Hub : Genes

NFATC4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.073	0.025	0.00047	0.039	0.032	0.016	0.031	0.023	1.3e-05	8.5e-05	0.00370	9.3e-05	0.00065
2	GTEx	Pituitary	0.329	0.112	0.00560	0.153	NA	0.146	NA	0.053	1.2e-04	NA	0.00017	NA	0.01900
3	GTEx	Spleen	0.452	0.130	0.00710	0.004	NA	0.004	NA	0.003	2.5e-01	NA	0.25000	NA	0.26000
4	TCGA	Thyroid Carcinoma	0.042	0.023	0.00270	0.017	0.015	0.008	NA	0.011	7.4e-03	1.1e-02	0.05500	NA	0.02500

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	1.0	1.6	3.1	-1.8	-0.1	-1.4	-1.1
Bipolar Disorder or Schizophrenia	0.1	0.3	0.8	-0.5	0.3	-0.9	-0.4
Depressed Affect (Nagel 2018)	0.2	0.3	0.7	0.0	-0.6	-0.5	-0.9
Depression (Nagel 2018)	0.6	0.9	1.9	1.4	-0.9	0.9	0.2
Intelligence (Savage-Jansen 2018)	0.3	0.9	2.3	-0.6	-1.5	-0.6	-0.8
Neuroticism (Nagel 2018)	0.2	0.5	0.9	0.9	-0.6	-1.0	-0.0
Schizophrenia (2018)	0.1	0.3	0.5	0.7	0.5	-0.1	0.4
Schizophrenia vs Biploar Disorder	1.1	1.5	2.7	1.6	1.1	1.3	0.7
Worry (Nagel 2018)	0.4	0.8	1.5	0.9	-0.7	-1.2	0.4
Alzheimer’s Disease (in mother)	0.1	0.1	0.2	-0.0	-0.1	-0.4	-0.2
Alzheimer’s Disease (in father)	2.5	2.7	4.5	1.9	-2.1	1.4	0.9
Alzheimer’s Disease (including proxy)	0.7	1.0	2.9	1.0	-1.7	0.3	-0.1
Crohns Disease (2017)	0.9	2.0	4.0	1.3	-0.7	2.0	1.4
Irritable Bowel Disease (IBD)	0.9	2.1	5.1	0.7	-0.9	2.3	1.4
Ulcerative Colitis (UC)	0.5	0.9	2.0	-0.3	-1.3	1.4	0.1
Major Depression (MDD)	1.6	2.0	4.2	-1.4	2.1	-0.9	-0.9
Reaction Time	1.1	2.1	4.8	2.2	-1.7	0.9	0.1
Verbal and Numeric Reasoning (VNR)	0.6	1.4	2.7	-1.1	-1.6	-0.7	-1.1
Breast Cancer	0.6	1.4	4.0	1.0	0.4	0.7	2.0
Ovarian Cancer	1.0	1.3	3.2	0.9	0.7	0.9	1.8
Prostate Cancer	0.5	0.7	1.5	0.4	0.2	1.2	-1.0
Age at First Birth	0.4	0.6	2.1	-0.0	-0.6	-1.5	-0.0
Bipolar Disorder (2011)	0.7	0.7	1.6	0.4	-1.3	0.0	1.1
Body Mass Index (BMI) (2010)	0.3	0.4	1.0	-0.3	1.0	0.7	-0.4
Coronary Artery Disease (CAD)	0.8	0.9	1.6	-0.8	0.9	1.3	0.7
Crohns Disease (2012)	1.8	2.9	9.4	1.1	-0.2	0.9	3.1
Mean Putamen Volume	1.1	1.3	4.2	-0.3	-0.9	-2.0	0.1
Fasting Glucose	0.1	0.1	0.2	0.4	-0.1	0.4	0.0
HbA1C	0.5	0.5	0.7	-0.8	-0.8	-0.8	-0.2
HDL Cholesterol	0.2	0.3	0.9	0.9	0.2	-0.3	0.4
LDL Cholesterol	2.3	3.6	8.2	2.0	-0.5	1.4	2.9
Lupus	3.3	5.0	15.7	-0.8	1.6	-4.0	-1.1
Neuroticism (2016)	0.1	0.1	0.2	-0.0	-0.4	-0.1	0.4
Primary Biliary Cirrhosis	0.6	0.8	2.5	-0.4	1.6	0.4	-0.7
Rheumatoid Arthritis	0.7	1.0	1.6	-1.2	-0.1	-1.3	0.9
Schizophrenia (2014)	0.2	0.5	1.5	-0.2	1.2	-0.4	0.6
Triglycerides	0.5	0.8	2.7	-0.4	1.7	0.3	0.2
Type 2 Diabetes (T2D) (2012)	0.2	0.3	0.4	0.6	0.4	-0.4	-0.6
Ulcerative Colitis	0.2	0.3	0.3	-0.6	0.6	0.3	0.6
Blood Eosinophil Count	0.2	1.6	4.6	0.8	2.1	0.7	0.8
