Best TWAS P=1.93e-08 · Best GWAS P=1.27e-12 conditioned to 3.61e-13
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CCDC53 | 0.21 | 0.15 | blup | 448 | 0.19 | 2.4e-22 | 3.8 | -5.5 | 3.1e-08 | -0.06 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | CCDC53 | 0.10 | 0.18 | lasso | 1 | 0.17 | 1.5e-12 | 5.5 | -5.5 | 3.1e-08 | 0.08 | 0.95 | 0.05 | FALSE |
| 3 | GTEx | Colon Transverse | CHPT1 | 0.25 | 0.04 | enet | 36 | 0.18 | 5.1e-09 | 3.9 | -5.2 | 1.5e-07 | -0.10 | 0.81 | 0.01 | FALSE |
| 4 | GTEx | Heart Left Ventricle | CCDC53 | 0.14 | 0.20 | lasso | 4 | 0.18 | 9.6e-10 | 5.6 | -5.2 | 2.4e-07 | 0.08 | 0.96 | 0.04 | FALSE |
| 5 | GTEx | Spleen | CCDC53 | 0.25 | 0.19 | lasso | 11 | 0.16 | 5.8e-05 | 5.6 | -5.6 | 1.9e-08 | 0.09 | 0.48 | 0.10 | TRUE |
| 6 | METSIM | Adipose | DRAM1 | 0.12 | 0.03 | enet | 24 | 0.08 | 1.1e-12 | 3.9 | 5.4 | 5.7e-08 | 0.07 | 0.99 | 0.01 | TRUE |
| 7 | YFS | Blood | DRAM1 | 0.33 | 0.13 | enet | 101 | 0.19 | 1.6e-58 | 5.3 | 5.2 | 2.1e-07 | 0.03 | 0.98 | 0.02 | FALSE |
| 8 | The Cancer Genome Atlas | Esophageal Carcinoma | CCDC53 | 0.14 | 0.08 | blup | 50 | 0.08 | 1.8e-03 | 5.6 | -5.4 | 6.6e-08 | 0.13 | 0.14 | 0.06 | FALSE |
| 9 | The Cancer Genome Atlas | Stomach Adenocarcinoma | CCDC53 | 0.04 | 0.07 | lasso | 4 | 0.06 | 2.1e-05 | 5.6 | -5.6 | 2.8e-08 | 0.09 | 0.79 | 0.05 | FALSE |