8.0	12.0	22.0	2.2	3.6	3.5	3.5	0.8	3.7	3.6	3.5	3.6	4.3	3.4	3.4	4.7	3.6	3.7	4.6	2.5	3.7	3.1	3.0	3.8	3.4	2.5	3.5	3.3
Chronic bronchitis/emphysema (mother)	7.9	9.2	16.1	2.2	2.9	2.8	2.7	2.4	2.8	3.6	4.0	3.0	3.1	3.0	2.9	2.8	2.8	3.1	3.2	2.8	3.0	2.8	2.6	4.0	2.8	3.7	2.9	3.3
Hip circumference	7.5	32.5	49.5	4.2	5.7	6.1	6.1	3.7	5.7	4.8	6.3	5.7	6.5	5.7	5.3	7.0	5.6	5.7	5.7	4.5	6.0	6.1	6.4	5.3	5.5	6.0	5.8	5.7
Chronic bronchitis/emphysema (father)	7.4	8.7	15.8	1.7	3.0	2.8	3.0	2.2	3.1	3.6	2.6	3.1	3.5	2.9	2.6	3.7	3.0	3.2	3.6	2.2	3.2	3.2	1.8	4.0	2.9	2.0	2.9	2.8
Smoking Status	7.3	17.5	27.3	3.7	4.1	4.4	4.1	2.5	4.3	5.0	4.5	4.2	4.7	4.1	3.8	4.7	4.1	4.3	4.9	3.2	4.2	4.0	3.6	5.2	4.0	3.5	4.1	4.2
Suffer from ‘nerves’	7.2	11.3	17.1	-2.1	-3.4	-3.5	-3.7	-1.3	-3.5	-3.1	-4.1	-3.4	-3.7	-3.4	-3.7	-3.2	-3.4	-3.5	-3.5	-3.2	-3.5	-3.5	-3.1	-3.4	-3.3	-3.6	-3.3	-3.6
Ever smoked	7.0	12.2	18.1	2.4	3.5	3.7	3.4	2.0	3.6	4.1	4.0	3.5	4.0	3.4	3.1	4.2	3.5	3.6	4.3	2.7	3.6	3.1	3.1	4.1	3.4	3.1	3.5	3.4
Worry (Nagel 2018)	6.9	14.6	19.8	-3.3	-3.8	-4.2	-4.3	-3.2	-4.0	-4.0	-4.5	-3.9	-3.8	-3.7	-3.9	-3.2	-3.7	-3.9	-3.4	-3.8	-3.8	-4.0	-3.2	-4.1	-3.7	-3.9	-3.8	-4.0
High blood pressure	6.8	19.0	28.6	4.5	4.5	4.5	4.0	2.0	4.5	4.9	4.4	4.5	5.2	4.6	4.4	5.3	4.4	4.6	4.8	3.3	4.5	4.0	3.6	4.2	4.4	3.8	4.4	4.5
Guilty feelings	6.7	10.1	15.7	-2.2	-3.3	-3.2	-3.1	-0.6	-3.2	-2.7	-4.0	-3.3	-3.6	-3.4	-2.9	-3.2	-3.2	-3.4	-3.8	-2.8	-3.4	-2.9	-3.7	-2.7	-3.3	-3.4	-3.3	-3.5
Eye problems/disorders: Glaucoma	6.7	7.9	13.6	-2.0	-2.8	-3.0	-2.6	-0.4	-2.7	-2.6	-3.4	-2.8	-3.7	-2.8	-2.5	-3.7	-2.6	-2.8	-3.6	-2.2	-2.9	-1.9	-2.9	-3.7	-2.7	-2.8	-2.8	-2.8
Cardiovascular Disease	6.5	21.6	28.8	4.8	4.8	4.9	4.5	2.4	4.9	5.0	5.0	4.8	5.4	4.9	4.7	5.1	4.7	5.1	5.1	3.8	4.8	4.2	3.4	4.5	4.7	4.2	4.7	4.8
Medication: Ramipril	6.1	7.8	14.2	2.4	3.1	3.1	2.4	1.6	3.2	3.8	2.5	3.2	3.1	2.9	3.0	2.9	3.0	3.2	2.9	2.6	3.0	2.3	2.3	2.2	3.0	2.0	2.9	2.7
Neuroticism (Nagel 2018)	5.9	14.0	23.3	-3.3	-3.7	-4.3	-4.0	-2.3	-3.9	-3.2	-4.8	-3.7	-3.9	-3.8	-3.2	-2.8	-3.7	-3.7	-3.7	-3.9	-3.6	-3.9	-3.2	-4.2	-3.6	-4.4	-3.7	-4.1
Illnesses of siblings	5.9	8.3	11.7	-2.5	-3.0	-2.9	-2.9	-0.9	-2.9	-2.3	-2.8	-3.0	-3.2	-3.1	-3.0	-3.4	-3.0	-3.0	-3.1	-2.7	-3.2	-2.2	-3.0	-2.6	-3.0	-3.2	-3.0	-3.1
Neuroticism score	5.8	12.1	15.9	-2.6	-3.5	-3.8	-3.7	-2.4	-3.6	-3.5	-4.0	-3.6	-3.9	-3.5	-3.2	-3.4	-3.5	-3.7	-3.9	-3.1	-3.6	-3.7	-3.0	-3.6	-3.4	-3.3	-3.5	-3.7
Ever unenthusiastic/disinterested for a whole week	5.7	7.0	10.4	3.2	2.7	3.1	3.2	3.1	2.8	2.6	2.8	2.7	1.4	2.8	3.0	0.8	2.7	2.7	0.9	3.0	2.6	2.1	2.6	2.2	2.8	2.7	2.8	2.8
Hypertension (Self-reported)	5.7	15.7	24.4	3.9	4.0	4.1	3.7	1.9	4.1	4.4	4.1	4.1	4.9	4.1	3.9	4.9	4.0	4.2	4.5	2.9	4.2	3.7	3.2	3.8	3.9	3.5	4.0	4.1
Depression (Nagel 2018)	5.6	8.4	10.2	-3.1	-3.0	-3.1	-2.7	-2.8	-3.0	-2.7	-3.2	-3.0	-2.9	-3.0	-2.5	-2.7	-2.9	-3.0	-2.4	-2.8	-2.9	-2.9	-2.9	-3.1	-2.9	-3.1	-2.9	-2.9
Lung FVC	5.6	28.7	66.0	4.4	5.6	5.5	5.2	4.3	5.8	8.1	5.0	6.0	5.3	5.4	4.9	5.2	5.6	6.0	5.8	4.7	5.8	4.4	3.8	5.2	5.4	4.1	5.5	5.3
Sensitivity / hurt feelings	5.6	9.6	13.3	-2.0	-3.2	-3.6	-3.4	-2.3	-3.4	-3.1	-3.3	-3.2	-3.3	-3.1	-3.1	-2.7	-3.1	-3.2	-3.6	-2.8	-3.3	-3.0	-2.7	-3.2	-3.1	-2.6	-3.2	-3.2
Heart attack/myocardial infarction (self-reported)	5.6	7.2	11.8	1.7	2.9	2.9	2.8	1.5	3.0	2.7	2.6	2.9	2.2	2.9	3.4	1.8	3.0	2.9	2.8	2.8	2.9	2.3	2.8	2.5	2.9	2.1	3.0	2.7
Heart attack	5.5	7.1	12.1	1.6	2.9	2.9	2.8	1.5	3.0	2.7	2.5	2.9	2.1	2.9	3.5	1.8	3.0	2.9	2.8	2.8	2.9	2.2	2.8	2.3	3.0	1.9	3.0	2.7
Nervous feelings	5.3	9.9	17.7	-2.5	-3.0	-3.3	-3.2	-2.1	-3.1	-3.8	-3.9	-3.1	-3.4	-2.9	-3.5	-3.0	-2.9	-3.1	-3.4	-2.9	-3.1	-3.0	-2.8	-4.2	-2.8	-3.2	-2.9	-3.0
Respiratory disease	5.2	11.6	43.6	3.6	3.0	3.0	3.0	3.6	3.2	6.6	4.1	3.5	3.0	2.9	1.7	2.6	2.9	3.8	3.5	2.8	3.3	4.0	1.5	4.6	2.9	2.9	2.9	2.8
Headache pain in last month	5.2	8.9	20.4	-2.1	-3.2	-3.1	-3.0	-1.5	-3.1	-2.4	-2.3	-3.2	-3.6	-3.2	-3.0	-4.5	-3.1	-3.3	-3.4	-1.9	-3.3	-2.8	-2.6	-2.8	-3.1	-1.9	-3.2	-3.1
Long-standing illness, disability or infirmity	5.2	7.9	15.3	1.6	2.7	2.7	2.6	2.2	2.8	3.9	3.2	2.9	3.2	2.8	2.2	3.3	2.7	3.1	3.6	2.0	3.1	2.3	2.5	3.2	2.7	2.4	2.7	2.7
Supplements: Zinc	5.1	5.6	7.7	-2.5	-2.3	-2.7	-2.5	-2.4	-2.4	-2.6	-2.8	-2.4	-2.0	-2.3	-2.3	-1.2	-2.2	-2.3	-1.4	-2.5	-2.4	-2.5	-2.6	-2.2	-2.3	-2.7	-2.4	-2.4
Asthma (self-reported)	5.1	10.2	31.2	3.8	3.0	3.0	2.7	2.7	3.2	5.6	3.6	3.4	2.8	3.0	2.1	2.2	2.9	3.6	3.2	2.9	3.2	3.8	1.3	4.3	3.0	2.7	2.9	2.8
Medication for cholesterol, blood pressure or diabetes	5.0	8.3	12.9	-2.6	-2.8	-3.0	-3.1	-2.3	-2.9	-2.7	-3.4	-2.8	-3.6	-2.9	-3.0	-3.5	-2.9	-3.0	-2.9	-2.3	-2.8	-2.6	-2.7	-2.2	-2.8	-2.8	-2.8	-3.0
Asthma	4.8	9.4	29.5	3.5	2.9	2.9	2.6	2.7	3.1	5.4	3.4	3.3	2.5	2.9	1.9	2.0	2.8	3.5	2.9	2.9	3.2	3.7	1.2	4.2	2.9	2.5	2.8	2.7
Diastolic blood pressure, automated reading	4.8	15.0	23.0	4.8	3.8	3.9	3.6	1.6	3.9	4.1	4.1	3.9	4.3	3.9	3.4	4.8	3.8	4.1	4.1	2.9	3.8	4.1	3.9	4.2	3.7	3.4	3.8	3.8
Glaucoma (self-reported)	4.6	5.4	12.3	-1.8	-2.3	-2.4	-2.2	0.2	-2.2	-1.8	-2.8	-2.3	-2.9	-2.4	-1.9	-2.8	-2.2	-2.3	-3.0	-1.9	-2.4	-1.5	-2.4	-3.5	-2.3	-2.4	-2.3	-2.3
Supplements: Vitamin C	4.4	5.1	8.3	-1.2	-2.3	-2.2	-2.3	1.1	-2.2	-1.8	-2.7	-2.2	-2.6	-2.4	-2.4	-2.2	-2.3	-2.2	-2.9	-2.3	-2.5	-2.1	-2.4	-1.9	-2.3	-2.5	-2.3	-2.5
Medication for hormone replacement therapy	4.2	4.6	6.8	-2.2	-2.4	-2.2	-2.4	-2.0	-2.3	-1.7	-2.0	-2.3	-1.4	-2.4	-1.9	-1.3	-2.4	-2.4	-1.5	-2.6	-2.2	-2.6	-2.2	-1.7	-2.4	-2.0	-2.4	-2.3
Supplements: Fish oil (including cod liver oil)	4.2	5.5	9.9	-2.1	-2.3	-2.6	-2.0	-1.6	-2.4	-2.1	-3.1	-2.2	-2.5	-2.4	-1.9	-2.1	-2.2	-2.2	-2.1	-2.5	-2.3	-2.3	-2.5	-2.7	-2.2	-3.1	-2.2	-2.5
Leg predicted mass (left)	4.1	21.9	33.5	3.9	4.5	5.0	4.8	4.0	4.6	3.7	5.7	4.5	5.3	4.7	4.2	5.8	4.5	4.6	4.5	3.6	4.7	4.2	5.3	5.0	4.4	5.2	4.6	4.7
Leg fat-free mass (left)	4.0	21.3	33.2	3.8	4.5	5.0	4.8	4.0	4.5	3.6	5.6	4.4	5.3	4.6	4.2	5.8	4.4	4.5	4.5	3.5	4.6	4.1	5.3	5.0	4.3	5.2	4.6	4.6
Average weekly spirits intake	3.9	4.8	7.4	-2.3	-2.2	-2.4	-2.1	-2.5	-2.2	-2.1	-2.7	-2.3	-2.0	-2.4	-2.3	-1.9	-2.2	-2.4	-1.6	-2.1	-2.2	-2.1	-1.8	-1.6	-2.3	-2.2	-2.3	-2.3
Hair/balding pattern: Pattern 4	3.9	9.4	16.1	-2.0	-3.0	-2.9	-3.0	-1.1	-3.1	-3.7	-3.6	-3.2	-3.2	-3.0	-2.4	-2.6	-3.1	-3.2	-4.0	-3.2	-3.3	-3.9	-2.8	-3.4	-3.0	-3.0	-3.0	-2.9
