Best TWAS P=2.03e-09 · Best GWAS P=2.6e-10 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | CCDC91 | 0.10 | 0.10 | lasso | 5 | 0.09 | 5.5e-07 | -5.6 | -5.7 | 1.4e-08 | 0.85 | 0.13 | 0.86 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | RP11-967K21.1 | 0.07 | 0.07 | lasso | 2 | 0.07 | 3.7e-06 | -5.9 | 6.0 | 2.0e-09 | -0.96 | 0.05 | 0.95 | TRUE |
| 3 | GTEx | Heart Atrial Appendage | RP11-967K21.1 | 0.08 | 0.09 | lasso | 1 | 0.08 | 2.3e-04 | -5.9 | 5.9 | 3.2e-09 | -0.91 | 0.04 | 0.92 | FALSE |
| 4 | GTEx | Muscle Skeletal | RP11-967K21.1 | 0.04 | 0.01 | lasso | 9 | 0.00 | 2.9e-01 | -5.5 | 5.2 | 2.6e-07 | -0.90 | 0.06 | 0.80 | FALSE |
| 5 | GTEx | Skin Not Sun Exposed Suprapubic | CCDC91 | 0.26 | 0.05 | lasso | 15 | 0.04 | 4.1e-03 | -6.3 | -5.4 | 5.7e-08 | 0.87 | 0.03 | 0.97 | FALSE |
| 6 | GTEx | Skin Sun Exposed Lower leg | CCDC91 | 0.09 | 0.01 | enet | 8 | 0.01 | 2.6e-02 | -5.9 | -5.6 | 2.3e-08 | 0.85 | 0.07 | 0.88 | FALSE |
| 7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CCDC91 | 0.04 | 0.04 | lasso | 3 | 0.03 | 1.8e-06 | -5.2 | -5.3 | 1.4e-07 | 0.94 | 0.20 | 0.80 | FALSE |
| 8 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | CCDC91 | 0.09 | 0.11 | lasso | 2 | 0.12 | 2.3e-05 | -5.4 | -5.4 | 8.2e-08 | 0.91 | 0.07 | 0.91 | FALSE |
| 9 | The Cancer Genome Atlas | Thyroid Carcinoma | CCDC91 | 0.40 | 0.12 | blup | 175 | 0.14 | 4.9e-13 | -5.6 | -5.2 | 2.1e-07 | 0.72 | 0.10 | 0.90 | FALSE |