Hub : Genes

MARVELD3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0750 0.0270 1.9e-07 0.050 0.059 0.087 0.066 0.089 1.0e-06 1.1e-07 8.5e-11 1.9e-08 5.7e-11
2 TCGA Prostate Adenocarcinoma 0.0534 0.0263 1.0e-05 0.007 0.043 0.038 NA 0.028 6.0e-02 2.3e-05 7.0e-05 NA 5.4e-04
3 TCGA Thyroid Carcinoma 0.0790 0.0370 1.3e-06 0.012 0.064 0.048 NA 0.042 2.3e-02 7.1e-07 1.6e-05 NA 5.3e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 1.7 2.7 4.6 -1.7 0.9 -2.1
Bipolar Disorder or Schizophrenia 0.6 1.5 2.9 -1.7 -1.3 0.2
Depressed Affect (Nagel 2018) 2.0 4.2 6.1 -2.4 -0.8 2.5
Depression (Nagel 2018) 6.4 9.7 15.3 -2.1 -3.1 3.9
Intelligence (Savage-Jansen 2018) 4.3 13.2 28.8 1.1 3.1 -5.4
Neuroticism (Nagel 2018) 1.2 2.7 6.1 -1.0 -1.1 2.5
Schizophrenia (2018) 1.6 3.3 5.4 -0.8 -2.3 1.9
Schizophrenia vs Biploar Disorder 5.1 6.8 10.1 -0.5 -3.2 3.2
Worry (Nagel 2018) 0.4 0.8 1.4 0.8 -0.6 1.2
Alzheimer’s Disease (in mother) 1.2 1.4 2.8 1.7 0.3 -1.1
Alzheimer’s Disease (in father) 1.3 1.4 2.5 -0.1 -1.6 1.3
Alzheimer’s Disease (including proxy) 1.7 2.4 6.1 2.5 -0.9 -0.6
Crohns Disease (2017) 0.6 1.2 2.3 -0.9 -0.7 1.5
Irritable Bowel Disease (IBD) 0.3 0.7 0.9 -1.0 0.3 1.0
Ulcerative Colitis (UC) 0.7 1.2 2.4 -1.1 1.5 -0.4
Major Depression (MDD) 2.1 2.5 4.8 -2.2 -1.2 1.1
Reaction Time 1.6 3.1 3.5 1.9 -1.7 -1.7
Verbal and Numeric Reasoning (VNR) 2.7 6.4 13.3 1.7 1.7 -3.6
Breast Cancer 2.4 5.9 16.4 -1.1 4.0 -0.3
Ovarian Cancer 0.9 1.2 2.7 -0.6 1.6 -0.9
Prostate Cancer 2.1 2.9 6.9 1.4 -2.6 0.3
Age at First Birth 1.2 1.8 4.8 0.7 -0.0 -2.2
Bipolar Disorder (2011) 0.8 0.8 2.0 0.0 -1.4 -0.6
Body Mass Index (BMI) (2010) 2.0 2.7 5.2 -2.3 1.0 1.4
Coronary Artery Disease (CAD) 1.2 1.4 3.5 -0.3 1.9 -0.8
Crohns Disease (2012) 0.7 1.2 2.7 -0.7 -0.6 1.6
Mean Putamen Volume 2.2 2.5 6.4 2.5 0.9 -0.6
Fasting Glucose 4.0 4.7 7.2 2.7 -2.4 -1.1
HbA1C 0.2 0.2 0.6 -0.8 -0.1 -0.2
HDL Cholesterol 2.0 3.4 8.2 -0.7 2.9 -1.2
LDL Cholesterol 2.6 4.1 10.8 0.4 1.2 -3.3
Lupus 0.3 0.5 1.3 -1.1 0.4 -0.1
Neuroticism (2016) 0.5 0.7 2.0 -0.1 1.4 -0.2
Primary Biliary Cirrhosis 0.6 0.8 2.3 -0.4 1.5 -0.2
Rheumatoid Arthritis 2.8 3.9 9.9 -0.1 -3.1 1.4
Schizophrenia (2014) 1.6 3.6 5.7 -1.3 -2.4 1.8
Triglycerides 0.4 0.7 1.7 0.4 0.3 -1.3
Type 2 Diabetes (T2D) (2012) 0.4 0.5 1.1 0.3 0.5 -1.1
Ulcerative Colitis 0.4 0.6 1.3 0.3 0.7 -1.2
Blood Eosinophil Count 0.6 4.6 11.0 0.1 -3.3 1.7
Blood Platelet Count 0.5 6.3 8.8 1.9 -3.0 2.5
