Hub : Genes

FAIM2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0870	0.0360	6.4e-04	-0.002	0.023	0.023	0.026	0.006	7.2e-01	7.5e-04	7.3e-04	3.7e-04	4.8e-02
2	GTEx	Artery Tibial	0.1662	0.0603	5.3e-03	0.032	NA	0.030	NA	0.029	1.3e-03	NA	1.9e-03	NA	2.1e-03
3	GTEx	Cells Transformed fibroblasts	0.4060	0.0630	4.4e-11	0.180	NA	0.244	NA	0.224	1.7e-13	NA	2.5e-18	NA	9.7e-17
4	GTEx	Testis	0.2720	0.0930	2.6e-03	0.091	NA	0.058	NA	0.063	7.7e-05	NA	1.5e-03	NA	9.3e-04
5	METSIM	Adipose	0.1458	0.0368	8.4e-08	0.071	0.067	0.055	0.071	0.067	7.4e-11	2.5e-10	9.5e-09	8.9e-11	3.1e-10
6	TCGA	Bladder Urothelial Carcinoma	0.1190	0.0430	1.5e-04	0.054	0.039	0.029	NA	0.038	2.3e-05	2.8e-04	1.7e-03	NA	3.6e-04
7	TCGA	Breast Invasive Carcinoma	0.0227	0.0109	2.9e-03	0.000	0.008	0.004	NA	0.002	4.0e-01	8.5e-03	3.8e-02	NA	1.0e-01
8	TCGA	Head and Neck Squamous Cell Carcinoma	0.1026	0.0316	2.3e-08	0.088	0.076	0.099	NA	0.089	4.0e-10	6.8e-09	3.7e-11	NA	3.1e-10
9	TCGA	Kidney Renal Clear Cell Carcinoma	0.1078	0.0340	2.6e-06	0.061	0.053	0.064	NA	0.058	1.8e-07	1.2e-06	9.2e-08	NA	3.9e-07
10	TCGA	Lung Squamous Cell Carcinoma	0.1261	0.0388	3.0e-08	0.084	0.090	0.081	NA	0.082	8.2e-10	1.9e-10	1.6e-09	NA	1.3e-09
11	TCGA	Prostate Adenocarcinoma	0.0661	0.0297	1.9e-03	0.024	0.013	0.009	NA	0.023	1.3e-03	1.4e-02	3.9e-02	NA	1.7e-03
12	TCGA	Thyroid Carcinoma	0.1370	0.0400	4.1e-09	0.043	0.073	0.055	NA	0.051	4.4e-05	1.2e-07	4.3e-06	NA	1.0e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Bipolar Disorder (2018)	0.8	1.2	4.0	-1.4	-2.0	-1.0	-0.1	-1.5	-1.3	-0.5	-1.0	-0.9	-0.6	-1.1	-0.4
Bipolar Disorder or Schizophrenia	0.8	1.9	5.4	-0.5	-2.3	-1.7	-0.5	-1.2	-1.9	-1.1	-1.1	-1.2	-0.8	-1.6	-1.3
Depressed Affect (Nagel 2018)	1.1	2.3	3.9	0.7	-2.0	-2.0	-1.6	-1.1	-1.4	-1.8	-0.6	-1.9	-1.6	-1.8	-0.7
Depression (Nagel 2018)	1.4	2.1	5.3	0.5	-1.2	-2.3	-0.3	-1.8	-1.3	-0.5	-1.4	-1.5	-2.0	-1.9	-1.0
Intelligence (Savage-Jansen 2018)	0.3	0.9	5.9	2.4	0.9	0.3	0.2	-0.7	-0.6	-0.6	-0.4	-0.2	-0.1	-0.2	-1.4
Neuroticism (Nagel 2018)	0.9	2.1	7.3	2.7	-1.3	-1.6	-1.8	-1.4	-1.2	-1.5	0.0	-1.3	-1.1	-1.4	-0.3
Schizophrenia (2018)	0.5	1.0	1.9	0.5	-1.4	-1.3	-0.6	-0.3	-1.3	-0.9	-0.6	-0.8	-0.6	-1.2	-1.3
Schizophrenia vs Biploar Disorder	0.4	0.5	2.3	0.6	0.3	0.0	0.9	1.5	1.1	-0.3	0.4	0.5	0.6	0.4	-0.1
Worry (Nagel 2018)	1.1	2.3	5.9	2.4	-2.1	-1.9	-0.9	-1.7	-1.2	-1.0	-0.7	-1.5	-1.4	-1.6	-0.8
Alzheimer’s Disease (in mother)	1.3	1.5	3.5	-0.7	1.9	1.0	0.7	1.2	1.2	0.8	0.8	1.6	1.1	1.3	1.6
Alzheimer’s Disease (in father)	1.4	1.5	3.1	0.0	0.6	1.8	-1.1	1.1	0.0	-0.6	1.8	1.5	1.8	1.7	0.8
Alzheimer’s Disease (including proxy)	1.5	2.2	3.9	-0.6	1.8	1.8	-0.4	1.4	0.9	0.6	1.5	1.9	2.0	1.8	1.8
Crohns Disease (2017)	0.9	1.9	5.4	0.2	1.5	1.8	-0.0	1.9	1.3	1.1	2.3	1.4	1.1	1.3	1.0
Irritable Bowel Disease (IBD)	0.5	1.2	4.2	0.3	1.1	1.2	-0.2	1.9	0.8	0.3	2.0	1.2	0.3	0.7	0.6
Ulcerative Colitis (UC)	0.1	0.3	1.0	0.3	0.5	-0.2	-0.1	0.6	-0.4	-0.8	0.2	-0.2	-1.0	-0.7	-0.3
Major Depression (MDD)	1.0	1.2	8.7	3.0	-0.2	-0.9	0.0	-0.4	-0.0	-1.5	-0.1	-0.8	-0.4	-0.7	-0.9
Reaction Time	0.9	1.7	4.8	1.9	-1.7	-1.5	-0.6	-0.5	-1.6	-2.2	-0.5	-0.6	-0.7	-1.0	-1.1
Verbal and Numeric Reasoning (VNR)	1.1	2.6	6.3	2.1	0.2	-1.0	0.6	-1.5	-2.1	-1.1	-1.6	-1.7	-1.9	-1.7	-2.5
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	4.4	5.8	10.0	-0.1	-3.0	-3.2	-0.2	-2.9	-2.4	-1.7	-2.7	-2.7	-2.9	-2.7	-2.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	2.7	3.9	8.1	0.7	1.4	2.1	-2.1	0.9	1.8	2.6	2.7	0.9	2.9	2.4	1.7
Bipolar Disorder (2011)	0.2	0.2	0.7	-0.6	0.2	0.2	0.0	-0.4	0.1	0.7	0.2	0.2	0.8	0.4	0.2
Body Mass Index (BMI) (2010)	3.8	5.2	31.4	2.8	0.1	-0.4	-5.6	-0.2	0.8	-3.2	1.2	-1.4	1.6	0.3	2.6
Coronary Artery Disease (CAD)	3.2	3.8	7.3	0.2	-1.9	-2.0	-2.0	-2.1	-2.7	-1.9	-1.9	-2.2	-1.9	-2.2	-1.5
Crohns Disease (2012)	2.1	3.4	5.7	-1.3	2.4	2.0	1.1	1.8	2.1	2.2	1.8	2.2	1.5	1.8	1.3
Mean Putamen Volume	0.9	1.1	3.7	0.1	0.4	-1.9	0.6	-1.0	-0.9	0.5	-1.6	-0.9	-0.7	-1.3	-1.0
Fasting Glucose	0.1	0.1	0.7	0.3	0.0	0.2	-0.8	0.1	-0.5	-0.1	-0.1	-0.3	-0.3	0.3	-0.3
HbA1C	0.4	0.4	2.4	-0.6	-0.3	-0.1	0.1	0.6	-1.1	0.8	0.2	0.2	0.3	-0.1	-1.5
HDL Cholesterol	1.6	2.7	6.2	0.3	-1.0	-1.1	1.8	-2.5	-2.0	-0.8	-2.1	-1.1	-1.6	-1.6	-2.2
LDL Cholesterol	0.2	0.3	1.3	-0.5	1.1	0.4	-1.2	0.1	-0.1	0.4	-0.3	-0.8	-0.2	-0.1	0.4
Lupus	0.6	0.9	2.0	-0.2	-0.7	-0.1	0.9	-1.4	-1.4	-0.7	-1.0	-0.7	-0.8	-1.0	-1.3
