Best TWAS P=5.49e-11 · Best GWAS P=5.34e-11 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Aorta | INVS | 0.15 | 0.10 | enet | 19 | 0.12 | 4.9e-07 | 6.5 | 5.8 | 7.2e-09 | 0.86 | 0.02 | 0.98 | FALSE |
2 | GTEx | Cells Transformed fibroblasts | INVS | 0.16 | 0.10 | enet | 17 | 0.17 | 8.0e-13 | 6.5 | 5.9 | 3.6e-09 | 0.84 | 0.01 | 0.99 | FALSE |
3 | GTEx | Esophagus Muscularis | INVS | 0.21 | 0.16 | lasso | 5 | 0.22 | 8.9e-14 | 6.5 | 5.6 | 2.0e-08 | 0.85 | 0.02 | 0.98 | FALSE |
4 | GTEx | Heart Atrial Appendage | INVS | 0.08 | 0.03 | lasso | 3 | 0.04 | 4.9e-03 | -4.9 | 5.6 | 1.9e-08 | 0.81 | 0.06 | 0.88 | FALSE |
5 | GTEx | Heart Left Ventricle | INVS | 0.11 | 0.05 | enet | 15 | 0.04 | 2.6e-03 | 2.3 | 5.5 | 4.5e-08 | 0.70 | 0.04 | 0.85 | FALSE |
6 | GTEx | Muscle Skeletal | INVS | 0.12 | 0.03 | lasso | 10 | 0.10 | 1.3e-09 | 6.5 | 5.7 | 1.1e-08 | 0.82 | 0.02 | 0.98 | FALSE |
7 | GTEx | Skin Not Sun Exposed Suprapubic | TEX10 | 0.10 | 0.09 | lasso | 4 | 0.10 | 3.1e-06 | 4.4 | 5.7 | 1.4e-08 | 0.68 | 0.03 | 0.97 | FALSE |
8 | GTEx | Skin Sun Exposed Lower leg | INVS | 0.19 | 0.06 | enet | 30 | 0.11 | 1.5e-09 | 6.5 | 5.9 | 3.2e-09 | 0.74 | 0.01 | 0.99 | FALSE |
9 | GTEx | Skin Sun Exposed Lower leg | TEX10 | 0.27 | 0.27 | lasso | 8 | 0.28 | 7.0e-23 | 6.6 | 6.5 | 9.9e-11 | 0.77 | 0.01 | 0.99 | FALSE |
10 | GTEx | Thyroid | INVS | 0.22 | 0.11 | enet | 18 | 0.18 | 5.0e-14 | 6.5 | 5.4 | 6.8e-08 | 0.84 | 0.01 | 0.99 | FALSE |
11 | GTEx | Whole Blood | INVS | 0.07 | 0.02 | enet | 9 | 0.05 | 2.8e-05 | 1.7 | 5.2 | 2.3e-07 | 0.75 | 0.05 | 0.91 | FALSE |
12 | NTR | Blood | INVS | 0.01 | 0.01 | lasso | 4 | 0.01 | 3.6e-04 | -2.7 | 5.4 | 6.2e-08 | 0.73 | 0.03 | 0.92 | FALSE |
13 | YFS | Blood | INVS | 0.15 | 0.14 | lasso | 7 | 0.24 | 1.4e-77 | 2.5 | 5.6 | 2.4e-08 | 0.77 | 0.03 | 0.97 | FALSE |
14 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | INVS | 0.27 | 0.05 | lasso | 8 | 0.13 | 3.4e-11 | 4.7 | 5.5 | 4.6e-08 | 0.74 | 0.06 | 0.94 | FALSE |
15 | The Cancer Genome Atlas | Breast Invasive Carcinoma | INVS | 0.22 | 0.04 | lasso | 9 | 0.07 | 7.3e-15 | 6.3 | 5.5 | 4.5e-08 | 0.82 | 0.03 | 0.97 | FALSE |
16 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | INVS | 0.10 | 0.03 | blup | 107 | 0.07 | 4.0e-04 | 6.3 | 5.5 | 4.0e-08 | 0.63 | 0.03 | 0.91 | FALSE |
17 | The Cancer Genome Atlas | Lung Adenocarcinoma | INVS | 0.08 | 0.06 | blup | 106 | 0.07 | 7.0e-09 | -4.4 | 5.7 | 9.5e-09 | 0.84 | 0.44 | 0.56 | FALSE |
18 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | INVS | 0.09 | 0.02 | enet | 11 | 0.04 | 4.0e-05 | 4.7 | 5.9 | 3.2e-09 | 0.71 | 0.03 | 0.70 | FALSE |
19 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | INVS | 0.16 | 0.12 | enet | 8 | 0.08 | 2.8e-04 | 6.3 | 6.6 | 5.5e-11 | 0.99 | 0.01 | 0.98 | TRUE |
20 | The Cancer Genome Atlas | Prostate Adenocarcinoma | INVS | 0.09 | 0.04 | enet | 14 | 0.06 | 1.5e-06 | 4.7 | 5.5 | 5.0e-08 | 0.71 | 0.07 | 0.92 | FALSE |
21 | The Cancer Genome Atlas | Thyroid Carcinoma | INVS | 0.21 | 0.07 | enet | 13 | 0.18 | 4.0e-17 | -4.5 | 5.4 | 7.1e-08 | 0.81 | 0.05 | 0.95 | FALSE |