Best TWAS P=5.18e-09 · Best GWAS P=9.93e-08 conditioned to 0.00511
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Aorta | SNHG5 | 0.49 | 0.56 | enet | 22 | 0.52 | 5.4e-33 | 4.8 | -5.2 | 2.7e-07 | 0.26 | 0.18 | 0.81 | FALSE |
2 | GTEx | Brain Cerebellar Hemisphere | SNHG5 | 0.13 | 0.10 | lasso | 5 | 0.09 | 2.8e-03 | 5.2 | -5.1 | 3.0e-07 | 0.23 | 0.04 | 0.87 | FALSE |
3 | GTEx | Brain Nucleus accumbens basal ganglia | PKMP3 | 0.12 | 0.16 | lasso | 5 | 0.11 | 7.6e-04 | 5.3 | -5.2 | 2.4e-07 | 0.24 | 0.04 | 0.88 | FALSE |
4 | GTEx | Esophagus Gastroesophageal Junction | SNHG5 | 0.29 | 0.34 | lasso | 3 | 0.34 | 7.3e-13 | 4.8 | -5.8 | 5.2e-09 | 0.50 | 0.15 | 0.85 | TRUE |
5 | GTEx | Esophagus Muscularis | SNHG5 | 0.40 | 0.53 | enet | 23 | 0.52 | 5.4e-36 | 4.8 | -5.3 | 9.8e-08 | 0.34 | 0.17 | 0.82 | FALSE |
6 | GTEx | Liver | SNHG5 | 0.47 | 0.42 | enet | 25 | 0.52 | 1.0e-16 | 4.8 | -5.6 | 2.6e-08 | 0.34 | 0.08 | 0.91 | FALSE |
7 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | SYNCRIP | 0.07 | 0.04 | blup | 35 | 0.03 | 1.3e-02 | 4.9 | 5.7 | 1.4e-08 | -0.33 | 0.02 | 0.77 | FALSE |
8 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | SNHG5 | 0.58 | 0.58 | enet | 7 | 0.57 | 2.7e-19 | 4.8 | -5.2 | 2.6e-07 | 0.23 | 0.01 | 0.98 | FALSE |