Neuroticism (2016)	1.3	1.8	5.5	2.2	-0.1	-1.3	0.0	-2.3	-1.0	-1.4	-0.8	-1.4	-1.4	-1.3	-0.8
Primary Biliary Cirrhosis	0.5	0.7	2.0	-0.6	0.6	1.1	-0.6	1.0	0.5	0.1	1.0	0.7	1.4	1.0	0.6
Rheumatoid Arthritis	0.4	0.6	1.6	-0.5	-0.8	-0.8	-0.1	-0.6	-0.3	-0.3	-1.1	-1.2	-1.0	-1.0	0.2
Schizophrenia (2014)	0.3	0.6	1.5	0.5	-1.2	-1.2	-0.8	-0.4	-0.6	-0.9	-0.2	-0.9	-0.4	-1.0	-0.6
Triglycerides	1.3	2.1	4.0	-0.8	2.0	1.7	-0.6	1.4	2.0	0.8	1.5	0.9	1.0	1.6	2.0
Type 2 Diabetes (T2D) (2012)	0.4	0.5	2.3	0.4	0.4	0.3	-1.2	-0.1	0.1	-1.5	0.0	-1.0	0.0	-0.4	0.3
Ulcerative Colitis	0.2	0.3	1.2	0.8	0.9	0.0	0.2	0.2	-0.3	-0.5	0.2	-0.1	-0.4	-0.4	-1.1
Blood Eosinophil Count	0.1	0.6	4.7	0.7	0.0	0.2	-2.2	-0.2	-0.5	-0.2	1.1	0.1	0.8	0.5	-0.6
Blood Platelet Count	0.1	0.8	3.1	-1.3	-1.8	0.5	-1.5	-0.6	-0.6	-0.1	0.6	-0.7	-0.8	-0.1	-0.5
Blood Red Count	0.3	3.0	9.3	3.1	2.4	-0.3	-1.9	1.9	1.4	-0.4	2.1	0.5	2.0	1.2	1.0
Blood White Count	0.2	1.2	8.1	-2.8	-0.2	1.1	0.0	-0.5	0.6	0.6	1.2	0.8	0.6	1.0	-0.7
Heel T-Score	0.9	7.0	18.7	2.1	0.3	1.8	-4.3	3.1	3.1	-0.5	2.4	0.4	3.1	2.0	4.3
BMI	4.1	23.8	132.2	5.6	-2.7	-1.3	-11.5	-1.3	0.0	-8.3	1.1	-4.7	2.6	-0.9	3.4
Height	0.2	4.6	25.4	5.0	1.5	-0.9	-3.7	-0.8	0.5	-0.7	0.7	-1.1	1.7	0.2	2.6
Waist Hip Ratio (WHR)	0.4	1.7	4.7	-2.2	-1.1	-1.3	1.8	0.3	-0.1	-0.3	-1.6	0.0	-1.9	-1.2	-1.5
Systolic Blood Pressure	1.1	5.4	30.1	-5.5	-0.9	1.2	3.3	1.6	2.1	2.5	0.2	1.2	2.1	1.4	-0.9
Smoking Status	0.7	1.8	15.3	-3.9	-0.5	0.1	1.1	0.7	0.4	1.8	-0.2	-0.4	-0.3	0.5	0.3
Allergy or Eczema	0.9	2.4	7.0	-1.9	1.9	1.6	0.6	0.2	1.9	2.6	0.7	0.3	1.7	1.4	1.6
Cardiovascular Disease	0.6	2.0	6.1	-1.7	0.0	0.8	-2.2	1.5	1.5	-1.2	1.1	-0.4	2.5	1.0	0.8
Hypothyroidism (self reported)	0.3	0.7	3.1	0.2	-0.1	0.2	-1.8	-1.0	-0.4	-1.0	0.4	-0.4	0.9	0.4	1.2
Respiratory disease	0.5	1.1	2.5	-1.2	-0.1	0.6	0.3	1.4	1.6	1.4	1.2	0.9	1.5	0.9	0.4
Type 2 Diabetes (T2D) (2018)	0.3	0.6	4.3	-0.7	-0.5	-0.5	-0.4	-0.3	-0.0	-2.1	-0.0	-0.6	-0.1	-0.5	-0.9
Lung FEV1/FVC ratio	0.3	1.3	6.8	2.5	0.6	-0.0	-1.3	-0.1	-0.4	-2.6	0.6	0.2	-0.2	-0.4	0.0
Lung FVC	0.3	1.5	8.4	2.9	0.2	0.8	-1.6	-1.9	-0.9	-0.1	0.4	0.5	0.9	0.8	0.5
Neuroticism	2.0	4.8	10.8	3.3	-1.0	-2.5	-2.3	-3.0	-1.9	-2.0	-1.1	-2.6	-2.0	-2.3	-1.0
Chronotype (morning person)	0.2	0.4	1.0	0.2	0.2	-0.4	-0.4	-1.0	-0.8	-1.0	-0.7	-0.5	0.3	-0.7	-0.6
Hair Pigment	0.1	1.6	6.4	-2.5	-0.3	1.4	1.1	1.1	0.7	2.2	0.8	0.6	1.0	1.0	-0.2
Tanning	0.2	2.3	4.5	-0.8	-1.5	-1.8	0.5	-1.6	-0.8	-0.8	-2.1	-1.8	-2.0	-2.1	-1.1
Hand grip strength (left)	0.9	2.4	5.7	-0.4	1.8	2.0	-1.2	0.2	0.9	1.3	1.8	0.8	1.9	2.0	2.4
Number of treatments/medications taken	2.1	3.7	12.4	0.9	-2.7	-1.9	-1.5	-1.6	-1.2	-3.5	-1.1	-2.6	-0.8	-1.7	-1.4
Average weekly spirits intake	1.9	2.3	4.1	0.2	-1.7	-1.4	0.8	-2.0	-1.7	-1.7	-1.9	-1.6	-1.2	-1.7	-1.3
Sensitivity / hurt feelings	0.1	0.2	0.9	0.0	0.8	-0.3	0.7	-1.0	-0.0	-0.1	-0.3	-0.1	-0.3	-0.3	0.2
Frequency of depressed mood in last 2 weeks	1.7	2.4	5.5	0.0	-1.4	-2.2	0.4	-1.6	-1.3	-1.0	-1.6	-1.4	-2.3	-2.1	-1.6
Hearing difficulty/problems: Yes	0.6	0.9	3.2	-0.5	-1.1	0.3	1.4	1.4	-0.1	-0.0	1.0	1.8	0.7	0.5	-0.8
Relative age of first facial hair	0.7	1.4	5.1	-2.2	0.9	0.0	2.2	0.0	-0.2	1.9	-0.7	0.9	-0.7	0.2	-0.3
Other serious medical condition/disability diagnosed by doctor	2.8	3.6	9.4	0.1	-2.6	-1.9	1.0	-1.5	-2.2	-1.8	-2.0	-0.7	-2.0	-1.9	-3.1
Ever used hormone-replacement therapy (HRT)	1.9	2.4	7.0	-1.1	-2.1	-1.2	2.3	1.2	-1.2	-1.2	-0.9	0.1	-1.7	-1.1	-2.6
Ever had hysterectomy (womb removed)	1.6	1.8	11.5	-3.4	-0.3	0.8	2.0	1.4	0.7	1.4	0.2	0.4	-0.2	0.4	-0.1
Systolic blood pressure, automated reading	1.3	3.8	19.9	-4.5	-0.9	1.1	2.2	2.0	1.8	2.0	0.6	1.5	1.6	1.3	-0.7
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	1.5	0.5	-1.2	-1.2	-0.6	-0.4	-0.8	-1.2	-0.4	-1.0	-0.7	-1.0	-0.9
Angina	0.3	0.4	1.4	-1.0	-0.6	-0.3	-0.2	1.2	0.3	-1.2	-0.1	0.1	-0.1	-0.3	-0.5
Medication for hormone replacement therapy	1.8	2.0	7.0	-1.6	0.7	1.2	0.6	2.7	1.5	1.2	1.0	1.4	1.8	1.5	0.4
Vitamin and mineral supplements	1.0	1.4	5.3	1.6	-0.4	0.1	-2.3	-1.1	-0.9	-1.2	-0.3	-2.0	-0.0	-0.6	0.7
Supplements: Zinc	0.5	0.5	1.6	1.2	-0.1	0.5	1.1	0.3	-0.3	0.4	0.5	1.3	0.2	0.3	-0.9
Medication: Co-codamol	0.6	0.7	2.1	-1.2	-1.0	-0.9	0.4	-0.5	-0.4	-0.3	-0.5	-0.5	-1.4	-1.0	-1.1
Medication: Metformin	0.5	0.7	1.9	-0.8	-1.2	-0.3	-1.4	-0.6	-0.7	-1.3	0.4	-1.1	0.1	-0.3	-0.6
Diabetes (father)	0.8	0.9	2.2	0.5	0.6	0.9	-0.1	1.0	0.9	1.5	1.5	0.8	1.4	0.9	0.0
