TWAS hub - FAM108C1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0163	0.0078	0.01800	0.006	0.005	0.001	0.005	0.005	4.1e-03	0.00870	0.15000	0.0061	8.1e-03
2	TCGA	Lung Adenocarcinoma	0.0504	0.0244	0.00018	0.042	0.023	0.032	NA	0.045	1.1e-05	0.00087	0.00011	NA	5.6e-06
3	TCGA	Prostate Adenocarcinoma	0.0653	0.0302	0.00140	0.022	0.014	0.011	NA	0.023	1.9e-03	0.01200	0.02200	NA	1.7e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Number of treatments/medications taken	14.5	26.2	41.6	1.5	-5.9	-6.4
Medication: Blood pressure	14.3	25.2	33.5	3.5	-5.5	-5.8
Cardiovascular Disease	14.2	46.9	58.1	5.1	-7.5	-7.6
Medication for pain relief, constipation, heartburn	13.5	23.0	34.3	-1.2	5.9	5.8
High blood pressure	12.7	35.4	45.0	4.3	-6.5	-6.7
Medication: Amlodipine	12.7	17.9	24.8	2.3	-5.0	-4.9
Hypertension (Self-reported)	12.4	34.3	45.4	4.0	-6.5	-6.7
Vascular/heart problems diagnosed by doctor	12.2	33.3	43.6	-4.2	6.2	6.6
Medication: Blood pressure	10.8	20.5	28.1	2.7	-5.1	-5.3
Systolic blood pressure, automated reading	10.5	30.4	46.1	2.9	-6.8	-6.0
Medication for cholesterol, blood pressure or diabetes	10.4	17.2	24.1	-2.8	4.4	4.9
Systolic Blood Pressure	9.4	47.0	73.8	4.3	-8.6	-7.0
Medication: Bendroflumethiazide	8.2	12.5	18.9	2.0	-3.8	-4.3
Medication: Atenolol	7.5	9.4	12.3	2.4	-3.5	-3.2
Medication for cholesterol	7.5	11.3	16.1	-1.5	4.0	3.9
Deep venous thrombosis (DVT) (self-reported)	7.3	9.4	11.2	2.5	-3.3	-3.3
Waist circumference	7.2	26.5	35.9	4.7	-4.6	-6.0
Blood clot in the leg (DVT)	6.5	8.4	10.2	2.3	-3.2	-3.1
Leg fat mass (right)	6.5	25.1	35.3	4.8	-4.1	-5.9
Leg fat mass (left)	6.5	25.4	35.2	4.8	-4.3	-5.9
Weight	6.3	30.7	36.2	5.2	-5.4	-6.0
High blood pressure (siblings)	6.3	9.0	15.7	1.3	-4.0	-3.1
Smoking Status	6.1	14.5	20.7	3.2	-3.5	-4.6
Diastolic blood pressure, automated reading	6.1	18.8	26.3	2.5	-5.1	-4.9
Medication: Ramipril	6.0	7.7	9.5	3.1	-2.8	-2.4
Medication: Aspirin	6.0	7.8	13.2	1.1	-3.6	-3.0
Illnesses of father: None of the above (group 1)	6.0	7.4	10.6	-2.4	2.4	3.3
BMI	5.9	34.2	46.3	5.2	-5.4	-6.8
Medication: Paracetamol	5.8	9.7	15.7	0.6	-4.0	-3.6
Hip circumference	5.7	24.7	33.6	4.4	-4.6	-5.8
Pain all over the body in last month	5.6	6.0	9.4	0.8	-2.8	-3.1
Whole body fat mass	5.6	23.3	34.0	4.3	-4.2	-5.8
Number of self-reported non-cancer illnesses	5.6	9.8	13.0	1.9	-3.6	-3.6
Medication: Aspirin	5.5	7.3	12.8	0.9	-3.6	-2.9
Leg fat-free mass (right)	5.5	29.2	33.6	5.1	-5.8	-5.3