Blood Red Count 2.0 19.4 37.6 4.2 -1.6 -6.1
Blood White Count 0.1 1.0 1.8 0.2 -1.1 1.3
Heel T-Score 1.0 8.3 17.3 2.8 -4.2 -0.1
BMI 1.1 6.6 19.6 -4.4 -0.1 0.2
Height 1.7 32.0 84.1 -3.2 -1.3 9.2
Waist Hip Ratio (WHR) 0.1 0.5 1.4 0.2 0.3 1.2
Systolic Blood Pressure 2.6 12.8 28.6 2.5 1.8 -5.3
Smoking Status 2.5 6.0 11.1 -3.3 2.6 0.1
Allergy or Eczema 0.7 1.8 3.4 1.2 -1.9 -0.8
Cardiovascular Disease 2.7 9.0 13.5 -1.0 3.5 -3.7
Hypothyroidism (self reported) 0.7 1.5 3.2 -1.8 0.4 1.1
Respiratory disease 0.6 1.4 2.0 -1.3 -0.7 1.4
Type 2 Diabetes (T2D) (2018) 0.5 1.0 1.5 -0.9 0.8 -1.2
Lung FEV1/FVC ratio 0.2 1.0 2.2 -0.6 -0.7 1.5
Lung FVC 1.9 9.8 18.1 3.3 -4.2 0.4
Neuroticism 0.9 2.1 5.1 -0.7 -0.8 2.3
Chronotype (morning person) 2.8 6.4 18.9 0.6 0.0 4.3
Hair Pigment 0.2 6.9 13.8 2.1 1.5 -3.7
Tanning 1.1 13.4 23.7 -0.7 -4.0 4.9
Hand grip strength (left) 2.4 6.3 11.5 1.0 -2.5 3.4
Number of treatments/medications taken 2.8 5.0 7.4 -2.6 2.7 -0.9
Average weekly spirits intake 0.8 1.0 2.3 -1.5 0.8 -0.5
Sensitivity / hurt feelings 0.8 1.4 3.5 -0.3 -0.8 1.9
Frequency of depressed mood in last 2 weeks 2.6 3.6 6.8 -1.8 -0.8 2.6
Hearing difficulty/problems: Yes 6.4 9.8 18.7 -0.4 -4.3 3.2
Relative age of first facial hair 0.9 1.9 2.5 -1.6 1.6 0.9
Other serious medical condition/disability diagnosed by doctor 1.1 1.5 2.8 -0.6 -1.7 1.1
Ever used hormone-replacement therapy (HRT) 0.6 0.7 1.8 -1.3 0.3 0.5
Ever had hysterectomy (womb removed) 0.2 0.2 0.4 0.0 -0.4 0.6
Systolic blood pressure, automated reading 2.0 5.8 13.5 1.9 0.7 -3.7
Eye problems/disorders: Diabetes related eye disease 0.0 0.0 0.1 -0.1 0.1 -0.3
Angina 1.5 2.0 2.5 -1.6 1.5 -1.2
Medication for hormone replacement therapy 2.3 2.5 4.0 -2.0 1.5 1.2
Vitamin and mineral supplements 0.9 1.2 3.5 -0.3 -1.9 0.3
Supplements: Zinc 0.2 0.2 0.7 0.8 -0.2 0.0
Medication: Co-codamol 0.3 0.3 0.7 0.5 0.1 0.8
Medication: Metformin 0.9 1.3 3.3 -1.8 -0.1 0.7
Diabetes (father) 1.3 1.6 4.8 -2.2 -0.1 -0.1
Diabetes (mother) 0.7 0.9 1.4 -0.7 -0.9 1.2
Severe depression (siblings) 1.1 1.2 2.0 -1.4 1.2 -0.5
Pack years adult smoking proportion 1.1 1.7 2.6 -1.6 1.2 1.1
Impedance of leg (right) 1.2 5.7 16.0 4.0 0.7 -0.8
Leg fat-free mass (left) 3.4 18.1 31.7 -5.6 -0.9 4.7
Trunk fat percentage 0.8 3.2 7.3 -2.7 -0.6 1.4
Hand grip strength (right) 1.8 4.8 9.9 0.6 -2.1 3.2
Townsend deprivation index at recruitment 2.3 3.2 6.7 -2.6 0.3 1.7
Current tobacco smoking 1.7 2.7 6.5 -2.5 1.2 0.4