Diabetes (mother)	0.5	0.6	2.3	0.5	-1.0	-0.7	-1.2	0.2	-0.0	-1.5	-0.3	-0.7	-0.8	-0.6	0.2
Severe depression (siblings)	3.3	3.7	8.6	1.3	-1.4	-2.3	-0.1	-2.2	-2.1	-1.6	-1.5	-2.1	-2.9	-2.2	-1.8
Pack years adult smoking proportion	3.0	4.5	13.4	-1.1	-3.7	-1.9	0.3	-1.1	-2.3	-1.7	-2.4	-2.1	-1.9	-2.2	-2.8
Impedance of leg (right)	2.4	11.6	66.9	-3.2	2.6	0.1	8.2	1.4	1.4	5.8	-0.3	3.5	-0.7	0.8	-2.1
Leg fat-free mass (left)	3.2	17.1	94.9	5.3	-1.8	-0.9	-9.7	-1.6	0.0	-6.5	0.7	-3.9	2.1	-0.7	3.5
Trunk fat percentage	2.2	8.8	44.0	2.6	-2.0	-0.3	-6.6	-0.3	1.7	-4.9	0.9	-2.6	2.4	0.0	3.2
Hand grip strength (right)	0.4	1.2	2.7	-0.2	1.4	1.1	-1.6	-0.0	0.5	0.6	1.2	0.6	1.2	1.3	1.5
Townsend deprivation index at recruitment	0.5	0.8	5.2	1.1	-0.3	-0.1	-2.3	-0.2	-0.9	-0.1	0.3	-1.0	-0.1	-0.3	0.8
Current tobacco smoking	1.1	1.8	6.9	-2.6	-1.0	-0.8	1.6	-0.8	-1.1	1.0	-1.3	-1.2	-1.3	-1.0	-1.4
Average weekly fortified wine intake	0.2	0.2	0.8	-0.2	0.9	-0.3	0.2	-0.6	0.2	-0.1	-0.9	-0.2	-0.5	-0.3	0.6
Maternal smoking around birth	1.2	1.7	10.5	-3.2	-0.4	-0.5	2.0	1.7	0.6	1.2	0.1	0.9	0.1	0.0	-0.6
Fed-up feelings	1.4	2.6	5.5	-0.2	-1.4	-2.3	-0.0	-1.3	-1.5	-1.4	-1.4	-1.9	-2.2	-2.1	-1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.4	4.2	-0.3	-0.1	-2.0	0.5	-1.6	-0.5	-0.1	-1.4	-1.4	-1.8	-1.5	-0.6
Relative age voice broke	0.8	1.2	2.8	-0.6	0.4	-0.9	1.6	-1.7	-1.2	0.6	-1.3	-0.1	-1.1	-0.9	-1.4
Taking other prescription medications	0.7	1.1	6.5	-0.2	-2.5	-1.3	0.5	-0.5	-0.0	-1.7	-0.3	-0.7	-0.4	-0.7	-0.8
Age when periods started (menarche)	1.4	3.4	21.0	-2.0	1.3	-0.1	4.6	-0.2	-0.0	2.1	-1.4	1.3	-2.0	-0.3	-1.3
Bilateral oophorectomy (both ovaries removed)	1.7	1.9	4.4	-1.6	-0.0	1.7	1.5	2.1	1.6	0.8	1.4	1.6	1.2	1.4	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	5.2	2.0	-0.5	-0.4	-2.3	1.3	-0.1	-0.9	0.4	-0.6	0.7	-0.3	0.3
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	2.9	-0.4	-0.3	0.7	1.7	-0.6	-1.5	1.0	0.0	0.1	0.2	-0.1	-1.6
Qualifications: CSEs or equivalent	0.6	0.7	2.0	-1.3	0.5	-0.5	1.1	1.4	1.4	0.6	0.0	0.9	-0.1	0.4	0.6
Serious illness, injury or assault to yourself	1.3	1.6	3.8	1.5	-0.2	-1.6	-0.4	-0.4	-1.7	-1.3	-0.5	-0.4	-1.9	-1.3	-1.8
High blood pressure	0.3	0.7	3.5	-0.4	-0.7	-0.6	-1.3	0.2	-0.1	-1.9	-0.1	-0.9	0.9	-0.4	-1.0
Hayfever, allergic rhinitis or eczema	0.5	1.2	4.7	-1.4	1.5	0.8	-0.2	-0.7	0.8	2.2	0.0	-0.9	0.6	0.6	1.4
Multivitamins +/- minerals	0.6	0.7	2.5	-1.3	-0.5	-0.1	1.2	1.1	0.5	0.7	0.4	1.6	0.6	0.5	-0.7
Stomach or abdominal pain in last month	1.3	1.6	3.7	-0.0	-0.3	-1.9	0.2	-1.8	-1.6	-0.6	-1.6	-1.3	-1.2	-1.5	-1.2
Supplements: Glucosamine	0.8	1.0	4.6	2.1	-0.2	-1.0	-1.6	-1.3	-0.8	-0.7	-0.1	-0.4	0.0	-0.7	0.2
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	2.3	0.4	-1.3	-1.2	0.2	-1.3	-0.9	-1.5	-0.8	-0.7	-0.6	-0.9	-1.2
Medication: Atenolol	0.2	0.2	0.6	-0.4	-0.0	-0.3	-0.0	-0.5	-0.7	-0.6	-0.3	-0.4	-0.2	-0.5	-0.8
Medication: Levothyroxine sodium	0.7	1.1	3.1	-0.8	0.7	1.2	-1.6	0.3	0.4	-0.3	1.1	0.3	1.6	1.1	1.8
Sitting height	0.2	1.5	5.9	2.4	0.7	-1.3	-1.1	-1.5	-0.4	-1.3	-1.0	-1.4	-0.7	-0.9	0.1
Chronic bronchitis/emphysema (father)	1.1	1.3	6.7	-1.6	-1.1	-0.1	2.6	-0.1	-0.9	0.0	-0.4	0.3	-1.3	-0.8	-1.4
High blood pressure (mother)	0.6	0.9	2.9	-1.7	0.1	0.6	-0.8	1.0	1.0	1.1	0.5	-0.7	1.5	0.7	0.4
Body mass index (BMI)	3.0	13.0	68.8	2.9	-3.2	0.4	-8.3	-0.1	1.1	-6.0	1.6	-2.8	3.1	0.4	3.3
Impedance of leg (left)	2.2	10.9	60.4	-3.3	2.9	0.3	7.8	1.6	1.3	5.6	-0.5	3.2	-0.9	0.8	-1.6
Leg predicted mass (left)	3.2	17.1	93.8	5.4	-1.9	-0.9	-9.7	-1.7	-0.1	-6.6	0.6	-4.0	2.0	-0.8	3.3
Trunk fat mass	3.1	13.2	65.9	4.1	-2.1	-0.5	-8.1	-0.7	1.5	-6.0	1.0	-3.1	2.7	-0.1	3.6
Waist circumference	2.6	9.5	49.8	2.6	-2.8	-0.5	-7.1	-0.2	0.9	-5.4	1.0	-2.4	2.1	-0.2	2.7
Number of incorrect matches in round	0.7	1.1	5.7	1.0	0.1	0.1	-1.8	0.8	1.2	-0.1	0.9	0.7	-0.0	0.8	2.4
Past tobacco smoking	0.6	1.0	3.9	2.0	-0.1	-1.1	-0.9	-0.8	-1.0	-1.0	-0.8	-0.4	-1.0	-1.3	-0.5
Alcohol usually taken with meals	0.6	1.0	7.3	1.6	0.9	-0.2	-2.7	-0.4	-0.6	-0.9	0.5	-0.0	0.4	-0.0	0.5
Nervous feelings	2.0	3.7	7.0	0.7	-1.8	-2.6	1.3	-2.0	-1.8	-1.4	-2.2	-1.4	-2.5	-2.5	-2.1
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.5	6.0	-0.5	-0.3	-1.8	1.0	-0.8	-0.3	-0.3	-1.2	-1.1	-2.4	-1.6	-1.0
Hearing difficulty/problems with background noise	0.6	0.9	2.3	-1.0	0.6	1.0	1.4	0.7	-0.1	0.9	1.1	1.5	0.6	0.9	-0.5
