Best TWAS P=2.15e-11 · Best GWAS P=1.07e-10 conditioned to 0.203
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Cells Transformed fibroblasts | BRD3 | 0.29 | 0.23 | lasso | 4 | 0.27 | 3.7e-20 | -4.7 | 5.2 | 1.7e-07 | -0.01 | 0.00 | 0.99 | TRUE |
2 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ABO | 0.07 | 0.08 | lasso | 3 | 0.08 | 5.0e-16 | 5.9 | 5.9 | 4.7e-09 | 0.93 | 0.06 | 0.94 | FALSE |
3 | The Cancer Genome Atlas | Colon Adenocarcinoma | ABO | 0.27 | 0.31 | blup | 43 | 0.33 | 2.1e-19 | 5.8 | 5.6 | 1.9e-08 | 0.87 | 0.01 | 0.99 | FALSE |
4 | The Cancer Genome Atlas | Esophageal Carcinoma | ABO | 0.27 | 0.13 | lasso | 2 | 0.11 | 1.8e-04 | 5.8 | 5.8 | 6.6e-09 | 0.93 | 0.01 | 0.96 | FALSE |
5 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | ABO | 0.31 | 0.38 | lasso | 5 | 0.42 | 3.1e-26 | 6.5 | 6.1 | 1.1e-09 | 0.97 | 0.00 | 1.00 | FALSE |
6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ABO | 0.26 | 0.23 | enet | 10 | 0.26 | 6.0e-29 | 5.9 | 5.9 | 3.4e-09 | 0.87 | 0.06 | 0.94 | FALSE |
7 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | ABO | 0.23 | 0.23 | lasso | 2 | 0.24 | 2.2e-11 | 6.5 | 6.4 | 1.2e-10 | 1.00 | 0.00 | 1.00 | FALSE |
8 | The Cancer Genome Atlas | Lung Adenocarcinoma | ABO | 0.21 | 0.25 | lasso | 5 | 0.25 | 2.1e-29 | 5.9 | 6.0 | 1.5e-09 | 0.97 | 0.01 | 0.99 | FALSE |
9 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | ABO | 0.28 | 0.22 | lasso | 8 | 0.22 | 1.2e-14 | 5.9 | 5.9 | 2.9e-09 | 0.94 | 0.01 | 0.99 | FALSE |
10 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | ABO | 0.23 | 0.21 | lasso | 5 | 0.20 | 6.7e-09 | 6.5 | 5.9 | 2.8e-09 | 0.96 | 0.00 | 1.00 | FALSE |
11 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | ABO | 0.23 | 0.23 | lasso | 3 | 0.23 | 2.0e-09 | 5.8 | 6.0 | 2.3e-09 | 0.95 | 0.01 | 0.99 | FALSE |
12 | The Cancer Genome Atlas | Rectum Adenocarcinoma | ABO | 0.48 | 0.23 | enet | 10 | 0.27 | 4.7e-07 | 6.4 | 6.7 | 2.2e-11 | 0.89 | 0.00 | 0.98 | TRUE |
13 | The Cancer Genome Atlas | Soft Tissue Sarcoma | ABO | 0.32 | 0.18 | enet | 10 | 0.20 | 2.3e-12 | 5.9 | 5.2 | 2.3e-07 | 0.85 | 0.00 | 1.00 | FALSE |
14 | The Cancer Genome Atlas | Stomach Adenocarcinoma | ABO | 0.20 | 0.10 | blup | 42 | 0.18 | 5.8e-13 | 5.9 | 5.2 | 2.2e-07 | 0.83 | 0.00 | 1.00 | FALSE |
15 | The Cancer Genome Atlas | Thyroid Carcinoma | ABO | 0.44 | 0.57 | enet | 18 | 0.60 | 1.9e-73 | 5.9 | 6.0 | 2.4e-09 | 0.97 | 0.00 | 1.00 | FALSE |