Average weekly fortified wine intake 0.7 0.8 1.2 -1.1 0.7 -0.9
Maternal smoking around birth 0.0 0.1 0.1 0.1 -0.1 0.4
Fed-up feelings 4.6 8.4 12.8 -3.6 -0.4 3.5
Frequency of unenthusiasm / disinterest in last 2 weeks 5.7 7.5 13.5 -1.0 -2.9 3.7
Relative age voice broke 3.4 5.2 9.2 -2.4 0.9 3.0
Taking other prescription medications 0.9 1.4 1.9 -1.2 -0.9 1.4
Age when periods started (menarche) 0.9 2.1 5.3 2.3 1.0 -0.3
Bilateral oophorectomy (both ovaries removed) 1.8 2.1 3.7 -0.4 -1.9 1.6
Heel bone mineral density (BMD) T-score, automated (left) 0.8 1.8 3.6 1.9 -1.1 -0.7
Tinnitus: Yes, but not now, but have in the past 0.8 0.8 2.0 0.1 0.6 -1.4
Qualifications: CSEs or equivalent 2.1 2.7 5.4 -1.7 0.3 2.3
Serious illness, injury or assault to yourself 4.6 5.6 12.9 -3.6 2.0 0.1
High blood pressure 2.5 7.1 10.9 -1.3 3.3 -2.9
Hayfever, allergic rhinitis or eczema 0.7 1.4 2.2 1.4 -1.5 -0.4
Multivitamins +/- minerals 1.4 1.8 5.1 0.1 2.3 -0.4
Stomach or abdominal pain in last month 4.0 5.0 9.1 -2.2 -0.9 3.0
Supplements: Glucosamine 0.2 0.3 0.7 -0.9 0.3 -0.2
Diverticular disease/diverticulitis (self-reported) 1.4 1.6 3.7 0.4 -1.9 1.0
Medication: Atenolol 2.2 2.7 4.0 -1.0 1.8 -2.0
Medication: Levothyroxine sodium 0.8 1.4 2.7 -1.1 1.6 -0.4
Sitting height 0.9 6.6 14.1 -1.2 -2.1 3.8
Chronic bronchitis/emphysema (father) 2.0 2.4 3.7 1.6 -1.9 0.9
High blood pressure (mother) 0.5 0.8 1.7 0.4 1.3 -0.7
Body mass index (BMI) 1.6 6.9 17.4 -4.2 -1.3 1.2
Impedance of leg (left) 1.2 6.0 17.1 4.1 0.8 -0.3
Leg predicted mass (left) 3.4 17.8 31.2 -5.6 -0.9 4.6
Trunk fat mass 1.6 6.9 12.7 -3.6 -1.1 2.6
Waist circumference 1.5 5.5 10.0 -3.2 -1.1 2.3
Number of incorrect matches in round 0.7 1.2 2.2 1.1 0.3 -1.5
Past tobacco smoking 2.8 5.1 6.7 2.1 -2.6 2.0
Alcohol usually taken with meals 1.0 1.6 2.5 1.1 1.6 -1.0
Nervous feelings 1.7 3.2 3.9 1.7 -2.0 1.7
Frequency of tenseness / restlessness in last 2 weeks 1.1 1.6 2.1 0.9 -1.4 1.5
Hearing difficulty/problems with background noise 6.2 9.9 16.4 -3.1 -2.0 4.0
Hair/balding pattern: Pattern 2 0.2 0.2 0.3 -0.2 -0.5 0.6
Had menopause 0.7 0.9 2.5 0.4 -1.6 0.1
Had other major operations 2.1 2.6 4.7 -1.7 -0.6 2.2
Forced vital capacity (FVC) 2.6 10.2 14.8 1.7 -3.6 3.8
Heel bone mineral density (BMD) T-score, automated (right) 0.9 2.1 3.9 2.0 -1.5 -0.2
Ever unenthusiastic/disinterested for a whole week 1.4 1.8 4.5 -2.1 0.6 -0.6
Qualifications: None of the above 4.1 8.9 13.2 -1.6 -3.6 3.3
