TWAS
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Usage
Models
Genes
Traits
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Traits
:
Arm fat percentage (right)
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chr4:101,579,972-104,048,353
Best TWAS P=2.68e-08 · Best GWAS P=2.38e-30 conditioned to 3.4e-22
101.5M
102M
102.5M
103M
103.5M
104M
0
5
10
15
20
25
30
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
METSIM
Adipose
SLC39A8
0.18
0.15
lasso
6
0.14
5.7e-20
5.5
5.6
2.7e-08
0.28
1.00
0.00
TRUE
1
GTEx
Breast Mammary Tissue
AP001816.1
0.11
0.05
lasso
7
0.04
4.2e-03
5.1
-5.4
6.0e-08
-0.12
0.31
0.05
TRUE
3
The Cancer Genome Atlas
Prostate Adenocarcinoma
SLC39A8
0.07
0.05
lasso
2
0.04
5.0e-05
5.5
-5.1
3.0e-07
-0.24
0.30
0.02
FALSE