Best TWAS P=1.62e-14 · Best GWAS P=5.72e-15 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | REXO1 | 0.07 | 0.01 | bslmm | 391 | 0.01 | 1.7e-02 | -2.5 | 6.5 | 1.1e-10 | 0.16 | 0.28 | 0.03 | TRUE |
| 2 | GTEx | Artery Tibial | DOT1L | 0.09 | 0.06 | lasso | 5 | 0.05 | 7.3e-05 | 7.3 | 6.7 | 1.7e-11 | 0.78 | 0.06 | 0.93 | FALSE |
| 3 | NTR | Blood | C19orf35 | 0.03 | 0.01 | enet | 9 | 0.02 | 3.7e-07 | -2.9 | -6.3 | 3.4e-10 | -0.46 | 0.97 | 0.02 | TRUE |
| 4 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | DOT1L | 0.08 | 0.12 | enet | 8 | 0.10 | 2.5e-11 | 7.3 | 7.7 | 1.6e-14 | 0.84 | 0.02 | 0.98 | TRUE |
| 5 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | DOT1L | 0.09 | 0.08 | blup | 60 | 0.07 | 4.1e-04 | -6.4 | 7.2 | 7.1e-13 | 0.68 | 0.07 | 0.86 | TRUE |
| 6 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | JSRP1 | 0.03 | 0.00 | blup | 33 | 0.02 | 2.1e-03 | -3.7 | -6.0 | 1.7e-09 | -0.52 | 0.01 | 0.26 | FALSE |
| 7 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | DOT1L | 0.40 | -0.01 | enet | 20 | 0.03 | 3.6e-02 | -3.6 | 5.3 | 1.2e-07 | 0.50 | 0.01 | 0.19 | TRUE |