Best TWAS P=1.86e-09 · Best GWAS P=3.18e-11 conditioned to 0.000682
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellum | ARL14EP | 0.33 | 0.25 | lasso | 10 | 0.26 | 3.7e-08 | 5.2 | -5.3 | 8.9e-08 | -0.56 | 0.69 | 0.30 | FALSE |
| 2 | GTEx | Esophagus Gastroesophageal Junction | ARL14EP | 0.15 | 0.14 | lasso | 3 | 0.11 | 1.2e-04 | 5.2 | -5.2 | 1.6e-07 | -0.56 | 0.43 | 0.28 | FALSE |
| 3 | GTEx | Esophagus Muscularis | ARL14EP | 0.18 | 0.20 | lasso | 8 | 0.19 | 9.5e-12 | 5.3 | -5.8 | 6.1e-09 | -0.47 | 0.89 | 0.11 | FALSE |
| 4 | GTEx | Pancreas | ARL14EP | 0.16 | 0.08 | lasso | 6 | 0.07 | 1.0e-03 | 4.6 | -5.1 | 2.8e-07 | -0.47 | 0.29 | 0.12 | FALSE |
| 5 | GTEx | Pituitary | ARL14EP | 0.30 | 0.28 | lasso | 4 | 0.22 | 3.0e-06 | 6.1 | -6.0 | 2.5e-09 | -0.58 | 0.07 | 0.86 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | MPPED2 | 0.25 | 0.29 | lasso | 7 | 0.29 | 4.4e-37 | 6.0 | -6.0 | 1.9e-09 | -0.70 | 0.02 | 0.98 | TRUE |