Best TWAS P=3.81e-16 · Best GWAS P=6.43e-17 conditioned to 0.00061
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | GSDMC | 0.03 | 0.01 | blup | 57 | 0.02 | 1.4e-02 | -6.0 | -5.2 | 2.4e-07 | 0.51 | 0.07 | 0.09 | FALSE |
| 2 | The Cancer Genome Atlas | Breast Invasive Carcinoma | GSDMC | 0.05 | 0.06 | lasso | 7 | 0.05 | 1.5e-10 | -6.0 | -6.9 | 4.3e-12 | 0.70 | 0.83 | 0.17 | FALSE |
| 3 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | GSDMC | 0.21 | 0.14 | blup | 57 | 0.15 | 1.2e-07 | -6.1 | -8.1 | 3.8e-16 | 0.75 | 0.12 | 0.87 | TRUE |
| 4 | The Cancer Genome Atlas | Colon Adenocarcinoma | GSDMC | 0.13 | 0.08 | lasso | 7 | 0.09 | 5.0e-06 | -5.2 | -5.3 | 1.1e-07 | 0.51 | 0.58 | 0.06 | FALSE |
| 5 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | GSDMC | 0.25 | 0.30 | lasso | 5 | 0.32 | 4.6e-36 | -6.0 | -6.0 | 1.9e-09 | 0.62 | 1.00 | 0.00 | FALSE |
| 6 | The Cancer Genome Atlas | Lung Adenocarcinoma | GSDMC | 0.09 | 0.03 | enet | 5 | 0.06 | 7.0e-08 | -5.2 | -5.3 | 1.1e-07 | 0.47 | 0.57 | 0.36 | FALSE |
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GSDMC | 0.03 | 0.02 | blup | 57 | 0.02 | 1.4e-03 | -6.0 | -5.9 | 4.8e-09 | 0.66 | 0.04 | 0.60 | FALSE |