Hub : Genes

FAIM2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0870 0.0360 6.4e-04 -0.002 0.023 0.023 0.026 0.006 7.2e-01 7.5e-04 7.3e-04 3.7e-04 4.8e-02
2 GTEx Artery Tibial 0.1662 0.0603 5.3e-03 0.032 NA 0.030 NA 0.029 1.3e-03 NA 1.9e-03 NA 2.1e-03
3 GTEx Cells Transformed fibroblasts 0.4060 0.0630 4.4e-11 0.180 NA 0.244 NA 0.224 1.7e-13 NA 2.5e-18 NA 9.7e-17
4 GTEx Testis 0.2720 0.0930 2.6e-03 0.091 NA 0.058 NA 0.063 7.7e-05 NA 1.5e-03 NA 9.3e-04
5 METSIM Adipose 0.1458 0.0368 8.4e-08 0.071 0.067 0.055 0.071 0.067 7.4e-11 2.5e-10 9.5e-09 8.9e-11 3.1e-10
6 TCGA Bladder Urothelial Carcinoma 0.1190 0.0430 1.5e-04 0.054 0.039 0.029 NA 0.038 2.3e-05 2.8e-04 1.7e-03 NA 3.6e-04
7 TCGA Breast Invasive Carcinoma 0.0227 0.0109 2.9e-03 0.000 0.008 0.004 NA 0.002 4.0e-01 8.5e-03 3.8e-02 NA 1.0e-01
8 TCGA Head and Neck Squamous Cell Carcinoma 0.1026 0.0316 2.3e-08 0.088 0.076 0.099 NA 0.089 4.0e-10 6.8e-09 3.7e-11 NA 3.1e-10
9 TCGA Kidney Renal Clear Cell Carcinoma 0.1078 0.0340 2.6e-06 0.061 0.053 0.064 NA 0.058 1.8e-07 1.2e-06 9.2e-08 NA 3.9e-07
10 TCGA Lung Squamous Cell Carcinoma 0.1261 0.0388 3.0e-08 0.084 0.090 0.081 NA 0.082 8.2e-10 1.9e-10 1.6e-09 NA 1.3e-09
11 TCGA Prostate Adenocarcinoma 0.0661 0.0297 1.9e-03 0.024 0.013 0.009 NA 0.023 1.3e-03 1.4e-02 3.9e-02 NA 1.7e-03
12 TCGA Thyroid Carcinoma 0.1370 0.0400 4.1e-09 0.043 0.073 0.055 NA 0.051 4.4e-05 1.2e-07 4.3e-06 NA 1.0e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bipolar Disorder (2018) 0.8 1.2 4.0 -1.4 -2.0 -1.0 -0.1 -1.5 -1.3 -0.5 -1.0 -0.9 -0.6 -1.1 -0.4
Bipolar Disorder or Schizophrenia 0.8 1.9 5.4 -0.5 -2.3 -1.7 -0.5 -1.2 -1.9 -1.1 -1.1 -1.2 -0.8 -1.6 -1.3
Depressed Affect (Nagel 2018) 1.1 2.3 3.9 0.7 -2.0 -2.0 -1.6 -1.1 -1.4 -1.8 -0.6 -1.9 -1.6 -1.8 -0.7
Depression (Nagel 2018) 1.4 2.1 5.3 0.5 -1.2 -2.3 -0.3 -1.8 -1.3 -0.5 -1.4 -1.5 -2.0 -1.9 -1.0
Intelligence (Savage-Jansen 2018) 0.3 0.9 5.9 2.4 0.9 0.3 0.2 -0.7 -0.6 -0.6 -0.4 -0.2 -0.1 -0.2 -1.4