Leg predicted mass (right)	5.4	28.9	33.3	5.1	-5.8	-5.2
Arm fat-free mass (left)	5.4	27.3	29.3	5.4	-5.4	-4.9
Arm predicted mass (left)	5.4	27.4	29.8	5.5	-5.4	-4.9
Arm fat mass (right)	5.3	21.7	30.4	4.3	-4.0	-5.5
Basal metabolic rate	5.3	29.5	31.4	5.4	-5.6	-5.3
Pain experienced in last month	5.3	8.8	13.8	-1.3	3.3	3.7
Medication: Ventolin 100micrograms inhaler	5.2	6.6	7.7	2.3	-2.8	-2.7
Arm predicted mass (right)	5.2	26.6	28.8	5.3	-5.4	-4.8
Leg predicted mass (left)	5.1	27.3	28.9	5.0	-5.4	-5.3
Medication: Simvastatin	5.1	7.5	10.3	1.5	-3.1	-3.2
Smoking status: Previous	5.1	7.6	10.4	1.5	-3.2	-3.2
Medication: Paracetamol	5.1	7.9	11.8	0.6	-3.4	-3.4
Leg fat-free mass (left)	5.0	26.5	28.3	4.9	-5.3	-5.2
Body mass index (BMI)	5.0	21.2	30.6	4.1	-4.0	-5.5
Trunk fat mass	5.0	21.6	31.8	4.0	-4.2	-5.6
Illnesses of siblings	4.9	6.9	10.2	-1.9	3.2	2.6
Arm fat-free mass (right)	4.9	24.9	27.2	5.1	-5.2	-4.6
Taking other prescription medications	4.8	7.5	10.4	1.4	-3.2	-3.2
Whole body fat-free mass	4.8	27.6	30.8	5.3	-5.5	-4.9
Whole body water mass	4.7	26.9	30.7	5.2	-5.5	-4.8
Impedance of arm (left)	4.6	21.5	26.1	-5.1	4.5	4.2
Reason for reducing amount of alcohol drunk: Health precaution	4.6	5.4	8.8	-1.6	2.2	3.0
Impedance of whole body	4.6	23.4	25.1	-4.9	5.0	4.6
Knee pain experienced in last month	4.5	6.9	10.9	1.8	-2.6	-3.3
Arm fat mass (left)	4.5	18.7	26.7	3.9	-3.8	-5.2
Impedance of leg (right)	4.4	21.5	28.4	-3.9	5.3	4.6
Cholesterol lowering medication	4.3	6.3	9.2	1.0	-3.0	-3.0
Trunk predicted mass	4.1	23.2	27.0	5.0	-5.2	-4.2
Ovarian Cancer	4.0	5.2	7.9	-1.0	2.8	2.6
Trunk fat-free mass	4.0	23.1	27.0	5.0	-5.2	-4.2
Crohns Disease (2017)	3.9	8.6	16.5	4.1	-2.2	-2.1
Unable to work because of sickness or disability	3.9	5.0	9.1	1.4	-2.0	-3.0
Crohns Disease (2012)	3.8	6.1	7.9	2.8	-2.5	-2.1
Impedance of leg (left)	3.8	18.4	22.6	-3.8	4.8	4.3
HbA1C	3.7	4.1	7.1	2.7	-1.4	-1.8
Relative age voice broke	3.7	5.6	7.7	-2.0	2.3	2.8
Past tobacco smoking	3.7	6.7	9.9	-1.2	3.0	3.1
Length of working week for main job	3.7	4.1	6.3	-0.1	2.5	2.5
Exposure to tobacco smoke at home	3.7	4.1	4.8	-2.2	1.8	2.1
Family relationship satisfaction	3.7	4.6	7.2	-2.0	1.6	2.7
Impedance of arm (right)	3.6	17.0	19.8	-4.5	4.2	3.7
Leg fat percentage (left)	3.6	13.1	22.0	3.2	-2.7	-4.7
Age when periods started (menarche)	3.5	8.5	13.7	-2.0	2.8	3.7
High blood pressure (mother)	3.5	4.9	7.3	1.3	-2.7	-2.4
Nervous feelings	3.5	6.6	10.0	-2.1	2.3	3.2
