Hub : Genes

ANGPTL2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Muscularis	0.075	0.0370	0.00560	0.051	NA	-0.004	NA	0.011	0.00046	NA	0.6800	NA	0.06900
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.019	0.0141	0.00940	0.013	0.005	0.004	NA	0.006	0.01100	0.08400	0.1200	NA	0.06200
3	TCGA	Pheochromocytoma and Paraganglioma	0.102	0.0620	0.00051	0.083	0.086	0.067	NA	0.070	0.00034	0.00027	0.0012	NA	0.00096

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.7	1.2	2.5	0.6	0.8	-1.6
Bipolar Disorder or Schizophrenia	1.1	2.6	5.8	0.6	1.2	-2.4
Depressed Affect (Nagel 2018)	0.8	1.6	3.2	0.3	1.2	-1.8
Depression (Nagel 2018)	1.2	1.8	3.5	-0.5	1.3	-1.9
Intelligence (Savage-Jansen 2018)	2.5	7.7	8.1	-2.6	-2.8	2.8
Neuroticism (Nagel 2018)	1.2	2.9	6.1	0.6	1.5	-2.5
Schizophrenia (2018)	0.7	1.4	3.4	0.4	0.9	-1.8
Schizophrenia vs Biploar Disorder	0.1	0.2	0.4	-0.6	-0.3	0.1
Worry (Nagel 2018)	0.8	1.6	3.3	1.1	0.7	-1.8
Alzheimer’s Disease (in mother)	0.5	0.5	1.4	-0.0	0.5	-1.2
Alzheimer’s Disease (in father)	0.4	0.4	1.1	-1.0	-0.5	0.1
Alzheimer’s Disease (including proxy)	0.3	0.5	1.4	0.0	0.4	-1.2
Crohns Disease (2017)	0.5	1.0	1.3	1.1	1.1	-0.9
Irritable Bowel Disease (IBD)	0.0	0.0	0.0	0.1	-0.1	0.2
Ulcerative Colitis (UC)	0.1	0.3	0.4	-0.4	-0.6	0.5
Major Depression (MDD)	1.0	1.2	2.0	1.4	0.2	-1.2
Reaction Time	1.6	3.1	7.8	-2.8	-1.1	0.4
Verbal and Numeric Reasoning (VNR)	0.4	0.9	1.7	-1.3	-0.7	0.8
Breast Cancer	3.0	7.2	11.2	-0.5	-3.2	3.3
Ovarian Cancer	2.7	3.6	5.2	-1.4	-2.3	1.9
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	1.8	2.6	5.1	-0.3	-2.3	1.6
Bipolar Disorder (2011)	1.3	1.2	2.8	1.7	0.3	-0.9
Body Mass Index (BMI) (2010)	1.9	2.6	4.4	0.2	1.9	-2.1
Coronary Artery Disease (CAD)	0.0	0.0	0.1	0.3	-0.1	-0.1
Crohns Disease (2012)	1.6	2.6	4.3	1.5	1.1	-2.1
Mean Putamen Volume	0.7	0.8	0.9	-0.8	-0.9	1.0
Fasting Glucose	2.6	3.1	4.6	-2.1	-1.2	1.8
HbA1C	0.2	0.2	0.3	-0.4	0.4	-0.5
HDL Cholesterol	1.0	1.7	3.3	0.6	1.2	-1.8
LDL Cholesterol	2.1	3.3	5.1	-1.6	-1.6	2.2
Lupus	0.3	0.4	0.5	0.7	0.6	-0.6
Neuroticism (2016)	1.1	1.6	2.1	1.4	1.0	-1.5
Primary Biliary Cirrhosis	0.2	0.3	0.7	0.0	-0.6	0.8
Rheumatoid Arthritis	3.0	4.1	4.7	2.0	2.2	-1.9
Schizophrenia (2014)	0.7	1.6	4.4	0.2	0.6	-2.1
Triglycerides	0.4	0.6	1.4	-0.5	-0.3	1.2
Type 2 Diabetes (T2D) (2012)	0.9	1.1	2.2	0.3	1.0	-1.5
Ulcerative Colitis	0.3	0.5	0.9	-0.3	-1.0	0.7
Blood Eosinophil Count	0.1	0.5	1.0	1.0	-0.4	0.4
