Best TWAS P=4.11e-11 · Best GWAS P=7.77e-11 conditioned to 0.247
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Esophagus Mucosa | MARK3 | 0.11 | 0.03 | lasso | 4 | 0.04 | 1.5e-03 | 6.5 | 6.6 | 4.1e-11 | 0.91 | 0.04 | 0.84 | TRUE |
| 2 | GTEx | Thyroid | TRMT61A | 0.11 | 0.03 | lasso | 4 | 0.02 | 1.2e-02 | 6.5 | -6.0 | 1.6e-09 | -0.95 | 0.01 | 0.98 | FALSE |
| 3 | YFS | Blood | MARK3 | 0.04 | 0.04 | lasso | 3 | 0.04 | 1.6e-12 | 6.3 | 6.2 | 4.7e-10 | 0.87 | 0.03 | 0.97 | FALSE |
| 4 | The Cancer Genome Atlas | Thyroid Carcinoma | MARK3 | 0.10 | 0.03 | blup | 61 | 0.03 | 4.0e-04 | -4.5 | -5.2 | 2.2e-07 | -0.53 | 0.03 | 0.14 | FALSE |