Blood Platelet Count	0.1	1.4	4.8	-2.2	0.6	-0.5	-0.4
Blood Red Count	0.4	4.2	8.9	2.5	-1.2	3.0	0.6
Blood White Count	0.2	1.4	2.9	-1.0	0.3	1.2	-1.7
Heel T-Score	2.7	21.8	55.5	4.7	-1.3	2.9	7.5
BMI	0.2	1.2	1.9	-0.5	-1.3	-1.4	-0.9
Height	3.6	69.6	121.0	-9.1	1.7	-8.4	-11.0
Waist Hip Ratio (WHR)	0.1	0.5	1.4	-0.4	1.2	0.1	-0.6
Systolic Blood Pressure	0.6	2.8	5.0	-2.2	-1.5	-2.0	-0.4
Smoking Status	0.8	1.9	4.0	-1.5	-1.1	-2.0	-0.2
Allergy or Eczema	0.2	0.5	1.4	-0.5	-1.2	0.7	0.4
Cardiovascular Disease	0.3	1.0	2.8	-0.3	-0.4	-1.7	-1.0
Hypothyroidism (self reported)	0.7	1.6	3.7	-0.0	0.6	-1.9	-1.5
Respiratory disease	0.6	1.4	4.2	-0.8	0.5	-0.8	-2.0
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.2	1.1	-0.7	-0.2	-0.4
Lung FEV1/FVC ratio	0.7	3.3	8.8	-1.7	-0.2	-1.2	-3.0
Lung FVC	0.4	2.3	4.5	-2.1	-0.1	-0.9	1.9
Neuroticism	0.2	0.4	1.5	0.1	-0.3	-1.2	-0.2
Chronotype (morning person)	0.3	0.6	1.6	1.3	-0.9	-0.1	0.0
Hair Pigment	0.0	1.0	3.3	-0.2	0.6	0.3	1.8
Tanning	0.1	1.2	3.8	-0.4	-0.7	1.9	-0.5
Hand grip strength (left)	0.8	2.2	4.4	-0.2	0.5	-2.0	-2.1
Number of treatments/medications taken	1.3	2.4	4.5	-1.3	-1.3	-2.1	-1.2
Average weekly spirits intake	0.3	0.3	0.4	-0.5	-0.6	0.6	0.6
Sensitivity / hurt feelings	0.9	1.6	4.1	2.0	0.3	-0.3	1.4
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.9	0.7	-0.9	0.3	0.5
Hearing difficulty/problems: Yes	0.7	1.1	2.9	-1.7	-0.1	-1.2	-0.4
Relative age of first facial hair	4.1	8.3	28.8	1.7	0.0	1.3	5.4
Other serious medical condition/disability diagnosed by doctor	1.7	2.2	4.9	-1.9	0.4	-0.3	-2.2
Ever used hormone-replacement therapy (HRT)	1.9	2.5	6.3	-1.8	0.1	-0.7	-2.5
Ever had hysterectomy (womb removed)	1.0	1.1	2.7	-1.2	-0.4	-0.4	-1.6
Systolic blood pressure, automated reading	0.5	1.6	3.2	-1.0	-1.4	-1.8	-0.1
Eye problems/disorders: Diabetes related eye disease	2.2	2.5	6.0	2.5	1.0	1.7	0.1
Angina	0.5	0.6	1.2	1.1	0.5	0.9	-0.5
Medication for hormone replacement therapy	0.6	0.6	1.9	0.2	-0.6	-0.5	-1.4
Vitamin and mineral supplements	0.9	1.2	2.7	-0.1	-0.7	1.2	1.6
Supplements: Zinc	0.7	0.8	2.8	0.1	0.2	-0.5	-1.7
Medication: Co-codamol	0.8	0.9	3.0	-0.1	0.2	-0.7	-1.7
Medication: Metformin	0.5	0.7	1.4	1.2	-1.2	0.2	-0.1
Diabetes (father)	0.5	0.6	1.7	0.2	-0.5	-0.6	1.3
Diabetes (mother)	0.6	0.7	2.3	0.4	0.1	1.5	0.7
Severe depression (siblings)	0.3	0.4	1.0	1.0	-0.7	-0.4	0.2
Pack years adult smoking proportion	0.5	0.8	1.5	-1.1	0.4	-1.2	-0.4
Impedance of leg (right)	1.0	4.9	13.2	2.2	0.0	3.6	1.3
Leg fat-free mass (left)	2.4	13.0	24.5	-3.0	0.7	-5.0	-4.2
Trunk fat percentage	0.2	0.7	2.6	0.3	-0.0	0.1	-1.6
Hand grip strength (right)	0.6	1.6	4.3	0.6	0.8	-2.1	-1.1