Blood Platelet Count	0.3	3.3	7.9	1.0	2.8	-1.0
Blood Red Count	0.1	0.8	2.1	1.5	0.1	-0.3
Blood White Count	0.3	1.9	3.8	2.0	1.2	-0.5
Heel T-Score	1.1	8.7	16.6	-4.1	-1.9	2.4
BMI	0.8	4.4	7.7	-0.0	2.8	-2.3
Height	1.4	26.5	33.4	-3.8	-5.6	5.8
Waist Hip Ratio (WHR)	0.2	1.0	2.3	1.5	0.6	-0.7
Systolic Blood Pressure	0.2	1.0	2.7	1.6	0.4	-0.1
Smoking Status	0.2	0.4	0.6	-0.4	-0.8	0.7
Allergy or Eczema	0.7	2.0	3.0	-0.6	-1.6	1.7
Cardiovascular Disease	3.4	11.3	17.3	1.9	4.2	-3.6
Hypothyroidism (self reported)	0.2	0.4	0.7	0.8	0.5	-0.5
Respiratory disease	0.3	0.7	1.6	0.3	1.3	-0.7
Type 2 Diabetes (T2D) (2018)	0.0	0.1	0.1	-0.1	-0.2	-0.4
Lung FEV1/FVC ratio	0.3	1.4	3.0	-0.4	1.0	-1.7
Lung FVC	0.1	0.4	0.8	0.5	0.4	-0.9
Neuroticism	1.9	4.6	9.0	1.1	1.9	-3.0
Chronotype (morning person)	1.1	2.7	4.2	1.3	2.0	-1.5
Hair Pigment	1.1	30.7	36.1	-4.7	-5.8	6.0
Tanning	0.1	0.7	1.7	0.4	1.3	-0.5
Hand grip strength (left)	1.1	3.0	4.4	-0.5	-2.1	2.1
Number of treatments/medications taken	0.9	1.6	3.2	0.7	1.8	-1.1
Average weekly spirits intake	0.1	0.1	0.3	0.5	0.3	-0.2
Sensitivity / hurt feelings	0.8	1.4	3.1	-0.7	0.8	-1.7
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.6	-0.5	0.6	-1.3
Hearing difficulty/problems: Yes	0.3	0.5	1.3	-0.0	-1.1	0.3
Relative age of first facial hair	0.1	0.3	0.5	-0.7	-0.3	0.4
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.6	-0.3	-0.8	0.4
Ever used hormone-replacement therapy (HRT)	0.0	0.1	0.2	-0.4	0.1	-0.0
Ever had hysterectomy (womb removed)	0.5	0.5	0.7	-0.8	-0.4	0.8
Systolic blood pressure, automated reading	0.1	0.3	0.8	0.9	0.2	0.1
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	1.8	-0.2	-1.2	1.3
Angina	1.2	1.6	2.2	0.5	1.5	-1.5
Medication for hormone replacement therapy	0.0	0.0	0.1	-0.4	0.1	0.0
Vitamin and mineral supplements	0.3	0.4	0.6	0.8	0.2	0.8
Supplements: Zinc	0.3	0.3	0.9	-0.9	0.1	-0.2
Medication: Co-codamol	1.1	1.3	2.4	1.6	1.3	-0.0
Medication: Metformin	0.2	0.3	0.8	0.9	0.2	-0.4
Diabetes (father)	1.0	1.3	1.4	1.2	1.0	-1.2
Diabetes (mother)	0.1	0.1	0.2	0.5	-0.1	0.4
Severe depression (siblings)	5.4	6.1	12.0	0.3	2.5	-3.5
Pack years adult smoking proportion	0.1	0.2	0.3	0.5	0.5	0.1
Impedance of leg (right)	0.7	3.3	5.3	2.3	1.9	-0.9
Leg fat-free mass (left)	0.3	1.4	3.0	-1.7	-0.8	0.8
Trunk fat percentage	4.2	16.9	22.0	2.9	4.5	-4.7
Hand grip strength (right)	0.3	0.8	1.3	0.5	-1.1	0.9
Townsend deprivation index at recruitment	0.0	0.1	0.1	0.4	0.2	0.0
