TWAS hub - MPPED2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1190	0.0440	9.6e-04	0.000	NA	0.010	NA	0.004	2.9e-01	NA	4.8e-02	NA	1.5e-01
2	GTEx	Adrenal Gland	0.4317	0.1250	2.5e-04	0.332	NA	0.272	NA	0.305	1.2e-12	NA	2.6e-10	NA	1.5e-11
3	GTEx	Heart Left Ventricle	0.1321	0.0620	8.2e-03	0.006	NA	-0.005	NA	-0.005	1.4e-01	NA	8.2e-01	NA	8.1e-01
4	GTEx	Muscle Skeletal	0.0879	0.0295	9.4e-05	0.069	NA	0.056	NA	0.058	2.4e-07	NA	3.2e-06	NA	2.4e-06
5	GTEx	Nerve Tibial	0.0707	0.0314	5.2e-03	0.002	NA	0.008	NA	0.002	2.3e-01	NA	8.7e-02	NA	2.3e-01
6	GTEx	Testis	0.1800	0.0570	3.8e-05	0.169	NA	0.167	NA	0.164	6.1e-08	NA	6.9e-08	NA	9.4e-08
7	GTEx	Thyroid	0.1640	0.0530	7.9e-05	0.009	NA	0.075	NA	0.071	6.0e-02	NA	2.3e-06	NA	3.9e-06
8	ROSMAP	Brain Pre-frontal Cortex	0.2491	0.0432	0.0e+00	0.288	0.228	0.275	0.283	0.287	2.7e-37	6.6e-29	2.1e-35	1.4e-36	4.4e-37
9	YFS	Blood	0.0264	0.0104	1.5e-04	0.021	0.014	0.013	0.015	0.018	1.8e-07	1.5e-05	2.6e-05	7.6e-06	1.3e-06
10	TCGA	Lung Adenocarcinoma	0.0657	0.0297	7.1e-05	0.012	0.034	0.021	NA	0.019	1.2e-02	7.0e-05	1.4e-03	NA	2.2e-03
11	TCGA	Uterine Corpus Endometrial Carcinoma	0.2020	0.0920	5.7e-03	-0.011	0.046	0.003	NA	-0.006	9.4e-01	2.0e-02	2.7e-01	NA	5.3e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Seen doctor (GP) for nerves, anxiety, tension or depression	3.6	5.5	16.2	-1.0	-1.7	2.4	-4.0	2.5	2.7	-2.6	-1.1	2.0	-2.9	0.6
Chronotype (morning person)	3.5	8.0	34.1	-0.4	0.3	1.4	-1.7	0.1	1.8	-4.3	-5.8	0.8	-3.4	3.8
Falls in the last year	3.5	4.7	17.7	-2.5	0.7	1.1	-2.0	-0.4	0.1	-1.5	-3.9	-0.5	-4.2	2.2
Medication for cholesterol	3.2	4.8	14.8	3.7	-1.0	0.7	2.9	-2.2	-3.9	0.4	0.4	1.8	1.8	1.8
Number of self-reported non-cancer illnesses	3.2	5.5	14.5	-2.0	1.5	0.4	-2.9	2.4	2.3	-2.2	-3.5	0.6	-3.8	1.6
Blood Red Count	3.0	29.0	127.7	0.9	-5.8	0.7	8.2	-9.1	-11.3	-1.2	0.2	0.9	-2.1	-0.3
Medication: Blood pressure	3.0	5.8	21.9	-3.0	2.2	-1.4	-3.3	2.7	4.7	0.6	0.3	-0.9	-1.0	-2.3
Number of incorrect matches in round	2.9	4.8	13.1	-0.3	-3.4	1.5	0.7	-0.3	-2.8	-3.6	-1.9	0.9	-3.2	1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	2.9	3.8	9.7	0.1	-0.9	3.0	-3.1	1.2	1.1	-2.0	-1.9	1.6	-2.1	2.3
Hip circumference	2.7	11.7	55.3	-3.3	0.2	0.4	0.3	-1.5	0.9	-2.9	-7.4	-1.0	-6.0	3.7
Ever depressed for a whole week	2.7	3.3	13.3	-0.5	0.5	-2.4	-1.9	2.1	1.9	0.7	0.5	-3.6	-0.1	2.1
Wheeze or whistling in the chest in last year	2.6	4.6	11.5	-2.1	0.4	0.3	-3.3	2.0	1.3	-1.5	-3.4	0.7	-3.1	2.2
Had menopause	2.5	3.1	10.1	-0.8	-1.5	0.5	2.8	-2.1	-3.2	-0.9	-1.2	0.3	-2.2	1.3
Medication: Omeprazole	2.5	3.0	9.8	0.6	-1.0	1.9	-3.1	1.8	2.2	-0.8	0.6	2.5	-0.7	-1.6
Pack years adult smoking proportion	2.4	3.6	9.4	-1.0	-1.1	2.9	-1.0	-0.1	-0.2	-2.1	-3.0	1.4	-3.1	1.7
Waist circumference	2.4	8.6	34.7	-3.5	-0.5	-0.6	0.1	-1.4	0.2	-2.7	-5.9	-0.8	-5.6	2.4
Weight	2.4	11.7	51.6	-2.4	-0.4	1.5	0.6	-0.8	0.8	-3.9	-7.2	-1.0	-5.7	4.2
Hypertension (Self-reported)	2.4	6.7	21.8	-3.7	2.5	-0.4	-4.7	2.4	4.5	0.2	-0.3	0.1	-1.9	-1.4
Medication: Bendroflumethiazide	2.4	3.6	8.6	-2.9	2.7	-1.8	-2.7	0.4	2.3	0.7	0.7	-2.0	-0.3	-1.7
Pack years of smoking	2.4	3.6	10.0	-0.9	-1.3	2.9	-1.1	-0.1	-0.3	-2.0	-3.0	1.3	-3.2	1.7
High blood pressure	2.3	6.4	19.2	-3.8	2.4	-0.2	-4.4	2.3	4.3	-0.1	-0.8	0.2	-2.3	-1.1
Blood clot in the leg (DVT)	2.3	2.9	10.1	1.4	-1.8	1.0	0.6	-0.9	-1.2	-2.5	-2.3	-0.5	-1.2	3.2
Impedance of whole body	2.3	11.8	29.4	3.6	0.3	1.3	-5.4	5.1	3.9	1.4	5.0	1.5	3.9	-1.0
Cardiovascular Disease	2.2	7.3	20.0	-4.5	3.0	-0.4	-4.2	2.0	4.5	1.4	-0.4	-0.4	-1.6	-2.1
Impedance of arm (left)	2.2	10.1	26.1	3.2	1.2	0.8	-4.9	5.1	4.4	1.3	3.8	1.6	3.3	-0.1
Exposure to tobacco smoke outside home	2.2	3.0	9.5	1.7	1.7	-0.5	-1.6	1.9	3.1	1.3	-0.3	-1.6	1.7	1.8
Reaction Time	2.1	4.0	19.7	2.0	1.2	-0.2	-0.7	4.4	3.2	0.9	-0.5	1.7	0.2	1.8
Leg fat-free mass (left)	2.1	10.9	50.1	-2.5	0.8	1.7	1.6	-1.1	0.5	-3.3	-7.1	-1.5	-4.9	4.4
Taking other prescription medications	2.1	3.3	10.8	-1.3	1.4	0.5	-3.3	1.4	2.1	-1.7	-1.9	0.5	-2.7	0.8
Sitting height	2.1	14.9	40.7	0.4	-0.4	6.4	-2.4	2.3	2.8	-5.2	-5.5	-0.6	-3.7	5.7
Leg predicted mass (left)	2.1	10.9	50.0	-2.5	0.7	1.7	1.6	-1.1	0.4	-3.3	-7.1	-1.5	-4.9	4.3