Hair/balding pattern: Pattern 2	0.9	1.2	4.8	-2.2	0.3	0.9	2.1	-0.3	0.0	1.5	-0.1	0.9	0.2	0.7	-0.6
Had menopause	0.2	0.3	0.8	-0.7	-0.7	-0.3	0.9	-0.1	-0.2	0.2	-0.5	0.3	-0.6	-0.3	-0.9
Had other major operations	1.1	1.4	5.6	-0.4	-0.3	-1.1	1.4	-0.1	-1.6	-1.1	-1.1	-0.3	-1.2	-1.0	-2.4
Forced vital capacity (FVC)	0.5	1.8	9.2	3.0	2.3	0.0	-1.1	-1.1	0.7	0.1	0.5	0.7	1.3	0.7	1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	6.9	2.0	0.0	-0.1	-2.6	1.8	0.5	-0.9	1.0	-0.4	1.6	0.2	0.6
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	1.8	-0.6	-1.1	-0.9	1.3	-0.5	-0.1	-0.7	-1.3	-1.4	-1.0	-0.8	-0.7
Qualifications: None of the above	2.6	5.5	14.2	0.5	-3.6	-2.6	1.9	-0.1	-2.7	-2.6	-1.6	-1.0	-2.1	-2.6	-3.8
Financial difficulties in last 2 years	0.4	0.5	1.8	1.3	0.6	0.2	-0.7	0.2	0.6	1.4	1.0	-0.2	0.7	0.5	0.2
Mouth/teeth dental problems	0.4	0.7	2.4	1.2	0.8	0.8	0.1	-0.1	0.1	0.3	1.5	1.0	1.2	0.8	0.3
Heart attack	1.1	1.5	6.5	0.9	0.6	0.6	-2.5	1.4	1.2	-0.7	1.1	0.1	0.7	0.8	1.7
Allergy	0.3	0.8	3.3	0.8	-0.5	-0.4	0.6	0.2	-0.7	-1.8	-0.4	0.8	-1.2	-0.6	-1.1
Pain all over the body in last month	1.0	1.1	2.7	0.8	-1.0	-1.3	0.3	-0.2	-0.6	-1.6	-0.8	-1.3	-1.4	-1.2	-1.1
Diabetes (self-reported)	0.7	1.1	3.6	-1.5	-1.7	-0.6	-0.7	-0.7	-0.9	-1.9	-0.6	-1.1	-0.3	-0.8	-0.9
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	1.1	-1.0	-0.4	0.6	0.5	-0.5	-0.5	1.0	0.3	0.0	0.2	0.2	-0.6
Medication: Ramipril	0.3	0.4	1.3	-1.1	0.3	0.7	-0.3	0.2	0.8	-0.5	0.4	-0.3	0.6	0.6	0.7
Medication: Simvastatin	1.1	1.6	4.9	-0.3	1.1	1.3	-1.1	1.3	1.6	0.2	1.5	0.4	2.2	1.4	1.2
Fluid intelligence score	0.5	1.1	3.5	1.9	0.5	-0.4	-0.6	-0.7	-1.3	-0.5	-0.8	-1.3	-1.0	-0.8	-1.4
Illnesses of siblings	0.2	0.3	1.3	0.6	1.1	0.4	0.5	0.2	0.1	0.2	0.6	1.1	-0.2	0.6	-0.0
Neuroticism score	1.7	3.6	7.5	2.0	-1.4	-2.3	-0.5	-2.7	-1.6	-1.2	-1.5	-2.4	-2.2	-2.2	-1.3
Weight	3.5	17.1	94.1	4.9	-2.2	-0.3	-9.7	-0.7	1.0	-6.4	1.4	-3.3	3.2	0.1	3.9
Impedance of arm (right)	0.8	3.8	17.6	-2.1	1.8	0.0	4.2	0.8	0.7	3.6	-0.6	2.2	-0.6	0.3	-0.8
Arm fat percentage (right)	2.8	11.2	57.4	2.7	-2.8	0.5	-7.6	0.2	1.9	-5.1	1.7	-2.1	3.4	0.6	3.7
Trunk fat-free mass	1.8	10.5	53.7	5.6	-0.9	-0.5	-7.3	-1.2	-0.1	-4.7	0.9	-2.2	2.0	-0.1	2.5
Hip circumference	2.4	10.5	59.3	3.6	-1.5	0.1	-7.7	-0.6	0.8	-4.8	1.4	-2.4	3.0	0.3	3.3
Time employed in main current job	0.6	0.7	1.6	1.3	0.8	1.2	-1.0	-0.2	0.4	-0.2	1.0	0.6	0.7	1.0	0.9
Alcohol intake versus 10 years previously	0.3	0.5	1.1	1.0	-1.0	-0.5	-0.5	0.7	0.1	-1.0	0.9	0.3	0.8	0.1	0.1
Father’s age at death	0.6	0.8	4.3	0.5	2.1	-0.0	-0.8	1.1	0.2	1.3	-0.2	0.3	-0.0	0.0	1.3
Worrier / anxious feelings	2.4	4.5	9.7	3.1	-1.6	-2.5	0.6	-3.0	-1.6	-1.3	-1.3	-2.1	-2.5	-2.4	-1.8
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.4	5.9	-1.5	-1.8	-1.6	1.2	-0.5	-0.6	-1.3	-1.3	-1.4	-2.4	-1.9	-1.8
Falls in the last year	1.6	2.2	5.8	-0.9	-2.4	-1.4	0.4	-1.1	-1.6	-0.7	-1.2	-0.5	-1.9	-1.6	-2.4
Hair/balding pattern: Pattern 3	0.5	0.7	2.9	-0.8	-0.3	0.3	0.5	0.9	1.4	0.7	0.4	0.4	-0.2	0.8	1.7
Number of live births	2.1	3.0	9.2	0.3	-1.9	-1.1	3.0	-0.2	-1.9	-1.2	-1.2	0.3	-2.1	-1.5	-2.9
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	8.7	3.0	2.0	0.3	-1.3	-0.7	0.8	-0.5	1.1	1.1	1.6	0.9	1.2
Pulse rate	0.3	0.4	1.0	0.1	1.0	-1.0	0.5	-0.8	0.3	-0.3	-1.0	-0.5	-0.6	-0.7	-0.4
Happiness	4.6	5.6	10.7	-3.3	0.9	2.8	-0.6	2.6	1.8	2.9	2.5	1.9	1.9	2.9	2.6
Noisy workplace	1.8	2.2	6.5	-0.4	-2.5	-1.3	1.4	-0.5	-1.1	-2.0	-1.1	-1.5	-1.3	-1.6	-1.7
Qualifications: A levels/AS levels or equivalent	0.4	0.9	2.8	1.6	1.7	0.5	-1.0	-0.2	0.7	1.2	0.6	0.5	0.4	0.6	0.9
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	1.1	-0.2	0.2	0.3	0.0	-0.3	-0.5	1.0	0.0	-0.8	-0.0	0.1	-0.5
Mouth/teeth dental problems: Dentures	1.3	2.3	7.5	-2.7	-1.4	-1.0	1.9	0.3	-0.9	-0.6	-1.7	-0.8	-2.3	-1.1	-1.3
Asthma	0.5	1.0	2.7	-0.2	-0.3	0.4	0.4	1.1	1.5	1.4	1.3	0.8	1.6	1.0	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	1.2	-1.1	-0.6	-0.1	0.4	0.4	0.7	0.5	-0.2	-0.1	-0.3	0.1	0.6
Medication: Cholesterol lowering	1.1	1.8	9.9	-0.1	-0.1	0.9	-3.1	0.7	1.0	-0.7	1.4	-0.2	1.7	1.1	1.5
Depression (self-reported)	0.2	0.3	1.3	1.1	-0.9	-0.6	0.2	0.2	0.2	-0.2	0.8	0.1	-0.4	-0.1	-0.1
Medication: Lansoprazole	5.0	5.7	11.4	1.3	-2.2	-2.9	1.2	-2.0	-2.8	-2.6	-2.5	-1.6	-2.4	-2.6	-3.4
Prospective memory result	0.4	0.5	2.1	-0.7	0.4	0.4	1.4	-0.2	-0.0	-0.0	0.4	1.3	-0.4	0.6	0.6
Lung cancer (father)	1.3	1.5	12.6	-0.5	0.3	-0.2	3.5	0.1	0.0	-0.0	-0.4	1.1	-0.8	-0.4	-1.7
