TWAS hub - MARVELD3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0750	0.0270	1.9e-07	0.050	0.059	0.087	0.066	0.089	1.0e-06	1.1e-07	8.5e-11	1.9e-08	5.7e-11
2	TCGA	Prostate Adenocarcinoma	0.0534	0.0263	1.0e-05	0.007	0.043	0.038	NA	0.028	6.0e-02	2.3e-05	7.0e-05	NA	5.4e-04
3	TCGA	Thyroid Carcinoma	0.0790	0.0370	1.3e-06	0.012	0.064	0.048	NA	0.042	2.3e-02	7.1e-07	1.6e-05	NA	5.3e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Neck or shoulder pain in last month	8.6	12.3	24.3	-2.2	-2.7	4.9
Pain experienced in last month	8.2	13.7	29.0	2.2	2.7	-5.4
Medication: Cholesterol lowering	7.7	12.0	15.1	-2.5	3.9	-3.8
Overall health rating	6.8	14.6	24.9	-3.3	-2.8	5.0
Frequency of tiredness / lethargy in last 2 weeks	6.5	10.6	20.8	-2.9	-1.6	4.6
Depression (Nagel 2018)	6.4	9.7	15.3	-2.1	-3.1	3.9
Hearing difficulty/problems: Yes	6.4	9.8	18.7	-0.4	-4.3	3.2
Hearing difficulty/problems with background noise	6.2	9.9	16.4	-3.1	-2.0	4.0
Medication: Atorvastatin	6.2	7.6	18.1	0.8	2.0	-4.3
Back pain experienced in last month	6.0	8.8	13.8	-1.3	-3.3	3.7
Frequency of unenthusiasm / disinterest in last 2 weeks	5.7	7.5	13.5	-1.0	-2.9	3.7
Falls in the last year	5.6	7.6	12.9	-3.0	3.6	-1.0
Schizophrenia vs Biploar Disorder	5.1	6.8	10.1	-0.5	-3.2	3.2
Knee pain experienced in last month	5.1	7.9	13.2	-1.8	-2.7	3.6
Medication: Aspirin	4.9	6.4	10.8	-2.6	3.3	-1.2
Fed-up feelings	4.6	8.4	12.8	-3.6	-0.4	3.5
Serious illness, injury or assault to yourself	4.6	5.6	12.9	-3.6	2.0	0.1
Intelligence (Savage-Jansen 2018)	4.3	13.2	28.8	1.1	3.1	-5.4
Qualifications: None of the above	4.1	8.9	13.2	-1.6	-3.6	3.3
Age at first live birth	4.1	7.3	11.9	2.7	1.7	-3.5
Fasting Glucose	4.0	4.7	7.2	2.7	-2.4	-1.1
Stomach or abdominal pain in last month	4.0	5.0	9.1	-2.2	-0.9	3.0
Number of live births	4.0	5.6	11.6	0.4	-3.4	2.3
Arm fat-free mass (right)	4.0	20.4	35.6	-4.2	-2.8	6.0
Arm fat-free mass (left)	4.0	20.1	31.4	-4.7	-2.5	5.6
Irritability	4.0	6.7	12.8	-2.7	0.3	3.6
Medication for cholesterol, blood pressure or diabetes	3.9	6.4	9.9	1.6	-2.6	3.1
Arm predicted mass (right)	3.9	19.8	34.1	-4.1	-2.9	5.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.9	8.3	17.7	2.4	-4.2	1.2
Shortness of breath walking on level ground	3.8	4.5	7.1	-2.2	-1.2	2.7
High cholesterol (Self-reported)	3.8	6.8	17.7	1.1	1.2	-4.2
Commuting to job workplace: Car/motor vehicle	3.7	4.2	5.1	-1.7	-2.2	2.3
Whole body fat-free mass	3.7	20.9	31.7	-5.3	-1.8	5.6