Current tobacco smoking	0.2	0.4	0.6	-0.7	-0.4	0.8
Average weekly fortified wine intake	1.2	1.4	4.0	2.0	0.5	-0.3
Maternal smoking around birth	2.2	3.2	6.2	-2.5	-1.7	0.8
Fed-up feelings	0.0	0.0	0.0	0.0	-0.2	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.0	2.2	0.1	0.9	-1.5
Relative age voice broke	0.5	0.8	1.5	-0.4	1.2	-0.8
Taking other prescription medications	0.2	0.3	0.4	0.6	0.6	-0.3
Age when periods started (menarche)	0.1	0.3	0.5	0.5	-0.7	0.6
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	2.0	-1.4	-0.3	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.4	-1.2	-0.2	0.1
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.0	0.7	1.0	-0.3
Qualifications: CSEs or equivalent	0.8	1.0	1.5	0.4	1.1	-1.2
Serious illness, injury or assault to yourself	0.1	0.2	0.4	0.3	0.6	-0.3
High blood pressure	2.2	6.2	8.9	1.8	3.0	-2.5
Hayfever, allergic rhinitis or eczema	0.5	1.0	1.6	-0.6	-1.0	1.3
Multivitamins +/- minerals	0.9	1.2	2.4	0.4	1.0	-1.5
Stomach or abdominal pain in last month	0.4	0.5	1.0	1.0	-0.1	0.8
Supplements: Glucosamine	0.3	0.4	1.2	-1.1	-0.2	0.1
Diverticular disease/diverticulitis (self-reported)	0.0	0.0	0.0	-0.1	0.1	-0.0
Medication: Atenolol	0.8	1.0	1.4	0.9	1.2	-0.9
Medication: Levothyroxine sodium	0.5	0.9	1.7	1.3	1.0	-0.2
Sitting height	0.1	1.0	1.6	-0.9	-0.7	1.3
Chronic bronchitis/emphysema (father)	1.2	1.4	2.3	0.5	1.2	-1.5
High blood pressure (mother)	0.4	0.5	1.0	0.1	1.0	-0.8
Body mass index (BMI)	1.4	6.1	9.3	1.2	3.0	-2.8
Impedance of leg (left)	0.2	1.1	2.1	1.5	1.1	-0.2
Leg predicted mass (left)	0.2	1.3	2.8	-1.7	-0.8	0.8
Trunk fat mass	1.9	8.2	11.3	1.8	3.4	-3.1
Waist circumference	0.8	2.8	4.6	0.9	2.1	-1.7
Number of incorrect matches in round	1.3	2.2	4.7	0.9	1.0	-2.2
Past tobacco smoking	0.5	0.9	1.5	-0.6	-0.8	1.2
Alcohol usually taken with meals	1.2	2.0	4.9	-0.1	-1.0	2.2
Nervous feelings	0.1	0.2	0.3	0.5	-0.0	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.3	-0.5	-0.6	-0.4
Hearing difficulty/problems with background noise	0.5	0.9	2.3	-0.5	-1.5	-0.2
Hair/balding pattern: Pattern 2	0.4	0.5	0.5	-0.7	-0.7	0.6
Had menopause	0.2	0.2	0.3	-0.3	-0.4	0.5
Had other major operations	0.8	1.0	2.1	0.5	1.5	-0.7
Forced vital capacity (FVC)	1.1	4.1	5.5	-2.4	-1.8	1.8
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.7	4.4	-2.1	-0.5	0.7
Ever unenthusiastic/disinterested for a whole week	0.5	0.7	1.7	-1.3	0.3	-0.5
Qualifications: None of the above	1.8	3.8	6.3	0.8	2.5	-2.1