Illnesses of mother	2.2	2.7	13.1	3.6	-0.6	-1.1	-0.7	-2.7	-1.9	-1.2	-0.7	-0.9	-1.3	-1.2	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	2.0	14.7	3.8	1.8	-0.2	-1.3	-0.9	-0.1	-1.0	0.8	0.6	1.1	0.4	0.4
Pulse wave Arterial Stiffness index	0.7	0.8	2.1	-0.9	0.8	1.0	1.1	0.9	0.1	1.3	1.1	1.4	0.3	0.7	0.2
Impedance of arm (left)	0.8	3.5	18.1	-1.8	2.1	-0.3	4.2	0.1	0.4	3.2	-0.8	1.7	-0.9	-0.1	-1.0
Arm fat mass (right)	3.5	14.5	79.0	3.5	-2.4	0.5	-8.9	0.0	1.9	-5.6	1.9	-2.5	3.7	0.7	4.2
Trunk predicted mass	1.8	10.2	52.3	5.5	-0.9	-0.5	-7.2	-1.1	-0.0	-4.6	1.0	-2.1	2.0	-0.1	2.5
Standing height	0.4	4.2	23.3	4.8	2.0	-1.6	-3.5	-1.2	-0.2	-1.7	-0.2	-1.1	0.5	-0.6	1.6
Length of working week for main job	1.1	1.2	2.0	-0.1	-1.4	-1.0	0.2	-0.5	-1.4	-1.1	-1.4	-0.9	-1.1	-1.3	-1.4
Exposure to tobacco smoke at home	0.5	0.6	2.9	-0.9	-1.4	0.4	-1.7	0.6	0.3	0.4	0.1	-0.0	0.2	0.1	0.7
Breastfed as a baby	0.4	0.4	2.5	0.0	-0.2	1.2	0.4	0.0	-0.5	1.6	0.4	0.3	-0.0	0.4	-0.6
Tense / ‘highly strung’	1.5	2.5	4.9	1.6	-1.6	-1.8	1.3	-1.6	-1.5	-0.6	-1.3	-0.5	-2.2	-1.8	-2.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	2.5	0.6	-1.6	-0.4	0.4	-0.3	-0.1	-0.3	0.6	0.5	0.0	-0.2	-1.3
Hair/balding pattern: Pattern 4	1.0	2.3	7.4	0.4	0.6	1.7	-2.5	1.0	0.3	0.8	2.7	1.3	2.0	1.6	0.6
Birth weight of first child	0.9	1.6	3.6	0.8	-0.8	-1.7	-0.0	-0.9	-1.2	-0.6	-1.6	-1.1	-1.8	-1.9	-1.0
Peak expiratory flow (PEF)	0.7	1.7	4.0	0.5	1.7	0.8	-1.4	0.0	1.5	0.6	1.5	1.1	2.0	1.4	1.6
Pulse wave reflection index	1.1	1.4	4.2	-1.4	-0.1	1.4	0.8	0.6	-0.1	2.1	1.2	1.5	1.4	1.2	0.4
Ever highly irritable/argumentative for 2 days	0.3	0.3	1.4	0.7	-0.4	-0.2	0.2	-0.9	-0.3	-1.2	-0.3	-0.8	-0.4	-0.3	0.2
Loud music exposure frequency	0.5	0.6	2.1	-0.3	-1.0	-0.3	-1.2	-1.0	-0.7	0.2	-0.6	-1.4	-0.3	-0.3	0.1
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	5.6	1.1	2.4	0.5	-0.4	-0.7	0.3	0.6	-0.0	-0.1	0.1	0.6	0.9
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.7	-0.1	0.4	-0.4	-0.0	-0.3	0.3	0.1	-0.9	-0.5	-0.4	-0.5	-0.4
Blood clot in the leg (DVT)	0.5	0.6	2.5	1.3	-0.9	-0.1	-1.6	0.0	-1.2	-0.4	0.7	0.1	0.4	-0.1	-0.2
Medication: Paracetamol	0.7	1.1	3.4	1.0	-1.8	-1.3	0.1	-0.6	-0.8	-1.8	-0.3	-0.7	-0.8	-0.6	-1.1
Headache pain in last month	1.1	1.9	6.4	0.1	-2.5	-0.9	0.8	-1.6	-1.5	-1.3	-1.0	-0.6	-0.5	-0.9	-2.3
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	7.0	-0.6	0.8	0.3	2.7	0.0	-0.3	1.5	-0.3	1.2	-0.7	-0.2	-1.0
Glaucoma (self-reported)	0.3	0.3	1.0	-0.5	-0.0	0.8	-0.3	-0.8	-0.8	1.0	0.1	-0.3	0.4	0.3	-0.1
Gout (self-reported)	0.9	1.2	3.1	-1.0	-0.6	1.7	0.2	0.9	0.6	1.7	1.4	0.7	1.3	1.1	0.5
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	3.3	0.8	-0.2	0.1	-1.8	-0.9	-0.5	-1.4	0.7	-0.3	1.0	0.3	1.0
Medication: Amlodipine	0.2	0.2	0.9	0.5	0.2	-0.7	-0.4	-0.6	0.3	-0.6	0.3	-1.0	0.3	-0.2	0.1
Medication: Ventolin 100micrograms inhaler	2.2	2.8	6.5	1.9	-1.3	-2.5	0.2	-1.4	-0.9	-1.2	-1.6	-2.1	-1.9	-1.9	-1.9
Birth weight	0.6	1.3	3.8	1.3	0.1	-0.5	-1.6	-1.6	-1.5	-0.4	-0.6	-2.0	-0.4	-0.9	0.8
Chronic bronchitis/emphysema (mother)	2.1	2.5	8.4	-2.9	1.0	1.3	1.3	2.5	1.5	2.0	0.8	1.6	0.6	1.1	0.2
High blood pressure (siblings)	1.2	1.8	5.2	-1.9	0.8	0.3	-1.5	0.5	1.6	1.4	0.4	-0.7	1.8	0.8	2.3
Forced vital capacity (FVC), Best measure	0.5	1.9	13.6	3.7	1.7	-0.4	-1.3	-1.6	-0.4	-0.5	0.4	0.0	1.2	0.2	0.4
Body fat percentage	2.2	8.8	43.4	2.6	-2.4	-0.1	-6.6	-0.1	1.6	-5.0	1.1	-2.4	2.5	0.1	3.1
Leg fat percentage (right)	1.7	6.0	26.7	2.2	-2.6	-0.3	-5.2	0.0	1.0	-4.6	0.9	-1.7	2.1	-0.0	1.9
Arm fat-free mass (right)	2.0	10.1	51.7	4.8	-1.1	-0.5	-7.2	-1.0	0.4	-4.9	0.9	-2.8	2.0	-0.1	2.8
Exposure to tobacco smoke outside home	3.2	4.2	7.0	1.4	-2.6	-2.6	-0.4	-1.8	-2.5	-1.6	-2.0	-2.5	-1.6	-2.3	-2.1
Comparative body size at age 10	15.2	42.0	256.0	8.7	-1.9	-0.5	-16.0	-0.5	0.5	-8.3	3.7	-4.3	4.6	0.5	6.7
Number of full brothers	0.8	1.0	3.3	0.5	-0.7	-1.3	-0.5	-1.2	-0.6	-0.4	-1.1	-1.8	-1.1	-1.2	0.2
Worry too long after embarrassment	1.3	2.1	12.1	3.5	1.4	0.1	-2.6	-0.9	-0.3	0.2	1.3	-0.5	0.0	0.3	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.7	6.8	-0.2	-2.6	-1.3	1.0	-0.7	-1.1	-1.2	-0.9	-0.4	-1.3	-1.3	-1.7
Wheeze or whistling in the chest in last year	0.3	0.6	1.9	-1.4	-1.2	-0.4	1.3	0.9	0.7	0.5	-0.3	-0.0	0.0	-0.0	-0.4
Number of children fathered	0.4	0.5	1.6	-0.0	0.8	0.3	1.3	0.7	-0.1	0.3	0.9	0.7	0.4	0.4	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	2.9	0.1	-0.2	-1.2	1.7	-0.3	-0.7	-1.4	-1.4	-0.5	-1.1	-1.2	-1.2