Townsend deprivation index at recruitment	1.3	1.8	4.8	-2.2	-1.1	-0.4	-1.1
Current tobacco smoking	0.7	1.2	2.1	-1.4	-1.4	-0.6	-0.5
Average weekly fortified wine intake	0.2	0.2	0.4	0.3	-0.1	0.7	0.4
Maternal smoking around birth	0.9	1.3	4.2	0.5	-2.0	0.9	0.1
Fed-up feelings	0.5	1.0	1.9	-0.1	-1.1	-0.8	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	2.8	0.9	-1.7	0.5	0.2
Relative age voice broke	2.9	4.5	6.7	1.8	-2.1	1.8	2.6
Taking other prescription medications	0.6	0.9	1.4	-1.2	-0.5	-1.0	-0.9
Age when periods started (menarche)	0.7	1.7	2.9	0.5	1.2	-1.4	1.7
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	3.2	-0.1	0.5	-0.4	-1.8
Heel bone mineral density (BMD) T-score, automated (left)	1.7	3.8	12.5	1.3	0.0	1.0	3.5
Tinnitus: Yes, but not now, but have in the past	2.1	2.3	5.5	-2.3	-1.1	-1.1	-1.2
Qualifications: CSEs or equivalent	0.4	0.6	1.5	0.7	1.2	-0.2	0.4
Serious illness, injury or assault to yourself	0.7	0.8	2.5	-0.7	0.4	0.2	-1.6
High blood pressure	0.3	0.8	1.2	-1.1	-0.1	-0.9	-1.1
Hayfever, allergic rhinitis or eczema	0.6	1.3	3.5	-1.1	-1.9	0.7	-0.5
Multivitamins +/- minerals	0.3	0.4	0.8	0.3	0.0	-0.8	-0.9
Stomach or abdominal pain in last month	0.4	0.5	0.9	-0.3	0.9	-0.3	-1.0
Supplements: Glucosamine	0.9	1.1	3.1	0.1	-1.8	-1.2	-0.1
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.5	-0.6	0.7	-0.1	-0.7
Medication: Atenolol	0.7	0.9	2.3	-0.1	1.5	-0.9	0.6
Medication: Levothyroxine sodium	0.3	0.6	1.5	-0.2	0.1	-1.2	-0.8
Sitting height	1.7	12.1	25.0	-3.2	0.1	-5.0	-3.6
Chronic bronchitis/emphysema (father)	0.6	0.7	1.4	0.2	0.1	1.2	-1.1
High blood pressure (mother)	0.4	0.6	1.3	-1.2	-0.2	-0.4	0.9
Body mass index (BMI)	0.1	0.5	0.9	0.8	-0.1	-0.9	-0.7
Impedance of leg (left)	0.8	3.8	11.0	1.8	0.2	3.3	1.0
Leg predicted mass (left)	2.4	12.6	24.0	-3.0	0.7	-4.9	-4.1
Trunk fat mass	0.6	2.7	7.3	-0.9	0.3	-1.6	-2.7
Waist circumference	0.7	2.7	4.7	-1.4	0.2	-2.0	-2.2
Number of incorrect matches in round	0.8	1.3	2.7	0.9	1.6	1.1	0.8
Past tobacco smoking	0.6	1.2	1.9	1.0	0.8	1.4	-1.0
Alcohol usually taken with meals	0.4	0.6	1.6	0.3	-1.3	0.7	-0.5
Nervous feelings	1.1	2.1	4.9	2.2	-1.0	-0.1	1.6
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	0.8	0.6	-0.8	-0.6	0.9
Hearing difficulty/problems with background noise	0.2	0.3	0.9	-0.9	-0.5	-0.5	-0.0
Hair/balding pattern: Pattern 2	0.8	1.0	1.8	-1.0	1.3	1.2	-0.2
Had menopause	1.0	1.3	2.8	-0.9	1.2	-1.7	0.3
Had other major operations	4.2	5.1	9.9	-2.3	-0.8	-3.2	-2.1
Forced vital capacity (FVC)	1.1	4.3	10.6	-3.3	0.1	-2.5	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	1.5	3.5	8.5	1.9	0.9	1.1	2.9
Ever unenthusiastic/disinterested for a whole week	5.4	6.6	10.0	-3.2	-1.7	-2.8	-2.4
