Best TWAS P=5.03e-12 · Best GWAS P=2.79e-11 conditioned to 0.394
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Heart Atrial Appendage | ADCY4 | 0.28 | 0.14 | lasso | 4 | 0.10 | 2.1e-05 | 6.1 | 5.1 | 3.0e-07 | 0.48 | 0.06 | 0.87 | TRUE |
| 2 | GTEx | Spleen | NFATC4 | 0.45 | 0.00 | enet | 24 | 0.00 | 2.5e-01 | 4.4 | -6.0 | 2.1e-09 | -0.22 | 0.07 | 0.06 | TRUE |
| 3 | METSIM | Adipose | ADCY4 | 0.07 | 0.03 | lasso | 5 | 0.03 | 2.2e-05 | 6.4 | 6.9 | 5.0e-12 | 0.71 | 0.02 | 0.98 | TRUE |
| 4 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | ADCY4 | 0.03 | 0.01 | blup | 75 | 0.03 | 1.1e-03 | 3.9 | 5.1 | 3.1e-07 | 0.71 | 0.04 | 0.75 | FALSE |
| 5 | The Cancer Genome Atlas | Colon Adenocarcinoma | ADCY4 | 0.07 | 0.02 | lasso | 4 | 0.03 | 4.7e-03 | 4.5 | 5.2 | 1.6e-07 | 0.70 | 0.03 | 0.77 | TRUE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ADCY4 | 0.06 | 0.06 | lasso | 6 | 0.09 | 3.0e-10 | 5.9 | 6.7 | 2.2e-11 | 0.75 | 0.03 | 0.97 | FALSE |
| 7 | The Cancer Genome Atlas | Lung Adenocarcinoma | ADCY4 | 0.07 | 0.09 | lasso | 3 | 0.08 | 4.4e-10 | 4.4 | 5.6 | 1.8e-08 | 0.73 | 0.84 | 0.16 | FALSE |
| 8 | The Cancer Genome Atlas | Stomach Adenocarcinoma | LTB4R2 | 0.04 | 0.04 | lasso | 1 | 0.02 | 2.5e-02 | 5.5 | -5.5 | 3.4e-08 | -0.70 | 0.04 | 0.56 | FALSE |