Hub : Genes

FAM108C1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 NTR Blood 0.0163 0.0078 0.01800 0.006 0.005 0.001 0.005 0.005 4.1e-03 0.00870 0.15000 0.0061 8.1e-03
2 TCGA Lung Adenocarcinoma 0.0504 0.0244 0.00018 0.042 0.023 0.032 NA 0.045 1.1e-05 0.00087 0.00011 NA 5.6e-06
3 TCGA Prostate Adenocarcinoma 0.0653 0.0302 0.00140 0.022 0.014 0.011 NA 0.023 1.9e-03 0.01200 0.02200 NA 1.7e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 1.6 2.6 4.3 -1.7 0.7 2.1
Bipolar Disorder or Schizophrenia 0.4 0.9 2.3 -0.7 0.2 1.5
Depressed Affect (Nagel 2018) 0.8 1.6 2.3 1.3 -0.9 -1.5
Depression (Nagel 2018) 0.2 0.3 0.5 0.7 -0.2 -0.6
Intelligence (Savage-Jansen 2018) 1.1 3.3 5.9 -1.3 2.4 1.6
Neuroticism (Nagel 2018) 0.0 0.0 0.1 0.1 -0.2 -0.2
Schizophrenia (2018) 0.1 0.1 0.2 0.5 -0.4 0.3
Schizophrenia vs Biploar Disorder 0.4 0.6 0.9 0.4 -0.8 -1.0
Worry (Nagel 2018) 0.3 0.6 1.4 -0.1 0.7 1.2
Alzheimer’s Disease (in mother) 0.3 0.3 0.9 -0.4 0.9 0.2
Alzheimer’s Disease (in father) 0.2 0.2 0.6 0.3 -0.8 -0.0
Alzheimer’s Disease (including proxy) 0.6 0.9 1.2 0.6 -1.1 -1.0
Crohns Disease (2017) 3.9 8.6 16.5 4.1 -2.2 -2.1
Irritable Bowel Disease (IBD) 3.0 7.1 16.2 4.0 -1.7 -1.5
Ulcerative Colitis (UC) 1.1 2.1 5.5 2.3 -0.7 -0.6
Major Depression (MDD) 0.3 0.4 0.6 0.6 -0.3 -0.8
Reaction Time 1.3 2.6 6.5 -2.5 0.9 0.6
Verbal and Numeric Reasoning (VNR) 0.4 0.9 1.5 -0.7 1.2 0.9
Breast Cancer 1.0 2.5 2.9 1.7 -1.6 -1.5
Ovarian Cancer 4.0 5.2 7.9 -1.0 2.8 2.6
Prostate Cancer 3.1 4.4 6.2 1.9 -1.9 -2.5
Age at First Birth 2.5 3.7 7.8 -2.8 1.4 1.2
Bipolar Disorder (2011) 1.3 1.3 1.8 -1.3 0.6 1.3
Body Mass Index (BMI) (2010) 2.7 3.6 5.9 1.4 -1.8 -2.4
Coronary Artery Disease (CAD) 1.7 2.0 4.9 0.3 -2.2 -1.1
Crohns Disease (2012) 3.8 6.1 7.9 2.8 -2.5 -2.1
Mean Putamen Volume 2.2 2.5 5.6 2.4 -0.9 -1.1
Fasting Glucose 2.2 2.6 4.2 -0.6 1.8 2.1
HbA1C 3.7 4.1 7.1 2.7 -1.4 -1.8
HDL Cholesterol 3.3 5.5 7.5 -2.7 1.7 2.5
LDL Cholesterol 0.1 0.1 0.4 0.1 0.6 -0.0
Lupus 0.1 0.2 0.5 0.7 0.2 0.4
Neuroticism (2016) 0.1 0.2 0.3 -0.6 0.5 0.1
Primary Biliary Cirrhosis 0.4 0.5 0.9 0.9 -0.8 0.3
Rheumatoid Arthritis 0.9 1.2 2.0 1.4 -0.8 -1.0
Schizophrenia (2014) 0.1 0.2 0.3 -0.4 -0.1 0.5
Triglycerides 0.6 0.9 1.6 1.1 -0.3 -1.3
Type 2 Diabetes (T2D) (2012) 1.3 1.4 2.9 -1.2 -0.1 -1.7
Ulcerative Colitis 0.7 1.0 2.9 1.7 -0.1 0.4
Blood Eosinophil Count 1.0 8.0 12.9 -2.6 3.6 2.1
Blood Platelet Count 0.0 0.6 1.1 0.7 1.1 0.2
