[Hub]/) : Traits : Arm fat percentage (left) :

chr11:26,818,083-29,054,545

Best TWAS P=8.41e-21 · Best GWAS P=1.48e-28 conditioned to 1.33e-05

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous LIN7C 0.08 0.06 lasso 1 0.04 4.1e-04 9.26 9.3 2.1e-20 0.63 0.74 0.14 FALSE
2 GTEx Brain Putamen basal ganglia BDNF-AS 0.22 0.17 lasso 4 0.13 5.5e-04 -6.52 7.7 1.3e-14 0.33 0.23 0.05 TRUE
3 GTEx Cells Transformed fibroblasts LIN7C 0.26 0.22 lasso 6 0.25 1.4e-18 9.26 7.6 3.0e-14 0.62 1.00 0.00 FALSE
4 GTEx Esophagus Muscularis LIN7C 0.14 0.08 enet 11 0.07 5.4e-05 2.74 6.5 7.9e-11 0.60 0.70 0.15 FALSE
5 GTEx Liver METTL15 0.18 0.05 lasso 3 0.09 1.9e-03 -0.43 -6.9 5.6e-12 -0.68 0.02 0.83 FALSE
6 GTEx Nerve Tibial LIN7C 0.18 0.08 enet 27 0.12 4.2e-09 9.26 6.3 2.7e-10 0.56 0.61 0.36 FALSE
7 GTEx Thyroid LIN7C 0.08 0.04 lasso 4 0.04 6.0e-04 9.26 8.9 5.1e-19 0.69 0.52 0.36 FALSE
8 NTR Blood LIN7C 0.01 0.00 lasso 3 0.01 2.2e-03 9.56 -9.3 8.4e-21 -0.72 0.10 0.80 TRUE
9 ROSMAP Brain Pre-frontal Cortex METTL15 0.04 0.03 blup 364 0.03 4.6e-05 -2.96 -5.2 2.6e-07 -0.19 0.72 0.01 TRUE
10 The Cancer Genome Atlas Bladder Urothelial Carcinoma LIN7C 0.04 0.01 lasso 3 0.02 1.0e-02 -1.70 5.6 2.5e-08 0.46 0.02 0.82 FALSE
11 The Cancer Genome Atlas Colon Adenocarcinoma LIN7C 0.10 0.03 blup 32 0.08 2.8e-05 9.56 7.3 2.3e-13 0.57 0.01 0.95 FALSE
12 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma LIN7C 0.05 0.02 lasso 3 0.03 2.9e-04 9.55 8.5 2.6e-17 0.63 0.01 0.98 FALSE