Comparative height size at age 10	3.4	18.8	27.9	2.6	-5.3	-4.7
HDL Cholesterol	3.3	5.5	7.5	-2.7	1.7	2.5
Supplements: Zinc	3.3	3.6	5.3	0.9	-2.3	-2.2
Body fat percentage	3.3	13.1	23.1	2.9	-2.8	-4.8
Leg fat percentage (right)	3.3	11.9	20.4	3.1	-2.4	-4.5
Trunk fat percentage	3.2	12.7	22.4	2.7	-2.9	-4.7
Illnesses of mother	3.2	4.0	6.5	-0.8	2.6	2.2
Prostate Cancer	3.1	4.4	6.2	1.9	-1.9	-2.5
Arm fat percentage (right)	3.1	12.3	21.6	3.0	-2.5	-4.7
Irritable Bowel Disease (IBD)	3.0	7.1	16.2	4.0	-1.7	-1.5
Alcohol intake frequency.	2.9	6.8	9.7	3.1	-1.9	-2.7
Age at last live birth	2.8	4.1	5.7	-1.7	1.9	2.4
Miserableness	2.8	4.9	7.6	1.5	-2.2	-2.8
Body Mass Index (BMI) (2010)	2.7	3.6	5.9	1.4	-1.8	-2.4
Ever had hysterectomy (womb removed)	2.7	3.0	4.4	1.9	-1.1	-2.1
Overall health rating	2.7	5.7	9.6	1.4	-2.3	-3.1
Arm fat percentage (left)	2.7	10.9	19.6	2.7	-2.5	-4.4
Osteoarthritis (self-reported)	2.7	3.5	6.2	0.8	-2.5	-1.9
Medication: Metformin	2.6	3.7	6.5	0.4	-2.1	-2.5
Fed-up feelings	2.6	4.7	7.8	2.2	-1.2	-2.8
Alcohol usually taken with meals	2.6	4.2	5.2	-2.3	1.8	2.1
Mouth/teeth dental problems: Bleeding gums	2.6	3.4	4.4	-2.1	2.1	1.2
Supplements: Vitamin C	2.6	3.0	3.9	1.1	-2.0	-2.0
Medication: Lisinopril	2.6	3.3	5.9	1.5	-1.4	-2.4
Age at First Birth	2.5	3.7	7.8	-2.8	1.4	1.2
Hayfever/allergic rhinitis (self-reported)	2.5	3.3	4.4	-1.7	1.6	2.1
Medication: Cholesterol lowering	2.5	3.9	4.7	1.7	-2.1	-2.2
Risk taking	2.5	3.6	5.9	1.5	-1.7	-2.4
Medication: Omeprazole (e.g. Zanprol)	2.5	3.0	6.1	1.0	-1.4	-2.5
Current tobacco smoking	2.4	3.9	6.0	2.1	-1.1	-2.5
Financial difficulties in last 2 years	2.4	3.2	4.2	1.6	-2.0	-1.7
Time employed in main current job	2.4	2.7	4.7	1.3	-2.2	-1.4
Number of live births	2.4	3.3	4.1	-1.8	2.0	1.6
Medication: Omeprazole	2.3	2.8	5.7	0.7	-1.5	-2.4
Back pain experienced in last month	2.3	3.3	5.8	0.2	-2.0	-2.4
Ever smoked	2.3	4.0	7.1	0.9	-2.0	-2.7
Mean Putamen Volume	2.2	2.5	5.6	2.4	-0.9	-1.1
Fasting Glucose	2.2	2.6	4.2	-0.6	1.8	2.1
Pulse wave Arterial Stiffness index	2.2	2.5	3.4	1.4	-1.5	-1.8
Neck or shoulder pain in last month	2.2	3.1	4.5	0.9	-2.1	-2.0
High cholesterol (Self-reported)	2.2	4.0	6.7	0.1	-2.6	-2.3
Migraine (self-reported)	2.1	2.5	3.8	2.0	-1.0	-1.7
Heart disease (siblings)	2.1	2.6	3.4	1.3	-1.6	-1.9
Falls in the last year	2.0	2.7	4.5	0.1	-2.1	-1.9
Emphysema/chronic bronchitis	2.0	2.3	3.1	1.8	-1.3	-1.4
Smoking status: Current	2.0	3.2	4.9	1.9	-1.0	-2.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.9	2.5	4.8	-2.2	1.3	0.9