Blood Red Count 0.2 1.7 4.7 -2.2 0.3 0.6
Blood White Count 0.8 6.1 13.2 -1.2 3.6 1.9
Heel T-Score 0.4 3.5 4.8 -1.5 1.9 2.2
BMI 5.9 34.2 46.3 5.2 -5.4 -6.8
Height 0.0 0.8 2.0 -0.1 -1.4 0.7
Waist Hip Ratio (WHR) 0.3 1.3 3.4 1.8 0.1 -0.7
Systolic Blood Pressure 9.4 47.0 73.8 4.3 -8.6 -7.0
Smoking Status 6.1 14.5 20.7 3.2 -3.5 -4.6
Allergy or Eczema 0.8 2.0 4.0 -1.3 0.7 2.0
Cardiovascular Disease 14.2 46.9 58.1 5.1 -7.5 -7.6
Hypothyroidism (self reported) 0.0 0.0 0.1 0.0 0.3 0.1
Respiratory disease 0.9 2.1 3.6 0.4 -1.5 -1.9
Type 2 Diabetes (T2D) (2018) 0.8 1.5 2.2 1.2 -1.0 -1.5
Lung FEV1/FVC ratio 0.4 1.9 3.7 -0.2 1.4 1.9
Lung FVC 0.6 3.1 7.0 -2.7 0.7 1.4
Neuroticism 0.1 0.2 0.4 -0.6 -0.3 -0.3
Chronotype (morning person) 0.5 1.2 2.4 -0.1 1.6 1.1
Hair Pigment 0.1 2.3 5.2 -2.3 1.1 0.7
Tanning 0.1 1.8 5.1 2.3 -0.2 -0.5
Hand grip strength (left) 0.9 2.3 6.4 -0.7 -0.3 2.5
Number of treatments/medications taken 14.5 26.2 41.6 1.5 -5.9 -6.4
Average weekly spirits intake 1.5 1.9 2.9 0.6 -1.7 -1.5
Sensitivity / hurt feelings 0.1 0.1 0.3 0.5 -0.1 -0.4
Frequency of depressed mood in last 2 weeks 1.5 2.1 3.0 1.6 -0.8 -1.7
Hearing difficulty/problems: Yes 0.1 0.1 0.3 -0.3 0.5 -0.3
Relative age of first facial hair 1.7 3.4 4.5 -2.1 1.7 1.7
Other serious medical condition/disability diagnosed by doctor 1.5 2.0 3.2 1.3 -1.8 -1.1
Ever used hormone-replacement therapy (HRT) 0.1 0.1 0.1 -0.4 -0.2 0.1
Ever had hysterectomy (womb removed) 2.7 3.0 4.4 1.9 -1.1 -2.1
Systolic blood pressure, automated reading 10.5 30.4 46.1 2.9 -6.8 -6.0
Eye problems/disorders: Diabetes related eye disease 0.7 0.8 2.0 -1.4 -0.3 0.3
Angina 0.1 0.1 0.3 0.1 -0.5 -0.4
Medication for hormone replacement therapy 1.2 1.4 2.3 -1.5 0.6 1.2
Vitamin and mineral supplements 0.2 0.3 0.6 -0.4 0.3 0.8
Supplements: Zinc 3.3 3.6 5.3 0.9 -2.3 -2.2
Medication: Co-codamol 0.1 0.1 0.3 0.1 -0.2 -0.5
Medication: Metformin 2.6 3.7 6.5 0.4 -2.1 -2.5
Diabetes (father) 0.3 0.3 0.9 -0.3 0.9 0.1
Diabetes (mother) 0.9 1.1 1.3 0.9 1.1 1.1
Severe depression (siblings) 0.6 0.7 1.1 0.8 -1.0 -0.6
Pack years adult smoking proportion 0.0 0.1 0.1 0.1 -0.4 -0.1
Impedance of leg (right) 4.4 21.5 28.4 -3.9 5.3 4.6
Leg fat-free mass (left) 5.0 26.5 28.3 4.9 -5.3 -5.2
Trunk fat percentage 3.2 12.7 22.4 2.7 -2.9 -4.7
Hand grip strength (right) 1.8 4.9 13.0 -0.9 0.9 3.6
Townsend deprivation index at recruitment 0.1 0.1 0.2 0.4 0.3 -0.3
Current tobacco smoking 2.4 3.9 6.0 2.1 -1.1 -2.5
