[Hub]/) : Traits : Leg predicted mass (left) :

chr19:1,127,720-5,153,606

Best TWAS P=2.94e-13 · Best GWAS P=1.83e-13 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex REXO1 0.07 0.01 bslmm 391 0.01 1.7e-02 -2.9 6.9 6.7e-12 0.16 0.28 0.02 TRUE
2 CommonMind Brain Pre-frontal Cortex UBXN6 0.27 0.25 enet 28 0.29 4.6e-36 4.7 -5.8 6.4e-09 0.11 0.07 0.93 FALSE
3 GTEx Adipose Visceral Omentum NFIC 0.20 0.00 lasso 5 0.02 2.2e-02 5.8 -6.2 5.2e-10 -0.04 0.07 0.22 TRUE
4 GTEx Adipose Visceral Omentum CHAF1A 0.24 0.26 lasso 3 0.26 6.2e-14 5.3 -5.1 3.0e-07 0.09 0.01 0.99 FALSE
5 GTEx Artery Aorta UBXN6 0.13 0.02 lasso 5 0.03 5.7e-03 -5.2 -6.3 3.2e-10 0.09 0.02 0.95 FALSE
6 GTEx Artery Aorta CTB-50L17.5 0.16 0.15 lasso 7 0.15 1.0e-08 5.6 -5.5 4.2e-08 0.09 0.01 0.99 FALSE
7 GTEx Artery Coronary CTB-50L17.9 0.43 0.14 lasso 6 0.12 6.5e-05 5.0 -5.2 2.3e-07 0.07 0.06 0.74 FALSE
8 GTEx Artery Tibial DOT1L 0.09 0.06 lasso 5 0.05 7.3e-05 6.6 6.1 1.4e-09 0.78 0.11 0.85 TRUE
9 GTEx Artery Tibial NFIC 0.14 0.13 enet 11 0.12 7.6e-10 5.8 -6.0 1.5e-09 -0.02 0.21 0.79 FALSE
10 GTEx Artery Tibial UBXN6 0.18 0.07 lasso 3 0.14 6.3e-11 5.7 -6.4 1.9e-10 0.11 0.01 0.99 FALSE
11 GTEx Artery Tibial AC005306.3 0.25 0.12 enet 59 0.11 3.9e-09 -3.5 -5.3 1.3e-07 -0.11 1.00 0.00 TRUE
12 GTEx Brain Caudate basal ganglia CTB-50L17.9 0.27 0.25 lasso 2 0.24 1.8e-07 5.6 -5.5 3.9e-08 0.09 0.01 0.97 FALSE
13 GTEx Brain Cerebellar Hemisphere CHAF1A 0.62 0.40 lasso 8 0.36 3.5e-10 5.6 -5.5 4.4e-08 0.09 0.01 0.99 FALSE
14 GTEx Brain Cerebellum CHAF1A 0.51 0.35 lasso 4 0.34 9.7e-11 5.6 -5.5 5.1e-08 0.09 0.02 0.98 FALSE
15 GTEx Brain Cerebellum CTB-50L17.9 0.53 0.41 lasso 2 0.50 3.6e-17 5.0 -5.6 1.7e-08 0.10 0.02 0.98 FALSE
16 GTEx Brain Frontal Cortex BA9 UBXN6 0.31 0.06 enet 5 0.12 3.5e-04 5.0 -5.2 1.6e-07 0.11 0.02 0.88 FALSE
17 GTEx Brain Frontal Cortex BA9 CTB-50L17.9 0.27 0.21 lasso 3 0.19 7.9e-06 5.0 -5.5 3.1e-08 0.10 0.03 0.95 FALSE
18 GTEx Brain Nucleus accumbens basal ganglia CHAF1A 0.31 0.28 lasso 2 0.24 4.0e-07 5.3 -5.3 1.5e-07 0.09 0.02 0.97 FALSE
19 GTEx Brain Nucleus accumbens basal ganglia CTB-50L17.9 0.45 0.25 lasso 8 0.23 8.6e-07 5.6 -6.6 3.3e-11 0.09 0.02 0.97 FALSE
20 GTEx Cells Transformed fibroblasts UBXN6 0.09 0.10 lasso 1 0.08 1.5e-06 -5.2 -5.2 2.4e-07 0.05 0.05 0.94 FALSE
21 GTEx Colon Sigmoid UBXN6 0.34 0.15 lasso 6 0.14 1.7e-05 5.0 -5.5 3.1e-08 0.09 0.03 0.95 FALSE
22 GTEx Esophagus Muscularis UBXN6 0.35 0.24 enet 20 0.29 3.7e-18 5.0 -5.2 1.6e-07 0.09 0.02 0.98 FALSE
23 GTEx Heart Atrial Appendage UBXN6 0.34 0.12 lasso 6 0.21 6.5e-10 5.6 -6.2 6.8e-10 0.09 0.02 0.98 FALSE
24 GTEx Heart Atrial Appendage CTB-50L17.9 0.32 0.34 lasso 3 0.34 3.8e-16 5.0 -5.2 1.6e-07 0.09 0.13 0.87 FALSE
25 GTEx Heart Left Ventricle CHAF1A 0.17 0.12 lasso 2 0.11 1.9e-06 5.6 -5.6 2.2e-08 0.09 0.01 0.99 FALSE
26 GTEx Heart Left Ventricle UBXN6 0.21 0.14 lasso 6 0.16 5.6e-09 -5.2 -6.0 1.8e-09 0.08 0.03 0.97 FALSE
27 GTEx Muscle Skeletal CHAF1A 0.18 0.21 lasso 2 0.20 9.7e-20 5.6 -5.5 3.4e-08 0.09 0.01 0.99 FALSE
28 GTEx Muscle Skeletal UBXN6 0.19 0.14 lasso 5 0.18 4.1e-17 -5.2 -6.3 3.0e-10 0.08 0.05 0.95 FALSE
