TWAS
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Models
Genes
Traits
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Traits
:
Leg predicted mass (left)
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chr12:191,619-1,795,687
Best TWAS P=4.24e-10 · Best GWAS P=1.36e-13 conditioned to 4.92e-07
0.2M
0.4M
0.6M
0.8M
1M
1.2M
1.4M
1.6M
1.8M
0
5
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Adipose Visceral Omentum
RAD52
0.14
0.07
lasso
3
0.10
1.1e-05
-5.1
-6.2
4.2e-10
-0.44
0.38
0.55
TRUE
2
GTEx
Artery Tibial
B4GALNT3
0.49
0.24
enet
24
0.34
6.5e-28
4.5
-5.3
1.1e-07
-0.02
1.00
0.00
TRUE
4
The Cancer Genome Atlas
Esophageal Carcinoma
RAD52
0.25
0.13
blup
66
0.19
1.1e-06
6.9
-6.0
2.4e-09
-0.61
0.01
0.99
FALSE
3
GTEx
Testis
RAD52
0.29
0.19
lasso
3
0.18
2.3e-08
5.7
-5.2
2.4e-07
-0.49
0.63
0.36
FALSE