Whole body water mass	3.7	21.1	31.6	-5.3	-1.8	5.6
Basal metabolic rate	3.7	20.6	29.7	-5.5	-1.6	5.4
Arm predicted mass (left)	3.7	18.9	28.9	-4.5	-2.7	5.4
Trunk fat-free mass	3.6	20.5	33.3	-4.9	-2.0	5.8
Trunk predicted mass	3.6	20.6	33.3	-4.9	-2.0	5.8
Leg predicted mass (right)	3.6	19.3	32.4	-5.7	-0.9	5.0
Leg fat-free mass (right)	3.5	18.8	31.6	-5.6	-0.9	4.9
Leg fat-free mass (left)	3.4	18.1	31.7	-5.6	-0.9	4.7
Relative age voice broke	3.4	5.2	9.2	-2.4	0.9	3.0
Leg predicted mass (left)	3.4	17.8	31.2	-5.6	-0.9	4.6
Prospective memory result	3.4	4.2	6.7	-1.8	-1.7	2.6
Mean time to correctly identify matches	3.4	6.5	8.1	2.9	-2.1	-2.6
Comparative height size at age 10	3.4	18.9	35.4	-4.2	-2.0	6.0
Medication: Simvastatin	3.2	4.7	7.3	-1.9	1.8	-2.7
Forced vital capacity (FVC), Best measure	3.2	11.8	19.0	1.7	-4.4	3.7
Long-standing illness, disability or infirmity	3.2	4.9	13.2	-3.6	0.3	1.1
Medication: Bendroflumethiazide	3.2	4.9	10.4	0.8	2.0	-3.2
Ever had stillbirth, spontaneous miscarriage or termination	3.1	3.3	5.7	-2.4	1.7	1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.1	3.6	7.1	-1.9	0.2	2.7
Forced expiratory volume in 1-second (FEV1)	3.0	10.1	15.1	1.2	-3.7	3.9
Tense / ‘highly strung’	3.0	5.0	11.8	-1.8	0.1	3.4
Qualifications: College or University degree	3.0	9.4	13.9	0.8	3.7	-3.7
Medication: Aspirin	3.0	3.9	6.6	-1.7	2.6	-1.5
Commuting to job workplace: Public transport	3.0	3.6	5.5	0.6	2.3	-2.3
Weight	2.9	14.2	24.5	-5.0	-1.4	4.0
Exposure to tobacco smoke outside home	2.9	3.8	8.8	-3.0	1.6	0.5
Mother’s age at death	2.9	3.6	6.6	2.6	-1.8	-1.0
Rheumatoid Arthritis	2.8	3.9	9.9	-0.1	-3.1	1.4
Chronotype (morning person)	2.8	6.4	18.9	0.6	0.0	4.3
Number of treatments/medications taken	2.8	5.0	7.4	-2.6	2.7	-0.9
Past tobacco smoking	2.8	5.1	6.7	2.1	-2.6	2.0
Breast cancer (self-reported)	2.8	3.3	8.1	-0.4	-2.8	1.3
Verbal and Numeric Reasoning (VNR)	2.7	6.4	13.3	1.7	1.7	-3.6
Cardiovascular Disease	2.7	9.0	13.5	-1.0	3.5	-3.7
Medication: Blood pressure	2.7	5.2	9.9	0.5	2.4	-3.1
LDL Cholesterol	2.6	4.1	10.8	0.4	1.2	-3.3
Systolic Blood Pressure	2.6	12.8	28.6	2.5	1.8	-5.3
Frequency of depressed mood in last 2 weeks	2.6	3.6	6.8	-1.8	-0.8	2.6
Forced vital capacity (FVC)	2.6	10.2	14.8	1.7	-3.6	3.8
Forced expiratory volume in 1-second (FEV1), Best measure	2.6	8.2	13.3	1.0	-3.6	3.2
Eye problems/disorders: None of the above	2.6	3.0	4.7	1.8	-2.2	-1.1
Mood swings	2.6	4.7	7.0	-2.6	-0.3	2.6
Pain type(s) experienced in last month: Hip pain	2.6	3.3	7.9	-1.1	-1.0	2.8