Medication: Ibuprofen	3.9	4.6	6.5	-2.2	-2.1	-2.1	-2.4	-1.6	-2.1	-1.8	-2.4	-2.1	-2.5	-2.3	-1.8	-2.5	-2.1	-2.1	-1.9	-1.7	-2.1	-2.2	-2.4	-1.7	-2.1	-2.3	-2.2	-2.5
Illnesses of siblings: Diabetes	3.8	4.7	8.3	1.7	2.2	2.3	2.4	1.3	2.2	1.8	2.2	2.1	2.6	2.2	1.5	2.9	2.2	2.1	2.2	2.0	2.3	2.2	2.3	1.8	2.1	2.6	2.2	2.3
Osteoarthritis (self-reported)	3.7	4.9	7.2	1.8	2.2	2.3	2.2	0.5	2.3	2.6	2.7	2.3	2.3	2.2	2.0	1.6	2.3	2.5	2.6	2.6	2.2	1.6	2.1	2.0	2.2	2.3	2.3	2.4
Medication: Blood pressure	3.6	6.4	11.7	2.4	2.5	2.6	2.5	1.7	2.5	2.4	3.4	2.4	3.1	2.6	2.5	2.7	2.5	2.5	2.3	2.3	2.5	2.3	2.7	1.9	2.4	2.8	2.5	2.7
Worrier / anxious feelings	3.5	6.6	8.9	-2.0	-2.6	-2.9	-2.7	-1.7	-2.7	-2.5	-3.0	-2.7	-2.8	-2.5	-2.6	-2.4	-2.6	-2.6	-3.0	-2.3	-2.6	-2.9	-2.2	-2.7	-2.5	-2.3	-2.6	-2.6
Had major operations	3.5	4.2	8.2	1.0	2.0	1.9	2.0	0.8	2.1	2.5	2.1	2.1	2.5	2.0	1.9	2.4	2.1	2.1	2.9	1.6	2.3	1.9	1.8	2.2	2.0	1.6	2.0	2.0
Leg fat-free mass (right)	3.5	18.6	30.4	3.5	4.1	4.6	4.4	3.5	4.2	3.1	5.4	4.0	5.0	4.3	3.8	5.5	4.1	4.2	4.3	3.3	4.3	3.6	5.2	4.7	4.0	5.0	4.2	4.4
Bipolar Disorder (2011)	3.4	3.3	7.6	-2.4	-1.9	-1.7	-1.8	-2.8	-1.6	-2.1	-1.6	-1.9	-0.9	-1.9	-1.8	0.1	-1.6	-1.8	-0.5	-2.3	-1.7	-1.4	-1.6	-2.3	-1.9	-2.2	-1.8	-2.0
Rheumatoid Arthritis	3.4	4.7	10.6	-2.3	-2.5	-2.4	-2.2	-1.8	-2.3	-0.8	-1.5	-2.2	-1.6	-2.4	-3.3	-1.3	-2.5	-2.2	-1.2	-2.6	-2.0	-2.5	-2.1	-1.5	-2.4	-2.1	-2.4	-2.4
Hair/balding pattern: Pattern 2	3.4	4.3	7.0	-1.1	-2.1	-1.9	-1.7	0.0	-2.0	-2.0	-2.5	-2.1	-2.6	-2.2	-2.1	-2.2	-2.1	-2.2	-2.6	-2.0	-2.2	-2.0	-2.1	-1.6	-2.1	-2.6	-2.1	-2.3
Leg predicted mass (right)	3.4	18.2	30.5	3.5	4.1	4.5	4.4	3.5	4.1	3.1	5.3	4.0	5.0	4.2	3.7	5.5	4.0	4.1	4.3	3.2	4.3	3.6	5.1	4.7	3.9	5.0	4.2	4.3
Pulse wave Arterial Stiffness index	3.3	3.9	8.8	1.9	2.0	1.8	1.7	1.3	2.0	2.1	1.8	2.0	2.3	1.9	1.7	3.0	2.0	2.1	2.4	1.3	2.1	1.8	1.6	2.4	1.9	1.6	2.0	1.7
High cholesterol (Self-reported)	3.3	5.9	8.0	2.4	2.5	2.6	2.8	1.7	2.6	2.7	2.3	2.6	2.5	2.6	2.6	2.4	2.6	2.8	2.7	2.4	2.5	1.8	1.8	1.2	2.6	2.2	2.5	2.5
Medication: Cholesterol lowering	3.2	5.0	7.0	1.7	2.2	2.3	2.6	2.6	2.2	2.2	2.6	2.2	2.5	2.2	2.6	2.2	2.2	2.3	2.3	2.0	2.2	1.7	2.3	1.6	2.2	2.2	2.2	2.3
Pulse wave peak to peak time	3.2	3.8	8.1	-2.0	-2.0	-1.9	-1.6	-1.2	-2.0	-1.9	-1.8	-2.0	-2.3	-2.0	-1.7	-2.8	-2.0	-2.1	-2.4	-1.5	-2.1	-1.8	-1.6	-2.3	-1.9	-1.6	-2.0	-1.7
Basal metabolic rate	3.2	17.8	32.6	3.2	4.1	4.5	4.4	3.2	4.1	3.4	5.3	4.0	5.0	4.2	3.7	5.7	4.0	4.1	4.5	2.9	4.3	3.7	4.9	4.5	3.9	4.7	4.1	4.2
Ever depressed for a whole week	3.2	3.9	6.2	2.2	2.0	2.2	2.1	1.4	2.0	1.4	2.3	2.0	1.7	2.2	2.0	1.2	2.0	2.1	1.2	2.4	2.0	1.6	2.1	1.6	2.1	2.5	2.1	2.2
Depressed Affect (Nagel 2018)	3.1	6.6	11.0	-3.1	-2.5	-2.9	-2.3	-2.4	-2.7	-2.1	-3.3	-2.4	-2.6	-2.5	-2.0	-1.8	-2.5	-2.5	-2.1	-2.8	-2.3	-2.8	-2.2	-2.9	-2.4	-3.1	-2.4	-2.8
Vitamin and mineral supplements	3.1	4.2	5.5	2.3	2.1	2.1	2.1	1.7	2.1	2.1	2.2	2.2	1.8	2.1	1.7	1.5	2.1	2.2	2.0	2.2	2.2	1.9	2.1	2.1	2.1	2.0	2.1	2.2
Maternal smoking around birth	3.1	4.5	8.5	1.7	2.1	2.4	2.1	1.2	2.1	2.7	2.5	2.2	2.8	2.1	2.0	2.7	2.0	2.3	2.0	1.4	2.1	1.7	1.3	2.9	2.0	1.5	2.0	2.2
Handedness (chirality/laterality): Left-handed	3.1	3.8	7.0	-2.4	-1.8	-1.7	-1.8	-0.5	-1.8	-1.8	-2.2	-1.8	-2.6	-1.9	-2.0	-2.1	-1.9	-1.9	-2.2	-1.6	-1.8	-1.7	-2.1	-2.2	-1.8	-1.8	-1.8	-2.2
Miserableness	2.9	5.0	6.4	-2.1	-2.3	-2.3	-2.3	-1.7	-2.4	-2.1	-2.4	-2.3	-2.2	-2.3	-1.8	-1.6	-2.3	-2.5	-2.4	-2.4	-2.3	-2.5	-1.7	-2.2	-2.3	-2.2	-2.3	-2.4
Medication: Paracetamol	2.8	4.6	11.4	-2.3	-2.2	-2.2	-2.6	-0.3	-2.1	-1.6	-1.8	-2.2	-2.7	-2.2	-1.7	-3.4	-2.2	-2.2	-2.9	-1.2	-2.3	-2.1	-1.6	-2.2	-2.1	-1.5	-2.2	-2.1
Mineral and other dietary supplements	2.8	3.8	6.9	1.4	1.9	2.3	1.9	1.4	1.9	1.7	2.6	1.8	2.2	1.9	1.5	2.0	1.8	1.7	1.8	1.9	1.9	1.8	2.6	2.1	1.8	2.4	1.9	2.0
Medication: Atenolol	2.7	3.4	5.1	1.3	2.1	2.1	2.1	0.6	2.1	1.9	1.6	2.1	1.2	2.0	1.8	0.7	2.1	2.0	1.7	2.3	2.1	2.0	1.9	0.6	2.2	1.6	2.1	1.9
Financial difficulties in last 2 years	2.7	3.7	4.9	1.7	2.2	2.2	2.0	1.3	2.1	2.0	1.8	2.2	1.7	2.1	1.8	1.7	2.1	2.1	1.3	1.8	2.1	2.0	1.9	1.2	2.2	1.5	2.2	2.0
Impedance of leg (right)	2.6	12.6	27.9	-3.0	-3.2	-3.6	-2.9	-0.3	-3.1	-0.1	-5.1	-2.8	-5.0	-3.5	-2.5	-5.2	-3.2	-2.9	-4.5	-2.6	-3.1	-1.1	-5.3	-3.6	-3.1	-5.2	-3.4	-3.8
Arm fat-free mass (right)	2.6	13.5	27.1	2.7	3.6	3.8	3.8	2.1	3.5	2.5	4.7	3.4	4.5	3.7	3.0	5.2	3.5	3.5	4.2	2.5	3.7	2.8	4.5	3.8	3.4	4.2	3.6	3.7
Number of full sisters	2.6	3.1	4.5	1.0	2.1	1.8	1.9	1.4	1.9	1.9	1.4	2.1	1.3	2.1	1.7	1.1	2.0	1.9	1.2	1.9	2.1	1.9	1.8	1.4	2.1	1.7	2.1	1.8
Impedance of leg (left)	2.5	12.1	26.1	-2.9	-3.2	-3.7	-2.9	-0.5	-3.1	-0.3	-5.1	-2.8	-4.9	-3.5	-2.5	-4.9	-3.2	-2.9	-4.3	-2.6	-3.1	-1.1	-5.1	-3.5	-3.1	-5.0	-3.3	-3.7
Allergy	2.5	5.6	23.1	-2.5	-2.1	-2.2	-1.8	-4.2	-2.3	-4.8	-2.0	-2.5	-1.2	-1.9	-1.4	-0.7	-2.0	-2.6	-1.9	-2.4	-2.3	-2.9	-0.4	-3.4	-2.1	-1.7	-1.9	-1.7
Medication: Simvastatin	2.5	3.7	5.7	1.8	1.8	1.8	2.3	1.5	1.9	1.6	2.2	1.8	2.4	1.9	1.9	2.4	1.9	2.0	2.2	1.7	1.9	1.6	2.3	1.0	1.8	2.1	1.9	2.0
Medication: Ventolin 100micrograms inhaler	2.5	3.2	12.7	1.1	1.7	1.8	1.5	1.4	1.9	3.6	2.1	2.0	1.2	1.6	0.9	0.6	1.6	2.2	1.7	2.0	1.9	2.5	0.5	1.7	1.7	1.6	1.6	1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	2.5	3.3	5.0	1.4	1.8	1.8	1.8	1.0	1.8	1.9	2.1	1.8	2.1	1.9	1.6	1.9	1.8	1.8	1.8	1.5	1.9	1.6	2.2	1.7	1.8	1.9	1.9	2.0
Medication: Bendroflumethiazide	2.4	3.6	7.8	2.0	1.9	2.0	1.8	0.1	2.0	2.0	1.9	2.0	2.6	1.9	1.6	2.8	1.9	2.1	2.3	1.1	2.0	1.7	1.2	1.9	1.9	1.2	1.9	1.9
Arm fat-free mass (left)	2.4	12.4	28.9	2.5	3.3	3.6	3.6	2.2	3.3	2.5	4.6	3.2	4.5	3.4	2.8	5.4	3.3	3.3	4.2	2.1	3.5	2.9	4.1	3.7	3.1	4.0	3.4	3.5
Blood Eosinophil Count	2.3	17.6	54.3	2.8	4.0	4.1	4.5	5.3	4.2	7.4	4.5	4.5	2.8	3.9	3.5	2.3	3.9	4.6	3.8	4.8	4.4	3.8	3.3	4.4	4.0	4.3	3.9	3.6
Multivitamins +/- minerals	2.3	2.9	5.0	-1.5	-1.7	-1.6	-1.9	-1.4	-1.7	-1.9	-1.6	-1.8	-1.8	-1.7	-1.2	-1.5	-1.8	-1.8	-2.2	-1.6	-1.8	-1.6	-1.7	-1.9	-1.7	-1.5	-1.8	-1.8
Number of children fathered	2.3	2.6	6.5	-1.5	-1.7	-1.8	-1.6	-1.3	-1.8	-1.4	-1.0	-1.7	-1.5	-1.5	-1.5	-1.4	-1.7	-1.7	-1.6	-2.1	-1.6	-2.0	-1.4	-2.6	-1.6	-1.4	-1.6	-1.4
Arm predicted mass (right)	2.3	11.5	26.3	2.5	3.3	3.5	3.5	1.7	3.2	2.2	4.3	3.1	4.3	3.4	2.8	5.1	3.2	3.2	4.0	2.2	3.4	2.5	4.2	3.4	3.1	3.8	3.3	3.4
