TWAS hub - GLT25D2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.2967	0.0337	0.0e+00	0.231	0.185	0.226	0.221	0.232	3.9e-73	1.6e-57	2.7e-71	1.4e-69	1.4e-73
2	TCGA	Colon Adenocarcinoma	0.1000	0.0470	8.0e-03	0.053	0.026	0.013	NA	0.035	4.9e-04	1.1e-02	5.4e-02	NA	3.9e-03
3	TCGA	Head and Neck Squamous Cell Carcinoma	0.0479	0.0209	1.3e-03	0.010	0.027	0.036	NA	0.030	2.2e-02	5.1e-04	6.3e-05	NA	2.4e-04
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.1136	0.0463	1.3e-04	0.021	0.047	0.038	NA	0.043	1.7e-03	5.1e-06	3.5e-05	NA	1.3e-05
5	TCGA	Brain Lower Grade Glioma	0.1524	0.0414	1.7e-09	0.102	0.096	0.106	NA	0.104	1.2e-11	4.6e-11	4.5e-12	NA	7.6e-12
6	TCGA	Lung Adenocarcinoma	0.0566	0.0269	8.8e-03	0.036	0.013	0.025	NA	0.030	3.7e-05	9.8e-03	5.0e-04	NA	1.7e-04
7	TCGA	Thyroid Carcinoma	0.0850	0.0360	3.1e-04	0.004	0.042	0.023	NA	0.010	1.2e-01	5.4e-05	2.3e-03	NA	3.2e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Pulse wave Arterial Stiffness index	8.0	9.3	18.7	-2.8	-3.0	-4.3	-3.4	-2.6	-3.0	-1.5
Comparative height size at age 10	7.6	41.6	108.2	-2.4	-3.1	-10.4	-8.9	-3.1	-3.1	-8.4
Sitting height	7.3	51.5	127.7	-4.6	-5.3	-11.3	-8.2	-7.1	-5.3	-6.1
Height	6.9	133.6	408.0	-6.3	-7.5	-20.2	-14.9	-7.0	-7.5	-10.2
Standing height	6.3	62.3	187.7	-3.9	-4.7	-13.7	-10.4	-4.5	-4.8	-7.7
Pulse wave peak to peak time	5.1	6.1	11.1	2.4	2.5	3.3	2.5	2.4	2.5	1.0
Osteoarthritis (self-reported)	4.9	6.3	13.8	1.6	1.6	3.0	2.9	2.2	1.7	3.7
Arm fat-free mass (left)	4.8	24.3	54.5	-4.5	-4.8	-7.4	-5.4	-3.8	-4.8	-2.3
Arm predicted mass (left)	4.8	24.3	56.4	-4.3	-4.7	-7.5	-5.5	-3.7	-4.7	-2.7
Arm fat-free mass (right)	4.4	22.7	56.6	-4.0	-4.5	-7.5	-5.3	-3.5	-4.5	-2.3
Trunk fat-free mass	4.2	24.1	63.2	-3.5	-4.0	-8.0	-6.0	-3.6	-4.0	-3.6
Trunk predicted mass	4.2	24.2	63.0	-3.5	-4.0	-7.9	-5.9	-3.7	-4.0	-3.6
Arm predicted mass (right)	4.1	21.2	53.3	-3.8	-4.2	-7.3	-5.3	-3.4	-4.2	-2.2
Basal metabolic rate	4.1	22.5	56.6	-3.7	-4.2	-7.5	-5.8	-3.2	-4.2	-3.0
Pulse wave reflection index	3.9	4.9	9.1	-2.3	-2.4	-3.0	-2.0	-2.1	-2.4	-0.4
Whole body water mass	3.8	21.7	53.9	-3.5	-4.0	-7.3	-5.7	-3.4	-4.0	-3.1
Whole body fat-free mass	3.7	21.4	54.0	-3.5	-3.9	-7.3	-5.7	-3.4	-3.9	-3.1
Weight	3.6	17.5	44.9	-3.6	-3.9	-6.7	-5.2	-1.7	-3.9	-2.2
Trunk fat mass	3.3	14.3	35.9	-3.6	-3.8	-6.0	-4.6	-0.7	-3.7	-1.3
Medication: Ramipril	3.2	4.1	6.8	1.4	1.5	1.7	2.6	2.6	1.5	2.4
Depression (Nagel 2018)	3.1	4.6	6.7	-2.5	-2.6	-2.0	-0.4	-2.6	-2.5	1.4
Leg fat-free mass (left)	3.1	16.4	39.7	-3.0	-3.4	-6.3	-5.2	-2.8	-3.4	-2.7
Leg predicted mass (left)	3.0	16.1	38.2	-3.1	-3.4	-6.2	-5.2	-2.8	-3.4	-2.6
Back pain experienced in last month	3.0	4.4	6.0	2.3	2.3	2.5	0.4	2.3	2.3	-1.9
Illnesses of father: None of the above (group 1)	3.0	3.7	6.0	-2.3	-2.2	-1.3	1.1	-1.3	-2.2	2.5
Whole body fat mass	2.9	12.2	27.3	-3.5	-3.7	-5.2	-4.2	-0.6	-3.6	-1.0
Family relationship satisfaction	2.9	3.6	10.0	-1.9	-2.0	-3.2	-1.7	-0.0	-2.0	0.8
Hand grip strength (right)	2.8	7.6	16.5	-2.6	-2.9	-4.1	-2.9	-1.6	-3.0	-1.2
Leg fat mass (right)	2.8	10.8	22.2	-3.6	-3.7	-4.7	-3.5	-0.9	-3.7	-0.3
Leg fat mass (left)	2.6	10.3	21.4	-3.6	-3.7	-4.6	-3.2	-0.7	-3.6	-0.0
Alzheimer’s Disease (in father)	2.5	2.7	4.5	-2.1	-2.0	-1.6	-0.2	-1.4	-1.9	1.4
Hip circumference	2.5	10.8	25.0	-3.0	-3.2	-5.0	-4.1	-1.3	-3.2	-1.7