Ever smoked	2.6	4.5	6.4	-2.5	2.3	-1.3
Vascular/heart problems diagnosed by doctor	2.6	7.2	11.0	1.6	-3.3	2.8
Smoking Status	2.5	6.0	11.1	-3.3	2.6	0.1
High blood pressure	2.5	7.1	10.9	-1.3	3.3	-2.9
Eye problems/disorders: Cataract	2.5	2.9	8.7	0.2	3.0	-0.3
Risk taking	2.5	3.7	7.7	-2.8	1.6	1.0
Breast Cancer	2.4	5.9	16.4	-1.1	4.0	-0.3
Hand grip strength (left)	2.4	6.3	11.5	1.0	-2.5	3.4
Length of working week for main job	2.4	2.7	4.4	-0.5	1.9	-2.1
Ever taken oral contraceptive pill	2.4	2.7	4.3	-2.1	1.9	0.2
Medication for hormone replacement therapy	2.3	2.5	4.0	-2.0	1.5	1.2
Townsend deprivation index at recruitment	2.3	3.2	6.7	-2.6	0.3	1.7
Pain all over the body in last month	2.3	2.4	6.1	-0.3	-1.1	2.5
Arm fat mass (left)	2.3	9.5	22.8	-4.8	-0.8	2.2
Wears glasses or contact lenses	2.3	2.6	4.4	-0.5	1.8	-2.1
Fractured/broken bones in last 5 years	2.3	3.0	4.5	-2.1	1.7	1.2
Mean Putamen Volume	2.2	2.5	6.4	2.5	0.9	-0.6
Medication: Atenolol	2.2	2.7	4.0	-1.0	1.8	-2.0
Reason for reducing amount of alcohol drunk: Health precaution	2.2	2.5	3.7	1.9	-1.9	-0.5
Medication for pain relief, constipation, heartburn	2.2	3.8	8.4	2.9	-1.6	-0.8
Hypertension (Self-reported)	2.2	6.0	8.3	-1.3	2.9	-2.9
Smoking status: Current	2.2	3.5	7.7	-2.8	1.5	0.6
Major Depression (MDD)	2.1	2.5	4.8	-2.2	-1.2	1.1
Prostate Cancer	2.1	2.9	6.9	1.4	-2.6	0.3
Qualifications: CSEs or equivalent	2.1	2.7	5.4	-1.7	0.3	2.3
Had other major operations	2.1	2.6	4.7	-1.7	-0.6	2.2
Alcohol intake frequency.	2.1	4.9	9.3	1.3	-2.0	3.0
Guilty feelings	2.1	3.2	5.3	2.3	-1.9	0.7
Illnesses of father: High blood pressure	2.1	2.6	4.4	-0.4	1.8	-2.1
Depressed Affect (Nagel 2018)	2.0	4.2	6.1	-2.4	-0.8	2.5
Body Mass Index (BMI) (2010)	2.0	2.7	5.2	-2.3	1.0	1.4
HDL Cholesterol	2.0	3.4	8.2	-0.7	2.9	-1.2
Blood Red Count	2.0	19.4	37.6	4.2	-1.6	-6.1
Systolic blood pressure, automated reading	2.0	5.8	13.5	1.9	0.7	-3.7
Chronic bronchitis/emphysema (father)	2.0	2.4	3.7	1.6	-1.9	0.9
Heart attack	2.0	2.5	4.2	-1.8	2.0	-0.5
Arm fat mass (right)	2.0	8.4	21.7	-4.7	-0.5	1.8
Ever highly irritable/argumentative for 2 days	2.0	2.4	3.6	-0.6	-1.9	1.8
Medication: Lisinopril	2.0	2.6	4.7	-0.6	2.2	-1.7
Cholesterol lowering medication	2.0	2.9	7.8	0.9	-0.3	-2.8
Lung FVC	1.9	9.8	18.1	3.3	-4.2	0.4
Financial difficulties in last 2 years	1.9	2.6	3.8	-2.0	1.9	0.2
Fluid intelligence score	1.9	4.0	8.3	0.9	1.7	-2.9
Birth weight	1.9	4.0	7.5	-1.3	2.7	-1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.9	2.5	3.9	-1.5	-2.0	1.2
