Best TWAS P=5.51e-15 · Best GWAS P=1.34e-20 conditioned to 1.9e-07
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Frontal Cortex BA9 | NLRC3 | 0.50 | 0.18 | enet | 30 | 0.33 | 1.6e-09 | 2.9 | -5.9 | 3.3e-09 | 0.03 | 0.44 | 0.06 | TRUE |
| 2 | GTEx | Esophagus Mucosa | UBN1 | 0.12 | 0.06 | lasso | 3 | 0.08 | 5.1e-06 | 4.7 | -5.2 | 2.1e-07 | -0.05 | 0.03 | 0.97 | FALSE |
| 3 | GTEx | Nerve Tibial | UBN1 | 0.14 | 0.12 | lasso | 4 | 0.11 | 5.6e-08 | 5.2 | -5.3 | 1.3e-07 | -0.04 | 0.01 | 0.99 | TRUE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | RP11-462G12.1 | 0.11 | 0.07 | enet | 18 | 0.06 | 1.1e-08 | -8.9 | -7.8 | 5.5e-15 | 0.86 | 0.00 | 1.00 | TRUE |