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chr10:125,455,780-127,174,440

Best TWAS P=1.2e-08 · Best GWAS P=2.56e-08 conditioned to 3.31e-08

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	METTL10	0.20	0.26	lasso	9	0.26	4.5e-31	-5.3	-5.3	1.0e-07	-0.04	0.02	0.98	FALSE
2	GTEx	Brain Cerebellum	LHPP	0.41	0.03	enet	34	0.11	4.1e-04	3.6	5.1	2.8e-07	-0.15	0.20	0.10	FALSE
3	GTEx	Lung	METTL10	0.11	0.06	enet	6	0.05	1.7e-04	-5.3	-5.5	4.0e-08	-0.02	0.04	0.96	FALSE
4	GTEx	Testis	METTL10	0.26	0.14	lasso	9	0.08	2.3e-04	-5.4	-5.2	1.9e-07	-0.03	0.02	0.98	FALSE
5	GTEx	Thyroid	METTL10	0.19	0.09	enet	33	0.10	3.0e-08	-5.3	-5.2	2.0e-07	-0.02	0.02	0.98	FALSE
6	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	METTL10	0.09	0.08	blup	43	0.11	1.2e-09	-5.4	-5.3	1.3e-07	-0.02	0.01	0.99	FALSE
7	The Cancer Genome Atlas	Breast Invasive Carcinoma	METTL10	0.06	0.13	lasso	7	0.13	1.1e-25	-5.3	-5.4	7.4e-08	-0.04	0.01	0.99	FALSE
8	The Cancer Genome Atlas	Colon Adenocarcinoma	METTL10	0.09	0.14	lasso	9	0.12	3.1e-07	-5.0	-5.2	1.5e-07	-0.02	0.01	0.99	FALSE
9	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	METTL10	0.10	0.14	blup	43	0.14	7.4e-16	-5.4	-5.4	5.9e-08	-0.02	0.01	0.99	FALSE
10	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	METTL10	0.10	0.16	lasso	7	0.17	1.0e-18	-5.4	-5.3	9.2e-08	-0.04	0.01	0.99	FALSE
11	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	METTL10	0.11	0.12	lasso	5	0.13	8.4e-08	-5.3	-5.2	2.1e-07	-0.04	0.01	0.99	FALSE
12	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	METTL10	0.11	0.08	blup	43	0.12	4.8e-06	-5.2	-5.5	4.1e-08	-0.04	0.01	0.99	FALSE
13	The Cancer Genome Atlas	Lung Adenocarcinoma	METTL10	0.11	0.19	lasso	6	0.19	7.3e-22	-5.2	-5.3	9.1e-08	-0.03	0.01	0.99	FALSE
14	The Cancer Genome Atlas	Prostate Adenocarcinoma	METTL10	0.10	0.17	blup	43	0.18	1.9e-18	-5.3	-5.3	1.4e-07	-0.04	0.01	0.99	FALSE
15	The Cancer Genome Atlas	Rectum Adenocarcinoma	METTL10	0.25	0.11	lasso	4	0.23	3.8e-06	-5.3	-5.7	1.2e-08	0.01	0.02	0.90	TRUE