Chest pain or discomfort	1.9	2.8	5.8	-2.4	1.2	1.1
Leg pain on walking	1.9	2.3	3.8	-1.7	-0.5	2.0
Smoking status: Previous	1.9	2.9	4.5	-0.8	1.9	-2.1
Forced expiratory volume in 1-second (FEV1), predicted	1.9	4.0	10.4	-1.0	0.7	3.2
Number of self-reported non-cancer illnesses	1.9	3.3	5.2	-2.3	1.9	-1.0
Number of operations (self-reported)	1.9	2.9	4.6	-2.1	0.4	1.9
Diastolic blood pressure, automated reading	1.9	5.9	10.3	-0.9	2.6	-3.2
Heart attack/myocardial infarction (self-reported)	1.9	2.5	3.7	-1.9	1.9	-0.5
Hand grip strength (right)	1.8	4.8	9.9	0.6	-2.1	3.2
Bilateral oophorectomy (both ovaries removed)	1.8	2.1	3.7	-0.4	-1.9	1.6
Hip circumference	1.8	7.6	18.5	-4.3	-0.2	2.1
Standing height	1.8	17.4	45.7	-2.4	-0.8	6.8
Number of children fathered	1.8	2.0	5.3	0.6	-2.3	0.6
Whole body fat mass	1.8	7.7	15.4	-3.9	-1.1	2.5
Number of full sisters	1.8	2.2	3.9	-2.0	0.2	1.6
Bipolar Disorder (2018)	1.7	2.7	4.6	-1.7	0.9	-2.1
Alzheimer’s Disease (including proxy)	1.7	2.4	6.1	2.5	-0.9	-0.6
Height	1.7	32.0	84.1	-3.2	-1.3	9.2
Current tobacco smoking	1.7	2.7	6.5	-2.5	1.2	0.4
Nervous feelings	1.7	3.2	3.9	1.7	-2.0	1.7
Medication: Ramipril	1.7	2.2	3.4	-0.6	1.7	-1.9
Worrier / anxious feelings	1.7	3.3	8.6	2.9	-0.6	-1.0
Health satisfaction	1.7	2.3	3.8	-1.6	-0.8	1.9
Heart disease (siblings)	1.7	2.1	5.2	0.7	-2.3	0.8
Schizophrenia (2018)	1.6	3.3	5.4	-0.8	-2.3	1.9
Reaction Time	1.6	3.1	3.5	1.9	-1.7	-1.7
Schizophrenia (2014)	1.6	3.6	5.7	-1.3	-2.4	1.8
Body mass index (BMI)	1.6	6.9	17.4	-4.2	-1.3	1.2
Trunk fat mass	1.6	6.9	12.7	-3.6	-1.1	2.6
Impedance of arm (right)	1.6	7.2	13.6	1.7	3.7	-2.3
Father’s age at death	1.6	2.1	4.9	2.2	0.2	-1.2
Leg fat mass (right)	1.6	6.3	13.5	-3.7	-1.0	2.0
Medication for cholesterol	1.6	2.4	3.8	0.6	-1.7	1.9
Age started oral contraceptive pill	1.6	2.0	4.0	0.8	1.1	-2.0
Leg fat mass (left)	1.6	6.4	12.5	-3.5	-1.3	2.3
Angina	1.5	2.0	2.5	-1.6	1.5	-1.2
Waist circumference	1.5	5.5	10.0	-3.2	-1.1	2.3
Qualifications: O levels/GCSEs or equivalent	1.5	2.4	4.0	1.0	1.5	-2.0
Pulse rate, automated reading	1.5	4.7	7.3	-1.2	-2.7	2.3
Illness, injury, bereavement, stress in last 2 years	1.5	1.8	3.7	1.9	-1.3	0.0
Unable to work because of sickness or disability	1.5	1.9	4.0	-0.9	-0.9	2.0
Multivitamins +/- minerals	1.4	1.8	5.1	0.1	2.3	-0.4
Diverticular disease/diverticulitis (self-reported)	1.4	1.6	3.7	0.4	-1.9	1.0
Ever unenthusiastic/disinterested for a whole week	1.4	1.8	4.5	-2.1	0.6	-0.6
