TWAS
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Models
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Traits
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Traits
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Arm fat-free mass (right)
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chr14:103,161,201-104,699,495
Best TWAS P=4.11e-11 · Best GWAS P=7.77e-11 conditioned to 0.247
103.2M
103.4M
103.6M
103.8M
104M
104.2M
104.4M
104.6M
0
2
4
6
8
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Esophagus Mucosa
MARK3
0.11
0.03
lasso
4
0.04
1.5e-03
6.5
6.6
4.1e-11
0.91
0.04
0.84
TRUE
3
YFS
Blood
MARK3
0.04
0.04
lasso
3
0.04
1.6e-12
6.3
6.2
4.7e-10
0.87
0.03
0.97
FALSE
2
GTEx
Thyroid
TRMT61A
0.11
0.03
lasso
4
0.02
1.2e-02
6.5
-6.0
1.6e-09
-0.95
0.01
0.98
FALSE
4
The Cancer Genome Atlas
Thyroid Carcinoma
MARK3
0.10
0.03
blup
61
0.03
4.0e-04
-4.5
-5.2
2.2e-07
-0.53
0.03
0.14
FALSE