Financial difficulties in last 2 years	0.7	0.9	1.9	-0.0	0.9	-1.4
Mouth/teeth dental problems	0.1	0.2	0.3	-0.3	0.5	-0.5
Heart attack	2.3	3.0	4.2	1.3	1.7	-2.0
Allergy	0.0	0.1	0.2	0.2	-0.5	0.2
Pain all over the body in last month	2.4	2.6	3.4	1.8	1.7	-1.2
Diabetes (self-reported)	0.3	0.5	0.6	-0.7	-0.8	0.7
Hayfever/allergic rhinitis (self-reported)	0.7	1.0	1.9	0.6	0.8	-1.4
Medication: Ramipril	0.5	0.7	1.1	1.0	-0.4	0.9
Medication: Simvastatin	0.3	0.4	0.8	0.4	0.9	-0.6
Fluid intelligence score	0.2	0.3	0.5	-0.5	-0.4	0.7
Illnesses of siblings	3.3	4.7	7.0	-0.9	-2.7	2.5
Neuroticism score	0.6	1.2	2.8	-0.6	0.7	-1.7
Weight	0.2	0.8	1.9	-0.2	1.4	-0.7
Impedance of arm (right)	4.3	20.1	31.6	3.2	4.3	-5.6
Arm fat percentage (right)	6.8	26.9	36.8	3.2	5.8	-6.1
Trunk fat-free mass	1.7	9.8	13.3	-3.2	-2.5	3.6
Hip circumference	0.6	2.6	5.0	0.4	2.2	-1.6
Time employed in main current job	1.5	1.7	1.8	-1.3	-1.3	1.3
Alcohol intake versus 10 years previously	1.2	1.8	3.3	0.3	1.4	-1.8
Father’s age at death	5.3	7.1	11.3	-2.0	-2.4	3.4
Worrier / anxious feelings	0.5	0.9	1.7	0.9	0.2	-1.3
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	0.7	-0.4	0.9	-0.8
Falls in the last year	1.5	2.1	2.4	-1.4	-1.6	1.3
Hair/balding pattern: Pattern 3	0.6	0.8	2.1	-1.4	-0.5	0.4
Number of live births	0.5	0.8	1.8	1.4	0.7	0.3
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	1.3	-1.1	-0.9	0.6
Pulse rate	0.5	0.8	1.0	0.8	-0.9	1.0
Happiness	0.4	0.5	1.3	-1.2	-0.4	0.3
Noisy workplace	0.5	0.6	1.0	-0.4	1.0	-0.8
Qualifications: A levels/AS levels or equivalent	2.2	4.8	6.5	-2.0	-2.6	2.0
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	2.2	-1.5	0.2	0.8
Mouth/teeth dental problems: Dentures	0.2	0.4	1.1	1.1	0.1	-0.0
Asthma	0.5	1.0	2.1	0.0	1.4	-1.0
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	2.9	-0.8	-1.7	0.9
Medication: Cholesterol lowering	1.2	1.9	2.8	0.7	1.5	-1.7
Depression (self-reported)	5.7	6.8	11.7	1.9	2.3	-3.4
Medication: Lansoprazole	2.0	2.3	2.7	1.7	1.5	-1.3
Prospective memory result	2.5	3.0	4.3	1.1	2.1	-1.9
Lung cancer (father)	0.2	0.3	0.5	-0.5	-0.1	-0.7
Illnesses of mother	0.6	0.7	1.3	-0.3	-1.1	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	4.1	-2.0	-1.0	0.7
Pulse wave Arterial Stiffness index	0.1	0.1	0.2	-0.3	-0.0	0.4
Impedance of arm (left)	3.0	14.0	24.5	2.5	3.3	-5.0
Arm fat mass (right)	2.4	10.0	14.3	1.5	3.8	-3.6
Trunk predicted mass	1.7	10.0	13.4	-3.2	-2.5	3.7
Standing height	1.3	12.7	17.6	-3.0	-3.4	4.2