Impedance of arm (right)	2.1	9.8	32.3	2.5	1.6	0.2	-5.7	4.8	4.4	1.5	3.6	0.7	2.9	-0.3
Arm fat mass (right)	2.1	8.5	36.5	-3.0	0.5	-0.4	0.2	-0.7	0.8	-2.5	-6.0	-1.1	-5.3	3.2
Qualifications: O levels/GCSEs or equivalent	2.1	3.4	12.4	0.4	1.4	-2.4	0.3	0.2	0.3	2.1	2.4	-2.0	3.5	-1.6
Loneliness, isolation	2.1	2.9	9.7	-0.5	-1.3	1.8	0.6	-0.9	-1.3	-0.9	-2.3	2.2	-3.1	1.8
Basal metabolic rate	2.1	11.6	50.6	-2.6	0.1	2.0	1.7	-1.4	0.0	-3.7	-7.1	-1.6	-5.2	4.3
Bilateral oophorectomy (both ovaries removed)	2.0	2.3	12.5	-2.6	-0.8	-1.6	0.4	-0.4	-0.4	0.3	-1.5	-0.4	-3.5	-0.4
Whole body fat-free mass	2.0	11.2	47.7	-2.6	0.1	2.0	1.9	-1.5	-0.2	-3.6	-6.9	-1.7	-4.9	4.3
Leg fat-free mass (right)	2.0	10.8	49.6	-2.8	1.0	1.7	1.6	-1.1	0.4	-3.1	-7.0	-1.2	-4.9	4.3
Leg predicted mass (right)	2.0	10.8	49.6	-2.8	1.0	1.6	1.7	-1.0	0.4	-3.1	-7.0	-1.2	-4.9	4.3
Number of treatments/medications taken	1.9	3.5	9.9	-2.0	1.2	0.2	-3.1	1.3	2.4	-1.5	-1.9	-0.1	-3.1	0.2
Sensitivity / hurt feelings	1.9	3.3	9.3	-0.8	-1.8	1.4	2.3	-2.0	-3.0	-1.8	0.8	1.7	-1.8	-1.5
Impedance of leg (left)	1.9	9.1	29.1	3.3	-0.8	0.9	-4.3	3.8	2.4	1.4	5.4	0.9	3.8	-1.7
Heel bone mineral density (BMD) T-score, automated (right)	1.9	4.3	16.8	-1.7	0.3	-1.3	-3.0	3.1	4.1	-0.3	0.3	0.2	-2.2	-1.4
Trunk fat-free mass	1.9	10.7	42.8	-2.3	-0.3	2.2	2.0	-1.7	-0.6	-3.8	-6.5	-2.0	-4.6	4.2
Pulse wave Arterial Stiffness index	1.9	2.2	5.5	-1.9	-1.2	1.5	-2.3	-0.3	0.8	0.2	-1.1	1.6	-1.8	-1.9
Number of children fathered	1.9	2.2	6.1	-0.7	1.6	-0.8	1.0	2.0	1.7	1.2	1.5	1.5	0.6	-2.5
Neck or shoulder pain in last month	1.9	2.7	5.6	1.9	0.9	0.1	-2.4	2.4	2.3	0.5	1.9	-0.8	1.8	0.5
Whole body water mass	1.9	11.1	46.2	-2.5	0.0	2.1	1.9	-1.6	-0.3	-3.7	-6.8	-1.7	-4.9	4.2
Arm fat mass (left)	1.9	7.8	33.5	-2.7	0.2	-0.2	0.5	-0.5	0.9	-2.4	-5.8	-0.9	-5.1	3.3
Arm fat-free mass (left)	1.9	9.7	38.6	-2.8	-0.3	2.0	1.6	-1.9	-0.7	-3.5	-6.2	-1.7	-4.8	3.4
Myopia	1.9	2.8	10.9	0.5	1.2	-0.6	-1.3	1.3	1.3	-2.1	-2.7	-0.5	-0.9	3.3
Vascular/heart problems diagnosed by doctor	1.9	5.2	13.5	3.7	-2.4	-0.0	3.6	-2.2	-3.6	-0.1	0.9	-0.6	2.4	0.9
Arm predicted mass (left)	1.9	9.5	38.2	-2.4	-0.4	1.8	1.9	-2.0	-1.1	-3.4	-6.2	-1.6	-4.6	3.7
Rheumatoid Arthritis	1.8	2.5	9.0	0.1	0.3	-1.0	-2.2	3.0	2.9	0.1	0.5	-1.8	0.2	0.4
BMI	1.8	10.3	43.2	-4.0	1.2	-2.4	1.4	-1.5	0.4	-1.2	-6.6	-2.7	-5.3	2.3
Systolic Blood Pressure	1.8	8.8	19.4	-1.9	3.4	-4.3	-2.5	0.9	3.0	3.6	2.3	-2.1	2.3	-4.4
Impedance of leg (right)	1.8	8.8	27.7	3.6	-1.0	0.8	-4.2	3.6	2.4	1.1	5.3	0.3	3.9	-1.5
Hand grip strength (right)	1.8	5.0	12.8	0.8	-1.0	1.8	2.8	-1.8	-2.7	-2.2	-3.4	-0.5	-1.3	3.6
Townsend deprivation index at recruitment	1.8	2.5	10.7	-0.1	-1.3	0.8	-3.3	1.1	0.9	-1.1	-1.9	1.2	-1.4	1.9
Stomach or abdominal pain in last month	1.8	2.2	8.1	-0.5	0.6	1.2	-2.8	1.0	1.5	-1.5	-1.4	2.0	-1.7	0.0
Trunk predicted mass	1.8	10.3	41.9	-2.3	-0.2	2.2	2.0	-1.7	-0.6	-3.7	-6.5	-1.9	-4.5	4.0
Exposure to tobacco smoke at home	1.8	2.0	6.1	2.5	-0.4	1.9	-1.9	1.2	0.7	-1.6	-1.1	0.2	-0.1	1.7
Peak expiratory flow (PEF)	1.8	4.2	14.0	0.5	-3.0	2.0	-1.2	0.4	2.0	-3.7	-2.6	-0.8	-1.9	1.5
Arm fat-free mass (right)	1.8	9.2	34.8	-2.1	-0.6	2.4	2.5	-1.6	-0.9	-3.4	-5.9	-1.3	-4.4	3.7
Arm predicted mass (right)	1.8	9.2	36.1	-2.2	-0.3	2.2	2.3	-1.3	-0.6	-3.3	-6.0	-1.3	-4.5	3.8
Leg pain on walking	1.8	2.3	6.7	0.3	-0.0	0.1	-1.5	2.1	1.5	-1.3	-2.6	0.4	-1.8	2.0
Qualifications: NVQ or HND or HNC or equivalent	1.8	2.2	7.2	-2.0	-0.6	1.0	0.5	-1.0	-1.5	-1.6	-1.9	-0.9	-2.7	0.8
Supplements: Vitamin C	1.8	2.1	4.5	1.2	-1.8	1.7	-2.0	0.5	1.7	-1.8	-0.5	2.1	0.1	0.3
Deep venous thrombosis (DVT) (self-reported)	1.8	2.3	8.2	1.1	-1.7	0.9	0.3	-0.8	-0.8	-2.3	-2.0	-0.5	-1.0	2.9
Ever used hormone-replacement therapy (HRT)	1.7	2.2	6.6	-2.2	-1.7	0.7	0.7	-0.5	-1.2	-1.0	-1.4	-1.4	-2.6	1.2
Trunk fat mass	1.7	7.4	32.0	-2.0	-0.1	0.7	-0.6	0.5	1.5	-2.7	-5.7	-0.5	-4.9	3.3
Medication: Simvastatin	1.7	2.5	6.7	-2.0	2.6	-0.9	-1.2	2.0	1.8	2.0	0.7	0.3	0.2	-1.3
Medication: Amlodipine	1.7	2.4	5.6	-2.1	2.1	0.5	-2.4	1.0	2.2	0.7	1.4	-0.3	0.3	-1.9
Pulse wave peak to peak time	1.7	2.0	5.2	2.2	1.2	-0.9	1.9	0.7	-0.5	-0.4	1.0	-1.3	1.7	2.3
Health satisfaction	1.7	2.2	10.3	-0.8	-0.2	-1.5	-2.1	3.2	2.1	0.3	-0.2	-0.6	-0.7	1.0