29 GTEx Nerve Tibial UBXN6 0.17 0.08 enet 20 0.09 4.4e-07 5.0 -5.8 8.0e-09 0.13 0.03 0.97 FALSE
30 GTEx Nerve Tibial CTB-50L17.5 0.11 0.08 enet 4 0.08 1.6e-06 5.3 -5.4 6.9e-08 0.09 0.02 0.98 FALSE
31 GTEx Skin Not Sun Exposed Suprapubic AC007292.6 0.11 0.08 lasso 6 0.07 7.8e-05 5.7 -5.3 1.0e-07 0.10 0.02 0.96 FALSE
32 GTEx Skin Sun Exposed Lower leg CHAF1A 0.19 0.18 lasso 1 0.17 5.1e-14 5.3 -5.3 1.4e-07 0.09 0.02 0.98 FALSE
33 GTEx Stomach AC007292.4 0.27 0.09 lasso 5 0.04 4.0e-03 -5.6 5.7 1.0e-08 -0.05 0.01 0.93 FALSE
34 GTEx Testis CHAF1A 0.18 0.09 lasso 2 0.07 4.0e-04 5.6 -5.2 1.7e-07 0.08 0.01 0.90 FALSE
35 GTEx Testis UBXN6 0.20 0.10 lasso 3 0.10 2.9e-05 5.0 -5.2 2.6e-07 0.09 0.04 0.95 FALSE
36 GTEx Testis CTB-50L17.9 0.39 0.30 enet 36 0.34 9.4e-16 5.0 -5.6 2.2e-08 0.08 0.08 0.92 FALSE
37 GTEx Thyroid UBXN6 0.25 0.19 lasso 5 0.23 8.8e-18 5.7 -5.6 2.4e-08 0.11 0.01 0.99 FALSE
38 GTEx Vagina CTB-50L17.9 0.38 0.26 lasso 5 0.23 5.7e-06 5.6 -5.5 4.5e-08 0.11 0.02 0.95 FALSE
39 ROSMAP Brain Pre-frontal Cortex KLF16 0.12 0.08 bslmm 372 0.08 1.0e-10 -5.4 -5.8 6.6e-09 -0.01 1.00 0.00 TRUE
40 The Cancer Genome Atlas Breast Invasive Carcinoma UBXN6 0.03 0.03 lasso 3 0.03 2.3e-06 -5.2 -5.4 5.3e-08 0.06 0.02 0.97 FALSE
41 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma UBXN6 0.05 0.01 blup 57 0.04 6.6e-05 5.6 -7.3 2.9e-13 0.10 0.01 0.97 TRUE
42 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma CHAF1A 0.12 0.11 lasso 3 0.12 7.9e-13 5.3 -5.6 2.6e-08 0.10 0.02 0.98 FALSE
43 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma DOT1L 0.08 0.12 enet 8 0.10 2.5e-11 6.6 7.0 3.6e-12 0.84 0.04 0.96 TRUE
44 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma UBXN6 0.18 0.17 enet 18 0.18 9.9e-20 5.6 -5.2 1.6e-07 0.09 0.01 0.99 FALSE
45 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma CHAF1A 0.15 0.12 lasso 2 0.12 3.2e-07 5.3 -5.3 1.1e-07 0.09 0.06 0.94 FALSE
46 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma FZR1 0.21 0.07 lasso 3 0.07 5.6e-05 -4.4 -5.3 1.1e-07 -0.03 0.00 0.36 FALSE
47 The Cancer Genome Atlas Liver Hepatocellular Carcinoma DOT1L 0.09 0.08 blup 60 0.07 4.1e-04 -5.6 6.3 2.3e-10 0.68 0.12 0.74 TRUE
48 The Cancer Genome Atlas Lung Adenocarcinoma CHAF1A 0.05 0.04 lasso 4 0.03 2.3e-04 5.6 -5.2 2.1e-07 0.09 0.02 0.96 FALSE
49 The Cancer Genome Atlas Lung Squamous Cell Carcinoma JSRP1 0.03 0.00 blup 33 0.02 2.1e-03 -3.7 -5.7 1.0e-08 -0.52 0.01 0.26 TRUE
50 The Cancer Genome Atlas Lung Squamous Cell Carcinoma UBXN6 0.04 0.03 lasso 2 0.02 1.6e-03 5.0 -5.4 5.8e-08 0.09 0.01 0.78 FALSE
51 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma CHAF1A 0.20 0.11 lasso 2 0.11 5.6e-05 5.7 -5.8 6.2e-09 0.11 0.01 0.96 FALSE
52 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma UBXN6 0.23 0.11 lasso 5 0.12 2.5e-05 5.0 -6.1 9.3e-10 0.12 0.02 0.63 FALSE
53 The Cancer Genome Atlas Prostate Adenocarcinoma UBXN6 0.13 0.10 lasso 2 0.10 1.3e-10 5.6 -5.9 2.8e-09 0.09 0.01 0.99 FALSE
54 The Cancer Genome Atlas Testicular Germ Cell Tumors DOT1L 0.40 -0.01 enet 20 0.03 3.6e-02 -4.0 5.7 9.5e-09 0.50 0.01 0.22 FALSE
55 The Cancer Genome Atlas Thyroid Carcinoma UBXN6 0.16 0.12 lasso 2 0.12 5.4e-12 5.6 -5.8 6.6e-09 0.09 0.01 0.99 FALSE