Length of working week for main job	0.2	0.2	0.4	0.7	-0.5	0.1
Exposure to tobacco smoke at home	2.8	3.2	5.3	1.2	2.3	-1.7
Breastfed as a baby	0.6	0.7	1.8	-1.3	0.0	-0.6
Tense / ‘highly strung’	1.9	3.2	5.6	0.6	1.9	-2.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	2.5	-0.2	0.5	-1.6
Hair/balding pattern: Pattern 4	5.2	12.6	15.8	2.6	3.9	-4.0
Birth weight of first child	3.8	6.9	7.6	2.7	2.4	-2.8
Peak expiratory flow (PEF)	0.2	0.5	0.7	0.8	0.6	-0.7
Pulse wave reflection index	0.2	0.3	0.7	-0.8	0.3	-0.3
Ever highly irritable/argumentative for 2 days	2.9	3.4	5.0	1.4	1.8	-2.2
Loud music exposure frequency	4.4	4.8	7.8	-1.9	-2.8	1.7
Qualifications: O levels/GCSEs or equivalent	5.2	8.3	10.8	-2.2	-3.3	3.0
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.1	0.3	-0.4	-0.2
Blood clot in the leg (DVT)	3.0	3.9	6.9	0.6	2.6	-2.1
Medication: Paracetamol	0.2	0.3	0.3	0.4	0.6	-0.5
Headache pain in last month	0.7	1.2	2.6	-1.6	-0.8	0.5
Medication for cholesterol, blood pressure or diabetes	1.5	2.4	4.1	-0.1	-1.8	2.0
Glaucoma (self-reported)	5.5	6.5	9.4	-1.5	-2.8	3.1
Gout (self-reported)	0.4	0.6	1.0	1.0	0.1	-0.9
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	1.4	1.2	0.2	-0.1
Medication: Amlodipine	1.6	2.2	3.1	0.5	1.8	-1.8
Medication: Ventolin 100micrograms inhaler	2.0	2.5	2.8	1.7	1.6	-1.5
Birth weight	0.2	0.4	1.0	0.5	1.0	-0.3
Chronic bronchitis/emphysema (mother)	1.5	1.7	2.9	0.2	1.5	-1.7
High blood pressure (siblings)	2.6	3.8	5.9	0.2	2.4	-2.3
Forced vital capacity (FVC), Best measure	0.9	3.3	5.8	-2.4	-1.4	1.4
Body fat percentage	4.4	17.4	22.3	2.9	4.7	-4.6
Leg fat percentage (right)	3.5	12.6	19.1	2.9	4.4	-3.2
Arm fat-free mass (right)	2.0	10.2	15.9	-2.8	-2.7	4.0
Exposure to tobacco smoke outside home	1.2	1.6	3.3	-1.8	-0.9	0.9
Comparative body size at age 10	0.2	0.6	1.0	0.7	0.5	-1.0
Number of full brothers	1.7	2.2	2.7	1.6	1.6	-1.1
Worry too long after embarrassment	1.8	3.1	5.4	-2.3	-1.7	0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.2	2.0	0.4	1.2	-1.4
Wheeze or whistling in the chest in last year	1.4	2.5	4.3	1.0	2.1	-1.5
Number of children fathered	1.2	1.4	3.0	1.7	0.7	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.7	-0.3	-0.8	-0.3
Age at first live birth	2.2	3.9	4.5	-2.1	-2.1	1.6
Pulse wave peak to peak time	0.0	0.0	0.1	0.1	-0.1	-0.2
Health satisfaction	0.2	0.3	0.5	-0.6	0.7	0.1
Shortness of breath walking on level ground	0.2	0.2	0.3	-0.3	0.4	0.6
