Best TWAS P=7.83e-13 · Best GWAS P=1.09e-12 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CCDC91 | 0.08 | 0.06 | lasso | 6 | 0.07 | 9.4e-09 | -6.7 | 6.0 | 1.9e-09 | -0.87 | 0.10 | 0.90 | FALSE |
| 2 | GTEx | Artery Aorta | RP11-967K21.1 | 0.07 | 0.02 | lasso | 7 | 0.01 | 7.9e-02 | 4.5 | 6.5 | 8.7e-11 | -0.83 | 0.08 | 0.78 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | CCDC91 | 0.10 | 0.10 | lasso | 5 | 0.09 | 5.5e-07 | -6.5 | -6.6 | 3.2e-11 | 0.85 | 0.13 | 0.87 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | RP11-967K21.1 | 0.07 | 0.07 | lasso | 2 | 0.07 | 3.7e-06 | -7.0 | 7.2 | 7.8e-13 | -0.96 | 0.05 | 0.95 | TRUE |
| 5 | GTEx | Colon Transverse | CCDC91 | 0.11 | 0.01 | lasso | 6 | 0.00 | 4.6e-01 | -6.4 | -6.3 | 3.0e-10 | 0.80 | 0.09 | 0.75 | FALSE |
| 6 | GTEx | Heart Atrial Appendage | CCDC91 | 0.10 | 0.06 | lasso | 8 | 0.04 | 4.4e-03 | -6.5 | -6.1 | 8.3e-10 | 0.85 | 0.06 | 0.86 | FALSE |
| 7 | GTEx | Heart Atrial Appendage | RP11-967K21.1 | 0.08 | 0.09 | lasso | 1 | 0.08 | 2.3e-04 | -7.0 | 7.0 | 2.2e-12 | -0.91 | 0.05 | 0.90 | FALSE |
| 8 | GTEx | Muscle Skeletal | RP11-967K21.1 | 0.04 | 0.01 | lasso | 9 | 0.00 | 2.9e-01 | -6.4 | 5.9 | 3.5e-09 | -0.90 | 0.07 | 0.77 | FALSE |
| 9 | GTEx | Skin Not Sun Exposed Suprapubic | CCDC91 | 0.26 | 0.05 | lasso | 15 | 0.04 | 4.1e-03 | -7.1 | -6.2 | 7.3e-10 | 0.87 | 0.06 | 0.93 | FALSE |
| 10 | GTEx | Skin Sun Exposed Lower leg | CCDC91 | 0.09 | 0.01 | enet | 8 | 0.01 | 2.6e-02 | -7.0 | -7.0 | 1.8e-12 | 0.85 | 0.07 | 0.88 | FALSE |
| 11 | GTEx | Thyroid | CCDC91 | 0.15 | 0.12 | enet | 42 | 0.12 | 2.9e-09 | -6.8 | -5.3 | 1.2e-07 | 0.81 | 0.07 | 0.93 | FALSE |
| 12 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CCDC91 | 0.04 | 0.04 | lasso | 3 | 0.03 | 1.8e-06 | -6.7 | -6.7 | 2.1e-11 | 0.94 | 0.09 | 0.91 | FALSE |
| 13 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | CCDC91 | 0.06 | 0.02 | blup | 174 | 0.04 | 2.9e-05 | 3.9 | -6.1 | 8.4e-10 | 0.79 | 0.38 | 0.60 | FALSE |
| 14 | The Cancer Genome Atlas | Lung Adenocarcinoma | CCDC91 | 0.09 | 0.01 | blup | 170 | 0.02 | 1.0e-03 | -6.8 | -5.8 | 5.1e-09 | 0.75 | 0.10 | 0.82 | FALSE |
| 15 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | CCDC91 | 0.09 | 0.11 | lasso | 2 | 0.12 | 2.3e-05 | -6.8 | -6.8 | 8.3e-12 | 0.91 | 0.06 | 0.92 | FALSE |
| 16 | The Cancer Genome Atlas | Thyroid Carcinoma | CCDC91 | 0.40 | 0.12 | blup | 175 | 0.14 | 4.9e-13 | -6.8 | -5.8 | 8.2e-09 | 0.72 | 0.08 | 0.92 | FALSE |