Leg fat-free mass (right)	2.5	13.2	32.8	-2.6	-3.0	-5.7	-4.7	-2.5	-3.0	-2.7
Leg predicted mass (right)	2.5	13.2	32.6	-2.7	-3.0	-5.7	-4.6	-2.5	-3.0	-2.5
Medication: Lisinopril	2.5	3.3	6.0	1.9	1.9	1.5	2.4	1.7	2.0	0.5
Tinnitus: Yes, but not now, but have in the past	2.4	2.6	7.6	-1.6	-1.5	-1.0	1.0	-1.1	-1.6	2.8
Forced expiratory volume in 1-second (FEV1), predicted	2.4	5.0	20.0	-0.9	-1.3	-4.5	-2.6	-0.8	-1.4	-1.9
Illnesses of father: High blood pressure	2.4	3.0	6.2	1.9	1.9	2.5	0.4	1.9	1.9	0.2
Frequency of depressed mood in last 2 weeks	2.3	3.2	5.5	-1.9	-2.0	-2.3	-1.2	-1.8	-2.0	0.6
Age started oral contraceptive pill	2.2	2.7	6.2	1.6	1.7	0.7	2.5	1.2	1.7	1.5
Myopia	2.2	3.2	8.9	-1.4	-1.6	-2.3	-3.0	0.1	-1.6	-1.1
Heart disease (siblings)	2.2	2.7	5.0	2.2	2.2	0.7	1.1	1.5	2.2	-0.1
Pain type(s) experienced in last month: Hip pain	2.1	2.6	5.8	1.2	1.2	1.9	1.2	2.4	1.4	1.6
Trunk fat percentage	2.0	8.1	17.4	-3.1	-3.1	-4.2	-3.3	0.1	-3.0	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	2.0	2.7	3.6	-1.9	-1.9	-1.8	-1.3	-1.2	-1.8	1.3
Leg fat percentage (right)	2.0	7.3	11.9	-3.4	-3.4	-3.3	-2.1	-0.3	-3.4	0.9
Type 2 Diabetes (T2D) (2018)	1.9	3.6	9.5	-1.9	-1.9	-3.1	-1.8	-1.0	-1.9	0.7
Arm fat mass (right)	1.9	7.6	13.5	-3.2	-3.2	-3.7	-3.0	-0.6	-3.2	-0.1
Forced vital capacity (FVC), Best measure	1.9	7.0	22.2	-2.0	-2.3	-4.7	-2.0	-2.6	-2.4	-1.0
Eye problems/disorders: Cataract	1.9	2.2	6.6	0.7	0.7	0.6	2.6	0.6	0.7	2.6
Arm fat mass (left)	1.9	7.9	14.6	-3.2	-3.3	-3.8	-2.9	-0.6	-3.2	0.1
Body fat percentage	1.8	7.1	13.2	-3.1	-3.1	-3.6	-2.8	0.3	-3.0	0.1
Medication: Blood pressure	1.8	3.2	4.3	2.0	2.0	1.6	1.9	1.7	2.1	0.7
Leg fat percentage (left)	1.8	6.3	11.0	-3.3	-3.3	-2.9	-1.5	0.1	-3.2	1.2
Ulcerative Colitis (UC)	1.7	3.2	5.2	-1.8	-1.8	-1.6	-2.3	-2.1	-1.9	-0.3
Hand grip strength (left)	1.7	4.4	9.1	-2.0	-2.2	-3.0	-2.1	-1.4	-2.3	-1.2
Exposure to tobacco smoke at home	1.7	1.9	2.9	-1.7	-1.7	-0.6	-0.4	-1.3	-1.6	1.6
Qualifications: NVQ or HND or HNC or equivalent	1.7	2.0	3.3	-1.8	-1.8	-0.4	0.1	-1.2	-1.7	1.7
Loneliness, isolation	1.7	2.3	3.6	1.9	1.9	1.4	1.1	1.6	1.8	-0.1
Fed-up feelings	1.6	3.0	4.5	-2.0	-2.1	-1.8	-1.6	-1.4	-2.1	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.1	3.1	1.7	1.8	1.0	0.2	1.5	1.7	-1.5
Long-standing illness, disability or infirmity	1.6	2.5	3.6	1.8	1.9	1.9	0.1	1.9	1.9	-0.2
Basal cell carcinoma (self-reported)	1.6	1.9	5.2	1.5	1.4	1.3	-0.5	2.3	1.4	-0.4
Ulcerative Colitis	1.5	2.1	4.0	-1.6	-1.5	-1.4	-2.0	-1.1	-1.6	-0.9
Forced vital capacity (FVC)	1.5	5.6	19.5	-1.6	-1.8	-4.4	-1.4	-2.8	-1.9	-0.7
Number of children fathered	1.5	1.7	3.0	-1.7	-1.7	-0.5	-0.9	-1.3	-1.7	0.7
Commuting to job workplace: Car/motor vehicle	1.5	1.7	5.8	-0.9	-0.7	1.7	0.9	-0.6	-0.7	2.4
Wears glasses or contact lenses	1.5	1.7	2.7	1.6	1.6	1.6	0.9	0.9	1.6	-0.7
Tinnitus: Yes, now most or all of the time	1.5	1.7	3.7	1.3	1.4	1.4	1.9	0.2	1.5	0.4
Unable to work because of sickness or disability	1.5	1.9	7.0	0.4	0.5	0.2	1.2	2.0	0.5	2.6
Diabetes (father)	1.4	1.7	3.3	1.7	1.6	0.5	-0.7	0.5	1.5	-1.8
Forced expiratory volume in 1-second (FEV1), Best measure	1.4	4.6	14.5	-1.8	-2.0	-3.8	-1.2	-2.0	-2.1	-0.3
Mineral and other dietary supplements	1.4	1.9	3.3	-1.3	-1.4	-1.0	-1.6	-1.8	-1.5	-0.3
Schizophrenia vs Biploar Disorder	1.3	1.7	2.7	1.7	1.5	1.4	-0.0	1.1	1.5	-1.2
