Best TWAS P=1.6e-10 · Best GWAS P=2.16e-12 conditioned to 0.0151
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | TSEN15 | 0.23 | 0.18 | lasso | 9 | 0.18 | 4.7e-21 | 6.5 | 6.4 | 1.6e-10 | 0.90 | 0.02 | 0.98 | TRUE |
| 2 | GTEx | Adipose Visceral Omentum | RP11-181K3.4 | 0.13 | 0.06 | lasso | 3 | 0.14 | 8.3e-08 | 4.8 | 5.6 | 2.3e-08 | 0.04 | 0.04 | 0.95 | TRUE |
| 3 | GTEx | Brain Cerebellar Hemisphere | TSEN15 | 0.38 | 0.08 | lasso | 13 | 0.16 | 5.3e-05 | 6.5 | 6.0 | 1.7e-09 | 0.83 | 0.01 | 0.96 | FALSE |
| 4 | METSIM | Adipose | TSEN15 | 0.06 | 0.02 | enet | 28 | 0.04 | 1.3e-06 | 6.5 | 5.7 | 1.3e-08 | 0.76 | 0.02 | 0.98 | FALSE |
| 5 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | GLT25D2 | 0.05 | 0.01 | enet | 10 | 0.04 | 6.3e-05 | 3.4 | -6.2 | 6.4e-10 | -0.69 | 0.01 | 0.94 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | GLT25D2 | 0.11 | 0.02 | blup | 119 | 0.05 | 5.1e-06 | -1.8 | -5.2 | 2.6e-07 | -0.50 | 0.14 | 0.31 | FALSE |
| 7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | TSEN15 | 0.11 | 0.08 | blup | 52 | 0.10 | 6.7e-12 | 6.5 | 6.0 | 2.6e-09 | 0.78 | 0.02 | 0.98 | FALSE |