Long-standing illness, disability or infirmity	1.9	2.8	4.9	0.7	-1.8	-2.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.9	2.3	4.7	0.1	-1.5	-2.2
Hand grip strength (right)	1.8	4.9	13.0	-0.9	0.9	3.6
Maternal smoking around birth	1.8	2.6	3.3	1.7	-1.3	-1.8
Pulse wave reflection index	1.8	2.3	4.0	0.7	-2.0	-1.5
Comparative body size at age 10	1.8	4.9	5.9	2.4	-1.7	-2.4
Asthma (self-reported)	1.8	3.6	5.9	1.1	-1.9	-2.4
Coronary Artery Disease (CAD)	1.7	2.0	4.9	0.3	-2.2	-1.1
Relative age of first facial hair	1.7	3.4	4.5	-2.1	1.7	1.7
Asthma	1.7	3.3	5.2	1.1	-1.8	-2.3
Headache pain in last month	1.7	3.0	4.0	1.4	-1.7	-2.0
Alcohol drinker status: Never	1.7	2.0	6.0	2.5	-0.2	-0.1
Bipolar Disorder (2018)	1.6	2.6	4.3	-1.7	0.7	2.1
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.0	2.9	-0.6	-1.6	-1.7
Wheeze or whistling in the chest in last year	1.6	2.9	4.4	1.7	-1.1	-2.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.6	3.4	5.4	-0.8	2.0	2.3
Illnesses of father: High blood pressure	1.6	2.0	3.1	1.2	-1.7	-1.3
Average weekly spirits intake	1.5	1.9	2.9	0.6	-1.7	-1.5
Frequency of depressed mood in last 2 weeks	1.5	2.1	3.0	1.6	-0.8	-1.7
Other serious medical condition/disability diagnosed by doctor	1.5	2.0	3.2	1.3	-1.8	-1.1
Sitting height	1.5	10.4	21.5	1.9	-4.6	-2.5
Mouth/teeth dental problems	1.5	2.3	6.7	2.6	0.3	0.3
Fluid intelligence score	1.5	3.0	5.0	-2.2	1.4	1.4
Pulse wave peak to peak time	1.5	1.8	2.3	-1.3	1.2	1.5
Eye problems/disorders: None of the above	1.5	1.7	3.6	1.9	-0.7	-1.1
Eye problems/disorders: Cataract	1.5	1.7	2.7	-1.7	1.3	0.9
Guilty feelings	1.5	2.2	4.0	-0.5	-2.0	-1.6
Bilateral oophorectomy (both ovaries removed)	1.4	1.6	2.8	0.4	-1.4	-1.7
Diverticular disease/diverticulitis (self-reported)	1.4	1.6	3.1	0.5	1.3	1.8
Qualifications: A levels/AS levels or equivalent	1.4	3.0	5.4	-1.2	1.5	2.3
Illnesses of siblings: Diabetes	1.4	1.7	3.6	1.9	-1.1	-0.6
Myopia	1.4	2.1	5.6	2.4	-0.2	-0.8
Reaction Time	1.3	2.6	6.5	-2.5	0.9	0.6
Bipolar Disorder (2011)	1.3	1.3	1.8	-1.3	0.6	1.3
Type 2 Diabetes (T2D) (2012)	1.3	1.4	2.9	-1.2	-0.1	-1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.5	3.4	1.8	-0.7	-0.9
Illnesses of father: Heart disease	1.3	1.9	3.8	0.5	-1.2	-1.9
Medication for hormone replacement therapy	1.2	1.4	2.3	-1.5	0.6	1.2
Shortness of breath walking on level ground	1.2	1.4	3.7	1.9	0.7	-0.3
Pain type(s) experienced in last month: Hip pain	1.2	1.6	3.2	-0.4	-1.2	-1.8