Illness, injury, bereavement, stress in last 2 years	2.3	2.8	4.3	-1.5	-1.9	-2.1	-1.7	-1.7	-2.0	-2.1	-1.1	-1.9	-1.2	-1.7	-1.9	-1.2	-1.8	-1.9	-0.8	-1.5	-1.9	-2.0	-1.5	-1.6	-1.9	-0.7	-1.9	-1.7
Eye problems/disorders: Cataract	2.3	2.6	4.3	-2.1	-1.8	-2.0	-1.2	-0.3	-1.8	-2.1	-1.7	-1.8	-1.4	-1.7	-1.0	-1.3	-1.7	-1.7	-1.6	-1.7	-1.7	-1.6	-1.8	-1.5	-1.8	-1.2	-1.7	-1.6
Medication: Aspirin	2.3	3.0	6.0	2.1	1.9	2.0	1.8	1.7	1.9	1.8	1.3	1.9	1.1	1.8	2.4	0.8	1.9	2.0	0.8	2.2	1.7	1.5	1.3	0.9	2.0	1.4	1.9	1.8
High blood pressure (siblings)	2.2	3.2	6.7	1.3	1.7	1.5	1.6	-1.2	1.6	0.8	2.2	1.7	2.4	1.9	1.8	2.6	1.7	1.7	2.4	1.4	2.0	1.2	1.6	2.0	1.7	2.2	1.8	1.9
Number of operations (self-reported)	2.2	3.3	11.1	0.1	1.7	1.8	1.5	0.3	1.9	2.9	1.8	2.0	2.2	1.6	1.5	2.1	1.7	2.1	3.3	1.2	2.1	1.8	0.5	2.3	1.7	0.9	1.7	1.5
Hearing difficulty/problems: Yes	2.1	3.2	11.9	-0.1	1.8	1.7	1.3	-0.4	1.8	1.8	1.8	1.8	2.9	1.7	0.8	3.0	1.7	1.9	3.4	0.8	2.0	1.5	0.9	2.0	1.7	1.0	1.7	1.4
Overall health rating	2.1	4.5	9.3	1.7	2.1	2.2	1.9	1.0	2.2	3.0	2.1	2.3	2.5	2.1	1.9	2.8	2.1	2.3	2.5	1.5	2.2	1.9	1.5	2.5	2.1	1.5	2.1	1.9
Arm predicted mass (left)	2.1	10.8	25.6	2.4	3.1	3.4	3.3	2.1	3.0	2.2	4.4	2.9	4.2	3.2	2.6	5.1	3.0	3.1	3.9	1.9	3.2	2.5	4.0	3.3	2.9	3.9	3.2	3.3
Average weekly fortified wine intake	2.0	2.3	4.7	-0.7	-1.6	-1.6	-1.5	-1.2	-1.6	-1.8	-2.0	-1.6	-1.7	-1.6	-1.0	-1.6	-1.5	-1.6	-2.2	-1.4	-1.6	-0.9	-0.6	-1.4	-1.5	-1.8	-1.5	-1.7
Health satisfaction	2.0	2.6	3.6	1.6	1.7	1.9	1.2	0.2	1.8	1.4	1.4	1.7	1.7	1.6	1.8	1.7	1.8	1.7	1.2	1.4	1.7	1.7	1.9	1.9	1.7	1.4	1.7	1.5
Neck or shoulder pain in last month	2.0	2.9	4.8	-1.6	-1.8	-1.7	-2.1	-2.1	-1.7	-2.1	-1.6	-1.9	-1.3	-1.7	-1.9	-1.1	-1.7	-1.8	-1.1	-1.7	-1.8	-2.2	-1.2	-1.0	-1.8	-1.4	-1.8	-1.6
Whole body fat-free mass	2.0	11.2	24.3	2.3	3.1	3.5	3.3	2.2	3.1	2.4	4.5	3.0	4.2	3.2	2.9	4.9	3.0	3.1	4.0	2.1	3.3	2.4	4.0	3.9	2.9	4.0	3.1	3.3
Back pain experienced in last month	2.0	3.0	11.0	-2.6	-1.6	-1.6	-2.1	-3.3	-1.6	-1.1	-1.1	-1.6	-0.8	-1.6	-1.9	-0.4	-1.6	-1.6	-0.0	-1.9	-1.4	-3.0	-1.1	-0.7	-1.7	-1.2	-1.6	-1.8
Whole body water mass	2.0	11.5	25.0	2.4	3.1	3.5	3.4	2.1	3.1	2.4	4.6	3.0	4.3	3.3	2.9	5.0	3.1	3.2	4.0	2.1	3.3	2.5	4.1	3.8	3.0	4.0	3.2	3.3
Irritability	2.0	3.3	7.3	1.7	2.0	1.9	1.8	1.9	2.0	2.3	0.9	2.0	1.1	1.9	2.7	1.7	2.0	1.9	0.8	1.5	1.9	1.8	2.3	1.2	2.0	1.2	2.0	1.7
Blood White Count	1.9	14.1	19.7	4.4	3.9	4.0	4.2	2.7	4.0	2.7	3.8	3.8	3.2	4.0	3.8	2.8	4.0	3.9	2.4	4.2	3.8	3.5	4.2	3.0	4.0	4.1	4.1	4.0
Taking other prescription medications	1.9	3.0	10.0	1.0	1.4	1.5	1.5	2.3	1.7	3.2	1.1	1.7	1.8	1.4	1.5	2.3	1.4	1.9	2.2	0.8	1.8	2.4	0.6	2.1	1.4	0.7	1.4	1.4
Number of full brothers	1.9	2.4	4.1	1.7	1.5	1.5	1.3	-0.2	1.5	1.2	1.8	1.5	1.9	1.6	1.7	1.6	1.6	1.5	1.6	1.2	1.5	1.5	2.0	1.1	1.6	1.6	1.6	1.6
Pain experienced in last month	1.9	3.1	5.8	2.0	1.9	1.8	1.9	2.4	1.8	1.4	1.4	1.8	1.6	1.8	2.1	1.4	1.8	1.8	1.2	1.7	1.7	2.3	1.3	1.4	1.8	1.4	1.8	1.9
Impedance of whole body	1.9	9.9	26.6	-2.2	-2.8	-3.1	-2.3	1.6	-2.6	0.7	-4.6	-2.3	-4.7	-3.1	-2.0	-5.2	-2.8	-2.4	-4.4	-1.9	-2.6	-0.2	-4.8	-2.5	-2.7	-4.4	-3.0	-3.3
Medication: Ibuprofen (e.g. Nurofen)	1.8	2.3	4.4	-1.5	-1.5	-1.4	-1.8	-1.1	-1.4	-0.9	-1.5	-1.5	-1.9	-1.7	-1.2	-2.1	-1.6	-1.5	-1.4	-1.1	-1.6	-1.6	-1.6	-0.8	-1.5	-1.5	-1.6	-1.9
Pulse wave reflection index	1.8	2.2	3.2	0.9	1.6	1.5	1.4	0.9	1.6	1.7	1.1	1.6	1.6	1.5	1.2	1.8	1.6	1.6	1.6	1.1	1.8	1.6	1.1	1.7	1.6	1.1	1.6	1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.8	3.9	7.0	0.9	2.2	2.4	1.8	0.3	2.3	2.7	1.4	2.3	2.2	2.1	2.2	2.3	2.1	2.2	2.2	1.6	2.3	1.6	1.1	1.8	2.1	1.1	2.1	1.9
Other serious medical condition/disability diagnosed by doctor	1.7	2.2	5.8	1.1	1.3	1.2	1.2	0.7	1.3	2.0	1.4	1.5	1.7	1.3	0.7	2.2	1.3	1.6	2.4	1.0	1.6	1.2	1.4	2.4	1.3	1.1	1.4	1.2
Impedance of arm (right)	1.7	7.8	22.1	-1.9	-2.5	-2.6	-2.1	2.7	-2.3	1.0	-3.7	-2.0	-4.1	-2.8	-1.5	-4.7	-2.6	-2.1	-4.2	-1.7	-2.3	0.2	-4.3	-1.7	-2.5	-3.5	-2.7	-2.9
Medication: Aspirin	1.7	2.3	4.7	2.0	1.7	1.8	1.6	1.5	1.7	1.4	1.0	1.7	1.0	1.6	2.2	0.8	1.7	1.8	0.7	1.9	1.5	1.3	1.0	0.7	1.8	1.0	1.7	1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.7	2.0	5.3	0.7	1.3	1.3	1.1	0.6	1.2	0.8	2.2	1.3	1.7	1.5	1.2	1.5	1.2	1.5	1.8	1.4	1.4	1.0	1.2	1.4	1.3	2.3	1.4	1.6
Primary Biliary Cirrhosis	1.6	2.3	4.1	1.0	1.6	1.5	1.7	-0.1	1.6	1.5	1.5	1.6	1.6	1.6	1.8	2.0	1.6	1.7	1.9	1.2	1.7	1.5	1.3	1.0	1.6	1.1	1.6	1.5
Ever used hormone-replacement therapy (HRT)	1.6	2.0	3.4	-1.5	-1.5	-1.5	-1.7	-1.4	-1.5	-1.1	-1.7	-1.4	-1.1	-1.5	-1.2	-0.8	-1.5	-1.5	-0.8	-1.8	-1.3	-1.5	-0.8	-0.9	-1.5	-1.8	-1.5	-1.6
Wheeze or whistling in the chest in last year	1.6	2.9	10.5	1.8	1.4	1.4	1.4	2.2	1.6	3.2	2.1	1.8	1.2	1.5	0.2	0.7	1.4	1.9	1.6	1.7	1.6	2.1	0.2	2.4	1.5	1.7	1.4	1.5
Ever had stillbirth, spontaneous miscarriage or termination	1.6	1.7	3.4	1.1	1.5	1.7	1.3	1.1	1.5	0.8	1.6	1.4	0.8	1.4	1.4	0.4	1.5	1.4	0.6	1.8	1.2	1.1	1.4	0.7	1.5	1.3	1.5	1.5
Wears glasses or contact lenses	1.6	1.9	3.7	-1.7	-1.4	-1.4	-1.5	-0.8	-1.4	-1.1	-1.3	-1.4	-0.9	-1.4	-1.6	-0.5	-1.4	-1.4	-0.8	-1.6	-1.4	-1.4	-1.6	-1.9	-1.5	-1.2	-1.4	-1.4
HDL Cholesterol	1.5	2.5	9.4	-1.7	-1.4	-1.4	-1.3	0.6	-1.4	-0.3	-1.7	-1.2	-2.4	-1.6	-0.9	-3.1	-1.5	-1.3	-1.7	-0.8	-1.3	-1.7	-2.4	-1.0	-1.3	-1.9	-1.5	-1.7
Heel T-Score	1.5	12.2	30.9	-1.4	-3.3	-3.2	-3.7	-3.1	-3.4	-5.4	-3.5	-3.6	-3.7	-3.2	-4.3	-3.1	-3.2	-3.9	-3.9	-2.5	-3.8	-5.6	-0.3	-3.6	-3.2	-2.2	-3.2	-3.2
Type 2 Diabetes (T2D) (2018)	1.5	2.9	4.6	2.0	1.6	1.9	1.7	1.3	1.6	1.1	2.1	1.5	2.0	1.7	1.8	1.9	1.6	1.5	1.2	1.5	1.5	1.9	2.0	1.3	1.6	2.1	1.6	1.8
Eye problems/disorders: Diabetes related eye disease	1.5	1.6	2.9	1.7	1.4	1.3	1.3	0.8	1.4	1.1	1.1	1.4	1.1	1.4	1.4	1.0	1.4	1.3	1.1	1.4	1.3	1.1	1.2	1.1	1.4	1.2	1.4	1.4
Serious illness, injury or assault to yourself	1.5	1.8	3.7	0.5	1.4	1.4	1.5	1.4	1.6	1.9	0.9	1.5	1.0	1.3	1.8	1.0	1.5	1.6	1.2	1.3	1.6	1.9	0.7	1.1	1.4	0.5	1.4	1.2
Impedance of arm (left)	1.5	7.0	22.9	-1.6	-2.3	-2.4	-1.8	2.6	-2.1	0.9	-3.8	-1.8	-4.2	-2.6	-1.2	-4.8	-2.3	-1.8	-4.2	-1.3	-2.1	0.3	-3.9	-1.7	-2.2	-3.4	-2.4	-2.7
Loud music exposure frequency	1.5	1.6	3.5	-1.0	-1.3	-1.2	-1.6	-1.1	-1.3	-1.0	-1.2	-1.3	-1.1	-1.4	-1.4	-0.4	-1.3	-1.4	-1.1	-1.9	-1.4	-0.8	-0.7	-1.4	-1.4	-1.5	-1.3	-1.5