Average weekly fortified wine intake 0.5 0.6 1.7 1.3 0.2 0.3
Maternal smoking around birth 1.8 2.6 3.3 1.7 -1.3 -1.8
Fed-up feelings 2.6 4.7 7.8 2.2 -1.2 -2.8
Frequency of unenthusiasm / disinterest in last 2 weeks 1.0 1.3 2.2 0.9 -1.0 -1.5
Relative age voice broke 3.7 5.6 7.7 -2.0 2.3 2.8
Taking other prescription medications 4.8 7.5 10.4 1.4 -3.2 -3.2
Age when periods started (menarche) 3.5 8.5 13.7 -2.0 2.8 3.7
Bilateral oophorectomy (both ovaries removed) 1.4 1.6 2.8 0.4 -1.4 -1.7
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.3 0.3 0.6 0.6 0.5
Tinnitus: Yes, but not now, but have in the past 0.8 0.9 0.9 -1.0 -0.9 -0.9
Qualifications: CSEs or equivalent 0.9 1.2 3.3 1.8 -0.2 -0.5
Serious illness, injury or assault to yourself 0.7 0.8 1.1 1.0 -1.0 -0.7
High blood pressure 12.7 35.4 45.0 4.3 -6.5 -6.7
Hayfever, allergic rhinitis or eczema 0.6 1.3 3.0 -0.5 0.8 1.7
Multivitamins +/- minerals 0.2 0.2 0.5 0.7 0.1 -0.4
Stomach or abdominal pain in last month 0.4 0.5 0.7 0.8 -0.7 -0.5
Supplements: Glucosamine 0.7 0.9 1.3 0.9 -1.1 -0.7
Diverticular disease/diverticulitis (self-reported) 1.4 1.6 3.1 0.5 1.3 1.8
Medication: Atenolol 7.5 9.4 12.3 2.4 -3.5 -3.2
Medication: Levothyroxine sodium 0.2 0.4 0.6 0.7 0.8 -0.1
Sitting height 1.5 10.4 21.5 1.9 -4.6 -2.5
Chronic bronchitis/emphysema (father) 0.1 0.1 0.2 -0.5 0.5 -0.1
High blood pressure (mother) 3.5 4.9 7.3 1.3 -2.7 -2.4
Body mass index (BMI) 5.0 21.2 30.6 4.1 -4.0 -5.5
Impedance of leg (left) 3.8 18.4 22.6 -3.8 4.8 4.3
Leg predicted mass (left) 5.1 27.3 28.9 5.0 -5.4 -5.3
Trunk fat mass 5.0 21.6 31.8 4.0 -4.2 -5.6
Waist circumference 7.2 26.5 35.9 4.7 -4.6 -6.0
Number of incorrect matches in round 0.2 0.3 0.4 -0.4 -0.4 0.6
Past tobacco smoking 3.7 6.7 9.9 -1.2 3.0 3.1
Alcohol usually taken with meals 2.6 4.2 5.2 -2.3 1.8 2.1
Nervous feelings 3.5 6.6 10.0 -2.1 2.3 3.2
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.4 1.0 1.0 -0.5 -0.1
Hearing difficulty/problems with background noise 0.4 0.6 1.8 -1.3 0.1 -0.2
Hair/balding pattern: Pattern 2 1.0 1.2 2.4 0.3 1.6 1.1
Had menopause 0.9 1.1 1.7 -1.3 -0.8 -1.0
Had other major operations 1.1 1.4 3.1 0.5 -0.9 -1.8
Forced vital capacity (FVC) 0.3 1.1 2.6 1.6 -0.9 -0.1
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.2 0.3 0.1 0.5 0.5
Ever unenthusiastic/disinterested for a whole week 0.7 0.9 1.1 1.0 1.0 0.7
Qualifications: None of the above 0.6 1.2 1.5 -1.0 -1.1 -1.2
