Best TWAS P=5.37e-08 · Best GWAS P=2.5e-07 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | PRMT6 | 0.19 | 0.16 | lasso | 6 | 0.16 | 5.4e-19 | 5.2 | -5.1 | 2.8e-07 | -0.99 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Colon Transverse | PRMT6 | 0.29 | 0.24 | lasso | 7 | 0.19 | 1.4e-09 | 5.0 | -5.2 | 2.3e-07 | -0.96 | 0.01 | 0.99 | FALSE |
| 3 | GTEx | Heart Left Ventricle | PRMT6 | 0.16 | 0.12 | enet | 9 | 0.13 | 2.3e-07 | 4.9 | -5.2 | 1.7e-07 | -0.88 | 0.01 | 0.98 | FALSE |
| 4 | GTEx | Liver | PRMT6 | 0.60 | 0.52 | lasso | 6 | 0.58 | 1.0e-19 | 5.0 | -5.3 | 1.0e-07 | -0.99 | 0.01 | 0.99 | FALSE |
| 5 | GTEx | Muscle Skeletal | PRMT6 | 0.32 | 0.16 | enet | 13 | 0.16 | 2.8e-15 | 5.0 | -5.4 | 5.7e-08 | -0.94 | 0.01 | 0.99 | FALSE |
| 6 | GTEx | Thyroid | PRMT6 | 0.19 | 0.17 | enet | 14 | 0.19 | 1.7e-14 | 5.0 | -5.4 | 5.4e-08 | -0.97 | 0.01 | 0.99 | TRUE |
| 7 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | PRMT6 | 0.13 | 0.10 | lasso | 4 | 0.10 | 2.0e-08 | 5.0 | -5.1 | 2.9e-07 | -0.97 | 0.01 | 0.99 | FALSE |
| 8 | The Cancer Genome Atlas | Esophageal Carcinoma | PRMT6 | 0.33 | 0.26 | lasso | 3 | 0.25 | 2.0e-08 | 5.0 | -5.1 | 2.7e-07 | -0.97 | 0.01 | 0.99 | FALSE |
| 9 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | PRMT6 | 0.11 | 0.12 | enet | 7 | 0.12 | 2.3e-13 | 5.0 | -5.2 | 2.3e-07 | -0.96 | 0.01 | 0.99 | FALSE |
| 10 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | PRMT6 | 0.09 | 0.08 | blup | 36 | 0.08 | 3.3e-06 | 5.0 | -5.3 | 8.9e-08 | -0.94 | 0.01 | 0.99 | FALSE |