TWAS
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Usage
Models
Genes
Traits
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Traits
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Leg fat-free mass (left)
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chr17:6,524,791-8,041,014
Best TWAS P=5.54e-10 · Best GWAS P=3.82e-11 conditioned to 3.52e-06
6.6M
6.8M
7M
7.2M
7.4M
7.6M
7.8M
8M
0
2
4
6
8
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Prostate
RP11-104H15.8
0.54
0.01
enet
1
0.06
0.01560
-6.20
-6.2
5.5e-10
-0.17
0.04
0.44
TRUE
2
METSIM
Adipose
NEURL4
0.06
0.00
blup
454
0.01
0.00817
-0.64
-5.2
2.5e-07
-0.02
0.11
0.02
TRUE
4
The Cancer Genome Atlas
Thyroid Carcinoma
SENP3
0.07
0.04
enet
9
0.03
0.00027
1.99
5.1
2.7e-07
0.20
0.44
0.03
TRUE
3
The Cancer Genome Atlas
Prostate Adenocarcinoma
EFNB3
0.06
0.03
lasso
4
0.05
0.00001
-5.61
5.3
8.6e-08
0.19
0.65
0.29
FALSE