Best TWAS P=2.31e-09 · Best GWAS P=7.41e-08 conditioned to 0.114
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Coronary | RP11-773H22.4 | 0.18 | 0.11 | lasso | 5 | 0.06 | 0.00628 | -5.4 | 5.2 | 1.9e-07 | -0.97 | 0.02 | 0.72 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | SEH1L | 0.10 | 0.03 | enet | 18 | 0.04 | 0.00078 | 4.4 | 5.3 | 9.9e-08 | -0.71 | 0.03 | 0.95 | FALSE |
| 3 | GTEx | Esophagus Mucosa | SEH1L | 0.09 | 0.02 | enet | 25 | 0.03 | 0.00239 | -5.4 | 6.0 | 2.3e-09 | -0.72 | 0.01 | 0.98 | TRUE |
| 4 | GTEx | Pituitary | SEH1L | 0.22 | 0.07 | lasso | 6 | 0.05 | 0.02060 | -5.4 | 5.2 | 2.3e-07 | -0.89 | 0.03 | 0.64 | FALSE |
| 5 | The Cancer Genome Atlas | Colon Adenocarcinoma | CEP192 | 0.06 | 0.05 | blup | 84 | 0.04 | 0.00146 | 4.4 | 5.2 | 1.7e-07 | -0.59 | 0.22 | 0.33 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SEH1L | 0.03 | 0.01 | blup | 60 | 0.01 | 0.04010 | -5.2 | 5.2 | 1.7e-07 | -0.87 | 0.00 | 0.72 | FALSE |