Financial difficulties in last 2 years 2.4 3.2 4.2 1.6 -2.0 -1.7
Mouth/teeth dental problems 1.5 2.3 6.7 2.6 0.3 0.3
Heart attack 0.3 0.4 0.8 0.2 -0.9 -0.6
Allergy 0.1 0.1 0.3 -0.2 0.5 -0.2
Pain all over the body in last month 5.6 6.0 9.4 0.8 -2.8 -3.1
Diabetes (self-reported) 0.5 0.8 1.3 -0.4 -1.0 -1.1
Hayfever/allergic rhinitis (self-reported) 2.5 3.3 4.4 -1.7 1.6 2.1
Medication: Ramipril 6.0 7.7 9.5 3.1 -2.8 -2.4
Medication: Simvastatin 5.1 7.5 10.3 1.5 -3.1 -3.2
Fluid intelligence score 1.5 3.0 5.0 -2.2 1.4 1.4
Illnesses of siblings 4.9 6.9 10.2 -1.9 3.2 2.6
Neuroticism score 0.1 0.2 0.3 -0.1 -0.5 -0.5
Weight 6.3 30.7 36.2 5.2 -5.4 -6.0
Impedance of arm (right) 3.6 17.0 19.8 -4.5 4.2 3.7
Arm fat percentage (right) 3.1 12.3 21.6 3.0 -2.5 -4.7
Trunk fat-free mass 4.0 23.1 27.0 5.0 -5.2 -4.2
Hip circumference 5.7 24.7 33.6 4.4 -4.6 -5.8
Time employed in main current job 2.4 2.7 4.7 1.3 -2.2 -1.4
Alcohol intake versus 10 years previously 0.4 0.7 1.9 1.4 0.2 -0.2
Father’s age at death 0.9 1.1 2.1 0.2 1.1 1.4
Worrier / anxious feelings 0.2 0.4 0.5 0.7 0.5 0.7
Frequency of tiredness / lethargy in last 2 weeks 0.6 1.1 1.6 0.8 -1.2 -1.0
Falls in the last year 2.0 2.7 4.5 0.1 -2.1 -1.9
Hair/balding pattern: Pattern 3 0.8 1.1 2.6 0.3 -1.6 -0.9
Number of live births 2.4 3.3 4.1 -1.8 2.0 1.6
Forced expiratory volume in 1-second (FEV1) 0.3 1.1 1.8 1.1 0.6 1.3
Pulse rate 1.0 1.7 3.3 -0.3 1.8 1.4
Happiness 1.1 1.4 1.5 -1.1 1.2 1.1
Noisy workplace 0.1 0.1 0.1 -0.2 0.2 -0.3
Qualifications: A levels/AS levels or equivalent 1.4 3.0 5.4 -1.2 1.5 2.3
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.5 1.3 -1.1 -0.5 0.1
Mouth/teeth dental problems: Dentures 0.5 0.8 2.0 -1.4 -0.5 -0.5
Asthma 1.7 3.3 5.2 1.1 -1.8 -2.3
Medication: Ibuprofen (e.g. Nurofen) 1.6 2.0 2.9 -0.6 -1.6 -1.7
Medication: Cholesterol lowering 2.5 3.9 4.7 1.7 -2.1 -2.2
Depression (self-reported) 0.2 0.3 0.4 -0.6 0.4 0.5
Medication: Lansoprazole 0.8 0.9 1.4 1.1 -1.2 -0.4
Prospective memory result 0.3 0.4 1.0 1.0 0.3 -0.1
Lung cancer (father) 0.3 0.3 1.0 1.0 -0.2 0.1
Illnesses of mother 3.2 4.0 6.5 -0.8 2.6 2.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.4 3.0 0.1 1.2 1.7
Pulse wave Arterial Stiffness index 2.2 2.5 3.4 1.4 -1.5 -1.8
Impedance of arm (left) 4.6 21.5 26.1 -5.1 4.5 4.2
Arm fat mass (right) 5.3 21.7 30.4 4.3 -4.0 -5.5
Trunk predicted mass 4.1 23.2 27.0 5.0 -5.2 -4.2
Standing height 0.6 5.6 10.1 2.2 -3.2 -1.4