Intelligence (Savage-Jansen 2018)	1.1	3.3	5.9	-1.3	2.4	1.6
Ulcerative Colitis (UC)	1.1	2.1	5.5	2.3	-0.7	-0.6
Had other major operations	1.1	1.4	3.1	0.5	-0.9	-1.8
Happiness	1.1	1.4	1.5	-1.1	1.2	1.1
Ever taken oral contraceptive pill	1.1	1.2	2.0	0.1	1.4	1.3
Breast Cancer	1.0	2.5	2.9	1.7	-1.6	-1.5
Blood Eosinophil Count	1.0	8.0	12.9	-2.6	3.6	2.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	2.2	0.9	-1.0	-1.5
Hair/balding pattern: Pattern 2	1.0	1.2	2.4	0.3	1.6	1.1
Pulse rate	1.0	1.7	3.3	-0.3	1.8	1.4
Number of operations (self-reported)	1.0	1.5	2.6	0.3	-1.3	-1.6
Rheumatoid Arthritis	0.9	1.2	2.0	1.4	-0.8	-1.0
Respiratory disease	0.9	2.1	3.6	0.4	-1.5	-1.9
Hand grip strength (left)	0.9	2.3	6.4	-0.7	-0.3	2.5
Diabetes (mother)	0.9	1.1	1.3	0.9	1.1	1.1
Qualifications: CSEs or equivalent	0.9	1.2	3.3	1.8	-0.2	-0.5
Had menopause	0.9	1.1	1.7	-1.3	-0.8	-1.0
Father’s age at death	0.9	1.1	2.1	0.2	1.1	1.4
Medication: Ibuprofen	0.9	1.1	2.0	-0.9	-0.8	-1.4
Number of full sisters	0.9	1.0	1.9	0.0	1.1	1.4
Had major operations	0.9	1.1	2.4	0.1	-1.5	-0.9
Commuting to job workplace: Car/motor vehicle	0.9	1.0	2.9	1.7	0.1	0.4
Friendships satisfaction	0.9	1.2	2.5	-1.6	0.3	0.9
Age started oral contraceptive pill	0.9	1.1	1.6	-1.2	0.9	0.9
Depressed Affect (Nagel 2018)	0.8	1.6	2.3	1.3	-0.9	-1.5
Blood White Count	0.8	6.1	13.2	-1.2	3.6	1.9
Allergy or Eczema	0.8	2.0	4.0	-1.3	0.7	2.0
Type 2 Diabetes (T2D) (2018)	0.8	1.5	2.2	1.2	-1.0	-1.5
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	0.9	-1.0	-0.9	-0.9
Hair/balding pattern: Pattern 3	0.8	1.1	2.6	0.3	-1.6	-0.9
Medication: Lansoprazole	0.8	0.9	1.4	1.1	-1.2	-0.4
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	2.5	0.8	0.9	1.6
Age at first live birth	0.8	1.5	2.6	-0.9	1.0	1.6
Heart disease (mother)	0.8	0.9	2.2	0.3	-1.5	-0.7
Ulcerative Colitis	0.7	1.0	2.9	1.7	-0.1	0.4
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	2.0	-1.4	-0.3	0.3
Serious illness, injury or assault to yourself	0.7	0.8	1.1	1.0	-1.0	-0.7
Supplements: Glucosamine	0.7	0.9	1.3	0.9	-1.1	-0.7
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	1.1	1.0	1.0	0.7
Hair/balding pattern: Pattern 4	0.7	1.7	3.9	-0.1	2.0	1.1
Ever highly irritable/argumentative for 2 days	0.7	0.9	2.4	-1.6	-0.4	0.3
Worry too long after embarrassment	0.7	1.1	1.8	-0.8	1.0	1.3
Leg pain on walking	0.7	0.9	1.7	-0.6	-0.7	-1.3
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	1.7	0.3	-1.3	-0.8