Triglycerides	1.3	2.1	4.4	-2.1	-1.9	-1.3	-1.2	-0.4	-1.5	1.0
Hypothyroidism (self reported)	1.3	2.9	3.8	-1.9	-1.9	-1.0	-1.6	-1.9	-1.9	-1.3
Ever used hormone-replacement therapy (HRT)	1.3	1.7	3.3	1.8	1.8	1.1	0.7	0.3	1.8	-0.5
Supplements: Zinc	1.3	1.5	3.7	-1.2	-1.2	-1.0	-0.8	-1.9	-1.2	-0.7
Medication: Metformin	1.3	1.8	2.7	-1.3	-1.3	-1.7	-1.6	-0.7	-1.3	1.3
Prospective memory result	1.3	1.7	3.0	-1.7	-1.7	-0.4	-0.5	-1.4	-1.7	0.8
Breast cancer (self-reported)	1.3	1.5	5.4	0.7	0.7	0.4	1.6	1.0	0.6	2.3
Miserableness	1.3	2.3	3.6	-1.9	-1.9	-0.8	-0.4	-1.7	-1.9	1.3
Coronary Artery Disease (CAD)	1.2	1.4	8.0	0.2	0.2	0.2	-1.3	0.1	0.1	-2.8
Lung FVC	1.2	6.0	14.5	1.7	1.9	2.0	3.8	1.3	1.9	3.4
Heart attack	1.2	1.6	2.9	1.6	1.7	0.5	0.4	1.5	1.7	0.0
Pain all over the body in last month	1.2	1.3	3.2	0.4	0.6	1.8	1.5	1.0	0.7	1.3
Tense / ‘highly strung’	1.2	1.9	3.7	-1.4	-1.5	-1.9	-1.2	0.2	-1.5	1.3
Medication: Amlodipine	1.2	1.7	2.5	0.8	1.0	1.6	1.5	1.4	1.1	1.5
Angina (self-reported)	1.2	1.5	2.8	1.4	1.4	0.9	1.0	1.7	1.5	-0.2
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	3.2	1.8	1.7	0.6	0.6	0.5	1.6	-0.8
Supplements: Fish oil (including cod liver oil)	1.2	1.5	2.9	1.4	1.4	0.1	1.4	1.7	1.4	-0.1
Heart attack/myocardial infarction (self-reported)	1.2	1.6	2.9	1.6	1.7	0.7	0.5	1.5	1.7	0.3
Type 2 Diabetes (T2D) (2012)	1.1	1.2	4.8	0.6	0.3	0.2	-1.8	0.0	0.1	-2.2
Waist circumference	1.1	4.0	11.7	-1.7	-1.8	-3.4	-2.5	0.6	-1.7	-0.1
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	3.2	-1.7	-1.8	-0.5	-1.0	-1.3	-1.8	0.0
Migraine (self-reported)	1.1	1.4	6.7	0.2	0.3	-0.7	1.3	0.8	0.3	2.6
Medication: Seretide 50 evohaler	1.1	1.3	6.8	0.3	0.3	-0.1	-1.2	0.6	0.3	-2.6
Number of full sisters	1.1	1.4	2.4	1.1	1.2	1.0	0.6	1.5	1.1	1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	2.2	1.5	1.4	1.1	0.7	1.0	1.5	-0.4
Alzheimer’s Disease (including proxy)	1.0	1.5	3.1	-1.4	-1.4	-1.8	-1.1	-0.3	-1.4	-0.1
Irritable Bowel Disease (IBD)	1.0	2.3	7.1	-1.3	-1.3	-1.1	-2.7	-1.5	-1.4	-0.4
Vitamin and mineral supplements	1.0	1.3	4.0	-0.5	-0.4	-0.3	-1.1	-2.0	-0.5	-1.8
Fluid intelligence score	1.0	2.0	3.9	-1.3	-1.4	-1.6	-2.0	-1.1	-1.4	-0.9
Forced expiratory volume in 1-second (FEV1)	1.0	3.3	13.6	-1.2	-1.3	-3.7	-0.4	-2.1	-1.4	0.2
Ever highly irritable/argumentative for 2 days	1.0	1.2	1.8	-1.3	-1.4	-1.1	-1.0	-0.3	-1.4	0.7
Eye problems/disorders: None of the above	1.0	1.1	3.4	-0.0	-0.1	-1.0	-1.8	0.2	-0.1	-1.8
Commuting to job workplace: Walk	1.0	1.1	5.3	0.8	0.7	0.1	-0.6	0.0	0.8	-2.3
Medication: Gliclazide	1.0	1.1	4.3	0.8	0.8	-0.2	0.1	2.1	0.8	1.3
Medication: Blood pressure	1.0	1.9	3.5	1.8	1.7	0.4	0.7	1.6	1.9	0.1
Average weekly beer plus cider intake	1.0	1.5	4.6	0.8	0.7	0.3	0.6	2.1	0.7	1.9
Lupus	0.9	1.3	2.3	1.4	1.4	0.5	0.7	1.5	1.4	0.6
Neuroticism (2016)	0.9	1.3	2.9	-1.2	-1.2	-0.7	-0.2	-1.7	-1.4	0.8
Average weekly spirits intake	0.9	1.1	2.4	-1.6	-1.5	-0.6	-0.4	-0.1	-1.5	0.3
Stomach or abdominal pain in last month	0.9	1.1	3.0	-0.8	-0.9	-0.7	-1.2	-1.7	-1.0	-0.2
Number of incorrect matches in round	0.9	1.5	2.2	1.4	1.5	0.2	0.2	1.5	1.5	-1.4
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.2	3.5	0.6	0.6	0.8	1.8	-0.2	0.6	1.9
Lung cancer (father)	0.9	1.1	2.3	1.1	1.1	1.5	0.4	1.3	1.1	-0.4
Glaucoma (self-reported)	0.9	1.0	2.7	1.1	1.0	1.6	1.1	0.4	1.0	0.0
