Best TWAS P=1.99e-10 · Best GWAS P=1.53e-10 conditioned to 0.122
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Heart Left Ventricle | H2AFJ | 0.16 | 0.07 | lasso | 8 | 0.05 | 1.1e-03 | -6.2 | -6.1 | 7.9e-10 | 0.85 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Liver | H2AFJ | 0.18 | 0.11 | lasso | 8 | 0.04 | 2.7e-02 | -6.2 | -5.3 | 1.0e-07 | 0.79 | 0.03 | 0.82 | FALSE |
| 3 | ROSMAP | Brain Pre-frontal Cortex | WBP11 | 0.10 | 0.05 | lasso | 4 | 0.06 | 1.2e-08 | -4.7 | 6.2 | 7.5e-10 | -0.72 | 0.06 | 0.94 | FALSE |
| 4 | YFS | Blood | H2AFJ | 0.05 | 0.02 | bslmm | 360 | 0.03 | 2.9e-10 | -6.2 | -5.3 | 8.8e-08 | 0.68 | 0.01 | 0.99 | FALSE |
| 5 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | C12orf60 | 0.12 | 0.07 | enet | 8 | 0.07 | 5.4e-05 | 4.3 | 5.5 | 4.4e-08 | -0.64 | 0.08 | 0.80 | FALSE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | WBP11 | 0.03 | 0.03 | blup | 57 | 0.02 | 2.3e-03 | -6.2 | 6.4 | 2.0e-10 | -0.90 | 0.01 | 0.94 | TRUE |
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | C12orf60 | 0.16 | 0.16 | enet | 10 | 0.18 | 1.3e-17 | 4.3 | 5.6 | 2.4e-08 | -0.61 | 0.99 | 0.00 | FALSE |