Length of working week for main job 3.7 4.1 6.3 -0.1 2.5 2.5
Exposure to tobacco smoke at home 3.7 4.1 4.8 -2.2 1.8 2.1
Breastfed as a baby 0.1 0.1 0.1 -0.3 0.2 0.2
Tense / ‘highly strung’ 0.1 0.2 0.3 0.5 0.1 0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.7 0.8 -0.9 -0.9 -0.7
Hair/balding pattern: Pattern 4 0.7 1.7 3.9 -0.1 2.0 1.1
Birth weight of first child 0.5 0.8 1.8 -1.4 -0.0 0.8
Peak expiratory flow (PEF) 0.1 0.2 0.5 0.5 0.7 -0.0
Pulse wave reflection index 1.8 2.3 4.0 0.7 -2.0 -1.5
Ever highly irritable/argumentative for 2 days 0.7 0.9 2.4 -1.6 -0.4 0.3
Loud music exposure frequency 0.3 0.3 0.6 -0.8 0.2 0.5
Qualifications: O levels/GCSEs or equivalent 0.8 1.3 2.5 0.8 0.9 1.6
Mouth/teeth dental problems: Bleeding gums 2.6 3.4 4.4 -2.1 2.1 1.2
Blood clot in the leg (DVT) 6.5 8.4 10.2 2.3 -3.2 -3.1
Medication: Paracetamol 5.8 9.7 15.7 0.6 -4.0 -3.6
Headache pain in last month 1.7 3.0 4.0 1.4 -1.7 -2.0
Medication for cholesterol, blood pressure or diabetes 10.4 17.2 24.1 -2.8 4.4 4.9
Glaucoma (self-reported) 0.1 0.1 0.3 0.5 -0.1 0.1
Gout (self-reported) 0.5 0.6 1.5 1.2 0.7 -0.0
Hypothyroidism/myxoedema (self-reported) 0.1 0.3 0.4 0.5 0.3 -0.7
Medication: Amlodipine 12.7 17.9 24.8 2.3 -5.0 -4.9
Medication: Ventolin 100micrograms inhaler 5.2 6.6 7.7 2.3 -2.8 -2.7
Birth weight 0.3 0.6 0.9 0.4 0.9 0.8
Chronic bronchitis/emphysema (mother) 0.2 0.2 0.3 -0.5 0.5 0.2
High blood pressure (siblings) 6.3 9.0 15.7 1.3 -4.0 -3.1
Forced vital capacity (FVC), Best measure 0.1 0.3 0.9 -0.2 -0.1 0.9
Body fat percentage 3.3 13.1 23.1 2.9 -2.8 -4.8
Leg fat percentage (right) 3.3 11.9 20.4 3.1 -2.4 -4.5
Arm fat-free mass (right) 4.9 24.9 27.2 5.1 -5.2 -4.6
Exposure to tobacco smoke outside home 0.5 0.6 1.4 -0.4 -0.5 -1.2
Comparative body size at age 10 1.8 4.9 5.9 2.4 -1.7 -2.4
Number of full brothers 0.5 0.6 1.5 -1.2 0.6 0.0
Worry too long after embarrassment 0.7 1.1 1.8 -0.8 1.0 1.3
Seen a psychiatrist for nerves, anxiety, tension or depression 1.9 2.5 4.8 -2.2 1.3 0.9
Wheeze or whistling in the chest in last year 1.6 2.9 4.4 1.7 -1.1 -2.1
Number of children fathered 0.2 0.3 0.6 0.8 -0.0 -0.4
Reason for reducing amount of alcohol drunk: Health precaution 4.6 5.4 8.8 -1.6 2.2 3.0
Age at first live birth 0.8 1.5 2.6 -0.9 1.0 1.6
Pulse wave peak to peak time 1.5 1.8 2.3 -1.3 1.2 1.5
Health satisfaction 0.2 0.3 0.4 -0.3 -0.7 -0.6
Shortness of breath walking on level ground 1.2 1.4 3.7 1.9 0.7 -0.3
