Best TWAS P=7.31e-13 · Best GWAS P=8.9e-10 conditioned to 0.487
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Cells Transformed fibroblasts | FAM208A | 0.10 | 0.00 | lasso | 4 | 0.00 | 1.3e-01 | -6.1 | 5.8 | 8.0e-09 | -0.94 | 0.01 | 0.97 | FALSE |
2 | YFS | Blood | CCDC66 | 0.11 | 0.09 | lasso | 8 | 0.11 | 6.0e-34 | -5.3 | -5.3 | 1.3e-07 | 0.50 | 0.45 | 0.55 | FALSE |
3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CCDC66 | 0.09 | 0.03 | lasso | 8 | 0.05 | 4.2e-11 | -4.8 | -6.5 | 7.5e-11 | 0.65 | 0.18 | 0.82 | FALSE |
4 | The Cancer Genome Atlas | Glioblastoma Multiforme | CCDC66 | 0.19 | 0.02 | enet | 14 | 0.12 | 1.7e-04 | 2.5 | -5.1 | 2.9e-07 | 0.24 | 0.04 | 0.12 | FALSE |
5 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | CCDC66 | 0.05 | 0.05 | blup | 56 | 0.06 | 1.0e-07 | -6.1 | -7.0 | 2.9e-12 | 0.81 | 0.00 | 1.00 | FALSE |
6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C3orf63 | 0.03 | 0.01 | enet | 4 | 0.01 | 1.3e-02 | -6.1 | 5.5 | 4.8e-08 | -0.93 | 0.01 | 0.89 | FALSE |
7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CCDC66 | 0.09 | 0.05 | blup | 56 | 0.06 | 5.3e-07 | -5.3 | -5.1 | 3.0e-07 | 0.60 | 0.26 | 0.74 | FALSE |
8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CCDC66 | 0.16 | 0.13 | enet | 12 | 0.16 | 3.1e-17 | -5.3 | -5.3 | 1.0e-07 | 0.29 | 0.26 | 0.74 | FALSE |
9 | The Cancer Genome Atlas | Lung Adenocarcinoma | CCDC66 | 0.05 | 0.06 | blup | 56 | 0.05 | 9.7e-07 | -6.1 | -7.2 | 7.3e-13 | 0.80 | 0.00 | 1.00 | TRUE |
10 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | CCDC66 | 0.03 | 0.03 | blup | 56 | 0.03 | 9.6e-05 | -4.6 | -5.9 | 3.0e-09 | 0.57 | 0.20 | 0.56 | FALSE |
11 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | CCDC66 | 0.08 | 0.01 | blup | 56 | 0.07 | 7.2e-04 | -5.3 | -5.5 | 4.7e-08 | 0.36 | 0.10 | 0.25 | FALSE |
12 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CCDC66 | 0.15 | 0.10 | enet | 11 | 0.13 | 7.3e-14 | -4.6 | -5.4 | 6.4e-08 | 0.39 | 0.40 | 0.60 | FALSE |
13 | The Cancer Genome Atlas | Stomach Adenocarcinoma | CCDC66 | 0.05 | 0.01 | blup | 57 | 0.02 | 8.4e-03 | -4.8 | -6.0 | 1.9e-09 | 0.64 | 0.06 | 0.60 | FALSE |