Neuroticism (Nagel 2018) 0.9 2.1 7.3 2.7 -1.3 -1.6 -1.8 -1.4 -1.2 -1.5 0.0 -1.3 -1.1 -1.4 -0.3
Schizophrenia (2018) 0.5 1.0 1.9 0.5 -1.4 -1.3 -0.6 -0.3 -1.3 -0.9 -0.6 -0.8 -0.6 -1.2 -1.3
Schizophrenia vs Biploar Disorder 0.4 0.5 2.3 0.6 0.3 0.0 0.9 1.5 1.1 -0.3 0.4 0.5 0.6 0.4 -0.1
Worry (Nagel 2018) 1.1 2.3 5.9 2.4 -2.1 -1.9 -0.9 -1.7 -1.2 -1.0 -0.7 -1.5 -1.4 -1.6 -0.8
Alzheimer’s Disease (in mother) 1.3 1.5 3.5 -0.7 1.9 1.0 0.7 1.2 1.2 0.8 0.8 1.6 1.1 1.3 1.6
Alzheimer’s Disease (in father) 1.4 1.5 3.1 0.0 0.6 1.8 -1.1 1.1 0.0 -0.6 1.8 1.5 1.8 1.7 0.8
Alzheimer’s Disease (including proxy) 1.5 2.2 3.9 -0.6 1.8 1.8 -0.4 1.4 0.9 0.6 1.5 1.9 2.0 1.8 1.8
Crohns Disease (2017) 0.9 1.9 5.4 0.2 1.5 1.8 -0.0 1.9 1.3 1.1 2.3 1.4 1.1 1.3 1.0
Irritable Bowel Disease (IBD) 0.5 1.2 4.2 0.3 1.1 1.2 -0.2 1.9 0.8 0.3 2.0 1.2 0.3 0.7 0.6
Ulcerative Colitis (UC) 0.1 0.3 1.0 0.3 0.5 -0.2 -0.1 0.6 -0.4 -0.8 0.2 -0.2 -1.0 -0.7 -0.3
Major Depression (MDD) 1.0 1.2 8.7 3.0 -0.2 -0.9 0.0 -0.4 -0.0 -1.5 -0.1 -0.8 -0.4 -0.7 -0.9
Reaction Time 0.9 1.7 4.8 1.9 -1.7 -1.5 -0.6 -0.5 -1.6 -2.2 -0.5 -0.6 -0.7 -1.0 -1.1
Verbal and Numeric Reasoning (VNR) 1.1 2.6 6.3 2.1 0.2 -1.0 0.6 -1.5 -2.1 -1.1 -1.6 -1.7 -1.9 -1.7 -2.5
Breast Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Ovarian Cancer 4.4 5.8 10.0 -0.1 -3.0 -3.2 -0.2 -2.9 -2.4 -1.7 -2.7 -2.7 -2.9 -2.7 -2.0
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 2.7 3.9 8.1 0.7 1.4 2.1 -2.1 0.9 1.8 2.6 2.7 0.9 2.9 2.4 1.7
Bipolar Disorder (2011) 0.2 0.2 0.7 -0.6 0.2 0.2 0.0 -0.4 0.1 0.7 0.2 0.2 0.8 0.4 0.2
Body Mass Index (BMI) (2010) 3.8 5.2 31.4 2.8 0.1 -0.4 -5.6 -0.2 0.8 -3.2 1.2 -1.4 1.6 0.3 2.6
Coronary Artery Disease (CAD) 3.2 3.8 7.3 0.2 -1.9 -2.0 -2.0 -2.1 -2.7 -1.9 -1.9 -2.2 -1.9 -2.2 -1.5
Crohns Disease (2012) 2.1 3.4 5.7 -1.3 2.4 2.0 1.1 1.8 2.1 2.2 1.8 2.2 1.5 1.8 1.3
Mean Putamen Volume 0.9 1.1 3.7 0.1 0.4 -1.9 0.6 -1.0 -0.9 0.5 -1.6 -0.9 -0.7 -1.3 -1.0
Fasting Glucose 0.1 0.1 0.7 0.3 0.0 0.2 -0.8 0.1 -0.5 -0.1 -0.1 -0.3 -0.3 0.3 -0.3
HbA1C 0.4 0.4 2.4 -0.6 -0.3 -0.1 0.1 0.6 -1.1 0.8 0.2 0.2 0.3 -0.1 -1.5
