Best TWAS P=2.53e-09 · Best GWAS P=2.62e-09 conditioned to 0.00182
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | C3orf38 | 0.08 | 0.00 | enet | 14 | 0.04 | 2.3e-05 | -5.3 | -5.6 | 1.8e-08 | 0.56 | 0.06 | 0.90 | FALSE |
2 | GTEx | Artery Aorta | C3orf38 | 0.06 | 0.06 | lasso | 7 | 0.05 | 6.0e-04 | -5.3 | 5.4 | 7.5e-08 | -0.67 | 0.16 | 0.76 | FALSE |
3 | GTEx | Cells Transformed fibroblasts | ZNF654 | 0.08 | 0.09 | enet | 6 | 0.10 | 3.1e-08 | -5.9 | -6.0 | 2.5e-09 | 0.57 | 0.01 | 0.99 | TRUE |
4 | GTEx | Esophagus Mucosa | C3orf38 | 0.11 | 0.06 | lasso | 7 | 0.07 | 1.5e-05 | -5.3 | 5.8 | 8.0e-09 | -0.67 | 0.09 | 0.91 | FALSE |
5 | GTEx | Nerve Tibial | C3orf38 | 0.09 | 0.05 | lasso | 4 | 0.04 | 6.3e-04 | -5.3 | 5.4 | 8.0e-08 | -0.68 | 0.18 | 0.76 | FALSE |
6 | GTEx | Skin Not Sun Exposed Suprapubic | C3orf38 | 0.09 | 0.07 | lasso | 6 | 0.04 | 2.8e-03 | -5.3 | 5.2 | 2.2e-07 | -0.68 | 0.16 | 0.65 | FALSE |
7 | GTEx | Testis | C3orf38 | 0.11 | 0.01 | enet | 12 | 0.00 | 1.9e-01 | -5.2 | 5.2 | 2.5e-07 | -0.72 | 0.10 | 0.34 | FALSE |
8 | GTEx | Thyroid | C3orf38 | 0.12 | 0.08 | lasso | 18 | 0.07 | 1.0e-05 | -5.3 | 5.3 | 1.4e-07 | -0.68 | 0.21 | 0.78 | FALSE |
9 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C3orf38 | 0.01 | 0.01 | lasso | 3 | 0.01 | 1.2e-03 | -5.3 | 5.2 | 2.3e-07 | -0.65 | 0.02 | 0.49 | FALSE |
10 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | C3orf38 | 0.02 | 0.01 | blup | 24 | 0.02 | 2.0e-03 | -5.3 | 5.2 | 2.2e-07 | -0.65 | 0.04 | 0.53 | FALSE |
11 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C3orf38 | 0.02 | 0.03 | lasso | 1 | 0.03 | 1.9e-04 | -5.4 | 5.4 | 7.9e-08 | -0.69 | 0.03 | 0.63 | FALSE |
12 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C3orf38 | 0.03 | 0.05 | lasso | 1 | 0.05 | 8.1e-06 | -5.4 | 5.4 | 7.9e-08 | -0.69 | 0.07 | 0.91 | FALSE |
13 | The Cancer Genome Atlas | Thyroid Carcinoma | ZNF654 | 0.03 | 0.04 | lasso | 3 | 0.03 | 4.6e-04 | -5.4 | -5.4 | 6.2e-08 | 0.69 | 0.04 | 0.88 | FALSE |