Best TWAS P=6.34e-11 · Best GWAS P=2.34e-08 conditioned to 4.87e-07
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adrenal Gland | ERAP1 | 0.38 | 0.14 | lasso | 7 | 0.22 | 1.4e-08 | -5.1 | -5.1 | 2.8e-07 | -0.02 | 0.11 | 0.88 | FALSE |
| 2 | GTEx | Colon Transverse | ERAP1 | 0.44 | 0.28 | lasso | 11 | 0.31 | 2.2e-15 | -4.9 | -5.3 | 9.8e-08 | -0.02 | 0.13 | 0.86 | FALSE |
| 3 | GTEx | Esophagus Gastroesophageal Junction | ERAP1 | 0.29 | 0.18 | lasso | 8 | 0.13 | 2.6e-05 | -4.9 | -5.7 | 1.5e-08 | -0.01 | 0.18 | 0.67 | FALSE |
| 4 | GTEx | Esophagus Muscularis | ERAP1 | 0.19 | 0.06 | enet | 19 | 0.11 | 2.5e-07 | -3.7 | -5.3 | 1.3e-07 | -0.04 | 0.53 | 0.43 | FALSE |
| 5 | GTEx | Liver | CAST | 0.32 | 0.03 | enet | 23 | 0.12 | 4.4e-04 | -5.1 | -6.5 | 6.3e-11 | -0.09 | 0.14 | 0.25 | TRUE |
| 6 | GTEx | Liver | ERAP1 | 0.24 | 0.15 | lasso | 3 | 0.12 | 3.4e-04 | -4.9 | -5.2 | 2.3e-07 | 0.01 | 0.18 | 0.61 | FALSE |
| 7 | The Cancer Genome Atlas | Colon Adenocarcinoma | ERAP1 | 0.32 | 0.29 | blup | 130 | 0.36 | 6.4e-22 | -4.9 | -5.2 | 1.7e-07 | 0.00 | 0.01 | 0.98 | FALSE |