Age at first live birth	1.3	2.3	7.2	1.4	2.2	1.0	-1.9	-0.7	1.2	1.8	1.0	-0.4	1.1	1.2	2.7
Pulse wave peak to peak time	1.2	1.4	3.0	1.5	-0.8	-1.4	-1.5	-1.1	-0.3	-1.6	-1.2	-1.7	-0.4	-1.0	-0.2
Health satisfaction	0.4	0.5	1.6	-1.3	-0.7	0.9	-0.7	0.8	0.7	-0.6	0.5	-0.4	0.5	0.5	0.7
Shortness of breath walking on level ground	0.9	1.1	3.1	-0.8	-1.8	-1.0	-0.2	-0.7	-0.6	-0.9	-1.1	-1.8	-0.9	-1.2	-0.5
Qualifications: College or University degree	0.6	1.8	6.3	2.5	1.5	-0.4	-2.3	-1.8	-0.5	0.4	-0.2	-1.2	-1.1	-0.4	0.9
Eye problems/disorders: None of the above	0.3	0.4	1.7	-0.1	0.9	-0.1	-0.2	0.4	1.3	0.2	0.2	-0.3	0.2	0.3	1.2
Mouth/teeth dental problems: Loose teeth	1.5	1.8	3.6	0.7	1.0	0.8	-1.5	1.4	1.1	1.2	1.7	1.4	1.9	1.4	1.2
Emphysema/chronic bronchitis	1.2	1.4	3.4	1.0	-1.7	-1.3	-1.8	-1.0	-1.7	-0.7	-0.2	-1.2	-0.7	-0.8	-0.5
Medication for pain relief, constipation, heartburn	0.5	0.9	4.3	-0.7	1.5	0.4	1.0	0.4	0.8	2.1	-0.2	1.0	0.3	0.4	0.6
Neck or shoulder pain in last month	1.4	2.0	4.6	-1.2	-2.1	-1.5	0.7	-1.6	-1.2	-0.7	-1.7	-1.5	-1.0	-1.8	-1.4
Medication: Blood pressure	0.8	1.5	5.7	1.7	-1.3	-0.6	-2.4	-0.3	0.3	-1.9	0.1	-1.3	0.8	-0.0	0.6
Angina (self-reported)	0.3	0.4	2.1	-0.5	-0.9	-0.5	-0.4	1.0	-0.0	-1.5	-0.1	0.0	-0.2	-0.4	-0.6
Migraine (self-reported)	1.6	2.0	3.7	0.2	-1.8	-1.1	0.6	-1.1	-1.9	-1.5	-1.6	-0.8	-1.9	-1.3	-1.7
Medication: Ibuprofen	0.4	0.5	1.4	-1.2	-0.5	0.5	-0.9	0.7	1.0	0.5	0.4	0.0	0.3	0.6	1.1
Medication: Allopurinol	0.4	0.6	2.1	-0.9	-1.4	1.0	0.2	0.7	0.6	0.8	0.8	0.2	0.8	0.3	0.1
Medication: Omeprazole	1.1	1.3	3.7	1.7	-1.5	-0.5	-0.4	-1.3	-1.2	-1.0	0.2	-1.0	-0.5	-0.8	-1.9
Medication: Seretide 50 evohaler	0.5	0.5	2.0	-1.4	-0.2	0.2	-0.8	1.0	0.7	0.4	-0.1	-0.6	-0.7	-0.1	1.1
Mean time to correctly identify matches	0.4	0.7	2.4	1.1	-1.0	-0.8	0.2	-0.1	-1.4	-1.5	-0.2	-0.1	-0.5	-0.4	-0.9
Heart disease (mother)	0.5	0.6	1.6	-1.3	-1.2	-0.8	0.4	0.5	0.5	-0.5	-0.5	-0.6	-0.9	-0.8	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.9	0.5	0.3	0.8	-0.4	1.2	0.9	0.6	1.4	0.3	0.4	0.9	1.0
Whole body fat mass	3.1	12.9	65.6	3.9	-2.5	-0.3	-8.1	-0.6	1.3	-6.0	1.1	-3.0	2.7	-0.1	3.5
Leg fat mass (right)	3.0	11.6	56.7	3.4	-2.9	-0.5	-7.5	-0.6	1.1	-6.1	0.9	-2.9	2.5	-0.3	2.9
Arm predicted mass (right)	2.1	10.6	53.9	4.8	-1.3	-0.6	-7.3	-1.1	0.4	-5.1	0.9	-2.8	2.0	-0.2	2.7
Pulse rate, automated reading	0.8	2.6	5.4	0.4	-0.8	-2.1	1.9	-2.2	-0.6	-0.7	-1.8	-1.1	-2.1	-1.6	-2.3
Alcohol intake frequency.	1.0	2.3	7.3	2.7	-1.3	-0.7	-2.7	-0.9	-0.8	-2.7	0.5	-1.3	0.5	-0.5	-0.4
Comparative height size at age 10	1.1	6.3	28.2	5.3	0.4	-1.1	-5.2	-1.0	-0.3	-3.0	1.1	-1.3	1.6	-0.3	1.9
Number of full sisters	0.6	0.7	3.6	0.0	-1.9	-0.7	-0.0	-0.7	-0.8	-0.7	-0.6	-1.0	-0.6	-0.6	-0.4
Suffer from ‘nerves’	0.3	0.4	1.1	-0.1	-0.5	0.7	-0.5	0.0	0.5	1.0	1.1	0.5	0.7	0.7	0.7
Overall health rating	0.6	1.3	7.0	-1.2	-2.7	-1.3	0.2	0.4	0.1	-1.5	-0.4	-0.7	-0.2	-0.8	-1.3
Chest pain or discomfort	1.9	2.8	5.0	0.2	-1.6	-2.0	1.0	-1.8	-1.9	-1.4	-1.6	-1.5	-2.2	-1.9	-2.2
Had major operations	2.1	2.4	8.2	-2.9	1.5	1.8	1.0	1.4	1.0	2.4	0.9	1.3	1.1	1.3	0.8
Age at last live birth	0.8	1.1	5.8	2.4	1.4	0.3	-1.3	-1.2	0.2	0.5	0.6	-0.3	0.5	0.4	1.2
Family relationship satisfaction	5.3	6.6	11.0	-2.2	2.4	3.2	1.3	2.4	2.2	3.1	2.9	3.3	2.4	3.1	1.1
Leg pain on walking	0.5	0.6	3.0	-1.7	-0.9	1.1	-0.5	0.5	0.4	0.5	0.3	0.5	0.2	0.6	0.5
Qualifications: NVQ or HND or HNC or equivalent	5.3	6.3	12.4	-0.3	1.7	2.2	-1.7	3.2	3.5	1.7	3.0	2.3	2.9	2.5	3.2
Commuting to job workplace: Car/motor vehicle	3.2	3.7	7.7	-1.3	1.2	2.3	0.5	2.8	1.6	1.2	2.3	2.6	2.6	2.1	0.8
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	4.0	-0.8	0.9	0.9	-1.6	0.4	0.8	-0.1	0.6	0.9	1.5	0.8	2.0
Medication: Aspirin	0.6	0.9	5.6	0.2	-0.3	0.0	-1.4	-0.6	-0.6	-2.4	-0.0	-1.0	0.9	-0.3	0.1
Supplements: Vitamin C	0.3	0.3	1.7	-0.4	-0.4	-0.4	1.3	0.4	-0.3	-0.2	-0.5	1.0	-0.4	-0.1	-0.7
Knee pain experienced in last month	1.3	2.1	4.0	-0.6	-1.7	-1.8	-0.5	-1.6	-0.9	-1.3	-1.7	-2.0	-1.5	-1.8	-0.7
Hypertension (Self-reported)	0.2	0.7	3.2	-0.8	-0.7	-0.4	-1.1	0.2	-0.2	-1.8	-0.2	-0.8	1.0	-0.2	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	4.3	5.0	11.9	1.0	-1.3	-2.6	1.9	-2.3	-2.2	-2.8	-2.5	-1.4	-2.0	-2.4	-3.5
Illnesses of father: Heart disease	0.4	0.6	2.0	0.5	-1.4	-0.6	-0.9	-0.1	0.1	-1.2	-0.5	-0.7	-0.5	-0.5	-0.6