Diabetes (self-reported)	1.4	2.1	6.3	-2.5	-0.4	-0.1
Emphysema/chronic bronchitis	1.4	1.6	2.6	0.1	-1.5	1.6
Supplements: Vitamin C	1.4	1.7	2.1	-1.4	1.5	1.0
Ever had bowel cancer screening	1.4	1.7	3.5	-0.2	-1.9	1.2
Ever had prostate specific antigen (PSA) test	1.4	1.6	4.1	0.9	-2.0	-0.0
Alzheimer’s Disease (in father)	1.3	1.4	2.5	-0.1	-1.6	1.3
Diabetes (father)	1.3	1.6	4.8	-2.2	-0.1	-0.1
Pulse rate	1.3	2.2	3.7	-1.2	-1.3	1.9
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.6	3.8	-1.9	1.0	-0.0
Medication: Blood pressure	1.3	2.4	3.1	-1.4	1.4	-1.8
Age at last live birth	1.3	1.9	3.3	0.2	1.5	-1.8
Family relationship satisfaction	1.3	1.6	3.8	0.6	-2.0	0.7
Qualifications: nursing, teaching	1.3	2.0	2.9	0.9	1.7	-1.5
Average weekly beer plus cider intake	1.3	1.9	2.8	-1.7	-1.0	1.4
Neuroticism (Nagel 2018)	1.2	2.7	6.1	-1.0	-1.1	2.5
Alzheimer’s Disease (in mother)	1.2	1.4	2.8	1.7	0.3	-1.1
Age at First Birth	1.2	1.8	4.8	0.7	-0.0	-2.2
Coronary Artery Disease (CAD)	1.2	1.4	3.5	-0.3	1.9	-0.8
Impedance of leg (right)	1.2	5.7	16.0	4.0	0.7	-0.8
Impedance of leg (left)	1.2	6.0	17.1	4.1	0.8	-0.3
Arm fat percentage (right)	1.2	4.8	14.2	-3.8	0.6	-0.0
Impedance of arm (left)	1.2	5.4	11.5	1.5	3.4	-1.5
Pulse wave reflection index	1.2	1.5	1.8	-1.2	1.3	-1.1
Angina (self-reported)	1.2	1.6	2.0	-1.4	1.3	-1.1
Medication: Ibuprofen	1.2	1.4	2.6	-1.6	1.3	0.0
Had major operations	1.2	1.5	2.2	-1.5	1.5	-0.0
Arm fat percentage (left)	1.2	4.9	14.6	-3.8	0.2	0.4
Ever depressed for a whole week	1.2	1.5	4.4	-2.1	0.3	0.0
BMI	1.1	6.6	19.6	-4.4	-0.1	0.2
Tanning	1.1	13.4	23.7	-0.7	-4.0	4.9
Other serious medical condition/disability diagnosed by doctor	1.1	1.5	2.8	-0.6	-1.7	1.1
Severe depression (siblings)	1.1	1.2	2.0	-1.4	1.2	-0.5
Pack years adult smoking proportion	1.1	1.7	2.6	-1.6	1.2	1.1
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.6	2.1	0.9	-1.4	1.5
Neuroticism score	1.1	2.2	5.6	-0.8	-0.7	2.4
Average weekly red wine intake	1.1	1.6	2.7	-1.7	1.3	-0.5
Medication: Gliclazide	1.1	1.3	3.0	-1.7	-0.4	0.7
Miserableness	1.1	2.0	5.7	-2.4	0.5	0.2
Heel T-Score	1.0	8.3	17.3	2.8	-4.2	-0.1
Alcohol usually taken with meals	1.0	1.6	2.5	1.1	1.6	-1.0
Noisy workplace	1.0	1.2	2.7	-0.9	0.5	1.6
Qualifications: A levels/AS levels or equivalent	1.0	2.2	4.8	0.9	1.0	-2.2
Medication: Lansoprazole	1.0	1.1	2.2	-1.0	1.5	-0.4
Hypothyroidism/myxoedema (self-reported)	1.0	1.9	3.7	-1.9	1.2	0.6
Comparative body size at age 10	1.0	2.8	6.3	-2.5	0.7	1.2