Qualifications: O levels/GCSEs or equivalent	1.5	2.5	8.0	-2.8	-1.6	-1.7	-1.4	-2.8	-1.6	-2.1	-0.5	-1.6	-0.6	-1.5	-1.7	-0.5	-1.5	-1.5	-0.2	-1.5	-1.3	-2.0	-0.6	-1.7	-1.6	-0.6	-1.5	-1.3
Knee pain experienced in last month	1.5	2.4	3.9	1.2	1.6	1.3	1.6	0.3	1.6	1.7	2.0	1.7	1.2	1.7	1.1	0.9	1.7	1.6	1.6	1.9	1.6	1.6	1.5	1.5	1.7	1.9	1.7	1.7
Medication: Gliclazide	1.5	1.7	3.4	1.4	1.2	1.3	1.2	0.2	1.2	1.0	1.7	1.2	1.1	1.3	1.8	1.1	1.2	1.4	1.0	1.4	1.4	1.1	1.6	1.1	1.3	1.6	1.3	1.4
Mother’s age at death	1.5	1.9	4.8	-0.3	-1.2	-1.2	-0.9	1.4	-1.2	-1.7	-2.0	-1.3	-2.0	-1.3	-0.9	-1.5	-1.2	-1.3	-2.2	-0.9	-1.4	-1.0	-1.5	-1.6	-1.2	-1.4	-1.2	-1.3
Medication: Paracetamol	1.5	2.3	7.2	-1.5	-1.5	-1.6	-1.8	0.6	-1.5	-1.1	-1.4	-1.5	-2.1	-1.4	-0.9	-2.7	-1.5	-1.4	-2.2	-0.6	-1.5	-1.6	-1.2	-1.3	-1.4	-0.8	-1.5	-1.3
Crohns Disease (2012)	1.4	2.3	5.4	1.0	1.5	1.3	1.8	1.8	1.6	2.3	1.2	1.8	1.2	1.3	1.2	1.3	1.5	1.8	1.6	1.5	1.6	2.1	0.2	1.6	1.6	0.6	1.5	1.2
Chronotype (morning person)	1.4	3.2	6.2	2.0	1.6	1.5	1.3	0.9	1.5	1.5	2.5	1.6	2.4	1.8	1.4	2.1	1.6	1.8	2.0	1.8	1.6	1.1	1.7	2.2	1.6	2.4	1.6	1.9
Frequency of depressed mood in last 2 weeks	1.4	2.0	4.0	-1.5	-1.3	-1.4	-1.4	-2.0	-1.2	-1.3	-1.9	-1.4	-1.3	-1.3	-1.3	-1.0	-1.2	-1.5	-1.0	-1.3	-1.3	-1.6	-1.5	-1.6	-1.3	-1.7	-1.3	-1.5
Alcohol usually taken with meals	1.4	2.3	4.1	-1.5	-1.6	-1.8	-2.0	-1.2	-1.7	-2.0	-1.5	-1.7	-1.1	-1.5	-1.0	-0.9	-1.7	-1.6	-1.2	-1.7	-1.6	-1.8	-1.0	-0.7	-1.6	-1.1	-1.6	-1.5
Diabetes (self-reported)	1.4	2.2	3.6	1.5	1.5	1.8	1.6	1.0	1.6	1.1	1.5	1.4	1.7	1.4	1.7	1.9	1.5	1.4	1.1	1.1	1.4	1.7	1.9	1.0	1.4	1.3	1.5	1.5
Diabetes diagnosed by doctor	1.4	2.4	3.5	1.5	1.6	1.8	1.8	1.6	1.7	1.4	1.2	1.6	1.6	1.6	1.8	1.8	1.6	1.6	1.1	1.2	1.6	1.9	1.6	0.6	1.6	1.0	1.6	1.5
Medication: Metformin	1.3	1.9	3.1	1.1	1.4	1.4	1.7	1.1	1.4	1.1	1.5	1.4	1.4	1.3	1.8	1.6	1.4	1.4	1.1	1.1	1.5	1.3	1.2	1.3	1.4	1.1	1.4	1.3
Forced vital capacity (FVC)	1.3	5.1	25.3	1.8	2.1	2.3	2.3	3.1	2.3	5.0	2.1	2.5	1.3	1.9	2.1	1.1	2.0	2.6	1.6	2.0	2.2	1.7	0.9	2.9	2.0	1.1	2.0	1.7
Eye problems/disorders: None of the above	1.3	1.5	3.6	0.8	1.3	1.5	0.8	-0.4	1.3	1.2	1.3	1.3	1.8	1.2	1.0	1.7	1.2	1.2	1.9	0.8	1.2	0.8	1.6	1.4	1.2	0.6	1.2	1.1
Mouth/teeth dental problems: Loose teeth	1.3	1.5	4.0	0.7	1.0	1.0	1.2	0.1	1.0	0.6	1.8	1.0	1.4	1.2	0.8	1.4	1.1	1.0	1.3	1.1	1.1	1.2	1.8	1.6	1.0	2.0	1.2	1.2
Angina (self-reported)	1.3	1.7	3.6	1.4	1.2	1.3	1.5	0.8	1.3	0.8	1.7	1.2	1.2	1.3	1.8	0.7	1.3	1.3	1.4	1.4	1.2	0.7	1.0	1.9	1.2	1.4	1.2	1.5
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.7	5.1	-1.3	-1.8	-1.5	-1.7	-0.3	-1.8	-0.2	-1.1	-1.7	-2.0	-1.9	-1.9	-2.3	-2.0	-1.6	-1.7	-1.7	-1.7	-1.4	-2.0	0.2	-1.9	-1.5	-1.9	-1.9
Smoking status: Current	1.3	2.1	4.8	1.8	1.3	1.5	1.2	1.1	1.4	2.1	2.0	1.3	1.4	1.3	0.9	1.1	1.3	1.4	1.6	1.3	1.1	1.4	1.2	2.2	1.3	1.7	1.3	1.5
Coronary Artery Disease (CAD)	1.2	1.4	5.8	2.4	1.1	1.2	1.2	0.2	1.1	0.4	1.1	0.8	0.8	1.4	1.3	1.2	1.2	1.1	0.3	0.8	1.2	1.1	2.2	0.3	1.1	1.4	1.1	1.3
Number of treatments/medications taken	1.2	2.1	6.6	1.0	1.4	1.5	1.2	1.0	1.6	2.6	0.8	1.6	1.5	1.2	1.5	1.9	1.4	1.7	2.4	0.9	1.5	1.6	0.2	1.2	1.3	0.4	1.3	1.1
Angina	1.2	1.6	3.0	1.2	1.2	1.2	1.4	0.7	1.3	0.8	1.6	1.1	1.1	1.3	1.7	0.6	1.3	1.3	1.4	1.4	1.2	0.7	1.0	1.7	1.2	1.4	1.2	1.4
Number of live births	1.2	1.7	2.6	-1.5	-1.3	-1.2	-1.4	-1.4	-1.3	-1.1	-1.4	-1.3	-1.4	-1.4	-1.0	-1.2	-1.4	-1.4	-0.9	-1.4	-1.2	-1.2	-1.6	-0.2	-1.3	-1.5	-1.3	-1.5
Hearing aid user	1.2	1.4	2.8	-1.4	-1.1	-1.4	-1.6	-0.9	-1.2	-0.6	-1.3	-1.0	-0.5	-1.2	-1.6	-0.2	-1.2	-1.1	-0.2	-1.7	-0.9	-1.1	-1.3	-1.4	-1.1	-1.5	-1.1	-1.3
Medication: Blood pressure	1.2	2.3	4.1	1.4	1.7	1.7	1.3	0.1	1.7	1.8	0.9	1.7	1.8	1.6	1.3	1.9	1.6	1.7	2.0	1.3	1.6	1.7	1.0	1.3	1.6	0.7	1.6	1.3
Ever had prostate specific antigen (PSA) test	1.2	1.3	4.0	0.5	1.0	1.2	0.9	-0.2	1.0	1.3	1.3	1.0	1.5	1.0	1.0	1.3	0.9	1.1	2.0	0.9	1.0	0.3	1.4	2.0	0.9	1.4	0.9	1.2
Pain all over the body in last month	1.1	1.2	2.8	-1.6	-1.1	-0.9	-0.8	-1.7	-1.0	-0.9	-1.4	-1.1	-1.2	-1.2	-1.0	-1.0	-1.0	-1.0	-0.5	-1.1	-0.9	-0.8	-0.9	-0.6	-1.1	-1.6	-1.1	-1.2
Hayfever/allergic rhinitis (self-reported)	1.1	1.5	6.1	-1.0	-0.9	-1.1	-0.8	1.4	-0.8	0.8	-1.8	-0.7	-1.9	-1.0	-0.9	-2.1	-0.9	-0.7	-1.6	-0.4	-0.8	-0.2	-2.5	-0.9	-0.8	-1.5	-1.0	-1.3
Forced expiratory volume in 1-second (FEV1)	1.1	3.6	11.5	1.4	2.0	2.2	2.1	2.0	2.1	3.4	1.7	2.1	1.4	1.8	1.9	1.4	1.9	2.2	1.4	1.7	2.0	1.4	1.0	2.4	1.9	1.0	1.8	1.6
Medication: Seretide 50 evohaler	1.1	1.2	6.7	1.2	0.9	0.7	0.7	2.2	0.9	2.6	1.0	1.1	0.3	0.9	0.5	0.1	0.8	1.3	0.3	1.3	1.0	1.3	0.4	1.2	0.9	1.0	0.8	0.9
Tinnitus: Yes, now most or all of the time	1.1	1.3	3.0	-1.7	-1.2	-1.2	-1.5	-1.0	-1.1	-0.4	-1.2	-1.1	-0.5	-1.3	-1.1	-0.3	-1.2	-1.0	0.1	-1.2	-1.1	-1.0	-1.7	-0.6	-1.3	-1.5	-1.3	-1.4
Relative age voice broke	1.0	1.5	4.6	-1.4	-1.0	-1.1	-1.3	-2.1	-1.1	-1.3	-0.8	-1.1	-1.7	-1.1	-0.6	-2.1	-1.0	-1.0	-1.3	-0.5	-1.0	-1.1	-0.8	-1.6	-0.9	-1.0	-1.0	-1.2
High blood pressure (mother)	1.0	1.4	2.5	0.9	1.5	1.4	1.2	0.3	1.4	1.0	0.7	1.4	1.3	1.4	1.3	1.6	1.4	1.4	1.2	0.7	1.4	0.6	1.0	0.3	1.4	0.6	1.4	1.2
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.1	2.5	0.2	-1.1	-0.8	-1.4	-0.7	-1.1	-0.2	-0.8	-1.1	-0.9	-1.1	-1.1	-1.0	-1.3	-1.1	-1.6	-1.4	-1.1	-1.5	-1.0	-0.2	-1.2	-1.0	-1.2	-0.9
Average weekly red wine intake	1.0	1.5	3.8	1.7	1.2	1.1	1.1	1.3	1.1	1.3	0.4	1.2	1.7	1.2	1.6	1.9	1.1	1.3	1.2	0.6	1.3	0.7	1.1	1.6	1.1	0.5	1.1	1.2
Medication: Atorvastatin	1.0	1.2	4.3	1.0	1.2	1.1	1.2	2.1	1.2	1.9	0.0	1.3	0.2	1.0	1.4	0.2	1.2	1.3	0.6	1.2	1.1	1.1	-0.3	0.6	1.2	-0.1	1.1	0.8
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	3.6	-0.1	1.2	1.0	1.1	-0.3	1.2	1.3	0.7	1.2	1.2	1.2	1.2	1.3	1.2	1.3	1.9	0.9	1.4	1.2	0.3	0.9	1.2	0.6	1.2	0.9
Alzheimer’s Disease (in father)	0.9	1.0	2.1	-0.1	1.0	0.9	1.2	0.7	1.1	1.5	1.2	1.1	0.6	0.9	1.3	0.5	1.0	1.1	1.4	0.9	1.2	1.1	0.6	1.1	1.0	0.7	1.0	0.8
Major Depression (MDD)	0.9	1.1	3.1	-1.8	-1.2	-1.2	-1.1	-1.4	-1.2	-0.7	-0.4	-1.2	-0.6	-1.2	-0.9	-0.8	-1.3	-1.1	-0.3	-1.2	-1.0	-1.2	-1.0	-0.9	-1.2	-0.6	-1.2	-1.0
HbA1C	0.9	1.0	2.4	1.4	0.8	1.2	0.6	0.8	1.1	0.6	1.1	-0.3	1.4	1.2	1.1	0.8	0.9	1.1	1.0	0.4	1.1	0.7	1.2	1.5	0.4	1.1	-0.2	1.3
Schizophrenia (2014)	0.9	2.0	5.8	1.4	1.2	1.3	1.3	0.2	1.3	1.2	1.9	1.2	2.0	1.4	0.5	2.4	1.2	1.4	2.1	0.6	1.3	1.8	1.2	1.7	1.2	1.4	1.2	1.3