Financial difficulties in last 2 years 1.9 2.6 3.8 -2.0 1.9 0.2
Mouth/teeth dental problems 0.2 0.3 0.4 -0.7 0.5 -0.5
Heart attack 2.0 2.5 4.2 -1.8 2.0 -0.5
Allergy 0.2 0.4 0.8 -0.5 0.9 0.1
Pain all over the body in last month 2.3 2.4 6.1 -0.3 -1.1 2.5
Diabetes (self-reported) 1.4 2.1 6.3 -2.5 -0.4 -0.1
Hayfever/allergic rhinitis (self-reported) 0.3 0.3 0.7 0.6 -0.8 0.0
Medication: Ramipril 1.7 2.2 3.4 -0.6 1.7 -1.9
Medication: Simvastatin 3.2 4.7 7.3 -1.9 1.8 -2.7
Fluid intelligence score 1.9 4.0 8.3 0.9 1.7 -2.9
Illnesses of siblings 0.5 0.7 2.1 -0.1 1.5 0.2
Neuroticism score 1.1 2.2 5.6 -0.8 -0.7 2.4
Weight 2.9 14.2 24.5 -5.0 -1.4 4.0
Impedance of arm (right) 1.6 7.2 13.6 1.7 3.7 -2.3
Arm fat percentage (right) 1.2 4.8 14.2 -3.8 0.6 -0.0
Trunk fat-free mass 3.6 20.5 33.3 -4.9 -2.0 5.8
Hip circumference 1.8 7.6 18.5 -4.3 -0.2 2.1
Time employed in main current job 0.3 0.3 0.4 0.4 0.7 -0.6
Alcohol intake versus 10 years previously 0.8 1.2 2.6 0.1 -1.6 1.0
Father’s age at death 1.6 2.1 4.9 2.2 0.2 -1.2
Worrier / anxious feelings 1.7 3.3 8.6 2.9 -0.6 -1.0
Frequency of tiredness / lethargy in last 2 weeks 6.5 10.6 20.8 -2.9 -1.6 4.6
Falls in the last year 5.6 7.6 12.9 -3.0 3.6 -1.0
Hair/balding pattern: Pattern 3 0.3 0.4 0.6 0.3 -0.7 0.8
Number of live births 4.0 5.6 11.6 0.4 -3.4 2.3
Forced expiratory volume in 1-second (FEV1) 3.0 10.1 15.1 1.2 -3.7 3.9
Pulse rate 1.3 2.2 3.7 -1.2 -1.3 1.9
Happiness 0.1 0.1 0.2 -0.5 0.1 0.3
Noisy workplace 1.0 1.2 2.7 -0.9 0.5 1.6
Qualifications: A levels/AS levels or equivalent 1.0 2.2 4.8 0.9 1.0 -2.2
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 1.5 0.7 -0.5 -1.2
Mouth/teeth dental problems: Dentures 0.1 0.1 0.3 0.4 -0.5 -0.0
Asthma 0.3 0.7 1.3 -1.1 -0.3 0.8
Medication: Ibuprofen (e.g. Nurofen) 1.3 1.6 3.8 -1.9 1.0 -0.0
Medication: Cholesterol lowering 7.7 12.0 15.1 -2.5 3.9 -3.8
Depression (self-reported) 0.4 0.5 0.9 -0.5 0.9 -0.6
Medication: Lansoprazole 1.0 1.1 2.2 -1.0 1.5 -0.4
Prospective memory result 3.4 4.2 6.7 -1.8 -1.7 2.6
Lung cancer (father) 0.6 0.7 1.2 1.1 0.4 -0.9
Illnesses of mother 0.6 0.7 1.4 -0.6 -1.2 0.6
Forced expiratory volume in 1-second (FEV1), Best measure 2.6 8.2 13.3 1.0 -3.6 3.2
Pulse wave Arterial Stiffness index 0.9 1.0 2.0 -1.4 1.1 0.1
Impedance of arm (left) 1.2 5.4 11.5 1.5 3.4 -1.5
Arm fat mass (right) 2.0 8.4 21.7 -4.7 -0.5 1.8
Trunk predicted mass 3.6 20.6 33.3 -4.9 -2.0 5.8