Illnesses of siblings: Diabetes	0.8	1.0	2.6	0.9	-1.0	-0.8	-0.3	-0.4	-1.6	-0.9	-1.0	-1.1	-1.1	-1.2	-1.0
Smoking status: Previous	0.9	1.3	4.3	-2.1	0.4	1.1	0.8	1.0	1.6	0.9	0.9	0.7	1.1	1.5	0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	2.7	1.6	1.1	-0.3	0.0	0.8	0.8	-0.3	0.7	0.4	0.4	0.4	0.0
Whole body fat-free mass	2.4	13.7	72.9	5.6	-1.4	-0.7	-8.5	-1.4	-0.1	-5.6	0.8	-3.1	2.0	-0.4	3.1
Leg fat-free mass (right)	3.1	16.7	93.7	5.2	-1.7	-0.8	-9.7	-1.7	-0.2	-6.5	0.4	-4.1	1.7	-0.8	3.4
Arm fat percentage (left)	2.9	11.5	58.4	3.0	-2.8	0.1	-7.6	-0.3	1.6	-5.6	1.4	-2.6	3.0	0.2	3.4
Average weekly red wine intake	0.3	0.4	1.0	0.9	0.8	-0.7	-1.0	0.1	-0.1	-0.1	-0.4	-0.9	-0.1	-0.7	-0.4
Handedness (chirality/laterality): Left-handed	1.5	1.8	7.1	-2.4	0.5	0.4	2.7	0.8	1.5	1.8	-0.4	0.9	0.5	0.4	0.7
Mood swings	2.4	4.4	9.7	1.8	-3.1	-2.0	-0.3	-2.2	-1.8	-2.1	-1.6	-2.4	-2.4	-2.4	-1.8
Loneliness, isolation	0.6	0.8	2.2	0.7	-0.8	-1.5	0.2	-0.3	-0.9	-1.0	-0.2	-0.7	-1.1	-0.8	-1.3
Long-standing illness, disability or infirmity	0.7	1.0	5.6	-0.5	-2.4	-1.0	-1.3	-0.1	-0.3	-1.4	0.2	-0.6	0.1	-0.6	-1.1
Ever had bowel cancer screening	0.2	0.3	1.2	1.1	-0.4	-0.2	-0.0	0.1	-0.8	-0.7	-0.2	-0.2	-0.3	-0.6	-0.5
Diabetes diagnosed by doctor	0.7	1.2	6.5	-1.2	-1.3	-0.8	-0.8	-0.8	-0.3	-2.6	-0.7	-1.3	-0.1	-0.8	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	2.7	0.9	-1.1	-0.8	0.4	-0.9	-1.5	-1.0	-0.5	-0.1	-0.5	-0.7	-1.6
Friendships satisfaction	2.8	3.4	8.6	-2.9	1.0	2.3	0.0	2.2	1.4	1.9	1.7	2.0	1.1	2.2	1.5
Qualifications: nursing, teaching	0.4	0.6	3.0	1.0	1.0	-0.6	-0.8	-1.7	-0.2	-0.5	-0.4	-0.5	-0.3	-0.2	0.7
Commuting to job workplace: Walk	1.8	2.0	5.2	0.2	-1.3	-1.6	-0.3	-1.4	-2.3	-0.8	-1.4	-1.7	-1.7	-1.6	-1.0
Eye problems/disorders: Cataract	0.3	0.4	1.0	0.8	-1.0	0.5	-0.3	-0.0	-0.8	-0.7	0.3	0.9	0.3	0.3	-0.3
Mouth/teeth dental problems: Mouth ulcers	2.6	4.1	6.0	1.6	-2.1	-2.1	-1.0	-2.2	-2.4	-1.6	-2.3	-2.2	-2.3	-2.2	-1.4
Medication for cholesterol	0.2	0.3	1.5	0.9	-0.0	-0.1	-0.1	-1.2	-0.3	0.5	-0.2	0.3	-0.8	-0.1	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	2.9	-1.7	-0.6	-0.4	-0.0	0.2	-1.0	0.5	-0.5	-0.5	-0.1	-0.2	-0.3
Back pain experienced in last month	0.4	0.5	1.7	-0.2	-0.6	0.6	0.7	0.6	-0.4	0.5	1.1	1.1	0.7	0.4	-1.3
Mineral and other dietary supplements	0.9	1.2	7.5	-2.7	-0.3	1.4	0.0	1.5	0.7	0.6	0.2	-0.3	0.4	0.9	0.8
Breast cancer (self-reported)	0.5	0.6	3.7	1.1	-0.4	0.4	1.0	0.1	-0.7	-0.2	0.4	0.7	0.3	0.1	-1.9
Asthma (self-reported)	0.7	1.3	3.9	-0.2	-0.4	0.6	0.2	1.3	1.6	1.4	1.5	1.0	2.0	1.2	0.5
Osteoporosis (self-reported)	1.7	2.1	8.0	-1.7	-1.7	-0.8	2.8	-0.9	-0.6	0.2	-1.6	0.4	-1.1	-0.9	-2.2
Osteoarthritis (self-reported)	4.0	5.2	11.8	1.8	-3.4	-2.2	-0.9	-2.2	-2.9	-3.0	-1.5	-1.7	-2.0	-2.4	-2.2
Medication: Aspirin	0.8	1.0	5.0	0.0	0.1	0.3	-1.8	-0.6	-0.0	-2.2	-0.0	-1.1	1.1	-0.1	0.8
Medication: Gliclazide	0.3	0.4	1.5	-0.6	-0.8	-0.0	-1.0	0.3	-0.7	-1.2	-0.1	-0.4	-0.2	0.1	-0.4
Illnesses of father: None of the above (group 1)	0.3	0.4	1.7	0.6	0.4	-0.1	0.5	-1.3	0.1	0.7	-0.3	-0.5	-0.8	-0.4	0.8
Smoking status: Current	0.8	1.2	4.1	-2.0	-0.8	-0.6	1.2	-0.7	-1.0	1.1	-1.1	-1.1	-1.1	-0.8	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.8	6.0	2.4	2.4	0.8	-0.7	-0.1	1.0	-0.7	1.1	1.3	1.6	1.0	1.2
Whole body water mass	2.3	13.3	71.1	5.5	-1.3	-0.6	-8.4	-1.3	0.0	-5.5	0.9	-3.0	2.1	-0.3	3.1
Leg predicted mass (right)	3.1	16.7	94.8	5.1	-1.6	-0.8	-9.7	-1.6	-0.2	-6.4	0.5	-4.1	1.8	-0.7	3.5
Arm fat mass (left)	3.5	14.4	78.9	3.6	-2.5	0.1	-8.9	-0.3	1.6	-5.9	1.6	-2.8	3.3	0.4	4.0
Number of self-reported non-cancer illnesses	0.8	1.3	4.4	0.2	-2.0	-1.3	-1.0	-0.6	-0.6	-2.1	-0.5	-1.0	0.1	-1.0	-1.3
Average weekly champagne plus white wine intake	0.8	1.0	4.2	2.1	-0.5	-0.4	-1.0	-0.3	-1.4	-1.7	-0.7	-0.5	-0.6	-0.9	-0.4
Miserableness	0.4	0.6	1.5	-0.1	-1.2	-1.2	-0.9	-0.8	-0.1	-0.8	-0.1	-0.9	-0.9	-0.7	0.4
Guilty feelings	0.3	0.5	3.6	1.9	0.5	0.4	-0.4	-0.8	0.2	0.3	0.8	-0.2	-0.6	0.0	0.1
Wears glasses or contact lenses	0.6	0.7	2.5	-1.6	1.2	0.3	0.5	1.2	0.7	0.9	0.0	0.1	-0.7	0.3	0.5
Ever taken oral contraceptive pill	1.6	1.8	7.2	-2.7	0.8	0.4	0.8	2.2	1.4	1.6	0.7	0.9	1.0	0.8	0.2
Hearing aid user	1.1	1.3	4.0	-0.6	-2.0	-0.8	1.9	0.1	-1.0	-0.5	-0.8	-0.4	-0.9	-1.0	-1.7
Mother’s age at death	1.1	1.4	3.2	1.1	0.7	0.9	-0.5	1.4	1.2	0.9	1.1	1.2	1.8	1.5	1.3
Financial situation satisfaction	2.4	3.0	8.7	-2.7	1.7	2.2	1.0	2.0	0.9	3.0	1.6	1.1	0.8	1.5	0.1
