TWAS
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Models
Genes
Traits
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Traits
:
Leg fat-free mass (left)
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chr17:4,488,884-6,031,861
Best TWAS P=4.23e-08 · Best GWAS P=5.91e-07 conditioned to 0.23
4.4M
4.6M
4.8M
5M
5.2M
5.4M
5.6M
5.8M
6M
0
1
2
3
4
5
6
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
The Cancer Genome Atlas
Glioblastoma Multiforme
RABEP1
0.23
0.13
blup
79
0.15
3.4e-05
4.2
-5.5
4.2e-08
-0.77
0.04
0.77
TRUE
1
GTEx
Esophagus Gastroesophageal Junction
RABEP1
0.19
-0.01
lasso
13
0.00
4.2e-01
4.1
-5.2
1.5e-07
-0.82
0.03
0.68
FALSE
2
ROSMAP
Brain Pre-frontal Cortex
RPAIN
0.06
0.06
lasso
3
0.06
3.1e-08
5.0
-5.2
2.1e-07
-0.98
0.00
0.99
FALSE