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	2.0	-0.2	1.4	0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.4	2.1	1.4	-0.9	-1.2
Diabetes diagnosed by doctor	0.7	1.1	1.8	0.4	-1.1	-1.4
Qualifications: nursing, teaching	0.7	1.0	1.2	0.9	1.1	1.1
Breast cancer (self-reported)	0.7	0.8	1.3	-0.2	-1.1	-1.0
Alzheimer’s Disease (including proxy)	0.6	0.9	1.2	0.6	-1.1	-1.0
Triglycerides	0.6	0.9	1.6	1.1	-0.3	-1.3
Lung FVC	0.6	3.1	7.0	-2.7	0.7	1.4
Severe depression (siblings)	0.6	0.7	1.1	0.8	-1.0	-0.6
Hayfever, allergic rhinitis or eczema	0.6	1.3	3.0	-0.5	0.8	1.7
Qualifications: None of the above	0.6	1.2	1.5	-1.0	-1.1	-1.2
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.1	1.6	0.8	-1.2	-1.0
Standing height	0.6	5.6	10.1	2.2	-3.2	-1.4
Alcohol drinker status: Previous	0.6	0.7	2.0	0.2	-1.4	-0.4
Chronotype (morning person)	0.5	1.2	2.4	-0.1	1.6	1.1
Average weekly fortified wine intake	0.5	0.6	1.7	1.3	0.2	0.3
Diabetes (self-reported)	0.5	0.8	1.3	-0.4	-1.0	-1.1
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	1.3	-1.1	-0.5	0.1
Mouth/teeth dental problems: Dentures	0.5	0.8	2.0	-1.4	-0.5	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.4	3.0	0.1	1.2	1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	0.8	-0.9	-0.9	-0.7
Birth weight of first child	0.5	0.8	1.8	-1.4	-0.0	0.8
Gout (self-reported)	0.5	0.6	1.5	1.2	0.7	-0.0
Exposure to tobacco smoke outside home	0.5	0.6	1.4	-0.4	-0.5	-1.2
Number of full brothers	0.5	0.6	1.5	-1.2	0.6	0.0
Medication: Allopurinol	0.5	0.7	1.9	1.4	0.3	-0.2
Loneliness, isolation	0.5	0.7	1.0	0.7	-1.0	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.2	-1.1	-0.9	-0.6
Fractured/broken bones in last 5 years	0.5	0.7	1.4	0.4	-0.7	-1.2
Bipolar Disorder or Schizophrenia	0.4	0.9	2.3	-0.7	0.2	1.5
Schizophrenia vs Biploar Disorder	0.4	0.6	0.9	0.4	-0.8	-1.0
Verbal and Numeric Reasoning (VNR)	0.4	0.9	1.5	-0.7	1.2	0.9
Primary Biliary Cirrhosis	0.4	0.5	0.9	0.9	-0.8	0.3
Heel T-Score	0.4	3.5	4.8	-1.5	1.9	2.2
Lung FEV1/FVC ratio	0.4	1.9	3.7	-0.2	1.4	1.9
Stomach or abdominal pain in last month	0.4	0.5	0.7	0.8	-0.7	-0.5
Hearing difficulty/problems with background noise	0.4	0.6	1.8	-1.3	0.1	-0.2
Alcohol intake versus 10 years previously	0.4	0.7	1.9	1.4	0.2	-0.2
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.3	-1.1	-0.2	-0.0
Mean time to correctly identify matches	0.4	0.8	2.4	-1.6	0.3	-0.1
Handedness (chirality/laterality): Left-handed	0.4	0.5	0.8	0.3	0.9	0.8