Qualifications: College or University degree	1.1	3.4	4.8	-1.0	-2.2	2.1
Eye problems/disorders: None of the above	0.2	0.2	0.5	-0.7	-0.5	-0.1
Mouth/teeth dental problems: Loose teeth	0.4	0.4	0.8	-0.1	0.9	-0.7
Emphysema/chronic bronchitis	0.5	0.5	0.9	-0.6	0.9	-0.6
Medication for pain relief, constipation, heartburn	0.4	0.7	0.9	-0.6	-0.9	0.9
Neck or shoulder pain in last month	0.8	1.1	1.5	-1.2	-0.6	1.2
Medication: Blood pressure	2.3	4.1	6.8	0.4	2.3	-2.6
Angina (self-reported)	1.2	1.6	2.3	0.7	1.5	-1.5
Migraine (self-reported)	0.6	0.7	1.5	-1.2	0.7	0.3
Medication: Ibuprofen	0.2	0.3	0.4	-0.5	-0.7	0.2
Medication: Allopurinol	0.1	0.1	0.4	0.2	-0.0	-0.6
Medication: Omeprazole	0.4	0.5	1.1	-0.7	-0.2	1.1
Medication: Seretide 50 evohaler	0.4	0.4	1.3	-1.1	0.1	0.1
Mean time to correctly identify matches	2.0	3.7	9.4	-3.1	-1.2	0.5
Heart disease (mother)	0.2	0.2	0.5	-0.2	0.7	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.4	-0.3	-0.6	0.0
Whole body fat mass	1.9	7.8	11.1	1.8	3.3	-3.0
Leg fat mass (right)	1.3	5.2	9.0	1.5	3.0	-2.1
Arm predicted mass (right)	2.0	10.5	16.4	-2.8	-2.7	4.1
Pulse rate, automated reading	1.0	3.3	8.5	2.9	1.2	-0.2
Alcohol intake frequency.	3.7	8.6	11.0	2.8	3.3	-2.7
Comparative height size at age 10	0.1	0.4	0.9	-0.5	-0.2	0.9
Number of full sisters	5.0	6.1	9.2	1.2	2.8	-3.0
Suffer from ‘nerves’	0.7	1.2	2.5	1.6	0.2	-1.0
Overall health rating	0.3	0.7	1.4	1.2	0.9	0.3
Chest pain or discomfort	1.6	2.3	3.5	0.2	1.9	-1.8
Had major operations	1.3	1.5	1.9	1.4	1.0	-1.2
Age at last live birth	0.3	0.4	1.0	0.3	0.2	-1.0
Family relationship satisfaction	0.5	0.6	1.6	-1.2	-0.4	0.0
Leg pain on walking	0.3	0.4	1.1	1.1	0.2	-0.1
Qualifications: NVQ or HND or HNC or equivalent	2.4	2.8	2.9	1.7	1.7	-1.7
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.7	0.1	0.1	0.9
Illness, injury, bereavement, stress in last 2 years	1.1	1.4	2.5	-0.3	-1.6	1.2
Medication: Aspirin	1.3	1.7	2.9	0.2	1.5	-1.7
Supplements: Vitamin C	1.4	1.6	3.7	-1.9	0.1	-1.0
Knee pain experienced in last month	0.2	0.2	0.6	0.2	0.3	-0.8
Hypertension (Self-reported)	2.4	6.6	9.3	1.9	3.0	-2.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.0	0.0	0.1	-0.1	-0.1	0.3
Illnesses of father: Heart disease	2.1	3.0	4.7	1.0	2.2	-1.8
Illnesses of siblings: Diabetes	0.9	1.1	2.0	-0.2	1.2	-1.4
Smoking status: Previous	1.0	1.4	2.5	1.0	0.9	-1.6
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.3	2.4	-1.5	-1.5	1.6