Whole body fat mass	1.7	7.1	30.5	-2.2	-0.0	0.4	0.1	-0.2	0.8	-2.6	-5.5	-0.8	-4.9	3.3
Long-standing illness, disability or infirmity	1.7	2.7	12.5	-1.6	1.5	0.2	-3.5	2.0	2.3	-0.4	-0.2	-0.3	-1.4	0.4
Cholesterol lowering medication	1.7	2.4	7.8	-2.8	2.0	-0.7	-1.7	2.3	1.9	1.0	-0.1	-0.7	-0.4	-0.8
Medication: Omeprazole (e.g. Zanprol)	1.7	2.1	7.5	0.3	-0.5	1.8	-2.7	1.9	2.2	-0.5	0.3	1.4	-0.6	-1.1
Heart disease (siblings)	1.7	2.1	5.8	-2.4	0.6	-0.5	-1.0	0.1	1.5	-1.7	-1.3	-1.8	-2.4	-0.0
Schizophrenia (2014)	1.6	3.5	14.4	1.9	0.2	-0.6	0.6	0.9	-1.3	1.8	3.8	-1.2	3.5	-0.2
Body mass index (BMI)	1.6	6.7	27.2	-3.0	-0.3	-1.3	2.1	-1.9	-0.5	-1.6	-5.2	-0.9	-4.6	1.8
Hair/balding pattern: Pattern 2	1.6	2.1	10.6	0.7	0.6	0.8	-1.6	2.4	3.2	0.2	0.9	1.1	0.5	-0.3
Migraine (self-reported)	1.6	1.9	7.8	0.3	-2.3	1.1	-0.5	-1.0	-0.2	-2.8	-1.1	-0.9	-1.7	0.8
Had major operations	1.6	1.8	5.4	-0.5	0.2	-0.9	-1.1	-0.6	0.4	-2.3	-2.2	-1.4	-1.8	1.4
Friendships satisfaction	1.6	2.0	5.7	-1.6	-0.8	1.6	-0.4	-0.5	-1.0	-2.4	-1.8	0.1	-2.2	0.8
Pain type(s) experienced in last month: Hip pain	1.6	2.0	5.2	-1.4	-0.8	-0.7	-2.1	0.8	2.3	-1.0	-1.0	-2.0	-1.4	0.0
Medication: Lisinopril	1.6	2.1	5.9	-1.7	-0.3	0.8	-2.4	-0.6	1.9	-0.2	-1.3	-1.8	-1.9	-1.2
Alcohol drinker status: Previous	1.6	1.8	6.7	-0.8	1.7	0.2	-2.6	2.1	1.9	1.1	0.0	-0.2	0.0	0.2
Ever had hysterectomy (womb removed)	1.5	1.7	5.4	-1.9	-0.8	-1.7	1.1	-0.7	-1.2	0.4	-1.3	0.1	-2.3	-1.0
Serious illness, injury or assault to yourself	1.5	1.8	6.0	-2.0	2.4	0.4	-1.2	-0.0	-0.4	-0.3	-1.2	0.1	-2.2	1.5
Standing height	1.5	15.1	38.4	0.9	-0.0	6.0	-2.8	2.4	3.0	-5.4	-5.2	-0.9	-3.2	6.2
Pulse wave reflection index	1.5	1.8	5.1	-2.0	-0.6	-0.4	-1.9	-0.2	2.2	0.8	-0.2	0.6	-0.8	-2.3
Medication: Blood pressure	1.5	2.6	8.1	-2.6	2.9	0.4	-2.5	0.6	1.6	0.3	-0.7	0.1	-1.8	-0.9
Leg fat mass (right)	1.5	5.9	26.2	-2.1	-0.3	-0.0	0.9	-0.6	0.5	-2.0	-5.1	-1.1	-4.6	2.5
Commuting to job workplace: Car/motor vehicle	1.5	1.7	5.5	2.1	1.0	1.6	-0.4	2.4	1.4	0.6	-0.1	1.4	0.0	0.9
Wears glasses or contact lenses	1.5	1.8	4.9	-1.5	-2.0	0.4	0.7	-1.6	-1.1	-1.7	-1.1	0.0	-2.2	0.2
Eye problems/disorders: Glaucoma	1.5	1.8	8.4	-0.1	0.4	-0.3	2.5	-2.2	-2.9	0.3	-0.1	-0.3	0.4	0.0
Unable to work because of sickness or disability	1.5	1.9	6.5	-1.4	0.6	1.4	-1.9	1.1	0.9	-1.1	-0.9	1.3	-2.5	1.0
Leg fat mass (left)	1.5	5.8	26.1	-2.4	-0.2	0.1	0.8	-0.6	0.5	-1.8	-5.1	-0.9	-4.6	2.4
Schizophrenia vs Biploar Disorder	1.4	1.9	7.5	1.8	0.0	-1.0	0.3	0.3	0.1	1.6	2.7	-0.1	2.4	-0.3
Major Depression (MDD)	1.4	1.7	4.1	-0.6	-1.6	1.1	-1.9	1.0	0.7	-1.9	-0.2	1.4	-2.0	-0.1
HbA1C	1.4	1.6	4.7	-2.2	2.1	-1.6	1.1	-1.5	-0.2	0.6	0.4	-0.7	-0.3	-1.1
Height	1.4	27.3	85.2	2.1	-1.4	8.0	-4.3	3.7	3.5	-7.1	-6.1	-0.3	-3.4	9.2
Neuroticism	1.4	3.4	12.5	-0.3	-1.3	3.2	-0.9	-0.7	-1.1	-1.8	0.7	3.5	-2.2	-1.5
Hand grip strength (left)	1.4	3.7	8.4	0.6	-1.6	1.5	2.8	-1.5	-2.6	-2.0	-2.1	-1.1	-0.4	2.9
Average weekly spirits intake	1.4	1.8	5.1	-2.2	-0.6	0.5	0.9	-0.9	-1.5	0.7	-0.6	1.3	-2.1	-1.8
Diabetes (father)	1.4	1.7	6.6	0.8	-1.0	0.1	2.6	-0.9	-1.8	-1.4	-1.3	-0.3	-0.8	1.5
Tinnitus: Yes, but not now, but have in the past	1.4	1.5	5.8	-2.4	-0.8	0.5	-1.2	-0.5	-0.7	-1.5	-0.8	-1.5	-1.4	-0.5
Time employed in main current job	1.4	1.6	5.5	1.5	0.7	0.1	-0.7	2.3	0.1	1.6	1.9	0.2	1.6	0.8
Hair/balding pattern: Pattern 3	1.4	2.1	5.1	-0.0	-0.2	-0.1	1.9	-1.2	-2.2	0.9	2.2	-0.0	1.5	-2.3
Medication: Seretide 50 evohaler	1.4	1.6	5.2	0.9	-0.4	0.3	-2.0	0.2	1.0	-1.3	-1.2	-1.6	-0.6	2.3
Comparative height size at age 10	1.4	7.9	27.8	-0.5	1.3	2.5	-1.3	2.7	2.4	-2.0	-4.4	-1.4	-3.2	5.3
Illnesses of siblings: Diabetes	1.4	1.7	5.5	-1.2	-1.8	0.0	-0.3	-0.4	0.1	-1.8	-2.2	0.5	-2.3	0.6
Ever had bowel cancer screening	1.4	1.6	5.3	-0.7	-0.2	1.3	-2.3	0.8	1.3	-0.0	-0.7	2.0	-1.9	0.2
Back pain experienced in last month	1.4	2.1	8.3	0.9	-1.1	2.9	-1.3	-0.5	0.8	-2.0	-0.8	-0.1	-0.6	2.3
Osteoarthritis (self-reported)	1.4	1.8	4.5	0.2	0.2	-0.7	-1.7	1.6	1.7	-0.9	-1.5	-1.8	-0.4	2.1
Number of operations (self-reported)	1.4	2.1	8.9	-0.3	0.1	0.2	-1.2	-0.5	-0.1	-2.0	-2.2	-0.8	-3.0	1.8
Pain experienced in last month	1.4	2.3	9.3	-0.6	1.1	-1.7	3.1	-0.2	-1.2	2.6	0.4	0.1	1.1	-1.5
