Best TWAS P=1.04e-15 · Best GWAS P=3.19e-16 conditioned to 0.000917
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | The Cancer Genome Atlas | Breast Invasive Carcinoma | GSDMC | 0.05 | 0.06 | lasso | 7 | 0.05 | 1.5e-10 | -5.9 | -6.8 | 9.2e-12 | 0.66 | 0.85 | 0.15 | FALSE |
| 2 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | GSDMC | 0.21 | 0.14 | blup | 57 | 0.15 | 1.2e-07 | -6.0 | -8.0 | 1.0e-15 | 0.74 | 0.18 | 0.79 | TRUE |
| 3 | The Cancer Genome Atlas | Colon Adenocarcinoma | GSDMC | 0.13 | 0.08 | lasso | 7 | 0.09 | 5.0e-06 | -5.0 | -5.2 | 1.7e-07 | 0.44 | 0.59 | 0.05 | FALSE |
| 4 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | GSDMC | 0.25 | 0.30 | lasso | 5 | 0.32 | 4.6e-36 | -5.9 | -5.9 | 4.8e-09 | 0.57 | 1.00 | 0.00 | FALSE |
| 5 | The Cancer Genome Atlas | Lung Adenocarcinoma | GSDMC | 0.09 | 0.03 | enet | 5 | 0.06 | 7.0e-08 | -5.0 | -5.3 | 1.1e-07 | 0.41 | 0.64 | 0.27 | FALSE |
| 6 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GSDMC | 0.03 | 0.02 | blup | 57 | 0.02 | 1.4e-03 | -5.9 | -5.8 | 8.8e-09 | 0.65 | 0.04 | 0.64 | FALSE |