Ever had bowel cancer screening	0.4	0.5	1.4	1.2	-0.2	0.1
Hearing aid user	0.4	0.4	0.9	-0.9	-0.2	-0.6
Worry (Nagel 2018)	0.3	0.6	1.4	-0.1	0.7	1.2
Alzheimer’s Disease (in mother)	0.3	0.3	0.9	-0.4	0.9	0.2
Major Depression (MDD)	0.3	0.4	0.6	0.6	-0.3	-0.8
Waist Hip Ratio (WHR)	0.3	1.3	3.4	1.8	0.1	-0.7
Diabetes (father)	0.3	0.3	0.9	-0.3	0.9	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	1.0	1.0	-0.5	-0.1
Forced vital capacity (FVC)	0.3	1.1	2.6	1.6	-0.9	-0.1
Heart attack	0.3	0.4	0.8	0.2	-0.9	-0.6
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	1.8	1.1	0.6	1.3
Prospective memory result	0.3	0.4	1.0	1.0	0.3	-0.1
Lung cancer (father)	0.3	0.3	1.0	1.0	-0.2	0.1
Loud music exposure frequency	0.3	0.3	0.6	-0.8	0.2	0.5
Birth weight	0.3	0.6	0.9	0.4	0.9	0.8
Qualifications: College or University degree	0.3	1.1	2.0	-0.6	0.9	1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	0.7	0.5	-0.3	-0.9
Pulse rate, automated reading	0.3	1.0	1.4	-1.0	1.2	0.9
Chest pain or discomfort	0.3	0.4	0.7	-0.0	-0.7	-0.8
Mood swings	0.3	0.5	0.9	0.7	-0.5	-0.9
Commuting to job workplace: Walk	0.3	0.4	0.8	0.1	-0.9	-0.5
Average weekly champagne plus white wine intake	0.3	0.4	0.8	-0.5	0.9	0.5
Mother’s age at death	0.3	0.4	0.8	0.9	-0.4	-0.6
Irritability	0.3	0.6	0.9	-0.5	-0.8	-1.0
Supplements: Calcium	0.3	0.4	0.5	-0.4	0.7	0.6
Depression (Nagel 2018)	0.2	0.3	0.5	0.7	-0.2	-0.6
Alzheimer’s Disease (in father)	0.2	0.2	0.6	0.3	-0.8	-0.0
Blood Red Count	0.2	1.7	4.7	-2.2	0.3	0.6
Vitamin and mineral supplements	0.2	0.3	0.6	-0.4	0.3	0.8
Multivitamins +/- minerals	0.2	0.2	0.5	0.7	0.1	-0.4
Medication: Levothyroxine sodium	0.2	0.4	0.6	0.7	0.8	-0.1
Number of incorrect matches in round	0.2	0.3	0.4	-0.4	-0.4	0.6
Worrier / anxious feelings	0.2	0.4	0.5	0.7	0.5	0.7
Depression (self-reported)	0.2	0.3	0.4	-0.6	0.4	0.5
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.3	-0.5	0.5	0.2
Number of children fathered	0.2	0.3	0.6	0.8	-0.0	-0.4
Health satisfaction	0.2	0.3	0.4	-0.3	-0.7	-0.6
Mineral and other dietary supplements	0.2	0.3	0.4	-0.2	0.7	0.6
Wears glasses or contact lenses	0.2	0.2	0.4	-0.4	-0.7	0.3
Eye problems/disorders: Glaucoma	0.2	0.2	0.5	0.2	0.3	0.7
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.4	-0.2	-0.7	-0.5
Commuting to job workplace: Cycle	0.2	0.3	0.7	-0.1	-0.4	-0.9
Schizophrenia (2018)	0.1	0.1	0.2	0.5	-0.4	0.3
LDL Cholesterol	0.1	0.1	0.4	0.1	0.6	-0.0
Lupus	0.1	0.2	0.5	0.7	0.2	0.4
Neuroticism (2016)	0.1	0.2	0.3	-0.6	0.5	0.1
