[Hub]/) : Traits : Leg fat-free mass (left) :

chr20:42,816,319-44,279,989

Best TWAS P=2.39e-13 · Best GWAS P=2.28e-12 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex PABPC1L 0.17 0.16 lasso 1 0.15 8.0e-18 6.9 -6.9 6.2e-12 -0.99 0.01 0.99 FALSE
2 GTEx Adipose Subcutaneous YWHAB 0.13 0.17 lasso 2 0.15 2.8e-12 7.0 -7.0 2.7e-12 -1.00 0.00 1.00 FALSE
3 GTEx Adipose Visceral Omentum YWHAB 0.19 0.07 lasso 4 0.05 1.1e-03 6.9 -7.2 7.8e-13 -0.99 0.01 0.99 FALSE
4 GTEx Adrenal Gland PABPC1L 0.32 0.07 lasso 8 0.07 1.9e-03 6.9 -6.5 5.8e-11 -0.88 0.01 0.94 FALSE
5 GTEx Adrenal Gland YWHAB 0.23 0.15 lasso 3 0.10 1.4e-04 7.0 -6.9 4.2e-12 -1.00 0.01 0.99 FALSE
6 GTEx Artery Aorta YWHAB 0.29 0.17 lasso 5 0.15 1.3e-08 7.0 -7.2 5.4e-13 -0.99 0.01 0.99 FALSE
7 GTEx Artery Tibial YWHAB 0.17 0.15 lasso 3 0.16 3.5e-12 7.0 -7.0 2.0e-12 -1.00 0.00 1.00 FALSE
8 GTEx Brain Cerebellar Hemisphere YWHAB 0.42 0.22 lasso 4 0.18 2.3e-05 6.9 -7.2 6.4e-13 -0.99 0.01 0.98 FALSE
9 GTEx Brain Cerebellum YWHAB 0.43 0.19 lasso 7 0.16 1.7e-05 6.9 -7.3 2.4e-13 -0.97 0.01 0.98 TRUE
10 GTEx Brain Nucleus accumbens basal ganglia YWHAB 0.22 0.11 lasso 3 0.07 6.5e-03 6.9 -7.1 1.7e-12 -0.97 0.01 0.95 FALSE
11 GTEx Breast Mammary Tissue YWHAB 0.18 0.09 lasso 6 0.08 5.2e-05 7.0 -6.4 1.2e-10 -0.97 0.01 0.99 FALSE
12 GTEx Cells EBV-transformed lymphocytes YWHAB 0.27 0.12 enet 13 0.18 1.2e-06 6.5 -6.9 4.3e-12 -0.95 0.01 0.99 FALSE
13 GTEx Cells Transformed fibroblasts PABPC1L 0.12 0.03 enet 22 0.08 2.0e-06 3.6 5.6 1.9e-08 0.72 0.04 0.96 FALSE
14 GTEx Cells Transformed fibroblasts YWHAB 0.29 0.20 enet 21 0.26 1.5e-19 6.8 -6.1 9.1e-10 -0.84 0.01 0.99 FALSE
15 GTEx Colon Sigmoid YWHAB 0.27 0.14 lasso 4 0.10 1.7e-04 6.9 -6.0 1.6e-09 -0.94 0.01 0.98 FALSE
16 GTEx Esophagus Gastroesophageal Junction YWHAB 0.31 0.18 lasso 5 0.14 9.9e-06 6.6 -6.8 1.3e-11 -0.95 0.01 0.99 FALSE
17 GTEx Esophagus Mucosa YWHAB 0.25 0.27 enet 7 0.27 4.2e-18 7.0 -7.0 2.8e-12 -0.99 0.01 0.99 FALSE
18 GTEx Esophagus Muscularis YWHAB 0.16 0.11 lasso 3 0.14 1.5e-08 5.8 -6.7 2.3e-11 -0.92 0.01 0.99 FALSE
19 GTEx Lung YWHAB 0.10 0.04 lasso 4 0.04 6.5e-04 7.0 -7.0 2.5e-12 -0.99 0.01 0.99 FALSE
20 GTEx Muscle Skeletal YWHAB 0.09 0.07 lasso 5 0.07 4.5e-07 6.9 -6.9 4.1e-12 -0.98 0.01 0.99 FALSE
21 GTEx Nerve Tibial TOMM34 0.11 0.02 lasso 4 0.03 6.0e-03 3.6 5.2 2.0e-07 0.67 0.03 0.84 FALSE