Other serious medical condition/disability diagnosed by doctor	1.3	1.6	6.7	-2.1	0.7	0.3	-1.7	1.0	0.3	-0.8	-1.2	0.3	-2.6	0.0
Medication: Co-codamol	1.3	1.5	6.4	-0.8	1.5	-0.1	-2.5	1.2	1.7	0.7	-0.4	-1.2	-1.0	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	1.3	3.0	12.7	-1.8	1.1	-0.9	-1.8	2.3	3.6	0.3	0.7	-0.0	-1.5	-1.9
Medication: Atenolol	1.3	1.6	5.3	-1.5	1.8	0.3	-1.8	1.2	2.3	0.4	0.8	0.0	-0.2	-1.1
High blood pressure (mother)	1.3	1.8	5.4	-1.0	1.8	-0.3	-2.3	2.0	2.1	1.0	-0.4	-0.7	-0.4	0.0
Nervous feelings	1.3	2.4	9.5	1.6	-0.3	0.6	-0.1	-0.8	-1.8	1.0	1.6	3.1	0.3	-2.5
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	7.1	-0.1	0.0	0.8	-2.7	0.6	1.5	0.7	1.9	0.3	0.8	-1.3
Length of working week for main job	1.3	1.4	8.4	1.7	-0.5	2.9	0.3	-0.7	-0.7	-1.1	-0.5	0.2	-0.0	1.3
Number of full brothers	1.3	1.6	3.7	0.1	-1.9	0.9	-1.0	-0.7	0.4	-1.6	-1.6	-0.7	-1.9	1.5
Mean time to correctly identify matches	1.3	2.5	12.3	0.8	0.8	0.6	-0.9	3.5	2.4	-0.1	-0.7	2.0	-0.9	1.3
Mood swings	1.3	2.4	7.2	-0.7	-1.6	2.3	-1.5	1.3	0.5	-1.8	-0.4	1.7	-2.7	0.4
Fractured/broken bones in last 5 years	1.3	1.7	8.9	-0.3	0.6	1.2	0.8	-2.7	-3.0	0.2	-0.3	0.3	-0.4	-0.3
Schizophrenia (2018)	1.2	2.6	9.5	2.2	-0.4	-0.5	0.2	0.3	-1.3	1.6	3.0	-0.8	3.1	0.3
Vitamin and mineral supplements	1.2	1.6	5.2	-0.1	2.1	-0.1	2.3	0.1	-1.2	1.9	0.5	-1.3	0.8	0.2
Arm fat percentage (right)	1.2	4.6	18.4	-2.4	0.6	-1.4	-0.3	0.2	1.3	-1.2	-4.3	-0.3	-4.1	2.0
Alcohol intake versus 10 years previously	1.2	1.7	5.3	0.5	0.5	-0.7	-2.3	2.3	1.9	0.7	0.4	-1.4	0.1	1.1
Father’s age at death	1.2	1.6	5.7	1.8	-1.4	0.7	2.4	-1.1	-1.1	-1.2	0.7	0.0	1.4	0.4
Worrier / anxious feelings	1.2	2.4	5.7	1.0	-0.1	1.3	-1.7	0.3	1.2	-1.5	2.4	2.2	0.5	-2.3
Forced expiratory volume in 1-second (FEV1)	1.2	4.1	13.6	-1.3	-2.0	2.9	-0.5	-0.1	2.1	-3.7	-2.3	-1.5	-2.1	-0.1
Headache pain in last month	1.2	2.1	5.2	1.1	-0.3	2.0	-1.7	0.7	0.7	-2.3	-0.8	1.5	-0.6	2.2
Glaucoma (self-reported)	1.2	1.4	5.8	-0.5	0.1	0.0	1.9	-1.9	-2.4	-0.5	-0.8	-0.8	-0.1	0.2
High blood pressure (siblings)	1.2	1.7	5.4	-2.3	-1.1	0.7	-1.8	0.5	1.6	-0.1	0.0	0.2	-1.4	-1.9
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	2.5	1.2	-0.4	-0.1	-0.5	1.6	1.4	-1.3	-1.6	1.4	-1.0	1.4
Emphysema/chronic bronchitis	1.2	1.4	5.0	-0.7	0.8	0.4	-2.2	1.0	1.3	-0.4	-1.2	-0.4	-0.7	1.9
Pulse rate, automated reading	1.2	4.0	15.5	1.4	-2.5	0.7	1.1	-0.3	-3.3	-0.6	-2.0	0.9	-1.7	3.9
Overall health rating	1.2	2.5	10.3	-1.5	1.1	0.8	-3.2	0.8	1.6	-0.7	-1.1	1.6	-2.2	1.0
Ever taken oral contraceptive pill	1.2	1.4	3.4	-0.7	0.7	-1.6	-0.3	0.3	1.3	1.4	1.3	-1.8	0.8	-1.4
Depressed Affect (Nagel 2018)	1.1	2.3	6.2	-1.0	-1.9	2.3	-1.1	-0.2	0.2	-1.6	-0.1	2.5	-2.4	-0.2
Trunk fat percentage	1.1	4.5	17.0	-1.4	-0.1	0.1	-1.3	1.0	1.8	-1.8	-4.1	0.3	-3.9	2.3
Fed-up feelings	1.1	1.9	7.7	-1.1	-1.1	2.2	-0.2	0.5	0.1	-0.9	0.9	2.8	-1.4	-1.4
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.4	13.7	-1.1	-2.4	2.4	0.5	-0.9	1.5	-3.7	-1.6	-1.2	-1.7	-1.0
Breastfed as a baby	1.1	1.3	4.7	0.9	-0.2	-0.2	-1.9	1.0	2.2	1.1	0.3	-0.3	1.3	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.4	7.6	-0.9	0.7	-2.8	0.1	-0.1	-0.3	0.8	-0.0	-2.2	-0.7	-0.3
Suffer from ‘nerves’	1.1	1.7	7.3	2.7	0.2	2.1	-1.2	0.9	-0.0	0.3	0.7	1.7	0.6	0.5
Arm fat percentage (left)	1.1	4.3	17.8	-2.1	0.4	-1.1	0.1	0.4	1.4	-1.1	-4.2	-0.1	-4.0	2.1
Illnesses of father: None of the above (group 1)	1.1	1.4	9.2	0.8	0.2	1.0	-1.1	1.4	0.4	0.1	-0.5	3.0	-0.1	0.8
Ever had prostate specific antigen (PSA) test	1.1	1.3	4.5	1.1	0.9	-0.2	-2.1	1.6	1.7	0.5	-0.2	1.3	0.3	-0.2
Heel T-Score	1.0	8.2	35.4	-0.2	-1.6	0.6	-4.2	4.6	6.0	0.0	1.1	-0.4	-0.8	-3.3
Relative age of first facial hair	1.0	2.1	8.2	0.6	0.3	-0.1	-1.8	-0.5	2.9	0.8	1.7	-1.1	2.1	-1.3
Systolic blood pressure, automated reading	1.0	2.8	16.2	-1.1	1.3	-4.0	-0.4	-0.4	1.3	1.1	0.3	-1.2	0.4	-2.6
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	4.2	0.9	1.0	1.2	-2.0	1.5	1.3	0.7	1.3	-0.2	1.1	1.5
Pulse rate	1.0	1.7	9.7	1.2	-1.3	0.1	1.1	-0.2	-3.1	0.9	0.7	-0.1	0.2	1.8
Depression (self-reported)	1.0	1.1	6.5	0.2	-0.6	-0.1	-2.5	1.2	0.2	-0.9	-1.2	-0.2	-1.0	1.0
Illnesses of mother	1.0	1.2	3.5	1.7	-1.4	1.9	0.9	-0.8	-1.0	-0.9	0.1	0.7	-0.0	1.2