Schizophrenia (2014)	0.1	0.2	0.3	-0.4	-0.1	0.5
Neuroticism	0.1	0.2	0.4	-0.6	-0.3	-0.3
Hair Pigment	0.1	2.3	5.2	-2.3	1.1	0.7
Tanning	0.1	1.8	5.1	2.3	-0.2	-0.5
Sensitivity / hurt feelings	0.1	0.1	0.3	0.5	-0.1	-0.4
Hearing difficulty/problems: Yes	0.1	0.1	0.3	-0.3	0.5	-0.3
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.1	-0.4	-0.2	0.1
Angina	0.1	0.1	0.3	0.1	-0.5	-0.4
Medication: Co-codamol	0.1	0.1	0.3	0.1	-0.2	-0.5
Townsend deprivation index at recruitment	0.1	0.1	0.2	0.4	0.3	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.3	0.6	0.6	0.5
Chronic bronchitis/emphysema (father)	0.1	0.1	0.2	-0.5	0.5	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.3	0.1	0.5	0.5
Allergy	0.1	0.1	0.3	-0.2	0.5	-0.2
Neuroticism score	0.1	0.2	0.3	-0.1	-0.5	-0.5
Noisy workplace	0.1	0.1	0.1	-0.2	0.2	-0.3
Breastfed as a baby	0.1	0.1	0.1	-0.3	0.2	0.2
Tense / ‘highly strung’	0.1	0.2	0.3	0.5	0.1	0.5
Peak expiratory flow (PEF)	0.1	0.2	0.5	0.5	0.7	-0.0
Glaucoma (self-reported)	0.1	0.1	0.3	0.5	-0.1	0.1
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	0.4	0.5	0.3	-0.7
Forced vital capacity (FVC), Best measure	0.1	0.3	0.9	-0.2	-0.1	0.9
Angina (self-reported)	0.1	0.1	0.3	0.1	-0.5	-0.4
Medication: Seretide 50 evohaler	0.1	0.2	0.4	0.2	-0.7	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.1	-0.1	0.3	-0.3
Osteoporosis (self-reported)	0.1	0.1	0.2	0.5	-0.1	0.0
Medication: Gliclazide	0.1	0.1	0.2	-0.4	0.0	-0.1
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.1	-0.2	0.2	0.4
Commuting to job workplace: Public transport	0.1	0.1	0.2	-0.5	0.2	-0.2
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.4	-0.6	0.2	-0.2
Medication: Atorvastatin	0.1	0.1	0.3	0.5	0.1	-0.2
Average weekly beer plus cider intake	0.1	0.1	0.2	0.1	0.3	-0.4
Ever depressed for a whole week	0.1	0.2	0.3	0.2	0.3	0.6
Basal cell carcinoma (self-reported)	0.1	0.1	0.1	0.1	-0.4	-0.3
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.3	-0.1	-0.6	-0.3
Pack years of smoking	0.1	0.2	0.4	0.1	-0.7	-0.4
Neuroticism (Nagel 2018)	0.0	0.0	0.1	0.1	-0.2	-0.2
Blood Platelet Count	0.0	0.6	1.1	0.7	1.1	0.2
Height	0.0	0.8	2.0	-0.1	-1.4	0.7
Hypothyroidism (self reported)	0.0	0.0	0.1	0.0	0.3	0.1
Pack years adult smoking proportion	0.0	0.1	0.1	0.1	-0.4	-0.1
Suffer from ‘nerves’	0.0	0.0	0.0	0.1	-0.1	0.1
Average weekly red wine intake	0.0	0.1	0.2	-0.1	0.0	0.4
Financial situation satisfaction	0.0	0.0	0.0	-0.0	0.2	0.1

Hub : Genes

FAM108C1

Models

Trait associations