Best TWAS P=2.21e-10 · Best GWAS P=1.21e-11 conditioned to 0.000453
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | MARVELD3 | 0.07 | 0.05 | lasso | 3 | 0.09 | 5.7e-11 | -6.1 | -5.6 | 2.2e-08 | 0.57 | 0.27 | 0.73 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | PHLPP2 | 0.04 | 0.01 | bslmm | 456 | 0.02 | 4.7e-04 | -4.8 | -6.3 | 2.2e-10 | 0.65 | 0.24 | 0.70 | TRUE |
| 3 | GTEx | Adrenal Gland | AP1G1 | 0.22 | 0.06 | enet | 25 | 0.14 | 8.0e-06 | -6.0 | -6.0 | 2.5e-09 | 0.60 | 0.20 | 0.76 | FALSE |
| 4 | GTEx | Testis | PHLPP2 | 0.29 | 0.38 | enet | 20 | 0.37 | 3.0e-17 | -6.1 | 6.0 | 2.3e-09 | -0.70 | 0.24 | 0.76 | FALSE |
| 5 | YFS | Blood | PHLPP2 | 0.04 | 0.03 | bslmm | 459 | 0.05 | 5.5e-16 | -6.0 | 5.4 | 7.4e-08 | -0.56 | 0.29 | 0.71 | FALSE |
| 6 | The Cancer Genome Atlas | Esophageal Carcinoma | PHLPP2 | 0.18 | 0.03 | blup | 67 | 0.07 | 2.9e-03 | -6.1 | -5.3 | 9.3e-08 | 0.62 | 0.05 | 0.31 | FALSE |
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | AP1G1 | 0.11 | 0.02 | enet | 27 | 0.04 | 1.2e-04 | 2.9 | -5.2 | 1.6e-07 | 0.22 | 0.08 | 0.24 | FALSE |