Wheeze or whistling in the chest in last year	1.0	1.8	2.9	-1.5	-0.5	1.7
Impedance of whole body	1.0	5.2	11.0	3.3	1.9	-0.9
Ovarian Cancer	0.9	1.2	2.7	-0.6	1.6	-0.9
Neuroticism	0.9	2.1	5.1	-0.7	-0.8	2.3
Relative age of first facial hair	0.9	1.9	2.5	-1.6	1.6	0.9
Vitamin and mineral supplements	0.9	1.2	3.5	-0.3	-1.9	0.3
Medication: Metformin	0.9	1.3	3.3	-1.8	-0.1	0.7
Taking other prescription medications	0.9	1.4	1.9	-1.2	-0.9	1.4
Age when periods started (menarche)	0.9	2.1	5.3	2.3	1.0	-0.3
Sitting height	0.9	6.6	14.1	-1.2	-2.1	3.8
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.1	3.9	2.0	-1.5	-0.2
Pulse wave Arterial Stiffness index	0.9	1.0	2.0	-1.4	1.1	0.1
Gout (self-reported)	0.9	1.2	3.0	-1.7	0.4	-0.7
Pulse wave peak to peak time	0.9	1.1	2.0	1.4	-1.1	0.3
Loneliness, isolation	0.9	1.3	1.7	0.9	-1.2	1.3
Bipolar Disorder (2011)	0.8	0.8	2.0	0.0	-1.4	-0.6
Average weekly spirits intake	0.8	1.0	2.3	-1.5	0.8	-0.5
Sensitivity / hurt feelings	0.8	1.4	3.5	-0.3	-0.8	1.9
Trunk fat percentage	0.8	3.2	7.3	-2.7	-0.6	1.4
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.8	3.6	1.9	-1.1	-0.7
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	2.0	0.1	0.6	-1.4
Medication: Levothyroxine sodium	0.8	1.4	2.7	-1.1	1.6	-0.4
Alcohol intake versus 10 years previously	0.8	1.2	2.6	0.1	-1.6	1.0
Peak expiratory flow (PEF)	0.8	1.9	3.5	0.3	-1.5	1.9
Loud music exposure frequency	0.8	0.9	1.5	-0.4	-1.2	1.0
Headache pain in last month	0.8	1.4	2.3	-1.3	0.5	1.5
Medication: Allopurinol	0.8	1.0	2.3	-1.5	0.5	-0.7
Osteoporosis (self-reported)	0.8	1.0	2.7	0.0	1.6	-0.6
Ulcerative Colitis (UC)	0.7	1.2	2.4	-1.1	1.5	-0.4
Crohns Disease (2012)	0.7	1.2	2.7	-0.7	-0.6	1.6
Allergy or Eczema	0.7	1.8	3.4	1.2	-1.9	-0.8
Hypothyroidism (self reported)	0.7	1.5	3.2	-1.8	0.4	1.1
Diabetes (mother)	0.7	0.9	1.4	-0.7	-0.9	1.2
Average weekly fortified wine intake	0.7	0.8	1.2	-1.1	0.7	-0.9
Hayfever, allergic rhinitis or eczema	0.7	1.4	2.2	1.4	-1.5	-0.4
Number of incorrect matches in round	0.7	1.2	2.2	1.1	0.3	-1.5
Had menopause	0.7	0.9	2.5	0.4	-1.6	0.1
Body fat percentage	0.7	2.7	6.6	-2.6	-0.6	1.0
Diabetes diagnosed by doctor	0.7	1.2	3.0	-1.7	0.5	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	2.4	1.6	0.5	-0.8
Mineral and other dietary supplements	0.7	1.0	1.7	-1.3	-1.1	0.2
Supplements: Calcium	0.7	0.8	1.6	0.7	1.3	-0.6
Bipolar Disorder or Schizophrenia	0.6	1.5	2.9	-1.7	-1.3	0.2
Crohns Disease (2017)	0.6	1.2	2.3	-0.9	-0.7	1.5
