Best TWAS P=1.07e-11 · Best GWAS P=1.02e-11 conditioned to 0.115
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | RALGPS1 | 0.08 | 0.07 | enet | 27 | 0.09 | 3.8e-11 | -6.8 | -6.8 | 1.1e-11 | 0.90 | 0.02 | 0.98 | TRUE |
2 | GTEx | Brain Cerebellum | RALGPS1 | 0.28 | 0.17 | lasso | 7 | 0.19 | 2.8e-06 | -5.9 | -6.0 | 1.6e-09 | 0.89 | 0.09 | 0.90 | FALSE |
3 | GTEx | Skin Sun Exposed Lower leg | RALGPS1 | 0.06 | 0.02 | lasso | 6 | 0.01 | 2.5e-02 | 5.0 | 5.9 | 3.6e-09 | -0.74 | 0.28 | 0.60 | FALSE |
4 | GTEx | Testis | RALGPS1 | 0.23 | 0.32 | lasso | 9 | 0.29 | 2.7e-13 | 5.9 | 6.1 | 1.3e-09 | -0.85 | 0.22 | 0.78 | FALSE |
5 | GTEx | Thyroid | RP11-339B21.13 | 0.11 | 0.00 | enet | 17 | 0.00 | 1.7e-01 | 2.3 | 5.5 | 4.1e-08 | 0.00 | 0.01 | 0.04 | TRUE |
6 | GTEx | Whole Blood | RALGPS1 | 0.10 | 0.10 | enet | 10 | 0.08 | 1.2e-07 | -6.2 | 5.9 | 3.3e-09 | -0.89 | 0.14 | 0.86 | FALSE |
7 | METSIM | Adipose | RALGPS1 | 0.04 | 0.04 | lasso | 3 | 0.04 | 2.8e-06 | 5.0 | 5.2 | 2.1e-07 | -0.57 | 0.98 | 0.01 | FALSE |
8 | YFS | Blood | RALGPS1 | 0.08 | 0.13 | lasso | 18 | 0.15 | 1.1e-45 | 4.9 | 6.0 | 2.7e-09 | -0.75 | 0.99 | 0.01 | FALSE |
9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ANGPTL2 | 0.02 | 0.01 | lasso | 2 | 0.01 | 6.2e-02 | -6.1 | 5.8 | 7.6e-09 | -0.89 | 0.04 | 0.32 | FALSE |
10 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | ANGPTL2 | 0.10 | 0.08 | blup | 38 | 0.09 | 2.8e-04 | -5.9 | -6.1 | 1.3e-09 | 0.84 | 0.07 | 0.69 | FALSE |