Diabetes (father)	0.9	1.1	3.8	1.6	0.8	1.1	0.6	0.6	0.8	0.9	1.3	0.8	1.5	0.9	0.4	2.0	0.8	0.8	0.7	0.4	0.9	0.7	1.2	1.2	0.7	1.3	0.9	0.9
Bilateral oophorectomy (both ovaries removed)	0.9	1.1	8.9	-0.6	-1.0	-1.1	-0.9	-3.0	-1.0	-1.2	-0.4	-1.0	-0.2	-0.9	-1.2	-0.3	-1.0	-0.9	0.4	-0.9	-0.9	-1.1	-0.4	-0.4	-1.0	-0.6	-0.9	-0.8
Father’s age at death	0.9	1.2	5.5	-2.4	-1.1	-1.2	-0.9	-1.3	-1.0	-0.8	-1.1	-1.1	-0.3	-1.2	-1.3	0.1	-1.0	-1.1	0.3	-1.3	-0.9	-0.8	-0.8	-0.7	-1.2	-1.2	-1.1	-1.3
Financial situation satisfaction	0.9	1.1	2.1	1.3	1.2	1.0	0.8	1.3	1.1	1.0	0.5	1.2	0.1	1.1	1.4	-0.0	1.2	1.1	-0.3	1.4	1.0	1.0	1.1	0.4	1.3	0.6	1.2	1.1
Average weekly beer plus cider intake	0.9	1.3	3.3	1.5	1.2	1.2	1.3	1.8	1.1	1.1	1.2	1.1	0.7	1.2	1.0	0.6	1.2	1.1	0.2	1.3	1.0	0.7	1.5	0.6	1.2	1.3	1.2	1.2
Schizophrenia (2018)	0.8	1.6	4.4	1.5	1.0	1.2	1.0	0.3	1.0	1.1	2.1	1.0	1.6	1.1	0.4	1.7	0.9	0.9	1.6	0.7	1.0	1.6	1.6	1.4	0.9	1.7	1.0	1.1
Waist Hip Ratio (WHR)	0.8	3.6	27.7	2.0	1.6	1.6	1.5	3.4	1.9	5.3	0.6	2.0	1.1	1.3	1.4	1.6	1.5	2.1	0.8	0.9	1.8	2.3	-0.6	1.9	1.5	-0.3	1.3	1.0
Systolic Blood Pressure	0.8	3.9	7.0	-1.0	-1.9	-1.9	-2.4	-1.9	-2.0	-2.2	-2.0	-2.0	-1.6	-1.9	-1.4	-1.7	-2.0	-1.9	-1.8	-2.0	-2.2	-2.6	-2.0	-2.4	-1.9	-2.1	-2.0	-1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.0	1.5	-1.1	-1.0	-0.9	-1.0	-0.8	-1.0	-1.0	-1.1	-1.0	-1.2	-1.0	-1.1	-1.1	-1.0	-1.1	-1.0	-0.8	-1.0	-1.0	-1.0	-0.7	-1.0	-1.0	-1.0	-1.2
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	1.8	0.9	1.0	1.1	0.8	0.2	1.1	1.1	1.0	1.0	0.9	1.0	0.6	0.8	1.0	1.0	0.8	0.7	1.0	1.0	1.3	0.3	1.0	0.6	1.1	1.0
Fluid intelligence score	0.8	1.7	4.7	-1.5	-1.3	-1.0	-0.9	-1.6	-1.2	-1.0	-0.8	-1.3	-0.0	-1.3	-1.4	0.6	-1.3	-1.1	0.3	-2.0	-1.0	-2.2	-1.6	-0.9	-1.4	-1.4	-1.3	-1.4
Trunk fat-free mass	0.8	4.7	14.5	1.0	1.8	2.1	2.0	1.0	1.8	1.3	3.3	1.7	3.0	1.9	1.8	3.8	1.7	1.9	3.0	0.9	2.0	1.1	2.8	2.7	1.6	2.7	1.8	2.0
Falls in the last year	0.8	1.1	3.4	-1.8	-1.0	-1.2	-0.9	0.1	-0.9	0.5	-1.5	-0.8	-1.2	-1.2	-0.5	-0.7	-1.0	-0.9	-0.7	-0.9	-0.7	-0.6	-1.3	-1.2	-1.1	-1.5	-1.0	-1.3
Trunk predicted mass	0.8	4.7	14.7	1.0	1.8	2.1	2.0	0.9	1.8	1.4	3.3	1.7	3.1	1.9	1.8	3.8	1.7	1.9	3.1	0.9	2.0	1.2	2.8	2.7	1.6	2.7	1.8	2.0
Illnesses of father: None of the above (group 1)	0.8	1.0	2.5	-1.4	-0.8	-0.7	-0.7	0.5	-0.8	-1.3	-1.5	-0.8	-1.5	-0.9	-0.9	-1.5	-0.8	-0.9	-1.6	-0.3	-0.8	-0.3	-0.8	-1.6	-0.7	-1.0	-0.7	-1.0
Mean Putamen Volume	0.7	0.8	1.5	0.1	-1.0	-1.0	-1.2	-0.2	-1.1	-1.0	-0.7	-1.0	-0.7	-0.9	-1.2	-0.4	-1.1	-0.9	-0.8	-0.9	-1.0	-1.0	-0.5	-0.0	-1.0	-0.4	-1.0	-1.0
Allergy or Eczema	0.7	1.8	9.9	0.5	0.9	0.7	0.7	3.1	1.1	3.2	0.3	1.3	0.3	0.7	0.3	-0.1	0.9	1.4	1.4	1.5	1.1	1.9	-0.8	2.2	0.9	0.4	0.8	0.4
Hand grip strength (left)	0.7	1.8	3.6	0.5	1.4	1.4	1.4	-1.5	1.3	0.3	1.9	1.2	1.5	1.4	1.4	1.4	1.4	1.2	1.9	0.8	1.4	-0.1	1.7	1.2	1.4	1.1	1.4	1.5
Current tobacco smoking	0.7	1.1	3.3	1.4	0.8	1.1	0.7	0.7	0.9	1.4	1.8	0.8	0.9	0.9	0.4	0.5	0.8	0.9	1.1	1.0	0.7	1.0	1.0	1.6	0.8	1.5	0.9	1.1
Stomach or abdominal pain in last month	0.7	0.9	2.6	0.7	1.0	0.7	0.8	0.1	0.9	0.8	0.7	1.0	0.6	1.0	1.3	0.6	1.0	1.1	0.8	0.9	1.2	1.6	1.0	1.4	1.1	0.6	1.0	0.8
Hair/balding pattern: Pattern 3	0.7	1.0	3.4	0.0	1.0	0.5	0.6	-1.7	0.8	0.3	1.5	0.9	1.3	1.0	0.7	0.9	0.9	0.8	1.8	0.9	1.1	0.4	1.4	0.2	1.0	1.3	1.0	1.1
Qualifications: A levels/AS levels or equivalent	0.7	1.5	4.8	-0.9	-1.2	-1.1	-1.2	-1.3	-1.2	-2.2	-0.8	-1.3	-1.2	-1.1	-1.3	-1.3	-1.1	-1.3	-1.1	-0.9	-1.3	-1.7	-0.7	-1.3	-1.2	-0.7	-1.1	-1.0
Forced vital capacity (FVC), Best measure	0.7	2.5	16.0	1.5	1.3	1.6	1.4	2.7	1.5	4.0	1.5	1.7	0.8	1.1	1.0	0.6	1.2	1.8	1.1	1.1	1.4	0.9	0.1	2.3	1.2	0.6	1.2	1.0
Ever had bowel cancer screening	0.7	0.9	3.2	0.8	0.7	0.3	0.7	0.2	0.6	0.3	1.1	0.7	1.4	0.9	-0.0	1.3	0.8	0.8	1.8	0.7	0.9	0.5	1.3	1.4	0.7	1.2	0.8	1.0
Neuroticism (2016)	0.6	0.9	2.1	-0.7	-0.9	-1.2	-0.7	-0.5	-1.1	-1.2	-1.0	-0.9	-1.2	-0.8	-0.3	-0.7	-0.9	-0.9	-1.4	-0.9	-0.7	-0.9	-0.7	-1.3	-0.8	-1.1	-0.8	-1.2
Type 2 Diabetes (T2D) (2012)	0.6	0.7	3.0	0.9	0.8	0.5	0.3	-0.0	0.7	0.1	1.1	0.6	1.3	1.1	0.5	1.7	0.8	0.9	0.7	0.6	1.0	1.0	0.9	0.4	0.8	0.9	0.6	0.3
Blood Red Count	0.6	6.2	19.3	3.2	2.4	2.2	2.3	1.9	2.4	1.5	1.6	2.4	3.5	2.5	2.3	4.4	2.4	2.6	2.2	1.4	2.3	3.0	1.4	2.8	2.2	2.0	2.4	2.7
Severe depression (siblings)	0.6	0.6	1.6	-1.3	-0.9	-0.9	-0.9	-0.1	-1.0	0.3	-0.1	-0.8	-0.7	-0.9	-1.1	-0.7	-1.1	-0.9	-0.1	-0.8	-0.7	-1.0	-0.6	0.4	-0.9	-0.1	-1.0	-0.9
Birth weight of first child	0.6	1.1	4.2	-0.0	0.7	0.8	0.5	0.4	0.8	1.4	1.1	0.8	1.6	0.6	0.3	2.0	0.6	0.9	2.0	0.5	1.0	0.6	0.8	1.9	0.5	1.2	0.6	0.6
Mean time to correctly identify matches	0.6	1.2	2.0	-0.3	-1.3	-1.3	-1.4	-0.2	-1.3	-0.9	-1.2	-1.3	-0.5	-1.2	-1.4	-0.4	-1.3	-1.3	-0.8	-1.4	-1.3	-0.8	-1.0	-0.3	-1.3	-0.9	-1.3	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	4.0	-1.0	-0.5	-0.3	-0.2	-1.0	-0.4	-0.9	-1.1	-0.5	-1.2	-0.7	-0.6	-1.0	-0.4	-0.6	-0.6	-0.4	-0.5	-0.7	-0.6	-2.0	-0.5	-1.2	-0.5	-0.8
Comparative height size at age 10	0.6	3.5	13.8	0.9	1.5	1.5	1.8	2.7	1.5	3.7	2.1	1.8	1.5	1.4	1.9	2.2	1.3	2.0	1.4	0.8	1.9	2.7	1.5	2.5	1.4	1.2	1.4	1.1
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	2.2	-1.0	-0.9	-1.1	-1.0	-0.6	-1.0	-0.8	-1.0	-0.9	-1.0	-0.9	-0.5	-0.9	-1.0	-0.9	-0.9	-0.9	-0.9	-0.4	-1.2	-1.5	-0.9	-1.0	-1.0	-1.1
Ever taken oral contraceptive pill	0.6	0.7	2.6	-0.7	-0.8	-0.4	-0.4	0.1	-0.7	-0.4	-0.9	-0.7	-0.9	-0.9	-1.0	-1.1	-0.8	-0.9	-1.3	-0.8	-0.8	-0.5	-0.6	-1.6	-0.8	-0.8	-0.8	-0.9
Commuting to job workplace: Public transport	0.6	0.8	2.2	0.4	1.0	1.0	0.9	-0.6	1.0	0.1	0.8	0.9	0.2	1.0	1.1	-0.3	1.0	1.0	0.3	1.5	0.9	0.7	0.6	0.6	1.1	1.0	1.0	1.1
Alcohol drinker status: Never	0.6	0.7	2.6	-1.6	-0.7	-1.0	-0.8	-1.4	-0.8	-1.4	-0.3	-0.7	0.9	-0.5	-0.6	1.0	-0.7	-0.7	0.9	-0.9	-0.5	0.0	-0.8	-1.0	-0.7	-0.1	-0.7	-0.5
Cholesterol lowering medication	0.6	0.9	2.2	0.7	1.0	0.9	1.3	0.8	1.1	1.5	0.5	1.1	0.7	1.0	1.1	0.8	1.1	1.3	1.2	1.0	1.1	0.6	0.4	0.3	1.1	0.4	1.1	0.8
Crohns Disease (2017)	0.5	1.2	3.6	-0.2	1.1	0.8	1.5	1.3	1.2	1.8	0.9	1.3	0.7	1.0	0.5	0.7	1.2	1.3	1.1	1.2	1.2	1.9	0.1	0.4	1.2	0.4	1.1	0.9
Reaction Time	0.5	1.0	1.7	0.4	-1.1	-1.0	-1.0	-0.5	-1.1	-0.6	-1.2	-1.1	-0.8	-1.0	-1.3	-0.8	-1.1	-1.2	-1.1	-1.0	-1.2	-0.9	-1.2	-0.6	-1.1	-0.9	-1.1	-0.9