Whole body fat-free mass	1.1	6.6	7.9	-2.8	-2.0	2.8
Leg fat-free mass (right)	0.6	3.1	5.5	-2.3	-1.4	1.4
Arm fat percentage (left)	5.7	22.8	32.6	2.8	5.3	-5.7
Average weekly red wine intake	1.2	1.7	4.7	-2.2	-0.6	-0.1
Handedness (chirality/laterality): Left-handed	0.8	0.9	1.7	0.1	-1.3	1.0
Mood swings	0.1	0.2	0.4	-0.6	0.2	-0.5
Loneliness, isolation	7.9	10.9	17.9	1.7	3.5	-4.2
Long-standing illness, disability or infirmity	0.3	0.5	1.0	-0.1	-0.7	1.0
Ever had bowel cancer screening	0.4	0.4	0.7	0.1	0.8	-0.8
Diabetes diagnosed by doctor	0.1	0.1	0.3	-0.1	-0.6	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	0.9	0.0	0.7	-1.0
Friendships satisfaction	1.1	1.4	2.1	-1.5	-1.4	0.4
Qualifications: nursing, teaching	0.2	0.3	0.6	-0.8	-0.4	-0.3
Commuting to job workplace: Walk	0.7	0.7	1.8	0.3	0.4	-1.4
Eye problems/disorders: Cataract	0.4	0.4	0.6	0.5	0.8	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	2.1	-1.4	-0.7	0.7
Medication for cholesterol	1.1	1.6	3.1	-1.8	-1.0	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.5	1.9	1.4	1.3	-1.0
Back pain experienced in last month	0.2	0.3	0.5	-0.4	0.6	-0.7
Mineral and other dietary supplements	0.3	0.4	0.6	0.8	0.7	-0.4
Breast cancer (self-reported)	0.2	0.3	0.7	-0.9	0.3	0.3
Asthma (self-reported)	0.8	1.6	3.0	-0.1	1.7	-1.3
Osteoporosis (self-reported)	0.8	0.9	2.0	-0.1	-0.9	1.4
Osteoarthritis (self-reported)	3.5	4.5	5.7	2.4	2.2	-1.8
Medication: Aspirin	1.7	2.2	3.2	0.6	1.7	-1.8
Medication: Gliclazide	0.2	0.2	0.6	-0.3	0.2	-0.7
Illnesses of father: None of the above (group 1)	1.7	2.1	3.2	-0.9	-1.5	1.8
Smoking status: Current	0.4	0.6	1.0	-0.8	-0.5	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	1.7	-0.3	0.6	-1.3
Whole body water mass	1.2	6.6	7.8	-2.8	-2.1	2.8
Leg predicted mass (right)	0.6	3.1	5.4	-2.3	-1.4	1.4
Arm fat mass (left)	2.6	10.6	14.7	1.6	3.8	-3.8
Number of self-reported non-cancer illnesses	0.1	0.2	0.3	-0.3	0.6	-0.4
Average weekly champagne plus white wine intake	2.6	3.5	6.6	-2.6	-1.0	1.7
Miserableness	0.4	0.7	1.8	-0.2	0.6	-1.4
Guilty feelings	0.9	1.3	2.2	-1.1	0.7	-1.5
Wears glasses or contact lenses	1.1	1.2	1.9	-0.2	-1.4	1.3
Ever taken oral contraceptive pill	0.1	0.1	0.1	0.1	0.4	-0.2
Hearing aid user	0.6	0.7	1.0	0.6	1.0	-0.9
Mother’s age at death	0.1	0.2	0.3	-0.2	-0.5	0.4
Financial situation satisfaction	0.1	0.1	0.2	0.5	0.4	-0.0
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.2	0.3	-0.4	0.4