Qualifications: None of the above	0.4	0.9	2.3	-1.5	0.8	0.1	-0.9
Financial difficulties in last 2 years	0.2	0.2	0.4	-0.5	0.4	0.3	0.6
Mouth/teeth dental problems	0.9	1.4	3.3	-1.4	-0.5	0.2	-1.8
Heart attack	0.4	0.5	1.5	0.5	1.2	-0.2	-0.1
Allergy	0.2	0.4	0.9	0.8	0.9	-0.3	0.4
Pain all over the body in last month	1.3	1.4	2.7	-0.1	1.6	1.5	-0.7
Diabetes (self-reported)	0.6	0.9	1.6	1.3	0.8	0.8	-0.9
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.3	-0.6	-0.4	-0.6	-0.5
Medication: Ramipril	0.4	0.5	0.8	-0.7	0.9	-0.9	-0.2
Medication: Simvastatin	0.4	0.6	1.7	0.0	-1.3	-0.6	0.5
Fluid intelligence score	0.6	1.3	1.9	-1.0	-1.4	-0.8	-1.3
Illnesses of siblings	0.4	0.6	2.0	0.6	1.4	-0.2	-0.4
Neuroticism score	0.5	0.9	2.0	0.8	-1.4	-0.3	1.0
Weight	1.5	7.5	13.9	-1.8	0.6	-3.7	-3.5
Impedance of arm (right)	0.9	4.2	15.0	1.2	-0.7	3.9	0.2
Arm fat percentage (right)	0.2	0.8	1.1	0.9	-1.0	0.5	-1.0
Trunk fat-free mass	3.5	20.3	41.0	-4.1	0.9	-6.4	-4.7
Hip circumference	0.5	2.0	3.2	-1.3	0.3	-1.8	-1.8
Time employed in main current job	1.7	2.0	3.5	-1.7	0.4	-1.9	-1.2
Alcohol intake versus 10 years previously	0.5	0.8	2.0	-0.2	-1.4	0.5	-0.8
Father’s age at death	0.3	0.4	1.0	-0.3	-0.7	1.0	0.4
Worrier / anxious feelings	0.4	0.7	1.5	0.7	-1.2	-0.9	-0.1
Frequency of tiredness / lethargy in last 2 weeks	2.6	4.2	8.9	-2.1	-0.9	-1.6	-3.0
Falls in the last year	0.5	0.7	1.5	-0.6	-1.2	-0.4	-1.0
Hair/balding pattern: Pattern 3	0.4	0.6	1.6	0.2	-0.9	0.4	-1.3
Number of live births	0.9	1.3	2.9	-1.3	0.4	-1.7	-0.5
Forced expiratory volume in 1-second (FEV1)	1.6	5.5	13.3	-3.6	0.5	-2.6	-1.3
Pulse rate	1.7	2.9	6.6	1.7	0.5	2.6	1.4
Happiness	0.5	0.7	1.7	-0.3	-0.1	-0.9	-1.3
Noisy workplace	0.9	1.1	3.0	-0.9	1.7	-0.5	-0.5
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.7	0.5	-0.7	1.3	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.4	-0.3	-0.0	0.6	-0.3
Mouth/teeth dental problems: Dentures	0.6	1.0	1.9	-1.4	-1.0	-0.2	-1.0
Asthma	0.3	0.6	1.3	-0.0	-1.1	-1.0	-0.4
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	1.3	-1.1	-1.0	-0.2	-0.7
Medication: Cholesterol lowering	1.1	1.8	5.2	2.3	-0.6	1.1	-0.3
Depression (self-reported)	0.5	0.6	2.2	-0.3	-0.5	-1.5	-0.2
Medication: Lansoprazole	0.9	1.0	2.8	-0.8	-0.2	-0.7	-1.7
Prospective memory result	0.3	0.4	0.8	-0.2	0.7	-0.3	-0.9
Lung cancer (father)	1.4	1.7	5.9	-0.1	-2.4	-0.5	-0.7
Illnesses of mother	1.1	1.3	2.3	1.5	-1.2	-0.7	-1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.8	7.6	-2.8	0.6	-1.6	-0.9
Pulse wave Arterial Stiffness index	1.5	1.8	4.0	-1.3	0.9	-0.8	-2.0
Impedance of arm (left)	0.7	3.4	12.1	1.1	-0.2	3.5	0.4
Arm fat mass (right)	0.4	1.7	4.1	-0.4	-0.2	-1.6	-2.0