Gout (self-reported)	0.9	1.2	2.4	-1.4	-1.3	-1.6	-0.8	0.2	-1.4	-0.0
Mean time to correctly identify matches	0.9	1.8	2.8	1.7	1.6	1.2	0.1	1.4	1.6	-1.0
Alcohol intake frequency.	0.9	2.2	3.2	1.7	1.7	1.8	-1.0	1.2	1.7	-0.9
Irritability	0.9	1.5	3.1	-1.1	-1.2	-0.9	0.4	-1.6	-1.3	1.8
Alzheimer’s Disease (in mother)	0.8	0.9	1.6	-0.9	-1.0	-1.2	-1.2	-0.1	-1.0	-0.8
Relative age of first facial hair	0.8	1.6	2.4	1.4	1.4	1.5	1.0	1.2	1.5	0.1
Severe depression (siblings)	0.8	0.8	2.1	-0.8	-0.8	-0.9	-1.5	-0.7	-0.9	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.7	7.0	-0.6	-0.6	-0.0	1.1	1.7	-0.6	2.6
Financial difficulties in last 2 years	0.8	1.1	1.6	-1.2	-1.2	-1.1	-0.8	-0.9	-1.2	-0.2
Happiness	0.8	1.0	1.6	-1.0	-1.1	-1.3	-1.0	-1.0	-1.1	-0.2
Medication: Lansoprazole	0.8	0.9	3.3	0.8	0.7	0.7	0.5	1.8	0.8	0.5
Emphysema/chronic bronchitis	0.8	0.9	2.4	-0.9	-0.8	-0.1	1.2	-0.7	-0.7	1.6
Diabetes diagnosed by doctor	0.8	1.3	4.4	-0.9	-0.9	-2.1	-1.4	-0.2	-0.8	0.5
Risk taking	0.8	1.1	3.1	-1.2	-1.2	-0.1	0.5	-0.3	-1.3	1.8
Fractured/broken bones in last 5 years	0.8	1.0	5.8	-0.5	-0.6	-0.0	0.7	-0.2	-0.6	2.4
Bipolar Disorder or Schizophrenia	0.7	1.7	5.5	-1.3	-1.2	-0.8	-0.3	-2.3	-1.2	-1.0
Verbal and Numeric Reasoning (VNR)	0.7	1.7	3.4	-1.5	-1.5	-0.4	-1.8	-1.0	-1.5	-0.6
Fasting Glucose	0.7	0.8	3.0	0.1	0.3	0.1	-0.4	-1.2	-1.7	0.9
HbA1C	0.7	0.7	1.7	0.5	0.6	1.3	0.8	0.9	0.5	1.0
Primary Biliary Cirrhosis	0.7	1.0	1.8	1.4	1.3	0.6	0.4	1.0	1.4	0.1
Heel T-Score	0.7	5.2	12.2	0.6	0.8	2.4	3.2	2.5	0.8	3.5
Ever had hysterectomy (womb removed)	0.7	0.8	1.3	1.1	1.1	0.8	-0.2	0.5	1.1	-1.1
Diabetes (mother)	0.7	0.9	3.0	-0.0	-0.1	-0.9	-1.2	-1.0	-0.0	-1.7
Supplements: Glucosamine	0.7	0.9	1.9	0.9	0.9	1.4	1.1	0.6	1.0	-0.1
Medication: Atenolol	0.7	0.8	2.1	0.9	0.9	1.4	0.6	0.5	0.9	0.8
Had menopause	0.7	0.8	1.6	1.1	1.2	0.7	0.6	0.6	1.3	0.5
Arm fat percentage (right)	0.7	2.9	5.5	-2.3	-2.3	-1.4	-1.3	0.6	-2.2	0.9
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	2.3	-0.2	-0.4	-1.5	-0.7	-1.5	-0.5	-1.5
Exposure to tobacco smoke outside home	0.7	0.9	2.2	-0.6	-0.6	-1.5	-1.3	-1.2	-0.7	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.8	0.7	0.8	1.3	1.3	-0.3	0.8	-0.7
Arm fat percentage (left)	0.7	2.6	4.4	-2.1	-2.0	-1.7	-1.2	0.8	-2.0	1.1
Medication: Aspirin	0.7	0.9	5.4	0.1	0.1	-0.5	0.2	0.6	0.1	2.3
Hearing aid user	0.7	0.7	2.0	-0.9	-0.9	0.6	0.2	-1.4	-0.8	0.8
Ever depressed for a whole week	0.7	0.8	1.4	-0.9	-1.0	0.0	-1.1	-1.2	-1.0	0.0
Supplements: Calcium	0.7	0.8	1.1	1.0	1.0	0.7	1.0	0.4	1.1	1.0
Bipolar Disorder (2018)	0.6	0.9	2.2	-0.8	-0.8	-1.1	-0.3	-1.5	-0.8	-1.1
Depressed Affect (Nagel 2018)	0.6	1.2	1.9	-1.3	-1.4	-0.8	0.1	-1.3	-1.3	0.8
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.0	0.8	0.9	0.7	0.6	1.4	0.9	0.6
Impedance of leg (right)	0.6	2.8	11.2	-1.2	-1.3	-3.3	-1.8	0.0	-1.3	-0.7
Age when periods started (menarche)	0.6	1.5	3.6	1.0	1.0	1.8	0.5	1.9	1.1	-0.5
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	2.8	0.4	0.2	0.1	-1.0	-0.9	0.2	-1.7
Qualifications: CSEs or equivalent	0.6	0.8	1.4	-0.9	-1.0	-0.3	1.2	-0.1	-1.0	1.2
Hair/balding pattern: Pattern 2	0.6	0.7	1.4	-0.7	-0.8	-1.2	-0.9	0.8	-0.7	0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	6.4	-0.5	-0.5	-0.3	0.9	1.3	-0.5	2.5
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.2	-1.1	-1.0	-0.4	0.0	-0.9	-1.0	0.8
