Best TWAS P=9e-11 · Best GWAS P=1.89e-10 conditioned to 0.0185
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Nerve Tibial | PDIA2 | 0.12 | 0.01 | enet | 13 | 0.06 | 4.4e-05 | -6.4 | 6.4 | 1.9e-10 | -0.87 | 0.00 | 1.00 | FALSE |
| 2 | GTEx | Nerve Tibial | ARHGDIG | 0.13 | 0.07 | lasso | 2 | 0.07 | 8.0e-06 | -5.7 | 5.4 | 5.5e-08 | -0.61 | 0.05 | 0.82 | FALSE |
| 3 | GTEx | Testis | AXIN1 | 0.36 | 0.29 | lasso | 3 | 0.28 | 4.3e-13 | -5.7 | -5.4 | 7.2e-08 | 0.70 | 0.08 | 0.92 | FALSE |
| 4 | GTEx | Whole Blood | NME4 | 0.12 | 0.03 | lasso | 5 | 0.04 | 3.0e-04 | 2.6 | 5.6 | 1.9e-08 | -0.56 | 0.04 | 0.94 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | PDIA2 | 0.15 | 0.07 | lasso | 8 | 0.10 | 5.2e-13 | -5.6 | -6.4 | 1.2e-10 | 0.85 | 0.00 | 1.00 | FALSE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | AXIN1 | 0.03 | 0.01 | blup | 88 | 0.01 | 7.7e-03 | -5.6 | 6.5 | 9.0e-11 | -0.74 | 0.01 | 0.76 | TRUE |
| 7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LOC100134368 | 0.03 | 0.00 | enet | 5 | 0.01 | 2.8e-02 | -1.6 | -5.2 | 2.0e-07 | 0.40 | 0.01 | 0.57 | FALSE |
| 8 | The Cancer Genome Atlas | Prostate Adenocarcinoma | LOC100134368 | 0.05 | 0.00 | blup | 48 | 0.04 | 2.5e-05 | -4.3 | -5.6 | 2.5e-08 | 0.42 | 0.02 | 0.84 | FALSE |
| 9 | The Cancer Genome Atlas | Thyroid Carcinoma | LOC100134368 | 0.06 | 0.05 | blup | 47 | 0.07 | 3.9e-07 | 2.6 | -5.3 | 1.0e-07 | 0.38 | 0.36 | 0.51 | FALSE |