Trunk predicted mass	3.4	19.6	39.3	-4.1	0.9	-6.3	-4.7
Standing height	2.9	29.3	40.9	-5.7	1.5	-6.4	-6.4
Length of working week for main job	2.5	2.8	5.1	1.4	1.9	2.3	0.8
Exposure to tobacco smoke at home	0.4	0.4	1.2	0.5	-0.0	0.6	-1.1
Breastfed as a baby	0.4	0.5	1.3	-1.1	0.3	-0.0	0.9
Tense / ‘highly strung’	0.9	1.5	3.3	0.9	0.2	1.8	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.5	1.2	0.3	-0.5	-1.1	-0.8
Hair/balding pattern: Pattern 4	0.2	0.5	0.9	1.0	0.2	0.9	-0.1
Birth weight of first child	1.3	2.5	4.9	0.8	-1.9	-2.2	0.9
Peak expiratory flow (PEF)	0.8	1.8	5.6	-2.4	0.7	-0.5	-0.8
Pulse wave reflection index	1.0	1.2	3.8	0.3	-0.1	-1.0	-1.9
Ever highly irritable/argumentative for 2 days	1.1	1.3	2.5	-0.5	1.4	-1.6	0.9
Loud music exposure frequency	0.6	0.7	2.6	-0.2	-0.3	1.6	0.1
Qualifications: O levels/GCSEs or equivalent	1.2	1.9	6.3	0.5	-2.5	1.0	0.4
Mouth/teeth dental problems: Bleeding gums	2.0	2.6	4.4	2.1	-1.0	1.0	2.0
Blood clot in the leg (DVT)	0.7	1.0	1.8	0.9	-1.4	0.9	0.6
Medication: Paracetamol	0.4	0.7	1.5	-0.9	1.2	-0.4	-0.7
Headache pain in last month	3.0	5.1	6.3	-2.0	-2.0	-2.5	-2.5
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	1.6	-1.1	0.3	1.2	1.1
Glaucoma (self-reported)	0.6	0.7	2.2	-0.1	1.5	-0.0	0.8
Gout (self-reported)	2.6	3.5	7.4	-2.7	0.1	-1.2	-2.3
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	4.2	-0.0	0.2	-2.0	-1.5
Medication: Amlodipine	0.8	1.1	3.0	1.1	-0.1	-0.3	1.7
Medication: Ventolin 100micrograms inhaler	1.2	1.6	6.1	-0.0	0.4	-2.5	0.3
Birth weight	1.7	3.7	13.1	-1.0	0.6	-3.6	0.4
Chronic bronchitis/emphysema (mother)	0.9	1.1	1.8	0.8	-1.3	0.3	-1.3
High blood pressure (siblings)	1.4	2.1	3.4	-1.8	-0.7	-1.3	-1.7
Forced vital capacity (FVC), Best measure	0.6	2.3	6.4	-2.5	-0.2	-1.6	-0.1
Body fat percentage	0.2	0.6	1.8	0.6	0.0	0.6	-1.3
Leg fat percentage (right)	0.2	0.7	1.5	1.2	0.2	1.2	-0.4
Arm fat-free mass (right)	3.2	16.4	35.9	-3.4	1.6	-6.0	-4.0
Exposure to tobacco smoke outside home	0.8	1.1	3.5	-0.3	-0.5	-1.9	-0.6
Comparative body size at age 10	0.8	2.1	3.7	1.4	-1.5	-1.9	0.9
Number of full brothers	0.3	0.4	0.9	-0.8	-0.1	0.2	-1.0
Worry too long after embarrassment	0.3	0.6	1.6	-0.4	-1.3	-0.7	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.9	0.7	0.1	0.5	-1.0
Wheeze or whistling in the chest in last year	1.4	2.6	4.8	-1.5	1.7	-2.2	-0.6
Number of children fathered	0.3	0.4	1.5	1.2	-0.1	0.1	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.3	-0.1	0.2	0.1	0.5
Age at first live birth	0.8	1.5	2.8	1.3	-0.2	-1.1	1.7
Pulse wave peak to peak time	0.9	1.1	2.5	1.0	-0.8	0.3	1.6
Health satisfaction	2.2	2.8	5.0	-1.7	-1.0	-2.2	-1.5