Tinnitus: Yes, now most or all of the time	0.7	0.8	3.1	-0.2	-1.5	0.4	1.8	0.5	-0.6	0.7	0.5	0.4	-0.7	0.1	-1.4
Commuting to job workplace: Public transport	1.6	1.9	7.2	2.7	-1.0	-0.4	-2.1	-1.5	-1.2	-1.4	-0.8	-1.4	-0.7	-0.7	0.8
Eye problems/disorders: Glaucoma	0.5	0.6	2.7	-1.6	0.3	1.1	0.4	-0.2	-0.6	1.0	0.1	0.6	0.7	0.5	-0.4
Medication: Blood pressure	0.2	0.4	1.4	-1.2	-0.5	0.3	0.5	0.8	0.1	-0.7	0.0	-0.2	0.8	0.1	-0.8
Pain type(s) experienced in last month: Hip pain	2.4	3.0	11.7	-0.0	-3.4	-1.6	0.4	-1.3	-1.9	-1.8	-1.2	-1.4	-1.7	-1.7	-2.1
Supplements: Fish oil (including cod liver oil)	1.2	1.5	7.7	2.8	-0.1	-1.7	0.5	-1.6	-0.7	-0.7	-0.3	0.1	-0.6	-0.9	-1.6
High cholesterol (Self-reported)	1.0	1.8	4.4	-0.3	1.2	0.8	-2.1	0.4	1.8	-0.1	1.4	-0.0	2.0	1.2	2.0
Medication: Bendroflumethiazide	0.2	0.3	1.0	-0.6	-0.5	0.3	-0.6	-0.2	1.0	-0.5	0.1	-1.0	0.4	0.1	0.8
Medication: Paracetamol	0.3	0.4	1.9	0.8	-1.0	-0.8	-0.6	-0.2	0.1	-1.4	0.3	-0.5	-0.4	-0.1	-0.3
Medication: Lisinopril	0.7	1.0	5.5	0.7	-1.1	-0.3	-0.7	0.0	-0.6	-2.3	-0.7	-0.7	-0.3	-0.9	-1.2
Medication: Atorvastatin	1.1	1.3	4.0	0.9	-1.1	-0.7	-0.4	-1.2	-1.3	-2.0	-0.6	-1.5	-1.1	-1.1	-1.2
Illnesses of father: High blood pressure	0.3	0.4	1.7	0.2	0.6	-0.8	-0.8	0.3	0.9	-1.3	-0.2	-0.5	0.6	-0.3	-0.0
Alcohol drinker status: Never	1.3	1.5	5.7	1.0	-0.8	-0.6	-1.0	-1.9	-2.4	-1.5	-0.8	-1.1	-0.3	-1.0	-1.2
Ever smoked	0.4	0.8	2.7	-1.6	0.2	1.0	1.1	0.7	0.8	0.9	0.9	0.2	0.8	1.0	0.5
Basal metabolic rate	2.7	15.2	82.8	5.5	-1.6	-0.6	-9.1	-1.2	0.3	-5.9	1.0	-3.3	2.4	-0.2	3.5
Leg fat percentage (left)	1.9	6.9	33.1	2.3	-2.5	-0.0	-5.8	0.2	1.1	-4.7	0.9	-1.9	2.1	0.1	2.5
Arm fat-free mass (left)	2.2	11.3	60.7	4.9	-1.4	-0.3	-7.8	-0.6	0.6	-4.9	1.3	-2.5	2.4	0.2	3.3
Number of operations (self-reported)	0.4	0.6	3.4	-1.9	-0.3	-0.1	1.0	0.7	-0.6	0.3	-0.4	0.1	-0.5	-0.3	-1.1
Average weekly beer plus cider intake	1.5	2.2	11.0	-2.7	-0.9	0.3	3.3	1.1	0.1	1.8	-0.8	1.0	-0.2	0.2	-0.9
Irritability	1.2	2.1	6.0	2.4	0.0	-1.0	-1.1	-1.9	-0.8	-2.1	-0.9	-1.8	-0.9	-1.5	-0.8
Risk taking	0.1	0.2	0.9	0.0	-0.8	0.6	0.6	0.1	-1.0	-0.0	-0.1	-0.1	0.2	0.2	-0.2
Ever had prostate specific antigen (PSA) test	1.4	1.6	6.8	1.6	-1.1	-0.7	-2.6	-1.4	-1.8	-0.7	-0.2	-0.8	-0.9	-0.8	0.1
Fractured/broken bones in last 5 years	1.6	2.0	7.6	-2.8	0.7	1.3	2.4	0.5	1.6	2.0	0.6	1.1	0.0	0.6	0.5
Age started oral contraceptive pill	0.6	0.8	2.0	0.8	0.2	0.8	-0.9	1.2	0.9	-0.3	1.0	1.0	0.8	0.6	1.4
Diastolic blood pressure, automated reading	0.6	2.0	12.5	-3.5	-0.5	0.1	2.0	1.0	1.6	1.4	-0.7	0.2	0.8	0.4	-0.7
Ever depressed for a whole week	0.3	0.4	2.0	-0.3	-1.4	-0.4	0.8	0.5	0.6	-0.2	-0.1	0.2	-0.7	-0.2	-0.2
Unable to work because of sickness or disability	4.2	5.4	14.9	1.5	-2.7	-2.9	1.0	-1.5	-2.4	-2.4	-1.5	-1.1	-2.7	-2.6	-3.9
Commuting to job workplace: Cycle	0.3	0.4	1.3	0.1	0.8	0.3	-0.5	0.4	1.2	0.5	0.3	-0.1	0.1	0.6	1.1
Myopia	0.7	1.0	2.9	-1.5	1.7	0.8	0.0	0.0	1.2	1.0	-0.2	-0.2	0.4	0.8	1.7
Vascular/heart problems diagnosed by doctor	0.4	1.2	5.6	-0.0	1.2	0.9	1.4	-0.0	0.6	2.4	0.4	1.2	-0.6	0.8	1.3
Cholesterol lowering medication	0.3	0.4	1.1	-1.1	0.6	0.6	1.0	1.0	0.0	0.4	0.3	0.3	0.6	0.4	-0.7
Medication: Omeprazole (e.g. Zanprol)	2.0	2.5	6.4	2.3	-2.0	-0.8	-0.2	-1.5	-1.9	-1.9	-0.3	-1.1	-1.0	-1.3	-2.5
Pain experienced in last month	1.0	1.7	5.0	0.9	2.2	1.4	-0.1	1.5	1.1	0.6	1.4	1.7	1.1	1.4	1.1
Supplements: Calcium	0.8	0.9	2.8	0.1	-1.3	-0.7	1.7	-0.3	-0.7	0.2	-0.9	0.7	-0.8	-0.8	-1.5
Basal cell carcinoma (self-reported)	4.1	4.9	11.6	2.8	-1.4	-2.7	-2.9	-1.5	-1.7	-3.4	-1.6	-2.5	-1.6	-2.3	-0.5
Heart attack/myocardial infarction (self-reported)	1.2	1.6	5.0	0.7	0.7	0.8	-2.2	1.8	1.3	-0.5	1.4	0.5	1.0	1.0	1.8
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	2.7	1.4	-1.6	-0.6	-1.5	-0.5	-1.6	-1.0	0.1	-0.6	-0.2	-0.7	-0.6
Heart disease (siblings)	0.5	0.6	1.7	0.5	-0.1	-0.5	0.3	-0.7	-1.2	-0.4	-0.5	-1.2	-0.9	-0.8	-1.3
Alcohol drinker status: Previous	0.2	0.3	2.3	-0.2	-0.4	-0.4	0.1	-0.1	0.0	-0.4	-0.3	-0.2	0.2	-0.3	-1.5
Pack years of smoking	3.0	4.4	14.2	-1.1	-3.8	-1.9	0.1	-1.2	-2.2	-1.7	-2.4	-2.1	-1.9	-2.2	-2.4
Impedance of whole body	1.5	7.8	43.8	-2.9	2.6	-0.2	6.6	0.9	0.7	4.6	-0.9	2.5	-1.3	0.2	-1.6
Leg fat mass (left)	3.2	12.5	63.7	3.5	-2.8	-0.3	-8.0	-0.5	1.1	-6.1	0.9	-3.1	2.5	-0.2	3.3
Arm predicted mass (left)	2.2	11.3	60.1	4.9	-1.5	-0.7	-7.8	-1.0	0.2	-5.1	0.8	-2.8	2.1	-0.2	2.9