Best TWAS P=1.81e-09 · Best GWAS P=6.03e-52 conditioned to 2.38e-46
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | TMEM18 | 0.35 | 0.08 | enet | 28 | 0.19 | 9.2e-15 | 4.0 | 5.6 | 2.6e-08 | -0.19 | 1.00 | 0 | FALSE |
| 2 | GTEx | Artery Tibial | AC092159.2 | 0.38 | 0.24 | lasso | 5 | 0.30 | 5.6e-24 | 5.2 | 6.0 | 1.8e-09 | -0.19 | 1.00 | 0 | TRUE |
| 3 | GTEx | Esophagus Muscularis | TMEM18 | 0.37 | 0.20 | lasso | 8 | 0.18 | 2.0e-11 | 5.2 | 5.8 | 5.6e-09 | -0.28 | 1.00 | 0 | FALSE |
| 4 | GTEx | Esophagus Muscularis | AC092159.2 | 0.26 | 0.16 | enet | 7 | 0.20 | 5.3e-12 | 5.2 | 5.8 | 5.1e-09 | -0.30 | 1.00 | 0 | FALSE |
| 5 | GTEx | Heart Left Ventricle | TMEM18 | 0.22 | 0.19 | lasso | 7 | 0.16 | 8.3e-09 | 4.2 | 5.7 | 1.3e-08 | -0.19 | 0.99 | 0 | FALSE |
| 6 | GTEx | Heart Left Ventricle | AC092159.2 | 0.35 | 0.24 | lasso | 6 | 0.23 | 2.3e-12 | 4.2 | 5.2 | 2.0e-07 | -0.20 | 1.00 | 0 | FALSE |
| 7 | GTEx | Nerve Tibial | AC092159.2 | 0.18 | 0.09 | lasso | 5 | 0.10 | 1.5e-07 | 5.2 | 5.3 | 1.5e-07 | -0.16 | 0.99 | 0 | FALSE |