Ever highly irritable/argumentative for 2 days	1.0	1.1	2.9	-1.1	1.0	0.1	-0.6	1.7	1.7	0.6	-1.1	-0.7	-1.3	0.9
Medication: Paracetamol	1.0	1.7	4.9	-0.2	1.5	0.7	-1.5	-1.6	-0.1	-2.2	-1.7	-0.1	-1.4	1.2
Medication for cholesterol, blood pressure or diabetes	1.0	1.6	4.4	1.8	-2.1	-0.8	1.9	-0.4	-1.1	0.0	0.4	-0.6	1.6	1.2
Chest pain or discomfort	1.0	1.5	4.8	-1.4	-0.3	0.2	-2.2	1.5	1.4	-0.4	-0.3	1.2	-1.8	0.4
Knee pain experienced in last month	1.0	1.6	4.3	-0.8	0.6	-1.0	-1.3	-0.4	1.0	-0.7	-2.1	1.1	-2.0	1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	6.6	0.6	-0.6	0.3	-1.3	2.6	1.1	-0.2	-0.1	-0.0	-1.0	1.1
Commuting to job workplace: Walk	1.0	1.1	2.7	0.6	0.6	-1.5	0.9	-1.2	-1.6	-0.8	-0.8	-0.7	0.1	1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.1	4.0	1.1	0.7	2.0	-0.9	0.3	0.4	-1.6	-0.3	0.3	-0.8	1.5
Guilty feelings	1.0	1.4	5.3	0.1	-0.3	2.3	0.3	-1.6	-1.5	-0.8	-0.1	1.9	-1.1	-0.1
High cholesterol (Self-reported)	1.0	1.8	8.4	-2.9	1.7	-0.4	-1.4	1.0	1.1	0.8	-0.9	-0.1	-1.3	-1.0
Medication: Paracetamol	1.0	1.6	4.2	-0.3	0.7	0.2	-1.0	-1.3	-0.7	-2.0	-2.0	0.1	-1.9	1.3
Diastolic blood pressure, automated reading	1.0	3.1	9.5	-0.9	0.1	-0.9	-3.0	2.1	3.1	-0.1	-2.3	1.3	-1.7	0.2
Basal cell carcinoma (self-reported)	1.0	1.1	4.3	2.1	-0.4	0.4	0.2	-0.0	-0.4	-0.6	1.3	-0.3	1.7	1.6
Neuroticism (Nagel 2018)	0.9	2.1	7.2	-0.3	-1.1	2.4	-0.9	-0.5	-0.4	-1.1	1.3	2.7	-1.2	-1.8
Ovarian Cancer	0.9	1.2	4.7	-0.0	-1.2	1.6	-1.3	0.0	1.2	-2.2	-0.8	0.0	-1.0	-0.4
Blood White Count	0.9	6.5	18.6	-0.4	-0.4	2.0	3.5	-3.5	-4.3	-1.6	-2.3	0.2	-3.1	2.5
Frequency of depressed mood in last 2 weeks	0.9	1.3	3.3	1.0	0.2	1.3	-1.3	1.8	0.7	-1.1	0.0	0.8	-1.1	1.8
Allergy	0.9	2.2	5.4	1.7	-0.1	-0.1	0.8	-0.7	-1.1	2.2	2.0	0.7	2.3	-2.0
Illnesses of siblings	0.9	1.3	3.4	1.4	0.4	-0.4	1.8	-0.5	-1.4	1.2	0.9	0.9	1.8	-0.4
Neuroticism score	0.9	2.0	8.1	0.3	-0.7	2.9	-0.8	-0.4	-0.6	-1.3	0.6	2.6	-1.5	-0.7
Mouth/teeth dental problems: Loose teeth	0.9	1.1	2.2	-1.5	0.5	-1.3	-1.4	1.5	1.2	0.4	-0.9	-0.4	-1.0	0.5
Angina (self-reported)	0.9	1.2	3.3	0.5	1.8	-1.2	-0.6	0.4	-0.5	1.5	1.6	1.3	0.7	-0.3
Age at last live birth	0.9	1.3	5.9	2.4	-1.0	-0.1	0.5	0.0	-0.3	-0.4	-1.6	-0.6	1.4	1.6
Handedness (chirality/laterality): Left-handed	0.9	1.0	3.9	-0.0	2.0	-1.4	0.2	-0.3	0.1	1.6	1.0	-1.2	0.7	0.1
Mineral and other dietary supplements	0.9	1.2	3.5	0.2	0.6	0.1	1.6	-0.3	-1.7	1.9	0.6	0.2	1.3	-1.3
Risk taking	0.9	1.4	5.5	-0.6	-1.3	1.6	-0.0	0.8	0.4	-0.4	-1.2	-0.7	-1.4	2.4
Depression (Nagel 2018)	0.8	1.1	4.5	1.6	-0.1	1.4	-0.2	0.8	-0.9	-0.8	1.0	-0.3	-0.6	2.1
Fasting Glucose	0.8	1.0	2.5	-0.4	0.8	-1.2	0.9	-1.3	-1.6	-0.3	-0.5	-0.5	-0.7	1.6
LDL Cholesterol	0.8	1.3	5.6	-0.9	-2.4	-0.4	0.9	-0.5	-1.5	-1.1	-0.8	-0.1	-1.7	0.1
Lupus	0.8	1.2	2.8	0.6	-0.7	1.0	-0.4	-1.7	-0.9	-1.5	0.8	-1.2	0.8	-1.5
Type 2 Diabetes (T2D) (2018)	0.8	1.5	4.5	-0.4	0.9	0.5	0.5	-1.0	-1.1	-0.3	-1.6	-1.8	-2.1	1.7
Medication for hormone replacement therapy	0.8	0.9	3.2	0.0	-1.8	0.2	-0.3	-0.2	0.5	-1.2	-0.5	-1.4	-1.5	0.2
Medication: Metformin	0.8	1.1	4.9	-0.1	1.3	-0.4	0.8	-1.3	-2.2	0.6	0.4	-1.2	-0.6	1.1
Medication: Levothyroxine sodium	0.8	1.3	3.3	-1.7	-0.8	0.5	-1.8	0.3	0.7	-1.3	-1.0	1.0	-1.8	-0.3
Alcohol usually taken with meals	0.8	1.4	3.8	-0.7	-0.1	-1.4	1.9	-1.3	-0.8	-0.9	-1.8	0.5	-1.1	1.1
Had other major operations	0.8	1.0	2.8	0.5	-0.4	0.8	-0.2	0.8	0.8	-1.1	-1.4	0.8	-1.4	1.7
Forced vital capacity (FVC)	0.8	3.1	8.4	-1.3	-0.9	2.9	-0.6	-0.3	1.9	-2.8	-2.2	-2.2	-1.1	0.6
Fluid intelligence score	0.8	1.7	4.9	-0.6	2.2	-0.5	0.1	0.9	1.0	1.5	2.1	-0.2	1.8	-1.2
Noisy workplace	0.8	1.0	2.5	-1.4	-0.9	0.4	1.1	-1.0	-0.5	-0.5	-1.2	0.6	-1.6	-1.0
Loud music exposure frequency	0.8	0.9	2.5	1.1	0.1	-1.3	0.3	-0.6	-1.3	0.0	-1.2	-0.7	0.6	1.6
Gout (self-reported)	0.8	1.2	4.2	-1.7	2.0	-0.7	-1.1	0.3	1.3	-0.1	-0.7	0.4	-1.2	0.6
Body fat percentage	0.8	3.3	13.2	-1.6	-0.1	-0.7	-0.6	0.6	1.4	-1.3	-3.6	-0.0	-3.6	1.7
Comparative body size at age 10	0.8	2.2	4.4	-1.7	2.1	-1.8	1.9	-1.9	-0.1	-0.6	-1.4	-1.8	-1.1	-0.3
Number of full sisters	0.8	0.9	3.3	-1.8	-0.1	0.1	1.2	-1.1	-1.4	0.7	0.0	0.7	-0.3	-1.0
Family relationship satisfaction	0.8	1.0	3.4	-1.8	-0.3	0.2	0.7	-1.5	-1.4	-0.5	0.3	-0.1	-1.3	0.9