Shortness of breath walking on level ground	1.3	1.5	4.9	-2.2	0.1	-0.6	-0.9
Qualifications: College or University degree	0.1	0.4	0.9	0.2	-1.0	-0.7	-0.3
Eye problems/disorders: None of the above	0.4	0.5	1.2	0.5	-0.6	-0.2	-1.1
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.8	-0.5	0.8	0.6	1.4
Emphysema/chronic bronchitis	2.7	3.1	8.2	-1.7	2.9	-0.5	-1.0
Medication for pain relief, constipation, heartburn	0.5	0.8	1.8	1.2	-0.3	0.1	1.4
Neck or shoulder pain in last month	0.3	0.4	0.8	0.0	-0.9	0.4	-0.9
Medication: Blood pressure	0.9	1.6	4.0	0.0	-0.3	-1.6	-2.0
Angina (self-reported)	0.5	0.7	1.2	1.0	0.4	1.1	-0.7
Migraine (self-reported)	2.4	3.0	6.3	-2.5	-0.1	-0.6	-2.3
Medication: Ibuprofen	0.7	0.9	1.5	-1.2	-1.0	-0.7	-0.8
Medication: Allopurinol	2.6	3.5	7.3	-2.7	0.6	-0.4	-2.5
Medication: Omeprazole	0.4	0.4	1.2	-0.4	-0.1	-0.6	-1.1
Medication: Seretide 50 evohaler	1.3	1.5	3.0	-1.0	-1.1	-1.7	-0.9
Mean time to correctly identify matches	0.6	1.2	3.6	1.9	-0.4	1.0	-0.3
Heart disease (mother)	0.4	0.5	1.5	-1.2	0.2	-0.3	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.7	0.9	0.2	-0.1	0.3
Whole body fat mass	0.4	1.8	5.7	-0.5	0.1	-1.1	-2.4
Leg fat mass (right)	0.3	1.1	3.0	0.3	0.4	-1.0	-1.7
Arm predicted mass (right)	2.8	14.4	31.9	-3.3	1.4	-5.6	-3.6
Pulse rate, automated reading	1.1	3.4	9.4	0.4	1.0	3.1	1.8
Alcohol intake frequency.	0.8	1.8	3.6	-1.0	-1.9	0.3	-1.6
Comparative height size at age 10	5.3	29.2	43.5	-6.3	0.7	-5.7	-6.6
Number of full sisters	2.1	2.6	7.6	-2.8	1.4	0.1	0.8
Suffer from ‘nerves’	0.6	0.9	1.4	0.5	-0.7	-1.2	1.2
Overall health rating	1.1	2.4	5.7	-0.8	-2.4	-1.4	-1.1
Chest pain or discomfort	2.3	3.4	8.6	-1.0	1.4	-1.4	-2.9
Had major operations	0.5	0.6	1.3	0.1	1.1	-0.1	-1.0
Age at last live birth	0.6	0.9	2.6	-0.5	-0.5	-1.6	0.6
Family relationship satisfaction	0.2	0.3	1.0	1.0	0.1	-0.4	-0.1
Leg pain on walking	0.5	0.6	1.1	1.1	-0.7	-0.6	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.9	0.2	-0.5	0.9	-1.4
Commuting to job workplace: Car/motor vehicle	0.9	1.1	2.1	1.4	0.4	1.5	-0.1
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.6	-0.0	0.5	-0.8	0.4
Medication: Aspirin	0.4	0.5	1.1	1.0	0.4	0.1	0.9
Supplements: Vitamin C	0.2	0.2	0.5	0.7	0.1	-0.6	-0.1
Knee pain experienced in last month	0.7	1.1	2.0	-0.5	-1.4	-1.4	-0.3
Hypertension (Self-reported)	0.3	0.7	1.3	-0.7	0.1	-1.0	-1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	2.6	-0.7	-0.4	-0.2	-1.6
Illnesses of father: Heart disease	0.7	0.9	1.8	1.3	-0.6	1.1	0.4
Illnesses of siblings: Diabetes	0.5	0.6	1.2	-1.1	-0.6	0.7	-0.4
Smoking status: Previous	0.4	0.6	1.6	0.0	-0.4	-0.7	1.3
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.1	5.1	-1.3	-0.5	-2.3	-1.1