Standing height 1.8 17.4 45.7 -2.4 -0.8 6.8
Length of working week for main job 2.4 2.7 4.4 -0.5 1.9 -2.1
Exposure to tobacco smoke at home 0.1 0.1 0.1 -0.4 -0.2 0.2
Breastfed as a baby 0.1 0.1 0.1 0.3 0.4 -0.4
Tense / ‘highly strung’ 3.0 5.0 11.8 -1.8 0.1 3.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.7 1.0 -0.8 -0.7 1.0
Hair/balding pattern: Pattern 4 0.5 1.3 3.0 -1.7 0.9 0.3
Birth weight of first child 0.0 0.1 0.1 -0.3 0.3 0.2
Peak expiratory flow (PEF) 0.8 1.9 3.5 0.3 -1.5 1.9
Pulse wave reflection index 1.2 1.5 1.8 -1.2 1.3 -1.1
Ever highly irritable/argumentative for 2 days 2.0 2.4 3.6 -0.6 -1.9 1.8
Loud music exposure frequency 0.8 0.9 1.5 -0.4 -1.2 1.0
Qualifications: O levels/GCSEs or equivalent 1.5 2.4 4.0 1.0 1.5 -2.0
Mouth/teeth dental problems: Bleeding gums 0.1 0.1 0.4 -0.6 0.0 -0.1
Blood clot in the leg (DVT) 0.1 0.2 0.3 0.3 0.6 -0.4
Medication: Paracetamol 0.6 1.0 2.0 -0.7 -0.8 1.4
Headache pain in last month 0.8 1.4 2.3 -1.3 0.5 1.5
Medication for cholesterol, blood pressure or diabetes 3.9 6.4 9.9 1.6 -2.6 3.1
Glaucoma (self-reported) 0.1 0.1 0.3 -0.5 0.0 0.3
Gout (self-reported) 0.9 1.2 3.0 -1.7 0.4 -0.7
Hypothyroidism/myxoedema (self-reported) 1.0 1.9 3.7 -1.9 1.2 0.6
Medication: Amlodipine 0.1 0.2 0.4 -0.6 0.2 -0.2
Medication: Ventolin 100micrograms inhaler 0.5 0.7 0.8 -0.8 -0.8 0.9
Birth weight 1.9 4.0 7.5 -1.3 2.7 -1.7
Chronic bronchitis/emphysema (mother) 0.4 0.5 0.8 0.4 -0.9 0.7
High blood pressure (siblings) 0.5 0.7 1.5 -1.2 0.7 -0.5
Forced vital capacity (FVC), Best measure 3.2 11.8 19.0 1.7 -4.4 3.7
Body fat percentage 0.7 2.7 6.6 -2.6 -0.6 1.0
Leg fat percentage (right) 0.5 1.6 4.2 -2.0 -0.7 0.5
Arm fat-free mass (right) 4.0 20.4 35.6 -4.2 -2.8 6.0
Exposure to tobacco smoke outside home 2.9 3.8 8.8 -3.0 1.6 0.5
Comparative body size at age 10 1.0 2.8 6.3 -2.5 0.7 1.2
Number of full brothers 0.2 0.2 0.5 0.0 0.4 0.7
Worry too long after embarrassment 0.6 1.0 1.8 1.3 -1.1 0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 1.9 2.5 3.9 -1.5 -2.0 1.2
Wheeze or whistling in the chest in last year 1.0 1.8 2.9 -1.5 -0.5 1.7
Number of children fathered 1.8 2.0 5.3 0.6 -2.3 0.6
Reason for reducing amount of alcohol drunk: Health precaution 2.2 2.5 3.7 1.9 -1.9 -0.5
Age at first live birth 4.1 7.3 11.9 2.7 1.7 -3.5
Pulse wave peak to peak time 0.9 1.1 2.0 1.4 -1.1 0.3
Health satisfaction 1.7 2.3 3.8 -1.6 -0.8 1.9
Shortness of breath walking on level ground 3.8 4.5 7.1 -2.2 -1.2 2.7