Birth weight of first child	0.6	1.2	3.0	-0.5	-0.5	-1.1	-1.6	-0.8	-0.5	-1.7
Comparative body size at age 10	0.6	1.8	6.0	0.7	0.9	2.5	1.3	1.2	0.9	0.9
Overall health rating	0.6	1.4	2.6	1.2	1.2	0.9	-0.2	1.6	1.2	1.4
Leg pain on walking	0.6	0.7	1.5	-1.2	-1.1	-0.7	-0.5	-0.3	-1.1	0.6
Illnesses of siblings: Diabetes	0.6	0.7	2.5	-0.4	-0.5	-1.6	0.4	-1.0	-0.5	0.7
Osteoporosis (self-reported)	0.6	0.7	2.3	0.1	0.2	1.5	1.2	0.3	0.3	1.1
Commuting to job workplace: Public transport	0.6	0.7	1.9	0.5	0.5	-1.1	-0.5	0.9	0.4	-1.4
Major Depression (MDD)	0.5	0.7	1.9	-0.5	-0.6	-1.4	-0.7	-0.6	-0.7	-0.9
Reaction Time	0.5	0.9	1.8	1.2	1.1	0.3	-0.5	0.4	1.1	-1.3
Prostate Cancer	0.5	0.7	2.9	0.6	0.6	1.7	0.2	0.6	0.6	0.6
Body Mass Index (BMI) (2010)	0.5	0.6	2.9	0.0	0.1	1.7	-0.5	0.9	0.2	-0.8
HDL Cholesterol	0.5	0.8	2.7	0.5	0.4	1.6	0.2	-0.8	0.4	-1.3
Respiratory disease	0.5	1.2	2.4	-1.1	-1.1	-0.6	-1.1	-0.9	-1.1	-1.6
Angina	0.5	0.7	1.6	0.9	1.0	0.5	0.7	1.3	1.0	-0.2
Serious illness, injury or assault to yourself	0.5	0.7	1.2	1.0	1.1	0.4	0.5	0.7	1.1	0.8
High blood pressure (mother)	0.5	0.7	1.4	1.0	0.9	1.2	-0.2	0.6	0.9	-0.8
Body mass index (BMI)	0.5	2.0	3.9	-2.0	-1.9	-0.6	-0.5	0.4	-1.9	1.4
Diabetes (self-reported)	0.5	0.8	2.2	-0.8	-0.7	-1.3	-1.5	-0.0	-0.7	0.4
Medication: Simvastatin	0.5	0.8	3.0	0.4	0.3	-0.7	-1.7	1.0	0.3	-0.9
Alcohol intake versus 10 years previously	0.5	0.8	2.1	0.7	0.7	1.1	0.0	1.4	0.8	1.0
Falls in the last year	0.5	0.6	1.2	0.9	0.8	1.1	-0.4	0.1	0.8	-1.0
Medication: Cholesterol lowering	0.5	0.7	1.4	1.1	1.2	-0.1	-0.1	1.0	1.1	-0.2
Illnesses of mother	0.5	0.6	2.6	-0.3	-0.2	0.4	1.2	0.5	-0.2	1.6
Length of working week for main job	0.5	0.6	1.0	-0.4	-0.4	-1.0	-1.0	-0.7	-0.5	-0.9
Headache pain in last month	0.5	0.8	1.3	-0.9	-1.1	-0.8	-0.7	-1.1	-1.1	0.1
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	1.5	-1.2	-1.2	-0.1	-1.1	-0.9	-1.1	-0.4
Medication for pain relief, constipation, heartburn	0.5	0.8	4.9	-0.1	-0.1	-0.5	-0.7	-0.5	-0.2	-2.2
Medication: Ibuprofen	0.5	0.6	2.3	-0.4	-0.5	-0.1	1.1	-0.4	-0.5	1.5
Medication: Allopurinol	0.5	0.7	1.8	-0.7	-0.7	-0.4	-1.3	0.1	-0.8	-1.1
Chest pain or discomfort	0.5	0.7	1.0	0.8	0.9	0.4	1.0	1.0	0.9	-0.1
Medication: Aspirin	0.5	0.7	3.1	0.5	0.5	-0.3	0.4	0.9	0.5	1.8
Supplements: Vitamin C	0.5	0.6	1.8	-0.4	-0.4	-0.6	1.1	-0.1	-0.4	1.4
Hypertension (Self-reported)	0.5	1.5	3.4	0.8	0.9	0.9	1.9	1.6	1.0	1.2
Mother’s age at death	0.5	0.6	2.0	0.2	0.3	0.9	1.4	0.3	0.4	0.9
Financial situation satisfaction	0.5	0.6	2.3	0.0	0.0	0.7	1.1	0.4	-0.0	1.5
High cholesterol (Self-reported)	0.5	0.8	2.3	1.1	1.0	-0.5	-0.1	1.5	1.0	0.0
Number of operations (self-reported)	0.5	0.7	1.6	0.6	0.7	1.3	1.0	0.7	0.7	0.7
Schizophrenia (2018)	0.4	0.9	3.3	-1.0	-1.0	-0.1	-0.2	-1.8	-1.0	-0.4
Breast Cancer	0.4	1.0	2.9	-0.8	-0.6	-0.4	1.7	-0.5	-0.6	1.4
Bipolar Disorder (2011)	0.4	0.4	1.4	0.3	0.4	1.2	0.7	-0.6	0.3	0.5
Mean Putamen Volume	0.4	0.5	2.2	0.6	0.6	-0.3	-0.3	0.2	0.6	-1.5
LDL Cholesterol	0.4	0.6	1.8	0.5	0.6	0.3	0.4	1.4	0.5	-1.1
Allergy or Eczema	0.4	0.9	1.8	-1.4	-1.2	0.6	1.0	-0.6	-1.2	0.2
Number of treatments/medications taken	0.4	0.8	1.4	0.9	0.9	0.2	-0.1	1.1	1.0	1.2
Sensitivity / hurt feelings	0.4	0.7	1.4	-0.3	-0.3	1.1	1.2	-1.1	-0.2	0.9
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.6	0.4	0.6	1.3	0.8	0.2	0.6	0.4