Smoking status: Previous	0.8	1.2	4.6	-0.3	-1.8	-0.3	-1.5	1.3	2.1	0.4	0.6	0.1	-0.6	-0.7
Medication: Aspirin	0.8	1.1	4.0	-1.4	2.0	-1.1	-0.5	1.0	-0.2	1.8	-0.0	-0.6	0.2	0.1
Medication: Gliclazide	0.8	0.9	2.5	-0.6	1.0	-1.1	0.9	-0.5	-1.6	0.7	0.9	-1.6	0.1	0.5
Commuting to job workplace: Public transport	0.8	1.0	3.4	1.2	1.0	-0.4	-1.8	-0.4	1.2	0.2	-0.1	-1.0	1.1	-1.1
Irritability	0.8	1.3	8.1	-1.0	0.4	2.8	-0.6	0.7	0.3	-0.2	-0.5	1.1	-1.6	-0.4
Worry (Nagel 2018)	0.7	1.5	5.1	1.1	0.3	1.6	-1.0	0.2	0.1	-0.2	1.5	2.3	0.4	-2.0
Alzheimer’s Disease (in father)	0.7	0.7	2.3	-1.1	0.2	1.1	0.7	-1.5	-0.8	-0.1	-0.7	-0.2	-1.2	0.3
Verbal and Numeric Reasoning (VNR)	0.7	1.6	7.8	-1.0	2.8	-1.0	-0.8	0.7	1.5	1.7	0.2	-0.2	1.1	-0.8
Coronary Artery Disease (CAD)	0.7	0.9	2.8	-1.7	-1.2	-0.8	-0.7	-0.4	0.6	-1.4	-0.1	-0.6	-1.1	-0.5
Neuroticism (2016)	0.7	1.0	3.8	-0.1	-0.2	1.0	-1.0	-0.2	-1.0	-2.0	-0.7	1.6	-1.1	0.4
Smoking Status	0.7	1.7	6.6	-0.8	-0.1	-0.2	-2.5	0.6	2.6	0.7	-0.8	-1.3	-0.9	1.2
Lung FVC	0.7	3.4	13.8	-2.5	-0.3	1.5	2.1	-2.4	-0.0	-1.4	-0.1	-3.7	-0.2	-1.5
Angina	0.7	0.9	2.6	0.4	1.6	-0.9	-0.6	0.4	-0.6	0.9	1.2	1.6	0.4	0.1
Severe depression (siblings)	0.7	0.8	3.1	-0.2	-1.1	0.4	-0.5	0.1	-0.2	-1.7	-0.7	0.2	-1.8	0.4
Current tobacco smoking	0.7	1.1	2.5	-1.4	1.6	0.6	-1.3	0.0	0.8	1.4	-1.5	-0.5	-0.4	0.7
Hayfever, allergic rhinitis or eczema	0.7	1.5	3.8	-2.0	0.5	-1.4	-0.7	0.6	1.5	-1.5	-0.8	-1.5	-1.3	0.5
Diverticular disease/diverticulitis (self-reported)	0.7	0.9	3.5	-0.8	-0.4	-0.5	1.2	0.1	-0.4	0.3	0.7	1.9	0.3	-1.7
Pain all over the body in last month	0.7	0.7	3.6	-1.3	1.9	-0.8	-0.3	0.3	0.2	0.4	-0.1	-0.7	-0.9	0.3
Hayfever/allergic rhinitis (self-reported)	0.7	1.0	2.8	-1.7	1.4	-1.2	-0.3	0.6	0.8	1.3	0.4	0.3	-0.1	-1.2
Medication: Ibuprofen (e.g. Nurofen)	0.7	1.0	4.5	1.0	-0.7	1.0	-0.5	-0.8	-0.7	-0.3	-1.0	0.9	-0.1	2.1
Medication: Lansoprazole	0.7	0.8	3.7	1.2	-0.6	0.4	-1.2	1.0	-0.1	-0.3	0.0	-0.6	0.4	1.9
Birth weight of first child	0.7	1.3	4.3	0.2	2.0	-1.4	-0.3	1.0	0.9	1.0	0.3	-2.1	0.9	0.6
Forced vital capacity (FVC), Best measure	0.7	2.4	8.2	-1.1	-1.5	2.3	-0.1	-0.7	1.8	-2.9	-1.6	-1.7	-0.7	-0.5
Leg fat percentage (right)	0.7	2.5	10.8	-1.4	-1.1	-0.9	0.6	-0.2	0.4	-1.2	-3.0	-0.8	-3.3	0.9
Age at first live birth	0.7	1.2	3.6	1.5	0.9	-1.0	1.1	-0.6	0.2	0.3	-0.9	-1.7	1.9	-0.2
Medication for pain relief, constipation, heartburn	0.7	1.2	3.8	-0.4	-1.9	-1.1	1.9	0.0	-0.2	0.6	0.7	-0.5	0.4	-1.7
Medication: Ibuprofen	0.7	0.8	4.7	1.1	-0.7	0.6	-0.2	-0.6	-0.8	-0.2	-0.9	0.0	-0.2	2.2
Heart disease (mother)	0.7	0.8	3.8	-2.0	0.4	-1.5	-0.9	0.3	0.8	-0.0	-0.2	-0.2	-0.4	-1.1
Osteoporosis (self-reported)	0.7	0.9	3.6	0.6	-0.4	0.1	1.0	-0.9	-1.8	-0.1	0.7	1.9	-0.1	0.0
Smoking status: Current	0.7	1.0	2.7	-1.6	1.3	0.4	-1.1	-0.3	0.5	1.0	-1.6	-0.4	-0.8	0.8
Average weekly champagne plus white wine intake	0.7	1.0	2.7	0.9	0.3	0.1	1.6	-1.3	-0.5	0.7	1.0	1.4	1.3	0.6
Tinnitus: Yes, now most or all of the time	0.7	0.9	3.1	1.6	-0.2	1.8	0.3	-0.7	-0.0	-0.5	-0.7	0.6	0.1	1.4
Supplements: Fish oil (including cod liver oil)	0.7	0.9	4.0	-0.0	-0.4	-0.6	-1.6	0.6	2.0	-1.1	0.3	-0.6	0.2	0.7
Leg fat percentage (left)	0.7	2.7	12.1	-1.9	-1.1	-0.9	0.6	-0.3	0.4	-1.0	-3.1	-0.5	-3.5	0.7
Average weekly beer plus cider intake	0.7	1.0	2.8	-1.4	0.7	-0.7	-1.2	0.7	1.5	1.7	0.7	-0.7	0.2	-0.1
Bipolar Disorder (2018)	0.6	1.0	3.6	-0.3	0.3	0.2	0.7	-0.4	-0.2	-1.7	-1.4	-1.9	-1.0	-0.1
Alzheimer’s Disease (in mother)	0.6	0.7	1.4	1.1	0.0	0.8	0.8	0.3	0.6	-0.1	1.1	1.1	1.2	-0.9
Breast Cancer	0.6	1.5	4.1	-1.9	-0.5	0.9	-0.1	-1.6	-0.9	-0.8	-1.4	1.1	-2.0	-0.1
Crohns Disease (2012)	0.6	1.0	3.6	-0.7	0.5	-0.0	-1.8	0.4	1.6	0.3	0.7	-0.5	0.4	-1.9
Triglycerides	0.6	0.9	5.5	-1.4	-0.1	-0.3	-0.3	-1.0	-0.3	0.7	0.9	-2.3	-0.3	-0.4
Type 2 Diabetes (T2D) (2012)	0.6	0.6	2.0	-0.8	-1.1	0.4	0.8	-0.6	-0.9	-0.2	-0.1	0.6	-0.9	-1.4
Lung FEV1/FVC ratio	0.6	3.3	15.5	-3.0	-1.9	-0.4	-0.4	-0.1	1.2	-1.1	-0.8	-0.1	-3.9	-2.0
Hearing difficulty/problems: Yes	0.6	0.9	4.9	0.9	0.3	-0.3	1.0	-0.9	-0.6	-0.8	-0.5	-0.8	-0.6	2.2
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	1.3	0.6	0.5	0.5	-1.0	0.8	-1.1	0.5	0.8	-0.3	1.1	1.1