Qualifications: College or University degree 3.0 9.4 13.9 0.8 3.7 -3.7
Eye problems/disorders: None of the above 2.6 3.0 4.7 1.8 -2.2 -1.1
Mouth/teeth dental problems: Loose teeth 0.1 0.1 0.2 0.5 0.1 -0.3
Emphysema/chronic bronchitis 1.4 1.6 2.6 0.1 -1.5 1.6
Medication for pain relief, constipation, heartburn 2.2 3.8 8.4 2.9 -1.6 -0.8
Neck or shoulder pain in last month 8.6 12.3 24.3 -2.2 -2.7 4.9
Medication: Blood pressure 1.3 2.4 3.1 -1.4 1.4 -1.8
Angina (self-reported) 1.2 1.6 2.0 -1.4 1.3 -1.1
Migraine (self-reported) 0.5 0.7 2.0 -0.1 1.4 -0.0
Medication: Ibuprofen 1.2 1.4 2.6 -1.6 1.3 0.0
Medication: Allopurinol 0.8 1.0 2.3 -1.5 0.5 -0.7
Medication: Omeprazole 0.5 0.6 1.9 -1.4 0.1 0.0
Medication: Seretide 50 evohaler 0.4 0.5 1.0 -1.0 0.1 0.6
Mean time to correctly identify matches 3.4 6.5 8.1 2.9 -2.1 -2.6
Heart disease (mother) 0.5 0.6 1.0 -1.0 0.9 -0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 1.7 -0.3 0.0 1.3
Whole body fat mass 1.8 7.7 15.4 -3.9 -1.1 2.5
Leg fat mass (right) 1.6 6.3 13.5 -3.7 -1.0 2.0
Arm predicted mass (right) 3.9 19.8 34.1 -4.1 -2.9 5.8
Pulse rate, automated reading 1.5 4.7 7.3 -1.2 -2.7 2.3
Alcohol intake frequency. 2.1 4.9 9.3 1.3 -2.0 3.0
Comparative height size at age 10 3.4 18.9 35.4 -4.2 -2.0 6.0
Number of full sisters 1.8 2.2 3.9 -2.0 0.2 1.6
Suffer from ‘nerves’ 0.3 0.4 0.9 0.6 -0.9 0.2
Overall health rating 6.8 14.6 24.9 -3.3 -2.8 5.0
Chest pain or discomfort 1.9 2.8 5.8 -2.4 1.2 1.1
Had major operations 1.2 1.5 2.2 -1.5 1.5 -0.0
Age at last live birth 1.3 1.9 3.3 0.2 1.5 -1.8
Family relationship satisfaction 1.3 1.6 3.8 0.6 -2.0 0.7
Leg pain on walking 1.9 2.3 3.8 -1.7 -0.5 2.0
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.2 0.4 -0.5 -0.1 0.6
Commuting to job workplace: Car/motor vehicle 3.7 4.2 5.1 -1.7 -2.2 2.3
Illness, injury, bereavement, stress in last 2 years 1.5 1.8 3.7 1.9 -1.3 0.0
Medication: Aspirin 4.9 6.4 10.8 -2.6 3.3 -1.2
Supplements: Vitamin C 1.4 1.7 2.1 -1.4 1.5 1.0
Knee pain experienced in last month 5.1 7.9 13.2 -1.8 -2.7 3.6
Hypertension (Self-reported) 2.2 6.0 8.3 -1.3 2.9 -2.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.2 0.4 -0.7 0.4 -0.3
Illnesses of father: Heart disease 0.4 0.5 1.5 -0.2 1.2 -0.3
Illnesses of siblings: Diabetes 0.4 0.5 1.2 -1.1 -0.4 -0.2
Smoking status: Previous 1.9 2.9 4.5 -0.8 1.9 -2.1
Forced expiratory volume in 1-second (FEV1), predicted 1.9 4.0 10.4 -1.0 0.7 3.2