Medication: Co-codamol	0.4	0.4	1.8	0.1	0.2	-0.6	0.5	1.3	0.2	0.7
Taking other prescription medications	0.4	0.6	1.7	0.8	0.8	-0.1	-0.4	1.3	0.9	0.6
Chronic bronchitis/emphysema (father)	0.4	0.5	0.8	-0.9	-0.8	0.2	-0.7	-0.0	-0.8	-0.8
Impedance of leg (left)	0.4	2.0	8.2	-1.1	-1.2	-2.9	-1.1	0.2	-1.2	-0.3
Alcohol usually taken with meals	0.4	0.6	0.9	-1.0	-0.9	-0.9	-0.6	-0.8	-0.9	0.1
Impedance of arm (right)	0.4	1.7	4.5	0.9	0.9	-1.1	-1.6	1.1	0.9	-2.1
Father’s age at death	0.4	0.5	1.4	-0.2	-0.1	-1.2	0.7	0.9	-0.1	0.8
Impedance of arm (left)	0.4	1.7	3.1	1.1	1.0	-1.3	-1.3	1.4	1.0	-1.8
Breastfed as a baby	0.4	0.4	1.0	-0.5	-0.4	0.7	-0.7	-0.6	-0.5	-1.0
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	0.8	0.7	0.7	0.2	0.7	0.9	0.7	0.7
Chronic bronchitis/emphysema (mother)	0.4	0.4	1.1	-0.6	-0.5	-0.9	0.4	-0.1	-0.5	1.0
Wheeze or whistling in the chest in last year	0.4	0.7	3.2	0.2	0.3	1.8	0.4	0.6	0.3	1.0
Suffer from ‘nerves’	0.4	0.6	1.8	0.7	0.7	0.6	-0.1	1.3	0.8	0.7
Had major operations	0.4	0.5	1.8	-0.2	-0.1	-0.0	1.3	0.6	-0.0	1.1
Knee pain experienced in last month	0.4	0.6	2.8	-0.6	-0.5	0.5	0.2	0.5	-0.5	1.7
Diastolic blood pressure, automated reading	0.4	1.1	5.6	0.0	-0.1	-1.3	-0.6	2.4	-0.0	-0.1
Vascular/heart problems diagnosed by doctor	0.4	1.2	2.3	-0.7	-0.8	-0.7	-1.5	-1.3	-0.8	-1.3
Pack years of smoking	0.4	0.5	1.8	-0.7	-0.6	0.2	-0.7	-1.4	-0.7	0.4
Blood Platelet Count	0.3	3.7	10.1	1.6	1.7	2.4	1.4	3.2	1.7	0.1
Systolic Blood Pressure	0.3	1.3	5.5	1.1	1.0	-0.4	0.2	2.4	1.0	-0.5
Hearing difficulty/problems: Yes	0.3	0.4	0.8	0.8	0.8	0.3	0.0	0.9	0.8	0.1
Medication for hormone replacement therapy	0.3	0.3	1.5	-0.4	-0.3	-0.2	0.3	-1.2	-0.4	0.4
Pack years adult smoking proportion	0.3	0.5	1.5	-0.6	-0.5	0.3	-0.4	-1.2	-0.6	0.8
High blood pressure	0.3	0.9	2.5	0.4	0.5	0.6	1.6	1.1	0.5	1.1
Hayfever, allergic rhinitis or eczema	0.3	0.7	2.5	-0.4	-0.3	1.6	1.2	0.7	-0.2	0.6
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.6	0.1	0.1	1.3	-0.4	-0.6	0.1	-0.8
Past tobacco smoking	0.3	0.6	1.1	1.0	0.9	0.5	-0.3	0.3	0.9	-1.0
Had other major operations	0.3	0.4	1.1	0.3	0.3	1.0	0.5	0.8	0.3	0.8
Allergy	0.3	0.6	1.3	1.1	1.0	-0.9	-0.1	-0.4	0.9	-0.3
Time employed in main current job	0.3	0.4	0.9	-0.2	-0.2	-0.9	-0.8	-0.7	-0.2	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	1.6	-0.4	-0.5	-0.5	-1.3	-0.2	-0.5	-0.5
Hair/balding pattern: Pattern 3	0.3	0.4	0.8	0.9	0.8	0.8	0.2	0.3	0.8	-0.1
Number of live births	0.3	0.5	0.9	0.5	0.7	0.8	1.0	-0.4	0.8	0.2
Noisy workplace	0.3	0.3	0.6	-0.7	-0.7	-0.3	-0.3	-0.6	-0.8	0.3
Loud music exposure frequency	0.3	0.4	1.6	-0.4	-0.3	-0.4	-0.5	0.4	-0.4	1.2
Birth weight	0.3	0.7	1.2	0.9	0.9	0.4	0.8	1.1	0.9	0.6
Worry too long after embarrassment	0.3	0.6	2.3	-0.1	-0.2	-0.6	-1.5	-0.5	-0.2	-0.9
Health satisfaction	0.3	0.4	1.3	0.5	0.4	-0.5	-1.1	0.1	0.5	-0.9
Qualifications: College or University degree	0.3	1.1	3.1	-0.6	-0.5	-0.8	-1.2	-1.1	-0.6	-1.8
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.7	0.8	0.8	0.4	0.4	-0.1	0.7	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.5	-0.7	-0.6	0.5	0.6	0.4	-0.5	0.7
Illnesses of father: Heart disease	0.3	0.4	1.4	0.5	0.4	-0.1	-0.7	-0.4	0.4	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	1.7	-0.1	-0.1	0.3	1.3	-0.0	-0.0	0.4
Smoking status: Current	0.3	0.4	1.5	-0.6	-0.7	0.1	-1.2	0.3	-0.7	-0.4