Maternal smoking around birth	0.6	0.9	3.9	0.4	-0.8	0.4	0.6	-0.5	-0.3	-0.2	-1.4	-1.1	-1.1	2.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	3.0	0.2	0.5	1.4	-0.6	0.6	-0.4	-0.6	0.1	0.3	-1.7	1.5
Age when periods started (menarche)	0.6	1.4	7.2	1.5	-1.6	-0.2	-2.7	-0.2	0.7	0.1	0.1	-0.1	1.7	-0.2
Supplements: Glucosamine	0.6	0.8	3.6	-0.4	-0.6	-1.9	0.3	0.2	-0.4	-0.5	-0.2	-1.5	-0.7	1.2
Chronic bronchitis/emphysema (father)	0.6	0.7	2.8	-0.2	0.4	1.7	0.3	-1.1	-0.4	1.4	0.4	0.2	-0.6	-0.8
Past tobacco smoking	0.6	1.1	4.0	1.1	1.3	0.0	1.5	-1.3	-2.0	-0.8	-0.3	0.0	1.0	0.6
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	2.7	-0.8	0.4	1.2	-1.2	0.1	-0.3	-1.4	-0.6	0.2	-1.6	1.2
Hair/balding pattern: Pattern 4	0.6	1.5	5.4	-2.3	-0.1	-0.1	0.7	-0.6	-1.0	0.0	-2.3	-0.6	-1.9	0.5
Birth weight	0.6	1.3	5.4	-0.4	0.7	-2.3	0.0	0.3	-0.0	0.5	0.7	-1.9	1.4	-1.5
Shortness of breath walking on level ground	0.6	0.7	2.3	-0.2	0.3	-0.9	-0.8	0.9	1.5	0.4	0.1	1.1	-0.6	-1.3
Alcohol intake frequency.	0.6	1.5	6.1	-0.0	1.2	0.2	-2.5	1.6	1.0	-1.0	-0.7	-0.7	-1.1	1.4
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	3.5	-0.2	-0.4	-1.2	0.3	1.9	0.8	0.6	-1.1	0.4	-0.4	0.4
Medication: Aspirin	0.6	0.8	2.5	-1.2	1.6	-1.0	-0.1	0.5	-0.7	1.5	-0.0	-0.8	0.4	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	5.6	-0.3	-0.1	1.5	-1.2	1.3	2.4	-0.8	-0.7	0.2	-0.4	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	2.0	0.8	1.2	-0.1	-0.2	0.2	0.7	0.8	1.1	0.5	1.4	-0.9
Age started oral contraceptive pill	0.6	0.7	1.7	0.9	-1.3	-0.1	0.6	0.3	-0.7	0.2	1.1	1.0	1.3	0.7
Bipolar Disorder or Schizophrenia	0.5	1.1	3.2	1.5	-0.1	-0.2	0.6	0.0	-1.1	0.2	1.4	-1.8	1.8	0.2
Intelligence (Savage-Jansen 2018)	0.5	1.7	3.9	-1.6	1.9	-1.2	-0.7	0.4	2.0	1.5	-1.1	-0.9	0.4	-1.5
Alzheimer’s Disease (including proxy)	0.5	0.7	2.9	1.7	-0.7	1.3	0.9	-0.6	-0.4	-1.0	0.0	0.8	0.1	0.1
Irritable Bowel Disease (IBD)	0.5	1.2	4.8	-1.3	0.4	-0.7	1.0	-0.5	-0.2	-0.4	0.1	1.7	-1.2	-2.2
Ulcerative Colitis (UC)	0.5	0.9	3.7	-0.3	0.3	-0.4	1.6	-0.0	-0.3	0.0	0.3	1.9	-0.8	-1.6
Bipolar Disorder (2011)	0.5	0.5	2.0	0.9	-1.0	0.4	-0.4	0.4	0.1	-0.6	-0.9	0.0	0.2	1.4
Body Mass Index (BMI) (2010)	0.5	0.7	2.9	-0.0	-0.4	-0.5	0.1	-0.2	0.2	-0.4	-1.4	-1.7	-0.1	1.5
Ulcerative Colitis	0.5	0.7	2.4	-0.2	0.4	-0.9	1.5	0.0	-0.3	0.9	-0.4	1.2	-0.8	-0.9
Hypothyroidism (self reported)	0.5	1.2	3.1	-0.6	-0.8	0.8	-1.0	0.1	-0.1	-0.9	-1.7	1.7	-1.7	0.9
Average weekly fortified wine intake	0.5	0.6	1.9	-0.8	0.2	-0.1	1.4	-1.1	-1.2	-0.6	-0.7	0.6	-0.2	0.0
Qualifications: CSEs or equivalent	0.5	0.7	1.5	1.2	-0.9	-0.7	-0.4	-1.2	-0.7	-0.8	-0.4	-0.2	-0.3	1.2
Financial difficulties in last 2 years	0.5	0.7	1.8	1.1	0.2	-0.2	0.7	-1.3	-0.8	0.4	0.8	-0.7	1.4	-0.4
Diabetes (self-reported)	0.5	0.8	2.9	-0.0	1.3	0.8	0.3	0.6	-0.9	0.3	0.2	-1.3	-0.7	1.7
Number of live births	0.5	0.7	2.9	-0.4	-1.3	0.3	0.9	-0.2	-1.7	-0.1	-0.6	0.8	-0.7	-0.1
Medication: Cholesterol lowering	0.5	0.8	5.7	-0.5	2.4	-0.2	-0.6	0.4	0.4	0.8	0.1	0.5	-0.1	-1.0
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	2.1	0.1	0.2	0.6	0.1	-0.6	-1.0	1.4	1.2	-0.3	1.1	-0.1
Chronic bronchitis/emphysema (mother)	0.5	0.6	4.0	-0.3	2.0	-0.3	-1.2	-0.3	0.1	-0.0	0.6	-0.2	0.4	0.5
Worry too long after embarrassment	0.5	0.9	2.1	-0.2	0.5	1.2	1.1	-1.0	-1.5	-0.4	1.4	0.5	-0.4	-1.1
Qualifications: College or University degree	0.5	1.5	5.9	1.0	0.6	0.0	-1.9	2.0	2.4	-0.1	-0.0	-0.8	1.0	-0.3
Eye problems/disorders: None of the above	0.5	0.6	2.4	-0.5	0.0	0.6	0.8	-0.3	0.4	-1.0	-0.9	0.4	-1.5	0.6
Average weekly red wine intake	0.5	0.8	3.6	0.9	-0.3	0.5	0.6	-0.7	0.8	-1.9	-1.2	-0.7	0.3	0.6
Diabetes diagnosed by doctor	0.5	0.8	2.6	0.2	0.1	0.9	0.6	-0.4	-1.6	0.2	-0.4	-1.2	-1.3	1.3
Breast cancer (self-reported)	0.5	0.6	2.6	0.7	0.6	0.2	-0.0	0.0	1.1	0.7	1.0	-1.6	0.7	0.3
Asthma (self-reported)	0.5	0.9	3.0	-0.8	0.1	1.6	-0.2	-0.1	-0.1	-1.6	-0.8	0.7	-1.7	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	6.3	-1.5	0.3	0.0	0.2	-1.0	0.6	-0.1	0.8	-1.0	-0.2	-2.5
Miserableness	0.5	0.8	2.8	0.1	-0.0	0.9	-1.7	0.7	0.4	-0.5	1.6	1.4	0.0	0.2
Illnesses of father: High blood pressure	0.5	0.6	1.8	-0.9	0.5	-1.1	-0.4	1.1	1.4	0.7	-0.2	-1.0	-0.1	-0.3