Whole body fat-free mass 3.7 20.9 31.7 -5.3 -1.8 5.6
Leg fat-free mass (right) 3.5 18.8 31.6 -5.6 -0.9 4.9
Arm fat percentage (left) 1.2 4.9 14.6 -3.8 0.2 0.4
Average weekly red wine intake 1.1 1.6 2.7 -1.7 1.3 -0.5
Handedness (chirality/laterality): Left-handed 0.2 0.3 0.7 0.1 -0.3 0.8
Mood swings 2.6 4.7 7.0 -2.6 -0.3 2.6
Loneliness, isolation 0.9 1.3 1.7 0.9 -1.2 1.3
Long-standing illness, disability or infirmity 3.2 4.9 13.2 -3.6 0.3 1.1
Ever had bowel cancer screening 1.4 1.7 3.5 -0.2 -1.9 1.2
Diabetes diagnosed by doctor 0.7 1.2 3.0 -1.7 0.5 -0.6
Ever had stillbirth, spontaneous miscarriage or termination 3.1 3.3 5.7 -2.4 1.7 1.2
Friendships satisfaction 0.4 0.4 0.9 1.0 -0.6 -0.3
Qualifications: nursing, teaching 1.3 2.0 2.9 0.9 1.7 -1.5
Commuting to job workplace: Walk 0.4 0.4 0.6 0.3 0.6 -0.8
Eye problems/disorders: Cataract 2.5 2.9 8.7 0.2 3.0 -0.3
Mouth/teeth dental problems: Mouth ulcers 0.7 1.1 2.4 1.6 0.5 -0.8
Medication for cholesterol 1.6 2.4 3.8 0.6 -1.7 1.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 3.1 3.6 7.1 -1.9 0.2 2.7
Back pain experienced in last month 6.0 8.8 13.8 -1.3 -3.3 3.7
Mineral and other dietary supplements 0.7 1.0 1.7 -1.3 -1.1 0.2
Breast cancer (self-reported) 2.8 3.3 8.1 -0.4 -2.8 1.3
Asthma (self-reported) 0.3 0.5 0.7 -0.8 -0.5 0.8
Osteoporosis (self-reported) 0.8 1.0 2.7 0.0 1.6 -0.6
Osteoarthritis (self-reported) 0.1 0.1 0.1 -0.4 -0.3 -0.0
Medication: Aspirin 3.0 3.9 6.6 -1.7 2.6 -1.5
Medication: Gliclazide 1.1 1.3 3.0 -1.7 -0.4 0.7
Illnesses of father: None of the above (group 1) 0.1 0.2 0.4 0.1 0.6 -0.2
Smoking status: Current 2.2 3.5 7.7 -2.8 1.5 0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 3.9 8.3 17.7 2.4 -4.2 1.2
Whole body water mass 3.7 21.1 31.6 -5.3 -1.8 5.6
Leg predicted mass (right) 3.6 19.3 32.4 -5.7 -0.9 5.0
Arm fat mass (left) 2.3 9.5 22.8 -4.8 -0.8 2.2
Number of self-reported non-cancer illnesses 1.9 3.3 5.2 -2.3 1.9 -1.0
Average weekly champagne plus white wine intake 0.2 0.3 0.5 -0.4 0.7 -0.4
Miserableness 1.1 2.0 5.7 -2.4 0.5 0.2
Guilty feelings 2.1 3.2 5.3 2.3 -1.9 0.7
Wears glasses or contact lenses 2.3 2.6 4.4 -0.5 1.8 -2.1
Ever taken oral contraceptive pill 2.4 2.7 4.3 -2.1 1.9 0.2
Hearing aid user 0.2 0.2 0.5 0.4 -0.0 -0.7
Mother’s age at death 2.9 3.6 6.6 2.6 -1.8 -1.0
Financial situation satisfaction 0.5 0.7 1.7 -1.3 0.5 -0.2
Tinnitus: Yes, now most or all of the time 0.1 0.2 0.5 0.7 0.1 -0.1