Primary Biliary Cirrhosis	0.6	0.8	2.3	-0.4	1.5	-0.2
Blood Eosinophil Count	0.6	4.6	11.0	0.1	-3.3	1.7
Respiratory disease	0.6	1.4	2.0	-1.3	-0.7	1.4
Ever used hormone-replacement therapy (HRT)	0.6	0.7	1.8	-1.3	0.3	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.5	0.7	-0.5	-1.2
Lung cancer (father)	0.6	0.7	1.2	1.1	0.4	-0.9
Illnesses of mother	0.6	0.7	1.4	-0.6	-1.2	0.6
Medication: Paracetamol	0.6	1.0	2.0	-0.7	-0.8	1.4
Worry too long after embarrassment	0.6	1.0	1.8	1.3	-1.1	0.2
Medication: Paracetamol	0.6	0.9	2.5	-0.5	-0.3	1.6
Alcohol drinker status: Previous	0.6	0.7	1.4	-0.8	-0.3	1.2
Neuroticism (2016)	0.5	0.7	2.0	-0.1	1.4	-0.2
Blood Platelet Count	0.5	6.3	8.8	1.9	-3.0	2.5
Type 2 Diabetes (T2D) (2018)	0.5	1.0	1.5	-0.9	0.8	-1.2
High blood pressure (mother)	0.5	0.8	1.7	0.4	1.3	-0.7
Illnesses of siblings	0.5	0.7	2.1	-0.1	1.5	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	1.0	-0.8	-0.7	1.0
Hair/balding pattern: Pattern 4	0.5	1.3	3.0	-1.7	0.9	0.3
Medication: Ventolin 100micrograms inhaler	0.5	0.7	0.8	-0.8	-0.8	0.9
High blood pressure (siblings)	0.5	0.7	1.5	-1.2	0.7	-0.5
Leg fat percentage (right)	0.5	1.6	4.2	-2.0	-0.7	0.5
Migraine (self-reported)	0.5	0.7	2.0	-0.1	1.4	-0.0
Medication: Omeprazole	0.5	0.6	1.9	-1.4	0.1	0.0
Heart disease (mother)	0.5	0.6	1.0	-1.0	0.9	-0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.7	-0.3	0.0	1.3
Financial situation satisfaction	0.5	0.7	1.7	-1.3	0.5	-0.2
Leg fat percentage (left)	0.5	1.9	4.2	-2.0	-0.9	0.9
Myopia	0.5	0.7	1.1	-1.0	0.5	1.0
Basal cell carcinoma (self-reported)	0.5	0.6	1.0	0.6	-0.6	-1.0
Pack years of smoking	0.5	0.8	1.2	-1.1	1.1	0.2
Worry (Nagel 2018)	0.4	0.8	1.4	0.8	-0.6	1.2
Triglycerides	0.4	0.7	1.7	0.4	0.3	-1.3
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.1	0.3	0.5	-1.1
Ulcerative Colitis	0.4	0.6	1.3	0.3	0.7	-1.2
Depression (self-reported)	0.4	0.5	0.9	-0.5	0.9	-0.6
Chronic bronchitis/emphysema (mother)	0.4	0.5	0.8	0.4	-0.9	0.7
Medication: Seretide 50 evohaler	0.4	0.5	1.0	-1.0	0.1	0.6
Illnesses of father: Heart disease	0.4	0.5	1.5	-0.2	1.2	-0.3
Illnesses of siblings: Diabetes	0.4	0.5	1.2	-1.1	-0.4	-0.2
Friendships satisfaction	0.4	0.4	0.9	1.0	-0.6	-0.3
Commuting to job workplace: Walk	0.4	0.4	0.6	0.3	0.6	-0.8
Irritable Bowel Disease (IBD)	0.3	0.7	0.9	-1.0	0.3	1.0
Lupus	0.3	0.5	1.3	-1.1	0.4	-0.1
Medication: Co-codamol	0.3	0.3	0.7	0.5	0.1	0.8
Hayfever/allergic rhinitis (self-reported)	0.3	0.3	0.7	0.6	-0.8	0.0
Time employed in main current job	0.3	0.3	0.4	0.4	0.7	-0.6