LDL Cholesterol	0.5	0.8	4.1	0.5	0.9	1.0	0.8	2.0	0.9	1.9	0.4	1.0	0.2	0.8	0.9	0.3	0.8	1.1	0.3	1.1	1.0	0.1	0.6	0.5	0.9	0.7	0.8	0.5
Medication: Co-codamol	0.5	0.6	1.8	0.3	-0.8	-0.6	-0.5	0.4	-0.6	0.4	-0.5	-0.6	-1.3	-0.7	-1.0	-1.3	-0.8	-0.5	-1.1	-0.5	-0.7	-0.9	-1.2	-0.8	-0.6	-0.7	-0.7	-0.7
Diabetes (mother)	0.5	0.6	1.5	-0.9	-0.8	-0.7	-0.9	-0.4	-0.8	-1.1	-0.8	-0.9	-0.4	-0.8	-1.0	-0.5	-0.7	-0.9	-0.9	-1.0	-0.9	-0.7	-0.3	-1.2	-0.8	-0.7	-0.8	-0.6
Hand grip strength (right)	0.5	1.4	2.8	0.2	1.4	1.4	1.4	-1.1	1.3	0.5	1.3	1.2	1.1	1.3	1.4	1.0	1.3	1.1	1.7	0.7	1.3	0.1	1.2	1.3	1.3	0.8	1.3	1.3
Hayfever, allergic rhinitis or eczema	0.5	1.0	8.6	0.8	0.5	0.4	0.3	2.9	0.6	2.5	0.1	0.8	-0.2	0.3	0.1	-0.6	0.4	0.9	0.5	1.0	0.6	1.2	-1.2	1.4	0.5	0.3	0.3	0.0
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.9	-1.4	-0.8	-0.9	-0.9	-1.1	-0.6	0.4	-1.0	-0.6	-1.3	-0.9	-0.6	-1.4	-0.7	-0.7	-0.6	-0.5	-0.7	-0.3	-0.9	-0.8	-0.7	-1.3	-0.8	-1.0
Happiness	0.5	0.6	1.4	-0.0	1.0	0.9	0.7	-0.4	1.0	0.7	-0.0	1.0	0.3	0.9	1.2	0.4	1.0	0.9	0.6	0.9	1.0	0.9	0.6	0.7	1.0	0.1	1.0	0.7
Mouth/teeth dental problems: Dentures	0.5	0.9	3.5	-0.7	-1.0	-1.1	-0.7	0.9	-1.0	-0.3	-0.8	-0.9	-0.3	-1.0	-1.0	0.5	-1.1	-0.8	0.0	-1.9	-0.8	-0.5	-1.5	-0.1	-1.1	-1.2	-1.0	-1.0
Exposure to tobacco smoke at home	0.5	0.6	2.5	-0.3	0.7	0.7	0.6	-0.8	0.7	0.2	0.7	0.6	1.3	0.6	0.8	1.3	0.7	0.6	1.6	0.4	0.7	0.3	0.4	1.2	0.6	0.5	0.7	0.6
Hypothyroidism/myxoedema (self-reported)	0.5	1.1	1.8	-0.6	-1.1	-1.1	-1.0	0.6	-1.2	-0.9	-0.8	-1.1	-1.2	-1.1	-0.6	-1.3	-1.2	-1.0	-1.4	-1.0	-1.3	-0.7	-1.2	-0.7	-1.1	-0.7	-1.2	-1.1
Medication: Allopurinol	0.5	0.7	2.3	0.4	0.6	0.7	0.9	1.5	0.7	1.5	1.1	0.7	0.7	0.7	-0.1	0.9	0.7	0.7	0.6	0.6	0.7	1.3	0.8	0.1	0.6	1.1	0.6	0.7
Commuting to job workplace: Car/motor vehicle	0.5	0.6	2.8	1.0	0.6	0.6	0.6	1.4	0.6	0.6	0.4	0.5	1.1	0.6	0.7	1.7	0.6	0.5	0.7	-0.5	0.5	0.4	0.4	1.2	0.4	-0.0	0.5	0.5
Osteoporosis (self-reported)	0.5	0.6	2.7	0.8	0.6	0.4	0.9	1.3	0.6	1.6	0.3	0.8	0.3	0.6	0.6	0.8	0.6	1.0	0.8	0.6	0.8	1.5	-0.4	0.9	0.6	0.1	0.6	0.4
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	1.8	-1.0	-0.8	-0.5	-0.4	0.9	-0.6	-0.4	-1.1	-0.7	-1.0	-0.8	-0.9	-0.9	-0.8	-0.8	-0.7	-1.1	-0.7	-0.4	-1.4	-0.4	-0.8	-1.1	-0.8	-0.7
Bipolar Disorder or Schizophrenia	0.4	1.1	4.5	0.5	0.6	0.8	0.7	-0.8	0.8	1.0	1.6	0.7	1.8	0.7	-0.0	2.1	0.6	0.7	2.0	0.1	0.8	1.2	0.7	1.2	0.5	1.0	0.6	0.8
Alzheimer’s Disease (including proxy)	0.4	0.6	1.7	-0.6	0.6	1.0	0.9	0.4	0.8	0.9	1.3	0.6	0.6	0.6	0.5	0.2	0.7	0.7	1.0	0.9	0.7	0.9	0.7	0.7	0.6	1.0	0.6	0.6
Hypothyroidism (self reported)	0.4	1.0	1.9	-0.4	-1.1	-1.0	-0.9	0.5	-1.2	-1.0	-0.8	-1.1	-1.2	-1.1	-0.5	-1.3	-1.2	-1.0	-1.1	-0.9	-1.3	-0.4	-1.4	-0.5	-1.1	-0.5	-1.1	-1.0
Medication: Levothyroxine sodium	0.4	0.7	2.2	-0.4	-0.6	-0.7	-0.5	1.3	-0.6	-0.4	-1.4	-0.5	-1.4	-0.7	-0.2	-1.3	-0.6	-0.5	-1.1	-0.3	-0.8	0.2	-1.5	-0.7	-0.5	-0.9	-0.6	-0.8
Had other major operations	0.4	0.5	1.3	1.0	0.8	0.8	0.4	0.4	0.8	0.6	1.2	0.8	0.3	0.8	0.2	0.1	0.8	0.9	0.5	1.0	0.7	0.5	0.2	0.8	0.8	1.0	0.8	0.9
Mouth/teeth dental problems	0.4	0.6	2.1	0.7	0.9	1.0	0.9	0.3	0.9	0.3	0.6	0.8	0.3	0.8	0.8	-0.4	1.0	0.6	-0.2	1.5	0.6	0.5	1.0	-0.2	0.8	0.7	0.9	0.9
Alcohol intake versus 10 years previously	0.4	0.5	1.2	0.8	0.7	0.6	0.5	0.5	0.7	0.6	0.9	0.7	0.6	0.8	0.7	0.5	0.8	0.6	0.5	0.7	0.6	0.9	0.8	0.6	0.7	1.1	0.8	0.9
Depression (self-reported)	0.4	0.5	1.7	0.6	0.6	0.6	0.5	0.7	0.5	0.4	1.0	0.6	0.7	0.7	0.7	0.7	0.5	0.5	0.7	0.7	0.6	-0.3	1.1	1.0	0.6	1.3	0.7	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	6.2	1.1	1.1	1.4	1.1	1.9	1.2	2.5	1.0	1.3	0.7	1.0	0.9	0.8	1.0	1.3	0.7	0.7	1.1	0.5	0.1	1.7	1.0	0.4	1.0	0.9
Medication: Omeprazole	0.4	0.5	2.8	-0.5	0.6	0.4	0.6	-0.9	0.6	0.7	0.3	0.6	0.9	0.5	0.8	1.4	0.6	0.7	1.7	0.0	0.9	0.7	-0.2	0.3	0.5	-0.0	0.5	0.3
Heart disease (mother)	0.4	0.5	3.2	1.8	0.5	0.3	0.4	0.7	0.4	0.7	1.3	0.5	0.7	0.7	-0.1	0.6	0.5	0.6	0.6	0.3	0.4	0.1	0.2	1.2	0.6	0.9	0.6	0.9
Pulse rate, automated reading	0.4	1.2	5.1	1.0	0.7	0.6	0.6	-0.4	0.7	1.9	1.3	0.8	1.8	0.8	0.6	2.0	0.6	0.9	2.0	0.1	0.8	0.7	-0.0	2.3	0.6	1.0	0.7	0.8
Leg pain on walking	0.4	0.5	3.7	1.0	0.5	0.3	0.6	1.9	0.5	0.6	0.5	0.6	-0.1	0.6	0.2	-0.0	0.6	0.7	-0.4	1.2	0.4	0.6	0.3	-0.3	0.6	1.2	0.5	0.6
Risk taking	0.4	0.7	1.8	1.1	0.8	1.2	0.5	1.3	0.9	1.3	0.7	0.9	0.4	0.8	0.5	0.5	0.7	0.8	-0.1	0.6	0.7	1.0	0.7	0.7	0.8	0.5	0.8	0.8
Age started oral contraceptive pill	0.4	0.5	1.9	-1.4	-0.6	-0.6	-0.1	-0.2	-0.6	-0.9	-0.9	-0.7	-0.1	-0.7	-0.5	0.6	-0.6	-0.7	0.2	-1.3	-0.5	-0.4	-0.9	-0.8	-0.7	-1.1	-0.7	-0.8
Bipolar Disorder (2018)	0.3	0.4	2.7	-1.1	-0.2	-0.2	-0.1	-1.6	-0.1	0.3	-0.1	-0.1	0.9	-0.3	-0.5	1.3	-0.2	-0.1	1.2	-0.8	0.1	-0.1	-0.9	0.2	-0.3	-0.5	-0.2	-0.2
Verbal and Numeric Reasoning (VNR)	0.3	0.6	3.1	-1.0	-0.5	-0.5	-0.3	-1.5	-0.5	-0.0	-0.3	-0.6	0.3	-0.7	-0.5	0.7	-0.5	-0.4	0.7	-1.2	-0.3	-1.8	-1.1	0.0	-0.7	-1.3	-0.6	-0.8
Blood Platelet Count	0.3	3.6	10.2	0.7	1.7	1.9	1.7	-0.6	1.8	1.9	3.2	1.7	1.9	1.9	1.5	1.5	1.7	1.8	2.4	2.0	1.9	0.9	2.4	1.8	1.7	2.8	1.8	2.1
Ever had hysterectomy (womb removed)	0.3	0.3	2.3	0.3	0.2	0.1	-0.1	-0.6	0.2	0.3	0.0	0.2	1.1	0.1	-0.2	1.5	0.1	0.3	1.3	-0.5	0.2	0.3	-0.6	0.5	0.1	-0.5	0.1	0.2
Systolic blood pressure, automated reading	0.3	0.7	1.8	0.9	-0.9	-0.9	-1.1	-0.4	-0.9	-1.4	-0.7	-0.9	-0.7	-0.7	-0.5	-0.4	-0.8	-0.9	-1.2	-1.0	-1.1	-1.2	-0.2	-1.1	-0.8	-0.5	-0.8	-0.6
Fed-up feelings	0.3	0.5	3.2	-0.1	-0.4	-0.6	-0.0	0.6	-0.5	-0.2	-0.9	-0.4	-1.5	-0.4	-0.0	-1.5	-0.3	-0.5	-1.8	0.2	-0.5	-0.7	-0.3	-1.1	-0.3	-0.4	-0.3	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	3.1	0.2	-0.5	-0.4	-0.7	-0.0	-0.4	-1.8	-1.3	-0.7	-1.5	-0.5	-0.5	-1.4	-0.4	-0.8	-1.4	-0.1	-0.8	-1.4	-0.1	-0.8	-0.4	-0.6	-0.5	-0.5
Supplements: Glucosamine	0.3	0.4	1.1	-0.4	-0.7	-0.7	-0.7	-0.8	-0.7	-0.7	-0.4	-0.7	-0.6	-0.6	-0.3	-0.4	-0.7	-0.5	-0.4	-0.7	-0.7	-1.1	-0.9	-0.7	-0.7	-0.4	-0.7	-0.5
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	1.7	-1.3	0.1	0.4	0.0	-0.1	0.1	0.6	1.2	0.1	1.1	0.0	-0.3	0.8	-0.0	0.1	1.3	-0.1	0.3	-0.2	0.3	0.6	-0.1	0.7	0.0	0.1
Had menopause	0.3	0.4	1.1	-0.4	-0.8	-0.6	-0.7	-0.6	-0.8	-0.5	-0.0	-0.8	-0.0	-0.7	-1.1	0.1	-0.9	-0.8	-0.1	-0.9	-0.7	-0.5	-0.3	0.1	-0.9	0.0	-0.8	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	2.6	0.3	-0.3	-0.3	-0.4	0.4	-0.3	-1.5	-1.1	-0.5	-1.6	-0.3	-0.5	-1.5	-0.2	-0.6	-1.6	0.5	-0.7	-1.2	0.0	-0.5	-0.2	-0.1	-0.3	-0.3