Whole body fat-free mass	3.3	18.6	37.0	-3.8	1.0	-6.1	-4.6
Leg fat-free mass (right)	2.7	14.6	27.5	-3.4	0.7	-5.2	-4.4
Arm fat percentage (left)	0.1	0.5	1.0	1.0	-0.5	0.4	-0.7
Average weekly red wine intake	1.4	2.0	4.6	0.3	0.7	1.7	2.1
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.6	0.2	0.8	-0.2	-0.2
Mood swings	0.1	0.1	0.2	0.2	0.5	-0.2	0.5
Loneliness, isolation	1.2	1.7	6.1	0.8	-2.5	0.3	0.2
Long-standing illness, disability or infirmity	1.0	1.5	4.0	-0.6	-0.3	-1.2	-2.0
Ever had bowel cancer screening	1.1	1.3	2.3	-1.1	1.5	-0.8	1.1
Diabetes diagnosed by doctor	0.5	0.8	1.3	0.7	-0.3	1.0	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	2.4	1.6	-0.5	1.2	1.4
Friendships satisfaction	0.7	0.9	2.8	0.1	0.6	-1.7	-0.7
Qualifications: nursing, teaching	0.8	1.2	4.6	0.2	-2.1	0.3	0.1
Commuting to job workplace: Walk	1.6	1.7	2.9	-1.0	1.5	-0.8	1.7
Eye problems/disorders: Cataract	1.9	2.2	7.0	-0.2	1.3	0.1	2.7
Mouth/teeth dental problems: Mouth ulcers	3.6	5.7	15.3	3.9	1.6	-0.9	2.0
Medication for cholesterol	0.5	0.7	2.1	1.4	0.0	0.7	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.6	1.8	4.2	1.1	0.2	2.0	-1.4
Back pain experienced in last month	0.4	0.6	1.3	-0.4	-0.9	-1.1	-0.6
Mineral and other dietary supplements	0.6	0.9	2.7	-1.6	0.6	0.3	-0.5
Breast cancer (self-reported)	2.6	3.1	6.4	-1.9	-1.2	-2.5	-0.9
Asthma (self-reported)	0.4	0.8	1.6	0.1	-1.2	-1.2	-0.6
Osteoporosis (self-reported)	1.3	1.6	3.5	-1.6	-0.2	0.2	-1.9
Osteoarthritis (self-reported)	2.1	2.7	5.0	-2.2	0.4	-1.9	-1.4
Medication: Aspirin	0.4	0.6	1.4	0.9	-0.2	0.3	1.2
Medication: Gliclazide	1.6	1.8	3.3	1.8	-0.4	0.8	1.8
Illnesses of father: None of the above (group 1)	0.5	0.6	1.2	0.1	0.9	1.1	0.5
Smoking status: Current	0.9	1.4	2.4	-1.4	-1.6	-0.9	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.8	-0.7	0.2	-0.9	0.6
Whole body water mass	3.4	19.3	38.3	-3.9	1.0	-6.2	-4.7
Leg predicted mass (right)	2.8	14.8	27.8	-3.4	0.6	-5.3	-4.4
Arm fat mass (left)	0.3	1.3	3.6	-0.2	-0.1	-1.3	-1.9
Number of self-reported non-cancer illnesses	1.9	3.3	6.5	-1.6	-0.9	-1.8	-2.5
Average weekly champagne plus white wine intake	1.1	1.5	2.8	-0.6	-1.2	-1.7	-1.2
Miserableness	0.7	1.3	2.3	-1.0	-0.6	-1.5	-1.2
Guilty feelings	0.1	0.2	0.3	-0.3	-0.5	-0.5	0.2
Wears glasses or contact lenses	0.1	0.1	0.2	-0.4	0.0	-0.1	0.3
Ever taken oral contraceptive pill	1.9	2.1	3.2	1.8	0.1	1.5	1.7
Hearing aid user	2.1	2.3	5.5	-2.4	-0.1	-1.7	-1.0
Mother’s age at death	1.5	1.9	4.5	0.5	1.0	-1.3	2.1
Financial situation satisfaction	3.5	4.4	8.2	-2.8	0.1	-2.9	-1.2
Tinnitus: Yes, now most or all of the time	1.5	1.7	5.8	-0.1	0.7	-0.8	2.4