Qualifications: College or University degree 0.3 1.1 2.0 -0.6 0.9 1.4
Eye problems/disorders: None of the above 1.5 1.7 3.6 1.9 -0.7 -1.1
Mouth/teeth dental problems: Loose teeth 0.4 0.5 1.3 -1.1 -0.2 -0.0
Emphysema/chronic bronchitis 2.0 2.3 3.1 1.8 -1.3 -1.4
Medication for pain relief, constipation, heartburn 13.5 23.0 34.3 -1.2 5.9 5.8
Neck or shoulder pain in last month 2.2 3.1 4.5 0.9 -2.1 -2.0
Medication: Blood pressure 14.3 25.2 33.5 3.5 -5.5 -5.8
Angina (self-reported) 0.1 0.1 0.3 0.1 -0.5 -0.4
Migraine (self-reported) 2.1 2.5 3.8 2.0 -1.0 -1.7
Medication: Ibuprofen 0.9 1.1 2.0 -0.9 -0.8 -1.4
Medication: Allopurinol 0.5 0.7 1.9 1.4 0.3 -0.2
Medication: Omeprazole 2.3 2.8 5.7 0.7 -1.5 -2.4
Medication: Seretide 50 evohaler 0.1 0.2 0.4 0.2 -0.7 -0.1
Mean time to correctly identify matches 0.4 0.8 2.4 -1.6 0.3 -0.1
Heart disease (mother) 0.8 0.9 2.2 0.3 -1.5 -0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.4 0.7 0.5 -0.3 -0.9
Whole body fat mass 5.6 23.3 34.0 4.3 -4.2 -5.8
Leg fat mass (right) 6.5 25.1 35.3 4.8 -4.1 -5.9
Arm predicted mass (right) 5.2 26.6 28.8 5.3 -5.4 -4.8
Pulse rate, automated reading 0.3 1.0 1.4 -1.0 1.2 0.9
Alcohol intake frequency. 2.9 6.8 9.7 3.1 -1.9 -2.7
Comparative height size at age 10 3.4 18.8 27.9 2.6 -5.3 -4.7
Number of full sisters 0.9 1.0 1.9 0.0 1.1 1.4
Suffer from ‘nerves’ 0.0 0.0 0.0 0.1 -0.1 0.1
Overall health rating 2.7 5.7 9.6 1.4 -2.3 -3.1
Chest pain or discomfort 0.3 0.4 0.7 -0.0 -0.7 -0.8
Had major operations 0.9 1.1 2.4 0.1 -1.5 -0.9
Age at last live birth 2.8 4.1 5.7 -1.7 1.9 2.4
Family relationship satisfaction 3.7 4.6 7.2 -2.0 1.6 2.7
Leg pain on walking 0.7 0.9 1.7 -0.6 -0.7 -1.3
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.8 1.7 0.3 -1.3 -0.8
Commuting to job workplace: Car/motor vehicle 0.9 1.0 2.9 1.7 0.1 0.4
Illness, injury, bereavement, stress in last 2 years 0.7 0.8 2.0 -0.2 1.4 0.6
Medication: Aspirin 5.5 7.3 12.8 0.9 -3.6 -2.9
Supplements: Vitamin C 2.6 3.0 3.9 1.1 -2.0 -2.0
Knee pain experienced in last month 4.5 6.9 10.9 1.8 -2.6 -3.3
Hypertension (Self-reported) 12.4 34.3 45.4 4.0 -6.5 -6.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.3 1.5 3.4 1.8 -0.7 -0.9
Illnesses of father: Heart disease 1.3 1.9 3.8 0.5 -1.2 -1.9
Illnesses of siblings: Diabetes 1.4 1.7 3.6 1.9 -1.1 -0.6
Smoking status: Previous 5.1 7.6 10.4 1.5 -3.2 -3.2
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.4 2.1 1.4 -0.9 -1.2
