TWAS
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Traits
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Arm fat mass (left)
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chr12:49,569,311-51,256,065
Best TWAS P=6.56e-19 · Best GWAS P=2.7e-31 conditioned to 4.16e-07
49.6M
49.8M
50M
50.2M
50.4M
50.6M
50.8M
51M
51.2M
0
5
10
15
20
25
30
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Testis
FAIM2
0.27
0.09
lasso
5
0.06
0.00093
9.74
-8.9
6.6e-19
-0.77
0.05
0.84
TRUE
3
The Cancer Genome Atlas
Breast Invasive Carcinoma
FAIM2
0.02
0.00
blup
71
0.01
0.00853
-0.12
-5.9
3.3e-09
-0.36
0.16
0.13
TRUE
1
GTEx
Breast Mammary Tissue (Female)
CERS5
0.09
0.03
lasso
3
0.05
0.01750
-1.29
-5.6
2.5e-08
-0.53
0.05
0.22
FALSE