Commuting to job workplace: Public transport 3.0 3.6 5.5 0.6 2.3 -2.3
Eye problems/disorders: Glaucoma 0.1 0.2 0.3 -0.5 0.2 0.4
Medication: Blood pressure 2.7 5.2 9.9 0.5 2.4 -3.1
Pain type(s) experienced in last month: Hip pain 2.6 3.3 7.9 -1.1 -1.0 2.8
Supplements: Fish oil (including cod liver oil) 0.1 0.1 0.3 0.6 0.3 -0.1
High cholesterol (Self-reported) 3.8 6.8 17.7 1.1 1.2 -4.2
Medication: Bendroflumethiazide 3.2 4.9 10.4 0.8 2.0 -3.2
Medication: Paracetamol 0.6 0.9 2.5 -0.5 -0.3 1.6
Medication: Lisinopril 2.0 2.6 4.7 -0.6 2.2 -1.7
Medication: Atorvastatin 6.2 7.6 18.1 0.8 2.0 -4.3
Illnesses of father: High blood pressure 2.1 2.6 4.4 -0.4 1.8 -2.1
Alcohol drinker status: Never 0.1 0.1 0.2 0.2 0.2 -0.5
Ever smoked 2.6 4.5 6.4 -2.5 2.3 -1.3
Basal metabolic rate 3.7 20.6 29.7 -5.5 -1.6 5.4
Leg fat percentage (left) 0.5 1.9 4.2 -2.0 -0.9 0.9
Arm fat-free mass (left) 4.0 20.1 31.4 -4.7 -2.5 5.6
Number of operations (self-reported) 1.9 2.9 4.6 -2.1 0.4 1.9
Average weekly beer plus cider intake 1.3 1.9 2.8 -1.7 -1.0 1.4
Irritability 4.0 6.7 12.8 -2.7 0.3 3.6
Risk taking 2.5 3.7 7.7 -2.8 1.6 1.0
Ever had prostate specific antigen (PSA) test 1.4 1.6 4.1 0.9 -2.0 -0.0
Fractured/broken bones in last 5 years 2.3 3.0 4.5 -2.1 1.7 1.2
Age started oral contraceptive pill 1.6 2.0 4.0 0.8 1.1 -2.0
Diastolic blood pressure, automated reading 1.9 5.9 10.3 -0.9 2.6 -3.2
Ever depressed for a whole week 1.2 1.5 4.4 -2.1 0.3 0.0
Unable to work because of sickness or disability 1.5 1.9 4.0 -0.9 -0.9 2.0
Commuting to job workplace: Cycle 0.1 0.1 0.2 -0.1 0.2 -0.4
Myopia 0.5 0.7 1.1 -1.0 0.5 1.0
Vascular/heart problems diagnosed by doctor 2.6 7.2 11.0 1.6 -3.3 2.8
Cholesterol lowering medication 2.0 2.9 7.8 0.9 -0.3 -2.8
Medication: Omeprazole (e.g. Zanprol) 0.1 0.1 0.3 -0.6 -0.0 -0.1
Pain experienced in last month 8.2 13.7 29.0 2.2 2.7 -5.4
Supplements: Calcium 0.7 0.8 1.6 0.7 1.3 -0.6
Basal cell carcinoma (self-reported) 0.5 0.6 1.0 0.6 -0.6 -1.0
Heart attack/myocardial infarction (self-reported) 1.9 2.5 3.7 -1.9 1.9 -0.5
Deep venous thrombosis (DVT) (self-reported) 0.1 0.1 0.4 0.6 0.3 -0.0
Heart disease (siblings) 1.7 2.1 5.2 0.7 -2.3 0.8
Alcohol drinker status: Previous 0.6 0.7 1.4 -0.8 -0.3 1.2
Pack years of smoking 0.5 0.8 1.2 -1.1 1.1 0.2
Impedance of whole body 1.0 5.2 11.0 3.3 1.9 -0.9
Leg fat mass (left) 1.6 6.4 12.5 -3.5 -1.3 2.3
Arm predicted mass (left) 3.7 18.9 28.9 -4.5 -2.7 5.4