22 GTEx Nerve Tibial YWHAB 0.21 0.24 lasso 2 0.23 3.3e-16 6.6 -6.8 1.5e-11 -0.94 0.02 0.98 FALSE
23 GTEx Skin Not Sun Exposed Suprapubic YWHAB 0.33 0.24 lasso 4 0.26 1.6e-14 6.9 -7.0 2.4e-12 -0.96 0.01 0.99 FALSE
24 GTEx Skin Sun Exposed Lower leg YWHAB 0.17 0.18 lasso 2 0.17 4.7e-14 7.0 -7.0 2.6e-12 -1.00 0.00 1.00 FALSE
25 GTEx Testis YWHAB 0.23 0.23 enet 14 0.23 1.8e-10 7.0 -6.8 7.8e-12 -0.97 0.00 1.00 FALSE
26 GTEx Thyroid YWHAB 0.22 0.18 lasso 2 0.17 5.3e-13 7.0 -7.0 2.3e-12 -1.00 0.00 1.00 FALSE
27 GTEx Whole Blood YWHAB 0.20 0.10 lasso 9 0.10 1.6e-09 7.0 -6.6 4.4e-11 -0.98 0.01 0.99 FALSE
28 METSIM Adipose TOMM34 0.34 0.09 enet 73 0.16 2.5e-23 -4.7 5.2 1.8e-07 0.27 1.00 0.00 FALSE
29 NTR Blood YWHAB 0.16 0.19 lasso 5 0.19 2.2e-58 6.9 -6.9 6.1e-12 -0.99 0.01 0.99 FALSE
30 ROSMAP Brain Pre-frontal Cortex PABPC1L 0.24 0.21 lasso 3 0.21 8.1e-27 6.9 -6.4 1.6e-10 -0.98 0.01 0.99 FALSE
31 ROSMAP Brain Pre-frontal Cortex YWHAB 0.56 0.58 bslmm 418 0.59 7.7e-94 7.0 -7.0 1.8e-12 -1.00 0.00 1.00 FALSE
32 YFS Blood YWHAB 0.07 0.06 lasso 4 0.07 6.8e-21 6.6 6.8 1.5e-11 0.95 0.02 0.98 FALSE
33 The Cancer Genome Atlas Breast Invasive Carcinoma PABPC1L 0.02 0.02 lasso 4 0.02 2.2e-04 6.9 -6.9 6.6e-12 -0.99 0.01 0.99 FALSE
34 The Cancer Genome Atlas Esophageal Carcinoma YWHAB 0.15 0.14 lasso 5 0.10 4.6e-04 6.5 -6.5 1.1e-10 -0.85 0.03 0.88 FALSE
35 The Cancer Genome Atlas Brain Lower Grade Glioma PABPC1L 0.20 0.21 lasso 3 0.21 5.5e-23 6.9 -6.9 5.4e-12 -0.99 0.01 0.99 FALSE
36 The Cancer Genome Atlas Brain Lower Grade Glioma YWHAB 0.06 0.07 enet 6 0.09 7.4e-11 5.8 -6.9 4.2e-12 -0.94 0.01 0.99 FALSE
37 The Cancer Genome Atlas Lung Squamous Cell Carcinoma YWHAB 0.04 0.03 lasso 5 0.04 2.9e-05 6.6 -6.7 2.5e-11 -0.93 0.01 0.97 FALSE
38 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma YWHAB 0.07 0.06 lasso 2 0.06 1.3e-04 6.9 -7.1 1.2e-12 -0.99 0.01 0.97 FALSE
39 The Cancer Genome Atlas Prostate Adenocarcinoma PABPC1L 0.08 0.14 lasso 4 0.14 4.2e-14 6.9 -6.9 5.4e-12 -0.99 0.01 0.99 FALSE
40 The Cancer Genome Atlas Prostate Adenocarcinoma YWHAB 0.07 0.06 lasso 6 0.06 3.1e-07 6.9 -7.0 1.9e-12 -0.96 0.01 0.99 FALSE
41 The Cancer Genome Atlas Stomach Adenocarcinoma YWHAB 0.04 0.05 enet 10 0.03 2.3e-03 6.5 -6.8 1.3e-11 -0.88 0.01 0.92 FALSE
42 The Cancer Genome Atlas Thyroid Carcinoma YWHAB 0.12 0.13 lasso 5 0.12 4.3e-12 6.9 -6.9 5.8e-12 -0.99 0.01 0.99 FALSE