TWAS
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Usage
Models
Genes
Traits
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Traits
:
Leg fat-free mass (left)
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chr15:80,743,350-81,292,020
Best TWAS P=1.03e-07 · Best GWAS P=2.2e-10 conditioned to 0.000525
80.8M
80.9M
81M
81.1M
81.2M
81.3M
0
2
4
6
8
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
The Cancer Genome Atlas
Lung Adenocarcinoma
FAM108C1
0.05
0.04
lasso
3
0.04
5.6e-06
5.4
-5.3
1.0e-07
-0.86
0.06
0.93
TRUE
2
The Cancer Genome Atlas
Prostate Adenocarcinoma
FAM108C1
0.07
0.02
lasso
2
0.02
1.7e-03
-4.0
-5.2
2.2e-07
-0.82
0.03
0.60
FALSE