Pulse rate	0.3	0.4	1.3	0.6	-0.6	-0.4	-1.0	-0.5	-0.5	-0.2	-0.4	-0.6	0.1	-0.6	-0.8	0.8	-0.6	-0.5	0.3	-1.1	-0.6	-0.4	-0.9	1.0	-0.7	-0.7	-0.6	-0.7
Medication: Lansoprazole	0.3	0.3	1.0	-0.5	-0.5	-0.5	-0.6	0.5	-0.5	-0.2	-1.0	-0.5	-0.8	-0.6	-0.6	-0.7	-0.5	-0.5	-0.5	-0.5	-0.6	-0.7	-0.6	-0.7	-0.6	-0.6	-0.5	-0.4
Lung cancer (father)	0.3	0.4	1.6	0.2	0.3	0.5	0.7	1.3	0.5	1.0	0.4	0.4	0.9	0.2	0.2	1.1	0.3	0.4	1.0	0.1	0.5	1.1	-0.2	0.4	0.2	0.4	0.3	0.4
Standing height	0.3	2.6	6.1	-1.9	-1.7	-1.6	-0.9	2.5	-1.6	1.2	-1.4	-1.3	-1.9	-1.9	-0.8	-1.2	-1.8	-1.1	-1.6	-2.1	-1.2	0.2	-2.3	0.2	-1.8	-2.1	-1.8	-1.9
Ever highly irritable/argumentative for 2 days	0.3	0.4	2.4	0.1	-0.3	-0.4	-0.3	-0.1	-0.3	-0.4	-1.0	-0.3	-1.0	-0.4	0.2	-0.7	-0.2	-0.3	-1.6	-0.5	-0.4	-0.3	-1.0	-0.6	-0.3	-1.3	-0.3	-0.4
Blood clot in the leg (DVT)	0.3	0.4	1.2	-0.9	-0.5	-0.2	-0.2	0.9	-0.4	-0.3	-0.9	-0.4	-0.9	-0.6	-0.7	-0.7	-0.5	-0.6	-0.5	-0.8	-0.5	-0.2	-1.1	-0.2	-0.6	-0.9	-0.5	-0.5
Exposure to tobacco smoke outside home	0.3	0.4	3.5	0.6	0.3	0.3	0.2	1.9	0.4	0.6	0.5	0.4	-0.2	0.3	0.7	-0.6	0.4	0.4	-0.6	1.2	0.2	0.6	1.1	-0.0	0.4	0.8	0.4	0.3
Age at first live birth	0.3	0.6	3.0	0.5	-0.3	-0.5	-0.7	0.9	-0.3	-0.5	-1.2	-0.4	-1.3	-0.4	0.1	-1.4	-0.3	-0.3	-1.7	0.1	-0.7	-0.7	-0.5	-1.5	-0.3	-0.8	-0.4	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.1	0.3	-0.6	-0.4	-0.5	-0.1	-0.6	-0.8	-0.7	-0.6	-1.0	-0.6	-0.9	-0.6	-0.6	-0.6	-1.0	-0.5	-0.8	-0.2	-0.3	-0.9	-0.6	-0.4	-0.6	-0.5
Qualifications: nursing, teaching	0.3	0.5	1.8	-0.8	-0.5	-0.5	-0.8	-0.7	-0.5	-1.3	-0.3	-0.6	-0.9	-0.5	-0.0	-0.9	-0.6	-0.6	-0.7	-0.4	-0.7	-1.2	-0.5	-0.5	-0.5	-0.4	-0.5	-0.5
Myopia	0.3	0.5	1.8	-0.3	-0.5	-0.5	-0.9	0.0	-0.5	-0.2	-1.2	-0.4	0.2	-0.6	-0.8	0.8	-0.6	-0.4	-0.3	-1.2	-0.5	-1.1	-0.5	-0.8	-0.6	-1.3	-0.6	-0.7
Alcohol drinker status: Previous	0.3	0.4	0.9	0.7	0.7	0.4	0.8	0.1	0.7	0.5	-0.1	0.7	0.6	0.7	1.0	0.9	0.8	0.7	0.4	0.2	0.7	0.9	-0.0	0.4	0.7	-0.1	0.7	0.6
Schizophrenia vs Biploar Disorder	0.2	0.3	2.5	1.6	0.1	0.3	0.2	1.4	0.1	0.1	0.4	0.1	0.5	0.2	-0.3	0.4	0.0	0.1	0.0	0.1	0.0	0.4	0.3	0.9	0.1	0.6	0.1	0.4
Irritable Bowel Disease (IBD)	0.2	0.5	3.9	-0.5	0.5	0.3	0.9	1.0	0.6	2.0	0.2	0.8	0.0	0.4	-0.2	0.5	0.5	0.8	0.9	0.3	0.7	1.0	-0.4	-0.0	0.5	-0.3	0.6	0.3
Breast Cancer	0.2	0.4	2.1	0.8	0.1	-0.1	0.2	0.4	-0.1	-0.7	0.6	0.0	-0.2	0.3	0.5	-1.5	0.1	-0.1	-1.0	1.3	-0.1	-0.7	1.1	0.2	0.3	1.4	0.2	0.3
Prostate Cancer	0.2	0.2	1.3	-0.1	-0.4	-0.2	-0.1	-0.6	-0.3	-0.6	-0.6	-0.4	0.0	-0.4	-0.5	0.7	-0.4	-0.4	0.1	-1.0	-0.4	-0.3	-1.1	-0.1	-0.5	-0.6	-0.4	-0.2
Age at First Birth	0.2	0.3	2.1	1.4	-0.0	-0.2	-0.2	1.3	-0.1	0.3	0.6	-0.1	-0.6	0.0	-0.2	-1.3	-0.0	0.2	-0.4	0.9	-0.3	0.0	0.2	0.2	0.0	0.7	-0.1	0.0
Fasting Glucose	0.2	0.2	0.8	0.6	0.3	0.2	0.3	0.8	0.3	0.4	0.5	0.2	0.2	0.5	-0.2	-0.2	0.3	0.6	0.5	0.8	0.4	0.5	0.7	-0.3	0.4	0.9	0.3	0.6
Ulcerative Colitis	0.2	0.2	0.8	-0.7	-0.2	-0.4	-0.2	0.9	-0.2	0.9	-0.6	-0.1	-0.6	-0.3	-0.9	-0.1	-0.3	-0.1	0.3	-0.5	-0.1	-0.4	-0.5	-0.7	-0.3	-0.8	-0.2	-0.4
Height	0.2	4.0	18.3	-1.9	-1.7	-1.4	-0.5	4.3	-1.4	2.3	-1.9	-1.2	-2.7	-2.0	-0.1	-1.9	-1.8	-0.9	-2.4	-2.1	-1.1	1.1	-3.2	-0.1	-1.8	-2.9	-1.8	-2.1
Lung FEV1/FVC ratio	0.2	0.8	8.8	0.2	0.2	0.1	0.2	-1.8	-0.1	-3.0	0.1	-0.3	1.2	0.5	0.4	1.8	0.2	-0.3	-0.1	-0.2	0.1	0.0	0.3	-0.4	0.1	1.0	0.3	0.9
Relative age of first facial hair	0.2	0.4	2.2	-1.5	-0.5	-0.6	-0.5	-1.0	-0.5	-0.2	-0.3	-0.5	-0.7	-0.6	-0.4	-0.9	-0.5	-0.6	-0.4	-0.3	-0.4	-0.7	-0.5	-0.6	-0.5	-0.6	-0.5	-0.7
Pack years adult smoking proportion	0.2	0.3	1.0	-0.2	-0.7	-0.6	-0.8	0.4	-0.6	-0.3	-0.0	-0.7	-0.3	-0.5	-1.0	-0.2	-0.6	-0.6	-0.4	-0.7	-0.7	-0.4	-0.9	-0.4	-0.7	0.1	-0.6	-0.3
Qualifications: CSEs or equivalent	0.2	0.2	0.7	0.6	0.4	0.2	0.2	-0.5	0.4	0.8	0.5	0.5	0.2	0.5	0.7	0.1	0.4	0.5	0.3	0.2	0.4	0.2	0.7	-0.4	0.5	0.1	0.5	0.5
Number of incorrect matches in round	0.2	0.3	1.1	-0.3	-0.5	-0.3	-0.5	-0.6	-0.4	-0.6	-0.5	-0.5	0.6	-0.4	-0.5	1.0	-0.4	-0.4	0.6	-0.9	-0.4	-0.4	-1.0	-0.3	-0.6	-0.3	-0.5	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.4	1.3	0.6	0.6	0.5	0.5	-0.3	0.6	1.2	0.6	0.6	0.2	0.7	0.8	0.0	0.6	0.6	0.3	0.9	0.5	-0.1	0.4	1.0	0.7	0.6	0.6	0.6
Hearing difficulty/problems with background noise	0.2	0.3	1.3	-0.5	-0.3	-0.2	-0.6	-1.0	-0.3	0.1	0.2	-0.3	0.7	-0.3	-0.8	0.7	-0.3	-0.1	1.1	-0.6	-0.2	-0.4	-0.4	0.7	-0.3	-0.2	-0.3	-0.3
Qualifications: None of the above	0.2	0.3	4.5	0.7	0.2	0.1	0.2	2.1	0.2	1.0	-0.3	0.3	-0.2	0.3	0.0	-0.0	0.2	0.2	-0.4	0.2	0.2	1.2	-0.2	0.2	0.3	0.0	0.2	0.2
Prospective memory result	0.2	0.3	1.1	0.4	0.3	0.2	0.2	1.1	0.3	-0.1	0.6	0.3	0.0	0.4	-0.3	-0.6	0.4	0.2	0.1	1.0	0.3	0.9	1.1	0.1	0.4	1.1	0.4	0.6
Illnesses of mother	0.2	0.3	1.6	-1.3	-0.5	-0.6	-0.3	-0.7	-0.5	-0.7	-0.5	-0.5	-0.6	-0.6	0.0	-0.5	-0.5	-0.5	-0.4	-0.1	-0.3	-0.3	-0.2	-0.5	-0.5	-0.4	-0.5	-0.7
Length of working week for main job	0.2	0.2	1.3	-0.2	-0.4	-0.3	-0.6	-0.1	-0.4	-0.2	0.3	-0.5	-0.1	-0.4	-1.1	-0.2	-0.5	-0.4	-0.8	-0.7	-0.5	-1.0	0.1	-0.5	-0.4	-0.0	-0.4	-0.3
Breastfed as a baby	0.2	0.2	0.8	-0.9	-0.2	-0.4	-0.1	-0.2	-0.3	0.3	-0.9	-0.2	-0.3	-0.4	-0.4	0.2	-0.4	-0.1	0.4	-0.5	-0.1	0.1	-0.5	-0.5	-0.3	-0.7	-0.3	-0.8
Tense / ‘highly strung’	0.2	0.4	1.4	0.1	-0.4	-0.6	-0.7	-0.4	-0.4	-0.5	-1.2	-0.4	-1.1	-0.4	-0.3	-0.9	-0.3	-0.5	-1.1	-0.3	-0.5	-0.5	-0.3	-0.7	-0.3	-0.9	-0.4	-0.5
Shortness of breath walking on level ground	0.2	0.3	1.4	1.2	0.4	0.4	0.2	0.9	0.6	1.1	-0.1	0.5	-0.0	0.4	0.5	0.1	0.5	0.6	-0.4	0.5	0.4	0.2	0.2	0.5	0.4	-0.0	0.4	0.3
Emphysema/chronic bronchitis	0.2	0.3	3.2	0.5	0.2	0.5	0.1	1.0	0.3	1.8	1.0	0.4	0.3	0.2	-0.0	0.1	0.1	0.4	-0.1	0.1	0.2	-0.2	0.5	-0.5	0.2	0.4	0.2	0.1
Alcohol intake frequency.	0.2	0.5	3.0	-0.4	-0.3	-0.7	-0.2	-1.4	-0.4	-1.0	-0.1	-0.4	1.0	-0.1	-0.5	1.7	-0.1	-0.3	1.0	-0.9	-0.3	0.6	-0.8	-0.3	-0.3	-0.0	-0.2	0.1
Chest pain or discomfort	0.2	0.3	1.0	0.6	-0.4	-0.5	-0.5	0.8	-0.4	1.0	0.9	-0.2	0.2	-0.2	-0.6	0.1	-0.4	-0.1	0.2	-0.2	-0.4	-0.3	-0.5	0.9	-0.4	0.8	-0.4	-0.0
Illnesses of father: Heart disease	0.2	0.3	2.4	1.6	-0.4	-0.2	-0.3	0.2	-0.3	0.1	0.1	-0.3	-0.6	-0.2	0.2	-1.0	-0.4	-0.3	-1.2	0.1	-0.5	-1.2	0.1	-0.0	-0.3	0.4	-0.4	-0.1