Commuting to job workplace: Public transport	0.2	0.3	0.7	-0.3	-0.8	0.2
Eye problems/disorders: Glaucoma	2.4	2.8	4.2	-0.7	-1.9	2.0
Medication: Blood pressure	5.1	9.7	13.8	3.7	3.0	-2.5
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.5	0.1	0.7	-0.2
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.5	-0.7	-0.5	0.4
High cholesterol (Self-reported)	1.1	2.0	3.0	-0.7	1.7	-1.6
Medication: Bendroflumethiazide	6.1	9.2	11.1	3.1	3.3	-2.6
Medication: Paracetamol	0.2	0.3	0.5	0.7	0.7	-0.2
Medication: Lisinopril	0.2	0.3	0.5	-0.7	-0.7	-0.0
Medication: Atorvastatin	0.0	0.0	0.1	-0.3	-0.1	-0.0
Illnesses of father: High blood pressure	3.5	4.4	5.8	1.6	2.2	-2.4
Alcohol drinker status: Never	0.9	1.1	2.4	1.6	0.8	-0.5
Ever smoked	0.3	0.6	1.0	0.0	0.9	-1.0
Basal metabolic rate	0.5	2.8	4.1	-2.0	-1.1	1.8
Leg fat percentage (left)	2.1	7.7	12.7	2.1	3.6	-2.4
Arm fat-free mass (left)	1.2	6.0	10.0	-2.1	-1.8	3.2
Number of operations (self-reported)	3.2	4.7	7.4	1.6	2.7	-2.0
Average weekly beer plus cider intake	2.5	3.6	5.5	-2.4	-1.9	1.2
Irritability	0.2	0.3	0.4	-0.6	-0.6	0.1
Risk taking	0.3	0.4	0.6	-0.7	0.8	-0.4
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.2	-0.2	0.3	-0.4
Fractured/broken bones in last 5 years	1.7	2.1	4.5	-0.5	-1.3	2.1
Age started oral contraceptive pill	1.6	1.9	3.0	-1.4	-0.9	1.7
Diastolic blood pressure, automated reading	1.4	4.2	6.9	2.6	2.0	-1.3
Ever depressed for a whole week	0.6	0.7	2.0	-1.4	-0.3	0.2
Unable to work because of sickness or disability	1.1	1.4	2.3	1.5	1.2	-0.7
Commuting to job workplace: Cycle	4.4	5.3	9.1	-3.0	-2.0	1.7
Myopia	0.9	1.3	1.8	-1.4	-1.2	0.7
Vascular/heart problems diagnosed by doctor	1.7	4.7	6.6	-1.6	-2.6	2.2
Cholesterol lowering medication	0.3	0.4	1.2	-1.1	-0.1	0.4
Medication: Omeprazole (e.g. Zanprol)	0.4	0.4	1.2	-0.4	-0.0	1.1
Pain experienced in last month	0.3	0.5	1.2	1.1	0.2	-0.4
Supplements: Calcium	0.6	0.6	1.2	0.5	-1.1	0.6
Basal cell carcinoma (self-reported)	1.0	1.2	2.0	1.0	-0.8	1.4
Heart attack/myocardial infarction (self-reported)	2.3	2.9	4.1	1.4	1.7	-2.0
Deep venous thrombosis (DVT) (self-reported)	3.6	4.6	7.8	0.7	2.8	-2.3
Heart disease (siblings)	0.1	0.2	0.3	0.5	0.4	-0.2
Alcohol drinker status: Previous	1.6	1.8	2.3	-1.5	1.4	-1.2
Pack years of smoking	0.2	0.2	0.5	0.7	0.5	0.1
Impedance of whole body	1.6	7.9	10.2	2.6	2.6	-3.2
Leg fat mass (left)	0.9	3.6	6.7	1.1	2.6	-1.7
Arm predicted mass (left)	1.3	6.6	10.7	-2.2	-2.0	3.3