Whole body fat-free mass 4.8 27.6 30.8 5.3 -5.5 -4.9
Leg fat-free mass (right) 5.5 29.2 33.6 5.1 -5.8 -5.3
Arm fat percentage (left) 2.7 10.9 19.6 2.7 -2.5 -4.4
Average weekly red wine intake 0.0 0.1 0.2 -0.1 0.0 0.4
Handedness (chirality/laterality): Left-handed 0.4 0.5 0.8 0.3 0.9 0.8
Mood swings 0.3 0.5 0.9 0.7 -0.5 -0.9
Loneliness, isolation 0.5 0.7 1.0 0.7 -1.0 -0.9
Long-standing illness, disability or infirmity 1.9 2.8 4.9 0.7 -1.8 -2.2
Ever had bowel cancer screening 0.4 0.5 1.4 1.2 -0.2 0.1
Diabetes diagnosed by doctor 0.7 1.1 1.8 0.4 -1.1 -1.4
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.1 -0.1 0.3 -0.3
Friendships satisfaction 0.9 1.2 2.5 -1.6 0.3 0.9
Qualifications: nursing, teaching 0.7 1.0 1.2 0.9 1.1 1.1
Commuting to job workplace: Walk 0.3 0.4 0.8 0.1 -0.9 -0.5
Eye problems/disorders: Cataract 1.5 1.7 2.7 -1.7 1.3 0.9
Mouth/teeth dental problems: Mouth ulcers 0.5 0.8 1.2 -1.1 -0.9 -0.6
Medication for cholesterol 7.5 11.3 16.1 -1.5 4.0 3.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.9 2.3 4.7 0.1 -1.5 -2.2
Back pain experienced in last month 2.3 3.3 5.8 0.2 -2.0 -2.4
Mineral and other dietary supplements 0.2 0.3 0.4 -0.2 0.7 0.6
Breast cancer (self-reported) 0.7 0.8 1.3 -0.2 -1.1 -1.0
Asthma (self-reported) 1.8 3.6 5.9 1.1 -1.9 -2.4
Osteoporosis (self-reported) 0.1 0.1 0.2 0.5 -0.1 0.0
Osteoarthritis (self-reported) 2.7 3.5 6.2 0.8 -2.5 -1.9
Medication: Aspirin 6.0 7.8 13.2 1.1 -3.6 -3.0
Medication: Gliclazide 0.1 0.1 0.2 -0.4 0.0 -0.1
Illnesses of father: None of the above (group 1) 6.0 7.4 10.6 -2.4 2.4 3.3
Smoking status: Current 2.0 3.2 4.9 1.9 -1.0 -2.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.6 3.4 5.4 -0.8 2.0 2.3
Whole body water mass 4.7 26.9 30.7 5.2 -5.5 -4.8
Leg predicted mass (right) 5.4 28.9 33.3 5.1 -5.8 -5.2
Arm fat mass (left) 4.5 18.7 26.7 3.9 -3.8 -5.2
Number of self-reported non-cancer illnesses 5.6 9.8 13.0 1.9 -3.6 -3.6
Average weekly champagne plus white wine intake 0.3 0.4 0.8 -0.5 0.9 0.5
Miserableness 2.8 4.9 7.6 1.5 -2.2 -2.8
Guilty feelings 1.5 2.2 4.0 -0.5 -2.0 -1.6
Wears glasses or contact lenses 0.2 0.2 0.4 -0.4 -0.7 0.3
Ever taken oral contraceptive pill 1.1 1.2 2.0 0.1 1.4 1.3
Hearing aid user 0.4 0.4 0.9 -0.9 -0.2 -0.6
Mother’s age at death 0.3 0.4 0.8 0.9 -0.4 -0.6
Financial situation satisfaction 0.0 0.0 0.0 -0.0 0.2 0.1
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.1 -0.2 0.2 0.4
