Best TWAS P=9.83e-12 · Best GWAS P=9.36e-12 conditioned to 0.00513
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Thyroid | ADCY4 | 0.13 | 0.13 | lasso | 6 | 0.09 | 1.0e-07 | 4.0 | 5.2 | 2.4e-07 | 0.51 | 0.49 | 0.51 | FALSE |
| 2 | METSIM | Adipose | ADCY4 | 0.07 | 0.03 | lasso | 5 | 0.03 | 2.2e-05 | 6.3 | 6.8 | 9.8e-12 | 0.71 | 0.08 | 0.92 | TRUE |
| 3 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | ADCY4 | 0.03 | 0.01 | blup | 75 | 0.03 | 1.1e-03 | 4.2 | 5.3 | 9.9e-08 | 0.71 | 0.05 | 0.72 | FALSE |
| 4 | The Cancer Genome Atlas | Colon Adenocarcinoma | ADCY4 | 0.07 | 0.02 | lasso | 4 | 0.03 | 4.7e-03 | 4.6 | 5.4 | 5.8e-08 | 0.70 | 0.03 | 0.76 | FALSE |
| 5 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ADCY4 | 0.06 | 0.06 | lasso | 6 | 0.09 | 3.0e-10 | 5.9 | 6.7 | 2.5e-11 | 0.75 | 0.08 | 0.92 | FALSE |
| 6 | The Cancer Genome Atlas | Lung Adenocarcinoma | ADCY4 | 0.07 | 0.09 | lasso | 3 | 0.08 | 4.4e-10 | 4.7 | 5.9 | 4.8e-09 | 0.73 | 0.78 | 0.22 | FALSE |
| 7 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | LTB4R | 0.16 | 0.05 | blup | 73 | 0.08 | 4.9e-04 | 3.1 | -5.2 | 2.2e-07 | -0.70 | 0.02 | 0.60 | FALSE |
| 8 | The Cancer Genome Atlas | Stomach Adenocarcinoma | LTB4R2 | 0.04 | 0.04 | lasso | 1 | 0.02 | 2.5e-02 | 5.7 | -5.7 | 1.3e-08 | -0.70 | 0.04 | 0.54 | FALSE |