Number of self-reported non-cancer illnesses	0.3	0.5	1.9	-0.5	-0.5	0.4	0.1	0.7	-0.4	1.4
Average weekly champagne plus white wine intake	0.3	0.4	2.4	-0.2	-0.2	-1.6	0.4	0.4	-0.2	0.4
Guilty feelings	0.3	0.5	2.0	0.3	0.3	-0.3	-0.7	0.8	0.3	-1.4
Eye problems/disorders: Glaucoma	0.3	0.3	1.0	-0.3	-0.3	1.0	0.2	-0.7	-0.2	-0.8
Alcohol drinker status: Never	0.3	0.3	0.7	-0.6	-0.5	0.9	-0.5	-0.5	-0.5	0.1
Intelligence (Savage-Jansen 2018)	0.2	0.5	0.9	0.6	0.6	0.9	-0.4	0.9	1.0	0.2
Worry (Nagel 2018)	0.2	0.4	0.9	0.6	0.6	0.7	0.1	0.9	0.6	0.9
Ovarian Cancer	0.2	0.2	0.4	-0.5	-0.5	-0.5	0.3	-0.6	-0.5	-0.0
Crohns Disease (2012)	0.2	0.3	0.9	-0.1	-0.2	-0.2	-0.9	1.0	-0.3	-0.0
Rheumatoid Arthritis	0.2	0.2	0.6	0.5	0.4	-0.0	0.5	0.8	0.4	0.4
Blood Eosinophil Count	0.2	1.3	4.7	0.3	0.3	2.2	1.6	0.4	0.3	1.2
Blood Red Count	0.2	1.7	2.8	-0.8	-1.0	-0.9	-1.7	-1.7	-0.9	-1.6
Blood White Count	0.2	1.4	3.6	1.1	1.0	1.9	-0.3	1.3	1.0	-1.2
Waist Hip Ratio (WHR)	0.2	1.0	3.4	0.7	0.6	-1.8	-0.4	1.3	0.7	0.7
Smoking Status	0.2	0.5	2.0	-0.5	-0.6	-0.2	-1.4	-0.1	-0.6	-0.9
Lung FEV1/FVC ratio	0.2	0.8	2.6	-0.8	-0.8	-0.7	0.5	0.6	-0.8	1.6
Chronotype (morning person)	0.2	0.5	2.3	0.4	0.3	-0.1	0.0	1.1	0.4	1.5
Systolic blood pressure, automated reading	0.2	0.5	3.0	-0.2	-0.3	-0.5	-0.2	1.7	-0.2	-0.1
Townsend deprivation index at recruitment	0.2	0.3	0.6	0.7	0.7	0.7	0.0	0.4	0.7	0.2
Current tobacco smoking	0.2	0.3	0.8	0.0	0.0	0.9	-0.8	0.5	0.0	-0.8
Average weekly fortified wine intake	0.2	0.2	0.4	-0.5	-0.4	-0.2	-0.2	-0.6	-0.4	-0.7
Maternal smoking around birth	0.2	0.2	0.9	0.1	0.1	-0.9	-0.1	-0.3	0.2	-0.8
Multivitamins +/- minerals	0.2	0.3	0.6	-0.7	-0.8	-0.1	-0.3	0.3	-0.7	0.3
Medication: Levothyroxine sodium	0.2	0.3	0.7	-0.8	-0.8	0.4	-0.4	-0.0	-0.7	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.9	-0.2	-0.3	-1.4	-0.3	-0.1	-0.2	0.4
Hearing difficulty/problems with background noise	0.2	0.4	1.7	-0.6	-0.5	-0.1	0.4	-0.2	-0.4	1.3
Qualifications: None of the above	0.2	0.4	1.3	-0.3	-0.1	-0.1	-0.9	1.2	-0.1	0.4
Illnesses of siblings	0.2	0.2	0.9	-0.4	-0.3	0.5	0.4	-0.9	-0.4	-0.1
Neuroticism score	0.2	0.4	0.7	-0.6	-0.7	-0.3	-0.7	-0.5	-0.6	0.9
Worrier / anxious feelings	0.2	0.3	0.9	0.4	0.3	0.5	-0.9	0.4	0.4	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	0.9	0.4	0.5	0.6	-0.6	0.5	0.5	-1.0
Blood clot in the leg (DVT)	0.2	0.3	0.8	-0.7	-0.6	0.0	-0.9	0.2	-0.6	-0.3
Medication: Ventolin 100micrograms inhaler	0.2	0.3	1.2	0.0	-0.1	0.6	-0.6	0.0	-0.1	-1.1
High blood pressure (siblings)	0.2	0.2	0.8	-0.1	-0.1	0.1	-0.8	0.9	-0.1	-0.5
Number of full brothers	0.2	0.2	0.7	0.1	-0.0	-0.7	-0.8	0.4	-0.0	0.6
Shortness of breath walking on level ground	0.2	0.2	0.8	0.1	0.1	0.1	-0.9	-0.2	0.2	-0.8
Neck or shoulder pain in last month	0.2	0.3	1.8	-0.1	-0.3	-1.4	-0.2	-0.3	-0.3	0.3
Medication: Omeprazole	0.2	0.2	1.2	-0.1	-0.2	0.3	-1.1	-0.5	-0.0	-0.1
Heart disease (mother)	0.2	0.3	0.6	-0.8	-0.7	0.1	-0.2	-0.3	-0.6	0.6
Age at last live birth	0.2	0.3	1.0	0.0	0.1	1.0	0.6	-0.0	0.0	0.9
Average weekly red wine intake	0.2	0.3	0.6	0.2	0.3	0.5	0.6	0.8	0.3	0.6
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.8	0.3	0.3	0.9	0.6	-0.1	0.2	0.2
Ever had bowel cancer screening	0.2	0.3	1.4	-0.1	-0.2	-0.5	-1.2	0.1	-0.1	-0.5