Commuting to job workplace: Public transport 0.1 0.1 0.2 -0.5 0.2 -0.2
Eye problems/disorders: Glaucoma 0.2 0.2 0.5 0.2 0.3 0.7
Medication: Blood pressure 10.8 20.5 28.1 2.7 -5.1 -5.3
Pain type(s) experienced in last month: Hip pain 1.2 1.6 3.2 -0.4 -1.2 -1.8
Supplements: Fish oil (including cod liver oil) 0.1 0.1 0.4 -0.6 0.2 -0.2
High cholesterol (Self-reported) 2.2 4.0 6.7 0.1 -2.6 -2.3
Medication: Bendroflumethiazide 8.2 12.5 18.9 2.0 -3.8 -4.3
Medication: Paracetamol 5.1 7.9 11.8 0.6 -3.4 -3.4
Medication: Lisinopril 2.6 3.3 5.9 1.5 -1.4 -2.4
Medication: Atorvastatin 0.1 0.1 0.3 0.5 0.1 -0.2
Illnesses of father: High blood pressure 1.6 2.0 3.1 1.2 -1.7 -1.3
Alcohol drinker status: Never 1.7 2.0 6.0 2.5 -0.2 -0.1
Ever smoked 2.3 4.0 7.1 0.9 -2.0 -2.7
Basal metabolic rate 5.3 29.5 31.4 5.4 -5.6 -5.3
Leg fat percentage (left) 3.6 13.1 22.0 3.2 -2.7 -4.7
Arm fat-free mass (left) 5.4 27.3 29.3 5.4 -5.4 -4.9
Number of operations (self-reported) 1.0 1.5 2.6 0.3 -1.3 -1.6
Average weekly beer plus cider intake 0.1 0.1 0.2 0.1 0.3 -0.4
Irritability 0.3 0.6 0.9 -0.5 -0.8 -1.0
Risk taking 2.5 3.6 5.9 1.5 -1.7 -2.4
Ever had prostate specific antigen (PSA) test 0.2 0.2 0.4 -0.2 -0.7 -0.5
Fractured/broken bones in last 5 years 0.5 0.7 1.4 0.4 -0.7 -1.2
Age started oral contraceptive pill 0.9 1.1 1.6 -1.2 0.9 0.9
Diastolic blood pressure, automated reading 6.1 18.8 26.3 2.5 -5.1 -4.9
Ever depressed for a whole week 0.1 0.2 0.3 0.2 0.3 0.6
Unable to work because of sickness or disability 3.9 5.0 9.1 1.4 -2.0 -3.0
Commuting to job workplace: Cycle 0.2 0.3 0.7 -0.1 -0.4 -0.9
Myopia 1.4 2.1 5.6 2.4 -0.2 -0.8
Vascular/heart problems diagnosed by doctor 12.2 33.3 43.6 -4.2 6.2 6.6
Cholesterol lowering medication 4.3 6.3 9.2 1.0 -3.0 -3.0
Medication: Omeprazole (e.g. Zanprol) 2.5 3.0 6.1 1.0 -1.4 -2.5
Pain experienced in last month 5.3 8.8 13.8 -1.3 3.3 3.7
Supplements: Calcium 0.3 0.4 0.5 -0.4 0.7 0.6
Basal cell carcinoma (self-reported) 0.1 0.1 0.1 0.1 -0.4 -0.3
Heart attack/myocardial infarction (self-reported) 0.1 0.1 0.3 -0.1 -0.6 -0.3
Deep venous thrombosis (DVT) (self-reported) 7.3 9.4 11.2 2.5 -3.3 -3.3
Heart disease (siblings) 2.1 2.6 3.4 1.3 -1.6 -1.9
Alcohol drinker status: Previous 0.6 0.7 2.0 0.2 -1.4 -0.4
Pack years of smoking 0.1 0.2 0.4 0.1 -0.7 -0.4
Impedance of whole body 4.6 23.4 25.1 -4.9 5.0 4.6
Leg fat mass (left) 6.5 25.4 35.2 4.8 -4.3 -5.9
Arm predicted mass (left) 5.4 27.4 29.8 5.5 -5.4 -4.9