Commuting to job workplace: Public transport	0.9	1.1	3.9	-2.0	-0.4	-0.2	-0.6
Eye problems/disorders: Glaucoma	0.4	0.5	1.2	0.6	1.1	0.3	0.5
Medication: Blood pressure	0.9	1.7	5.8	-2.4	0.6	-0.7	-0.6
Pain type(s) experienced in last month: Hip pain	0.7	0.8	2.9	-0.1	0.5	-1.7	-0.5
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.7	1.3	0.3	0.1	0.5
High cholesterol (Self-reported)	0.8	1.5	2.6	1.2	-1.3	-0.2	1.6
Medication: Bendroflumethiazide	0.6	1.0	3.2	-0.1	1.8	-0.1	0.8
Medication: Paracetamol	0.3	0.5	0.7	-0.6	0.8	-0.6	-0.8
Medication: Lisinopril	1.7	2.2	4.9	-1.4	-0.6	-1.3	-2.2
Medication: Atorvastatin	0.4	0.4	1.0	0.8	-0.4	0.2	-1.0
Illnesses of father: High blood pressure	0.7	0.9	2.6	-1.6	-0.1	-0.2	-0.9
Alcohol drinker status: Never	0.4	0.5	0.7	-0.8	-0.6	-0.8	-0.6
Ever smoked	0.7	1.1	3.4	-0.7	-0.7	-0.4	1.9
Basal metabolic rate	2.9	16.2	30.1	-3.5	0.9	-5.5	-4.6
Leg fat percentage (left)	0.1	0.5	0.8	0.9	0.3	0.8	-0.6
Arm fat-free mass (left)	3.1	15.8	31.4	-3.6	1.1	-5.6	-4.2
Number of operations (self-reported)	2.0	3.0	6.2	-1.2	-1.0	-1.9	-2.5
Average weekly beer plus cider intake	0.6	0.9	2.6	-1.6	0.9	-0.3	-0.1
Irritability	0.3	0.4	1.2	1.1	0.5	-0.0	0.6
Risk taking	0.0	0.1	0.1	-0.0	0.3	-0.1	0.3
Ever had prostate specific antigen (PSA) test	0.8	0.9	2.5	0.3	-1.0	-0.1	1.6
Fractured/broken bones in last 5 years	0.4	0.6	1.0	1.0	0.6	-0.9	0.4
Age started oral contraceptive pill	1.7	2.1	7.4	-0.6	2.7	-0.8	0.3
Diastolic blood pressure, automated reading	1.8	5.4	12.1	-1.7	-1.3	-3.5	-2.2
Ever depressed for a whole week	2.1	2.6	5.9	-2.4	-0.2	-1.9	-0.9
Unable to work because of sickness or disability	1.8	2.4	8.0	0.3	-0.3	1.2	-2.8
Commuting to job workplace: Cycle	1.3	1.5	5.4	0.3	-0.4	-2.3	0.6
Myopia	0.5	0.8	1.7	-0.8	-0.4	-1.3	0.7
Vascular/heart problems diagnosed by doctor	0.1	0.4	0.5	0.7	-0.6	0.5	0.7
Cholesterol lowering medication	0.9	1.3	2.6	-0.5	-1.6	-0.4	1.5
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.5	-0.1	-0.0	-1.2	-0.6
Pain experienced in last month	1.5	2.4	7.3	0.9	0.8	1.0	2.7
Supplements: Calcium	0.6	0.7	1.0	-0.9	0.9	0.2	-1.0
Basal cell carcinoma (self-reported)	0.8	0.9	2.4	0.2	1.1	0.2	-1.6
Heart attack/myocardial infarction (self-reported)	0.5	0.7	2.1	0.7	1.4	-0.3	0.0
Deep venous thrombosis (DVT) (self-reported)	0.8	1.1	2.1	0.9	-1.4	0.9	0.7
Heart disease (siblings)	1.7	2.1	3.3	1.8	-1.4	0.1	1.8
Alcohol drinker status: Previous	0.9	1.0	3.7	0.3	-1.9	-0.2	-0.5
Pack years of smoking	0.7	1.0	1.9	-1.4	0.3	-1.4	-0.3
Impedance of whole body	0.8	3.9	12.7	1.4	0.1	3.6	0.9
Leg fat mass (left)	0.3	1.4	3.6	0.1	0.6	-1.2	-1.9
Arm predicted mass (left)	3.2	16.3	33.7	-3.6	1.1	-5.8	-4.2