Best TWAS P=8.41e-21 · Best GWAS P=1.48e-28 conditioned to 1.33e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | LIN7C | 0.08 | 0.06 | lasso | 1 | 0.04 | 4.1e-04 | 9.26 | 9.3 | 2.1e-20 | 0.63 | 0.74 | 0.14 | FALSE |
| 2 | GTEx | Brain Putamen basal ganglia | BDNF-AS | 0.22 | 0.17 | lasso | 4 | 0.13 | 5.5e-04 | -6.52 | 7.7 | 1.3e-14 | 0.33 | 0.23 | 0.05 | TRUE |
| 3 | GTEx | Cells Transformed fibroblasts | LIN7C | 0.26 | 0.22 | lasso | 6 | 0.25 | 1.4e-18 | 9.26 | 7.6 | 3.0e-14 | 0.62 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Esophagus Muscularis | LIN7C | 0.14 | 0.08 | enet | 11 | 0.07 | 5.4e-05 | 2.74 | 6.5 | 7.9e-11 | 0.60 | 0.70 | 0.15 | FALSE |
| 5 | GTEx | Liver | METTL15 | 0.18 | 0.05 | lasso | 3 | 0.09 | 1.9e-03 | -0.43 | -6.9 | 5.6e-12 | -0.68 | 0.02 | 0.83 | FALSE |
| 6 | GTEx | Nerve Tibial | LIN7C | 0.18 | 0.08 | enet | 27 | 0.12 | 4.2e-09 | 9.26 | 6.3 | 2.7e-10 | 0.56 | 0.61 | 0.36 | FALSE |
| 7 | GTEx | Thyroid | LIN7C | 0.08 | 0.04 | lasso | 4 | 0.04 | 6.0e-04 | 9.26 | 8.9 | 5.1e-19 | 0.69 | 0.52 | 0.36 | FALSE |
| 8 | NTR | Blood | LIN7C | 0.01 | 0.00 | lasso | 3 | 0.01 | 2.2e-03 | 9.56 | -9.3 | 8.4e-21 | -0.72 | 0.10 | 0.80 | TRUE |
| 9 | ROSMAP | Brain Pre-frontal Cortex | METTL15 | 0.04 | 0.03 | blup | 364 | 0.03 | 4.6e-05 | -2.96 | -5.2 | 2.6e-07 | -0.19 | 0.72 | 0.01 | TRUE |
| 10 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | LIN7C | 0.04 | 0.01 | lasso | 3 | 0.02 | 1.0e-02 | -1.70 | 5.6 | 2.5e-08 | 0.46 | 0.02 | 0.82 | FALSE |
| 11 | The Cancer Genome Atlas | Colon Adenocarcinoma | LIN7C | 0.10 | 0.03 | blup | 32 | 0.08 | 2.8e-05 | 9.56 | 7.3 | 2.3e-13 | 0.57 | 0.01 | 0.95 | FALSE |
| 12 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LIN7C | 0.05 | 0.02 | lasso | 3 | 0.03 | 2.9e-04 | 9.55 | 8.5 | 2.6e-17 | 0.63 | 0.01 | 0.98 | FALSE |