TWAS
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Genes
Traits
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Traits
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Arm fat percentage (right)
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chr16:2,890,210-5,627,737
Best TWAS P=5.51e-15 · Best GWAS P=1.34e-20 conditioned to 1.9e-07
3M
3.5M
4M
4.5M
5M
5.5M
0
5
10
15
20
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
4
ROSMAP
Brain Pre-frontal Cortex
RP11-462G12.1
0.11
0.07
enet
18
0.06
1.1e-08
-8.9
-7.8
5.5e-15
0.86
0.00
1.00
TRUE
1
GTEx
Brain Frontal Cortex BA9
NLRC3
0.50
0.18
enet
30
0.33
1.6e-09
2.9
-5.9
3.3e-09
0.03
0.44
0.06
TRUE
3
GTEx
Nerve Tibial
UBN1
0.14
0.12
lasso
4
0.11
5.6e-08
5.2
-5.3
1.3e-07
-0.04
0.01
0.99
TRUE
2
GTEx
Esophagus Mucosa
UBN1
0.12
0.06
lasso
3
0.08
5.1e-06
4.7
-5.2
2.1e-07
-0.05
0.03
0.97
FALSE