Best TWAS P=2.64e-10 · Best GWAS P=4.72e-10 conditioned to 0.213
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | RALGPS1 | 0.08 | 0.07 | enet | 27 | 0.09 | 3.8e-11 | -6.2 | -6.3 | 2.6e-10 | 0.90 | 0.02 | 0.98 | TRUE |
2 | GTEx | Brain Cerebellum | RALGPS1 | 0.28 | 0.17 | lasso | 7 | 0.19 | 2.8e-06 | -5.4 | -5.6 | 2.5e-08 | 0.89 | 0.06 | 0.93 | FALSE |
3 | GTEx | Skin Sun Exposed Lower leg | RALGPS1 | 0.06 | 0.02 | lasso | 6 | 0.01 | 2.5e-02 | 4.9 | 5.6 | 2.0e-08 | -0.74 | 0.17 | 0.75 | FALSE |
4 | GTEx | Testis | RALGPS1 | 0.23 | 0.32 | lasso | 9 | 0.29 | 2.7e-13 | 5.4 | 5.6 | 1.9e-08 | -0.85 | 0.11 | 0.89 | FALSE |
5 | GTEx | Thyroid | RP11-339B21.13 | 0.11 | 0.00 | enet | 17 | 0.00 | 1.7e-01 | 2.3 | 5.4 | 6.6e-08 | 0.00 | 0.01 | 0.03 | TRUE |
6 | GTEx | Whole Blood | RALGPS1 | 0.10 | 0.10 | enet | 10 | 0.08 | 1.2e-07 | -5.7 | 5.4 | 5.6e-08 | -0.89 | 0.06 | 0.94 | FALSE |
7 | YFS | Blood | RALGPS1 | 0.08 | 0.13 | lasso | 18 | 0.15 | 1.1e-45 | 4.8 | 5.7 | 1.5e-08 | -0.75 | 0.80 | 0.20 | FALSE |
8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ANGPTL2 | 0.02 | 0.01 | lasso | 2 | 0.01 | 6.2e-02 | -5.7 | 5.3 | 1.2e-07 | -0.89 | 0.04 | 0.44 | FALSE |
9 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | ANGPTL2 | 0.10 | 0.08 | blup | 38 | 0.09 | 2.8e-04 | -5.5 | -5.7 | 1.1e-08 | 0.84 | 0.06 | 0.76 | FALSE |