Hair/balding pattern: Pattern 3	0.3	0.4	0.6	0.3	-0.7	0.8
Asthma	0.3	0.7	1.3	-1.1	-0.3	0.8
Suffer from ‘nerves’	0.3	0.4	0.9	0.6	-0.9	0.2
Asthma (self-reported)	0.3	0.5	0.7	-0.8	-0.5	0.8
HbA1C	0.2	0.2	0.6	-0.8	-0.1	-0.2
Lung FEV1/FVC ratio	0.2	1.0	2.2	-0.6	-0.7	1.5
Hair Pigment	0.2	6.9	13.8	2.1	1.5	-3.7
Ever had hysterectomy (womb removed)	0.2	0.2	0.4	0.0	-0.4	0.6
Supplements: Zinc	0.2	0.2	0.7	0.8	-0.2	0.0
Supplements: Glucosamine	0.2	0.3	0.7	-0.9	0.3	-0.2
Hair/balding pattern: Pattern 2	0.2	0.2	0.3	-0.2	-0.5	0.6
Mouth/teeth dental problems	0.2	0.3	0.4	-0.7	0.5	-0.5
Allergy	0.2	0.4	0.8	-0.5	0.9	0.1
Number of full brothers	0.2	0.2	0.5	0.0	0.4	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.4	-0.5	-0.1	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.4	-0.7	0.4	-0.3
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.7	0.1	-0.3	0.8
Average weekly champagne plus white wine intake	0.2	0.3	0.5	-0.4	0.7	-0.4
Hearing aid user	0.2	0.2	0.5	0.4	-0.0	-0.7
Blood White Count	0.1	1.0	1.8	0.2	-1.1	1.3
Waist Hip Ratio (WHR)	0.1	0.5	1.4	0.2	0.3	1.2
Happiness	0.1	0.1	0.2	-0.5	0.1	0.3
Mouth/teeth dental problems: Dentures	0.1	0.1	0.3	0.4	-0.5	-0.0
Exposure to tobacco smoke at home	0.1	0.1	0.1	-0.4	-0.2	0.2
Breastfed as a baby	0.1	0.1	0.1	0.3	0.4	-0.4
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.4	-0.6	0.0	-0.1
Blood clot in the leg (DVT)	0.1	0.2	0.3	0.3	0.6	-0.4
Glaucoma (self-reported)	0.1	0.1	0.3	-0.5	0.0	0.3
Medication: Amlodipine	0.1	0.2	0.4	-0.6	0.2	-0.2
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.2	0.5	0.1	-0.3
Osteoarthritis (self-reported)	0.1	0.1	0.1	-0.4	-0.3	-0.0
Illnesses of father: None of the above (group 1)	0.1	0.2	0.4	0.1	0.6	-0.2
Tinnitus: Yes, now most or all of the time	0.1	0.2	0.5	0.7	0.1	-0.1
Eye problems/disorders: Glaucoma	0.1	0.2	0.3	-0.5	0.2	0.4
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.3	0.6	0.3	-0.1
Alcohol drinker status: Never	0.1	0.1	0.2	0.2	0.2	-0.5
Commuting to job workplace: Cycle	0.1	0.1	0.2	-0.1	0.2	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.3	-0.6	-0.0	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.4	0.6	0.3	-0.0
Eye problems/disorders: Diabetes related eye disease	0.0	0.0	0.1	-0.1	0.1	-0.3
Maternal smoking around birth	0.0	0.1	0.1	0.1	-0.1	0.4
Birth weight of first child	0.0	0.1	0.1	-0.3	0.3	0.2

Hub : Genes

MARVELD3

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Trait associations