Mood swings	0.2	0.3	1.1	-0.9	-0.4	-0.5	-0.6	-0.5	-0.5	-0.5	-1.0	-0.4	-0.7	-0.4	0.3	-0.4	-0.4	-0.6	-1.0	-0.5	-0.3	-0.7	0.1	-0.6	-0.3	-0.6	-0.4	-0.4
Loneliness, isolation	0.2	0.3	0.6	-0.6	0.5	0.3	0.7	-0.7	0.5	0.5	-0.0	0.6	0.2	0.4	0.5	0.5	0.6	0.4	0.5	0.4	0.8	0.5	0.7	-0.3	0.6	-0.2	0.6	0.2
Breast cancer (self-reported)	0.2	0.3	1.5	-0.8	-0.3	-0.3	-0.3	-1.0	-0.3	-0.5	-0.5	-0.3	0.7	-0.3	-0.2	1.2	-0.3	-0.2	0.5	-1.0	-0.2	-0.2	-0.6	-0.6	-0.4	-0.6	-0.3	-0.2
Average weekly champagne plus white wine intake	0.2	0.2	1.0	-0.8	-0.2	-0.2	-0.4	-0.3	-0.3	-0.8	-0.9	-0.3	0.1	-0.3	-0.1	0.5	-0.3	-0.3	0.1	-1.0	-0.2	-0.4	-0.4	0.2	-0.3	-0.9	-0.3	-0.3
Pain type(s) experienced in last month: Hip pain	0.2	0.2	1.0	-0.4	-0.5	-0.7	-0.3	-0.1	-0.6	0.0	-0.3	-0.4	-0.1	-0.4	-0.6	0.2	-0.5	-0.3	-0.0	-0.6	-0.4	-1.0	-0.6	-0.1	-0.5	-0.2	-0.5	-0.6
Illnesses of father: High blood pressure	0.2	0.2	2.7	-0.3	0.1	0.0	0.2	-1.7	0.1	-0.7	0.2	0.0	0.3	0.1	0.1	0.4	0.2	0.1	0.6	-0.1	0.1	-0.6	0.4	-0.3	0.1	-0.2	0.2	0.1
Unable to work because of sickness or disability	0.2	0.2	0.5	-0.7	-0.5	-0.2	-0.2	-0.5	-0.4	0.1	-0.1	-0.4	0.2	-0.5	-0.3	0.5	-0.5	-0.5	0.6	-0.7	-0.3	-0.6	-0.3	0.4	-0.6	-0.2	-0.5	-0.5
Supplements: Calcium	0.2	0.2	0.9	-0.2	-0.2	0.0	0.0	0.9	-0.1	0.4	-0.4	-0.1	-0.6	-0.4	0.1	-0.4	-0.2	-0.1	-0.8	-0.4	-0.1	0.1	-0.5	-0.7	-0.2	-0.9	-0.3	-0.5
Pack years of smoking	0.2	0.4	1.3	-0.4	-0.7	-0.7	-0.7	0.4	-0.7	-0.4	-0.3	-0.7	-0.1	-0.5	-1.1	0.2	-0.6	-0.6	-0.1	-0.9	-0.6	-0.2	-1.1	-0.5	-0.7	-0.2	-0.6	-0.3
Intelligence (Savage-Jansen 2018)	0.1	0.3	1.8	-0.3	-0.6	-0.3	-0.2	-0.3	-0.4	0.3	0.4	-0.5	0.4	-0.6	-0.1	0.3	-0.6	-0.3	0.2	-0.6	-0.4	-1.3	-0.7	0.8	-0.7	-0.2	-0.6	-0.6
Ulcerative Colitis (UC)	0.1	0.2	2.1	-0.4	0.0	-0.2	0.2	0.6	0.1	1.5	-0.2	0.2	-0.4	-0.0	-0.5	0.3	0.0	0.3	0.6	-0.4	0.2	-0.1	-0.3	-0.1	0.0	-0.6	0.1	-0.1
Lupus	0.1	0.1	0.6	0.3	-0.2	0.1	0.1	-0.3	-0.1	0.3	0.8	-0.2	-0.2	-0.1	-0.4	-0.4	-0.2	-0.1	-0.5	0.2	-0.3	-0.5	0.1	0.7	-0.2	0.7	-0.2	-0.0
Triglycerides	0.1	0.2	2.2	0.7	-0.0	0.2	-0.1	-0.2	-0.1	-0.1	0.1	-0.0	1.0	0.1	-0.3	1.5	-0.1	0.2	0.7	-0.5	-0.1	-0.0	0.1	0.6	-0.1	0.3	-0.1	0.0
Sitting height	0.1	0.7	3.3	-0.5	-0.7	-0.3	0.1	1.8	-0.6	0.5	-0.7	-0.6	-0.4	-0.9	-0.6	0.3	-0.8	-0.5	-0.1	-1.5	-0.5	0.5	-1.2	0.4	-0.9	-1.3	-0.8	-1.0
Time employed in main current job	0.1	0.1	0.6	0.1	0.0	-0.0	-0.2	-0.2	0.1	0.3	-0.4	0.1	-0.6	-0.1	0.1	-0.6	0.1	0.0	-0.6	0.0	-0.1	0.0	0.3	-0.8	0.0	-0.4	0.0	-0.1
Noisy workplace	0.1	0.1	0.9	0.6	0.2	0.5	0.2	0.2	0.3	0.8	1.0	0.3	0.2	0.2	-0.2	0.0	0.2	0.3	-0.0	0.1	0.2	0.5	0.2	0.3	0.2	0.3	0.2	0.2
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.2	1.5	0.3	-0.1	-0.1	-0.2	-1.2	-0.2	-0.9	0.6	-0.2	0.1	-0.0	-0.2	-0.1	-0.2	-0.2	0.2	0.1	-0.1	-0.1	0.6	0.4	-0.1	0.6	-0.1	-0.0
Peak expiratory flow (PEF)	0.1	0.1	0.6	0.7	0.2	0.6	0.1	-0.0	0.3	-0.1	0.6	0.2	0.1	0.2	0.3	0.0	0.2	0.2	-0.5	0.1	0.1	-0.7	0.4	0.8	0.2	-0.0	0.2	0.3
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.9	-0.3	-0.2	-0.4	-0.4	-0.9	-0.3	-0.3	0.0	-0.2	-0.1	-0.0	-0.6	0.2	-0.2	-0.0	0.1	-0.4	-0.0	-0.4	-0.3	-0.1	-0.1	-0.1	-0.1	-0.4
Gout (self-reported)	0.1	0.1	1.0	0.3	0.1	0.2	0.3	0.5	0.3	0.6	0.4	0.2	0.3	0.2	-0.4	0.4	0.2	0.2	0.3	0.1	0.1	1.0	0.3	-0.2	0.1	0.6	0.2	0.3
Birth weight	0.1	0.3	3.6	-1.0	0.2	0.2	-0.1	-1.9	0.1	-0.1	0.4	0.1	-0.1	0.1	-0.1	-0.2	0.0	0.1	0.6	0.3	0.3	-0.2	-0.3	0.8	0.1	0.2	0.1	-0.1
Qualifications: College or University degree	0.1	0.2	0.8	-0.1	-0.4	-0.2	-0.2	-0.5	-0.3	-0.6	-0.1	-0.5	-0.4	-0.4	0.2	-0.6	-0.4	-0.4	-0.4	0.1	-0.4	-0.9	-0.2	0.1	-0.4	0.1	-0.5	-0.4
Migraine (self-reported)	0.1	0.2	0.6	0.6	0.5	0.6	0.1	0.2	0.5	0.2	0.0	0.4	0.1	0.4	0.6	0.0	0.5	0.4	0.1	0.5	0.3	0.8	0.3	0.6	0.5	0.2	0.4	0.3
Age at last live birth	0.1	0.2	0.6	0.3	0.5	0.2	0.3	-0.0	0.5	-0.0	-0.6	0.4	-0.4	0.4	0.7	-0.2	0.6	0.4	-0.6	0.4	0.4	0.2	-0.1	-0.7	0.6	-0.8	0.4	0.2
Family relationship satisfaction	0.1	0.2	0.6	0.2	0.3	0.2	-0.1	-0.3	0.3	0.5	0.7	0.4	0.5	0.4	-0.0	0.3	0.3	0.4	0.3	0.3	0.4	0.6	0.4	0.7	0.3	0.5	0.3	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.3	-0.5	0.3	0.2	-0.1	0.2	0.2	0.5	-0.4	0.3	-0.1	0.1	0.2	-0.3	0.2	0.2	0.0	0.1	0.3	0.5	-0.3	-0.1	0.3	-0.5	0.2	0.0
Friendships satisfaction	0.1	0.1	1.0	0.2	0.2	0.0	-0.3	-1.0	0.1	-0.0	-0.0	0.1	0.2	0.1	0.1	-0.1	0.1	0.2	0.2	0.1	0.1	0.0	-0.2	0.4	0.1	-0.1	0.1	0.1
Commuting to job workplace: Walk	0.1	0.1	0.5	-0.7	-0.3	-0.2	-0.4	-0.4	-0.3	-0.4	-0.4	-0.3	0.1	-0.4	-0.4	0.0	-0.3	-0.4	-0.3	-0.3	-0.3	-0.5	0.0	-0.6	-0.4	-0.3	-0.3	-0.3
Medication for cholesterol	0.1	0.1	1.1	0.3	-0.2	-0.2	0.0	1.1	-0.2	-0.3	0.4	-0.3	-0.1	-0.1	-0.2	-0.1	-0.2	-0.2	-0.7	-0.1	-0.3	0.1	0.5	0.3	-0.2	0.4	-0.2	0.1
Medication: Lisinopril	0.1	0.1	1.0	-0.1	0.2	0.3	0.2	0.2	0.3	-0.1	0.1	0.2	0.3	0.2	0.5	0.3	0.3	0.2	0.2	0.2	0.1	0.8	-0.1	-1.0	0.2	-0.1	0.2	0.2
Commuting to job workplace: Cycle	0.1	0.1	0.4	-0.5	0.1	0.2	0.6	0.4	0.1	0.6	0.1	0.2	-0.4	0.1	0.5	-0.4	0.1	0.2	0.1	0.4	0.3	-0.2	0.4	-0.1	0.2	0.4	0.1	0.0
Basal cell carcinoma (self-reported)	0.1	0.1	0.8	-0.1	0.3	0.1	0.5	0.9	0.2	0.1	-0.1	0.3	-0.3	0.3	0.7	-0.2	0.2	0.4	-0.3	0.1	0.2	-0.6	-0.2	-0.6	0.4	-0.3	0.3	0.1
Heart disease (siblings)	0.1	0.2	1.1	0.1	-0.1	-0.1	-0.2	-1.0	-0.2	-0.8	0.2	-0.2	-0.0	-0.0	0.5	-0.1	-0.1	-0.3	-0.3	-0.0	-0.1	-0.7	0.8	-0.8	-0.1	0.4	-0.1	0.0
Alzheimer’s Disease (in mother)	0.0	0.1	0.3	-0.5	-0.2	0.3	0.1	-0.1	-0.1	-0.2	0.4	-0.2	0.2	-0.1	-0.5	-0.2	-0.2	-0.1	0.2	0.0	-0.1	0.1	0.2	0.1	-0.1	0.5	-0.2	-0.0
Ovarian Cancer	0.0	0.1	0.3	0.0	-0.1	-0.0	-0.1	0.2	-0.1	0.5	-0.1	-0.0	-0.1	-0.2	0.5	-0.3	-0.2	-0.1	-0.5	-0.0	-0.1	0.2	-0.3	-0.3	-0.0	-0.3	-0.1	-0.3
Hair Pigment	0.0	1.1	2.9	1.2	1.0	1.1	0.8	1.2	1.0	1.7	1.1	1.1	0.5	1.0	0.5	0.2	0.9	1.0	0.4	1.2	0.9	0.9	1.5	1.4	1.0	1.3	1.0	1.0
Tanning	0.0	0.2	1.5	1.0	-0.2	0.2	-0.3	0.5	-0.1	-0.3	0.1	-0.2	-0.6	-0.1	-0.1	-1.1	-0.2	-0.2	-1.2	0.2	-0.4	-0.4	0.2	0.4	-0.2	0.3	-0.2	0.1
Medication: Amlodipine	0.0	0.0	0.3	0.2	0.1	0.1	-0.0	-0.2	0.1	-0.3	-0.6	-0.0	0.3	0.1	-0.1	0.4	0.1	-0.1	0.2	0.1	0.0	-0.2	-0.1	-0.2	0.1	-0.2	0.1	0.1
Medication for pain relief, constipation, heartburn	0.0	0.1	0.5	0.3	-0.0	-0.2	0.4	-0.1	-0.2	-0.3	-0.0	-0.1	0.1	0.0	-0.7	0.6	-0.0	-0.2	0.0	-0.4	0.0	0.2	0.1	0.5	-0.1	-0.0	-0.0	0.1

Hub : Genes

MAP2K5

Models

Trait associations