Best TWAS P=1.86e-10 · Best GWAS P=2.1e-10 conditioned to 0.0539
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | KLHL24 | 0.42 | 0.60 | bslmm | 493 | 0.66 | 4.5e-107 | -5.9 | -5.9 | 4.7e-09 | -0.20 | 0.04 | 0.96 | FALSE |
2 | GTEx | Adipose Subcutaneous | KLHL24 | 0.15 | 0.10 | lasso | 6 | 0.10 | 1.4e-08 | -5.9 | 6.4 | 1.9e-10 | 0.33 | 0.04 | 0.96 | TRUE |
3 | GTEx | Brain Caudate basal ganglia | KLHL24 | 0.22 | 0.21 | lasso | 3 | 0.19 | 3.5e-06 | -5.9 | 5.9 | 3.1e-09 | 0.25 | 0.04 | 0.94 | FALSE |
4 | GTEx | Brain Cerebellar Hemisphere | KLHL24 | 0.31 | 0.10 | enet | 22 | 0.09 | 3.4e-03 | -5.9 | 5.5 | 4.4e-08 | 0.15 | 0.04 | 0.86 | FALSE |
5 | GTEx | Brain Cerebellum | KLHL24 | 0.52 | 0.14 | enet | 26 | 0.16 | 1.9e-05 | -5.9 | 5.7 | 1.5e-08 | 0.31 | 0.04 | 0.95 | FALSE |
6 | GTEx | Brain Cortex | KLHL24 | 0.21 | 0.15 | lasso | 3 | 0.07 | 6.1e-03 | -5.9 | 6.4 | 1.9e-10 | 0.35 | 0.04 | 0.88 | FALSE |
7 | GTEx | Brain Frontal Cortex BA9 | KLHL24 | 0.36 | 0.23 | lasso | 6 | 0.15 | 9.3e-05 | -5.9 | 5.6 | 1.8e-08 | 0.24 | 0.04 | 0.94 | FALSE |
8 | GTEx | Brain Hypothalamus | KLHL24 | 0.22 | 0.24 | lasso | 2 | 0.19 | 3.3e-05 | -5.3 | 5.2 | 1.6e-07 | 0.14 | 0.07 | 0.55 | FALSE |
9 | GTEx | Breast Mammary Tissue | KLHL24 | 0.25 | 0.13 | lasso | 5 | 0.11 | 3.4e-06 | -5.9 | 5.9 | 3.8e-09 | 0.30 | 0.04 | 0.96 | FALSE |
10 | GTEx | Esophagus Muscularis | KLHL24 | 0.10 | 0.12 | lasso | 1 | 0.09 | 4.4e-06 | -5.9 | 5.9 | 3.4e-09 | 0.25 | 0.04 | 0.96 | FALSE |
11 | GTEx | Lung | YEATS2-AS1 | 0.13 | 0.03 | enet | 27 | 0.07 | 3.3e-06 | 5.7 | -5.5 | 4.8e-08 | -0.64 | 0.16 | 0.75 | FALSE |
12 | GTEx | Nerve Tibial | KLHL24 | 0.08 | 0.06 | lasso | 3 | 0.05 | 1.5e-04 | -5.9 | 5.9 | 4.1e-09 | 0.25 | 0.04 | 0.94 | FALSE |
13 | GTEx | Skin Sun Exposed Lower leg | KLHL24 | 0.09 | 0.06 | lasso | 10 | 0.05 | 9.5e-05 | -5.9 | 5.8 | 5.3e-09 | 0.24 | 0.04 | 0.96 | FALSE |
14 | GTEx | Testis | KLHL24 | 0.17 | 0.10 | lasso | 4 | 0.10 | 4.0e-05 | -5.9 | 5.9 | 3.3e-09 | 0.25 | 0.04 | 0.96 | FALSE |
15 | METSIM | Adipose | MAP6D1 | 0.06 | 0.05 | bslmm | 473 | 0.06 | 2.3e-09 | 5.7 | 6.0 | 1.9e-09 | 0.68 | 0.40 | 0.60 | TRUE |
16 | YFS | Blood | KLHL24 | 0.02 | 0.01 | lasso | 2 | 0.01 | 1.4e-03 | -5.0 | 5.2 | 2.0e-07 | 0.29 | 0.05 | 0.94 | FALSE |
17 | The Cancer Genome Atlas | Brain Lower Grade Glioma | KLHL24 | 0.05 | 0.05 | blup | 53 | 0.05 | 1.1e-06 | -5.9 | 5.7 | 1.4e-08 | 0.15 | 0.02 | 0.98 | FALSE |
18 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | KLHL24 | 0.16 | 0.16 | blup | 53 | 0.21 | 4.3e-08 | -5.9 | 5.4 | 5.4e-08 | 0.11 | 0.02 | 0.98 | FALSE |
19 | The Cancer Genome Atlas | Thyroid Carcinoma | KLHL24 | 0.10 | 0.09 | blup | 53 | 0.09 | 1.7e-09 | -5.5 | 5.1 | 2.9e-07 | 0.07 | 0.02 | 0.98 | FALSE |