Friendships satisfaction	0.2	0.2	0.5	0.6	0.5	-0.7	0.2	0.4	0.5	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	1.1	-0.3	-0.3	-0.1	-1.0	-0.5	-0.3	-1.1
Medication for cholesterol	0.2	0.4	1.5	-0.5	-0.4	0.4	-0.3	-0.3	-0.5	-1.2
Ever taken oral contraceptive pill	0.2	0.2	0.5	-0.4	-0.4	-0.7	0.7	0.0	-0.5	0.2
Medication: Bendroflumethiazide	0.2	0.4	0.7	0.8	0.7	-0.8	0.1	0.6	0.7	-0.2
Medication: Paracetamol	0.2	0.2	0.6	-0.6	-0.6	0.0	-0.0	-0.0	-0.6	0.8
Medication: Atorvastatin	0.2	0.2	0.4	0.6	0.5	-0.2	-0.4	-0.7	0.5	0.1
Ever smoked	0.2	0.4	1.0	-0.8	-0.6	0.0	0.7	-0.3	-0.6	1.0
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.7	-0.4	-0.4	-0.6	-0.6	-0.1	-0.4	-0.9
Commuting to job workplace: Cycle	0.2	0.2	0.6	0.3	0.4	0.3	0.1	0.8	0.3	-0.8
Cholesterol lowering medication	0.2	0.2	0.4	0.6	0.5	-0.4	-0.5	0.4	0.5	0.3
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	1.0	0.2	0.1	0.5	-1.0	-0.2	0.2	0.2
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.9	-0.6	-0.5	0.3	-1.0	0.2	-0.6	-0.2
Alcohol drinker status: Previous	0.2	0.3	0.7	0.4	0.5	0.9	0.2	0.2	0.5	0.5
Impedance of whole body	0.2	1.1	4.0	-0.0	-0.1	-2.0	-1.3	0.8	-0.1	-1.2
Neuroticism (Nagel 2018)	0.1	0.2	0.6	-0.3	-0.4	-0.1	0.0	-0.8	-0.4	0.5
Crohns Disease (2017)	0.1	0.3	2.2	0.0	-0.0	-0.1	-1.5	-0.0	-0.1	-0.1
Schizophrenia (2014)	0.1	0.3	1.1	0.0	0.1	0.6	0.4	-1.0	0.0	-0.7
BMI	0.1	0.7	1.5	-0.9	-0.8	0.5	0.3	1.2	-0.7	1.2
Cardiovascular Disease	0.1	0.2	0.9	0.3	0.2	-0.1	0.9	0.2	0.2	0.6
Neuroticism	0.1	0.2	1.1	0.0	-0.1	-0.1	-0.3	0.1	-0.0	1.1
Tanning	0.1	0.8	2.7	0.8	0.9	0.4	1.6	-0.3	0.8	-0.3
Relative age voice broke	0.1	0.2	0.4	-0.4	-0.3	-0.6	-0.1	-0.4	-0.4	0.6
Nervous feelings	0.1	0.2	0.4	0.3	0.3	-0.3	-0.6	0.6	0.4	-0.1
Mouth/teeth dental problems	0.1	0.1	0.3	0.4	0.3	-0.2	0.6	0.6	0.3	0.3
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.5	-0.0	0.0	0.6	0.7	0.7	0.1	-0.0
Qualifications: A levels/AS levels or equivalent	0.1	0.2	1.1	-0.3	-0.4	-0.4	-0.1	-1.0	-0.5	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.4	-0.4	-0.4	0.1	-0.6	0.1	-0.4	-0.0
Mouth/teeth dental problems: Dentures	0.1	0.2	0.5	-0.2	-0.1	0.5	-0.4	-0.5	-0.1	-0.7
Asthma	0.1	0.3	0.5	-0.6	-0.6	0.5	-0.2	0.7	-0.6	-0.2
Depression (self-reported)	0.1	0.1	0.3	0.6	0.5	0.3	-0.0	0.4	0.5	-0.2
Hair/balding pattern: Pattern 4	0.1	0.2	0.5	0.4	0.4	-0.5	0.2	0.7	0.2	-0.1
Peak expiratory flow (PEF)	0.1	0.3	0.8	0.7	0.6	-0.1	0.9	0.2	0.6	0.1
Medication: Paracetamol	0.1	0.1	0.2	-0.4	-0.4	-0.1	-0.2	-0.1	-0.4	0.5
Age at first live birth	0.1	0.1	0.3	0.5	0.5	-0.0	0.5	0.3	0.3	0.1
Pulse rate, automated reading	0.1	0.5	1.9	0.3	0.3	0.8	0.4	0.4	0.4	1.4
Mood swings	0.1	0.3	1.2	-0.1	-0.1	0.0	0.6	0.5	-0.1	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.3	-0.6	-0.6	-0.1	0.1	-0.1	-0.5	0.0
Asthma (self-reported)	0.1	0.3	0.8	-0.5	-0.5	0.4	-0.2	0.9	-0.5	-0.1
Pain experienced in last month	0.1	0.1	0.5	-0.2	-0.1	0.1	0.5	-0.7	-0.1	-0.5
Age at First Birth	0.0	0.1	0.3	0.1	-0.0	-0.4	-0.5	0.2	-0.1	0.1
Hair Pigment	0.0	0.4	1.9	0.1	0.1	-0.3	-0.7	-0.1	0.2	-1.4
Pulse rate	0.0	0.1	0.3	0.1	0.1	0.5	-0.2	0.3	0.1	0.3
Smoking status: Previous	0.0	0.1	0.2	-0.3	-0.2	-0.2	0.2	-0.3	-0.2	0.4
Qualifications: nursing, teaching	0.0	0.0	0.1	-0.1	-0.1	0.1	-0.0	-0.3	-0.2	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.1	0.1	-0.3	-0.3	-0.3	0.0	-0.2	-0.4	0.1

Hub : Genes

GLT25D2

Models

Trait associations