Best TWAS P=1.08e-08 · Best GWAS P=1.37e-08 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | RP11-412D9.4 | 0.22 | 0.13 | lasso | 5 | 0.13 | 5.1e-11 | -5.1 | 5.6 | 1.8e-08 | -0.94 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Artery Tibial | RP11-412D9.4 | 0.06 | 0.05 | lasso | 3 | 0.06 | 2.9e-05 | -5.5 | 5.6 | 2.0e-08 | -0.93 | 0.01 | 0.98 | FALSE |
| 3 | GTEx | Breast Mammary Tissue | RP11-412D9.4 | 0.23 | 0.26 | lasso | 4 | 0.26 | 9.7e-14 | -5.5 | 5.4 | 7.8e-08 | -0.97 | 0.00 | 1.00 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | RP11-412D9.4 | 0.12 | 0.10 | lasso | 4 | 0.09 | 2.1e-07 | -5.1 | 5.7 | 1.5e-08 | -0.91 | 0.01 | 0.99 | FALSE |
| 5 | GTEx | Nerve Tibial | C12orf23 | 0.09 | 0.12 | enet | 10 | 0.12 | 1.1e-08 | -5.7 | 5.7 | 1.4e-08 | -0.97 | 0.00 | 1.00 | FALSE |
| 6 | GTEx | Nerve Tibial | RP11-412D9.4 | 0.18 | 0.18 | enet | 11 | 0.20 | 5.6e-14 | -5.1 | 5.5 | 3.2e-08 | -0.95 | 0.01 | 0.99 | FALSE |
| 7 | GTEx | Pancreas | RP11-412D9.4 | 0.09 | 0.06 | enet | 12 | 0.06 | 1.2e-03 | -5.7 | 5.2 | 2.2e-07 | -0.85 | 0.02 | 0.96 | FALSE |
| 8 | GTEx | Skin Sun Exposed Lower leg | C12orf23 | 0.06 | 0.04 | lasso | 3 | 0.03 | 8.0e-04 | -5.5 | 5.7 | 1.1e-08 | -0.98 | 0.01 | 0.99 | TRUE |
| 9 | GTEx | Testis | RP11-412D9.4 | 0.25 | 0.24 | lasso | 5 | 0.20 | 3.7e-09 | -5.7 | 5.7 | 1.5e-08 | -0.99 | 0.00 | 1.00 | FALSE |
| 10 | GTEx | Thyroid | RP11-412D9.4 | 0.10 | 0.10 | enet | 7 | 0.12 | 9.3e-10 | 5.2 | 5.7 | 1.1e-08 | -0.95 | 0.01 | 0.99 | FALSE |
| 11 | The Cancer Genome Atlas | Breast Invasive Carcinoma | MTERFD3 | 0.02 | 0.01 | lasso | 4 | 0.01 | 1.3e-03 | -5.1 | 5.6 | 1.6e-08 | -0.89 | 0.02 | 0.90 | FALSE |
| 12 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | C12orf23 | 0.06 | 0.05 | enet | 8 | 0.05 | 5.0e-03 | -5.7 | 5.5 | 4.9e-08 | -0.93 | 0.01 | 0.75 | FALSE |