Ever smoked	0.5	0.8	4.3	-0.7	-0.1	-0.0	-0.8	0.8	1.0	2.1	0.9	0.9	0.3	-0.8
HDL Cholesterol	0.4	0.6	1.9	0.8	0.2	0.0	1.4	-0.5	-0.6	0.9	0.1	0.9	0.7	-1.2
Allergy or Eczema	0.4	1.0	3.9	-1.1	0.9	-2.0	-1.0	0.9	1.1	-0.5	-0.3	-0.7	-0.6	0.8
Respiratory disease	0.4	0.9	2.3	-1.0	1.5	0.0	-0.4	0.5	-0.2	-0.7	-1.1	0.7	-1.5	1.2
Relative age voice broke	0.4	0.7	3.0	0.7	0.0	0.9	-0.8	-0.6	1.1	-0.0	0.1	-1.7	0.6	-0.6
Hearing difficulty/problems with background noise	0.4	0.7	2.9	0.9	1.1	-0.1	-1.0	-0.6	-0.5	-0.2	-1.0	-0.2	-0.5	1.7
Qualifications: None of the above	0.4	0.8	5.5	0.5	-1.3	0.3	-0.1	-0.1	-0.5	0.5	-0.1	2.4	-0.5	0.7
Heart attack	0.4	0.6	1.9	-0.5	0.8	0.5	0.1	0.1	-1.0	1.2	0.5	1.4	0.1	-0.3
Happiness	0.4	0.5	2.0	-0.9	0.0	0.4	-0.5	-0.4	-1.4	-0.0	0.8	0.6	-0.3	0.9
Mouth/teeth dental problems: Dentures	0.4	0.6	3.1	1.3	-0.4	-0.1	-0.4	0.4	-0.7	0.2	-0.6	-0.5	-0.4	1.8
Asthma	0.4	0.8	2.8	-0.6	0.1	1.7	-0.1	-0.2	-0.2	-1.5	-0.6	0.8	-1.4	0.6
Prospective memory result	0.4	0.5	1.9	0.6	-0.3	-1.4	-0.7	0.8	1.0	0.1	-0.7	-0.0	-0.1	0.5
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	3.2	-0.7	-0.7	1.1	-1.3	0.5	0.5	-0.3	-0.4	1.8	-0.8	0.1
Medication: Ventolin 100micrograms inhaler	0.4	0.6	1.6	-0.2	0.7	0.1	-0.3	-0.9	-0.0	-1.2	-1.1	-0.9	-1.0	0.5
Qualifications: nursing, teaching	0.4	0.6	3.2	0.2	0.4	-0.2	-0.1	-0.5	0.1	-0.4	-0.7	-1.8	1.2	0.7
Eye problems/disorders: Cataract	0.4	0.5	1.4	-1.0	0.4	-0.5	-0.4	0.2	0.1	0.7	1.2	-1.0	0.4	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	2.3	0.4	-0.5	1.0	0.4	-1.5	0.2	-0.9	1.3	1.0	0.2	-0.5
Financial situation satisfaction	0.4	0.6	3.0	-0.2	-0.8	0.5	0.7	-1.7	-0.5	-1.0	-0.4	0.5	-0.1	0.1
Alcohol drinker status: Never	0.4	0.5	1.8	1.1	-0.7	-1.4	-0.5	0.8	0.1	-0.5	0.3	-0.1	0.6	0.3
Supplements: Calcium	0.4	0.5	2.1	-0.2	-1.2	-0.7	-0.5	-0.3	-0.1	-1.4	0.1	0.0	-0.7	0.3
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.3	-0.7	0.9	0.2	-0.1	0.1	-1.2	1.1	0.2	1.1	-0.3	-0.3
Crohns Disease (2017)	0.3	0.6	3.3	-1.2	-0.0	0.3	-0.7	-0.4	0.0	-0.8	-0.2	0.1	-0.9	-1.8
Prostate Cancer	0.3	0.5	1.8	1.4	0.3	-0.3	-0.2	0.1	-0.7	0.4	0.7	-0.5	1.0	-0.9
Age at First Birth	0.3	0.4	1.1	0.5	0.7	-0.9	0.0	-0.8	-0.0	0.1	-0.1	-1.1	1.0	0.5
Supplements: Zinc	0.3	0.3	0.6	-0.6	-0.2	0.5	0.1	-0.7	-0.6	-0.7	-0.2	-0.7	-0.8	0.7
Diabetes (mother)	0.3	0.4	1.4	-0.4	0.6	0.1	0.7	-0.8	-0.3	0.1	-0.6	0.7	-1.2	-0.3
Multivitamins +/- minerals	0.3	0.4	1.4	0.3	-1.2	-0.5	-0.8	-0.5	0.3	-0.9	0.6	0.2	-0.2	-0.6
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	0.9	0.2	0.3	-0.5	0.2	0.4	0.4	0.7	0.8	-1.0	0.4	0.9
Mouth/teeth dental problems	0.3	0.5	2.2	-1.0	-0.1	-0.4	-0.1	0.9	1.5	-0.2	-0.1	-0.3	-0.2	-1.2
Medication: Ramipril	0.3	0.3	1.3	-1.1	0.9	0.1	0.1	0.9	-0.5	0.1	0.5	-0.1	-0.4	-0.3
Qualifications: A levels/AS levels or equivalent	0.3	0.8	3.2	0.8	1.0	-1.2	-0.3	-0.2	-0.2	-0.0	-0.5	-0.9	1.8	0.7
Lung cancer (father)	0.3	0.4	2.5	0.5	-0.6	-0.5	-1.6	0.0	0.4	0.0	0.5	-0.1	0.1	0.6
Medication: Allopurinol	0.3	0.3	1.7	-0.4	1.3	-0.9	-0.0	-0.5	-0.2	0.4	-0.1	-0.2	-0.2	0.6
Illnesses of father: Heart disease	0.3	0.4	1.4	-0.6	0.3	-0.7	-0.1	-1.2	-0.3	-0.4	-0.8	-1.0	-0.6	0.4
Hearing aid user	0.3	0.3	1.4	0.1	0.6	0.1	-0.1	0.2	0.8	-0.4	0.3	-1.2	-0.6	-0.2
Mother’s age at death	0.3	0.3	0.9	-0.1	-0.4	0.9	0.8	0.3	-0.9	0.5	0.2	-0.6	-0.4	0.2
Medication: Atorvastatin	0.3	0.4	2.0	0.2	1.4	0.2	-0.4	-0.5	-0.7	0.2	-1.1	0.4	-0.3	-0.0
Mean Putamen Volume	0.2	0.3	1.2	-0.1	0.6	0.0	-0.6	0.3	0.8	1.1	-0.1	-0.4	0.4	0.2
Blood Eosinophil Count	0.2	1.2	3.5	-0.1	0.7	-1.4	0.8	0.3	1.0	-0.6	-1.9	-0.7	-1.4	1.5
Waist Hip Ratio (WHR)	0.2	0.9	2.9	-0.5	-1.7	-0.4	-1.2	-0.0	-0.4	-0.9	0.5	1.5	-0.6	-0.9
Tanning	0.2	2.0	6.6	1.0	0.3	1.0	1.8	-1.0	-2.4	-0.2	0.6	-1.9	0.3	2.6
Tense / ‘highly strung’	0.2	0.3	1.0	-0.4	0.1	0.8	-0.7	0.1	-0.2	0.1	-0.4	1.0	-0.7	-0.4
Commuting to job workplace: Cycle	0.2	0.2	0.7	-0.9	0.4	0.6	-0.5	-0.6	-0.0	-0.2	0.3	0.1	-0.0	0.2
Primary Biliary Cirrhosis	0.1	0.2	0.8	-0.3	0.5	-0.3	0.1	0.9	0.5	-0.3	-0.2	0.1	-0.3	0.1
Blood Platelet Count	0.1	0.9	2.2	0.4	1.3	-1.5	-0.4	1.1	0.8	-0.8	-0.7	-0.3	-0.6	1.4
Hair Pigment	0.0	0.9	3.3	1.8	0.5	-0.4	0.7	0.9	0.6	0.1	-0.1	0.4	0.9	1.8

Hub : Genes

MPPED2

Models

Trait associations