HDL Cholesterol 1.6 2.7 6.2 0.3 -1.0 -1.1 1.8 -2.5 -2.0 -0.8 -2.1 -1.1 -1.6 -1.6 -2.2
LDL Cholesterol 0.2 0.3 1.3 -0.5 1.1 0.4 -1.2 0.1 -0.1 0.4 -0.3 -0.8 -0.2 -0.1 0.4
Lupus 0.6 0.9 2.0 -0.2 -0.7 -0.1 0.9 -1.4 -1.4 -0.7 -1.0 -0.7 -0.8 -1.0 -1.3
Neuroticism (2016) 1.3 1.8 5.5 2.2 -0.1 -1.3 0.0 -2.3 -1.0 -1.4 -0.8 -1.4 -1.4 -1.3 -0.8
Primary Biliary Cirrhosis 0.5 0.7 2.0 -0.6 0.6 1.1 -0.6 1.0 0.5 0.1 1.0 0.7 1.4 1.0 0.6
Rheumatoid Arthritis 0.4 0.6 1.6 -0.5 -0.8 -0.8 -0.1 -0.6 -0.3 -0.3 -1.1 -1.2 -1.0 -1.0 0.2
Schizophrenia (2014) 0.3 0.6 1.5 0.5 -1.2 -1.2 -0.8 -0.4 -0.6 -0.9 -0.2 -0.9 -0.4 -1.0 -0.6
Triglycerides 1.3 2.1 4.0 -0.8 2.0 1.7 -0.6 1.4 2.0 0.8 1.5 0.9 1.0 1.6 2.0
Type 2 Diabetes (T2D) (2012) 0.4 0.5 2.3 0.4 0.4 0.3 -1.2 -0.1 0.1 -1.5 0.0 -1.0 0.0 -0.4 0.3
Ulcerative Colitis 0.2 0.3 1.2 0.8 0.9 0.0 0.2 0.2 -0.3 -0.5 0.2 -0.1 -0.4 -0.4 -1.1
Blood Eosinophil Count 0.1 0.6 4.7 0.7 0.0 0.2 -2.2 -0.2 -0.5 -0.2 1.1 0.1 0.8 0.5 -0.6
Blood Platelet Count 0.1 0.8 3.1 -1.3 -1.8 0.5 -1.5 -0.6 -0.6 -0.1 0.6 -0.7 -0.8 -0.1 -0.5
Blood Red Count 0.3 3.0 9.3 3.1 2.4 -0.3 -1.9 1.9 1.4 -0.4 2.1 0.5 2.0 1.2 1.0
Blood White Count 0.2 1.2 8.1 -2.8 -0.2 1.1 0.0 -0.5 0.6 0.6 1.2 0.8 0.6 1.0 -0.7
Heel T-Score 0.9 7.0 18.7 2.1 0.3 1.8 -4.3 3.1 3.1 -0.5 2.4 0.4 3.1 2.0 4.3
BMI 4.1 23.8 132.2 5.6 -2.7 -1.3 -11.5 -1.3 0.0 -8.3 1.1 -4.7 2.6 -0.9 3.4
Height 0.2 4.6 25.4 5.0 1.5 -0.9 -3.7 -0.8 0.5 -0.7 0.7 -1.1 1.7 0.2 2.6
Waist Hip Ratio (WHR) 0.4 1.7 4.7 -2.2 -1.1 -1.3 1.8 0.3 -0.1 -0.3 -1.6 0.0 -1.9 -1.2 -1.5
Systolic Blood Pressure 1.1 5.4 30.1 -5.5 -0.9 1.2 3.3 1.6 2.1 2.5 0.2 1.2 2.1 1.4 -0.9
Smoking Status 0.7 1.8 15.3 -3.9 -0.5 0.1 1.1 0.7 0.4 1.8 -0.2 -0.4 -0.3 0.5 0.3
Allergy or Eczema 0.9 2.4 7.0 -1.9 1.9 1.6 0.6 0.2 1.9 2.6 0.7 0.3 1.7 1.4 1.6
Cardiovascular Disease 0.6 2.0 6.1 -1.7 0.0 0.8 -2.2 1.5 1.5 -1.2 1.1 -0.4 2.5 1.0 0.8
Hypothyroidism (self reported) 0.3 0.7 3.1 0.2 -0.1 0.2 -1.8 -1.0 -0.4 -1.0 0.4 -0.4 0.9 0.4 1.2
Respiratory disease 0.5 1.1 2.5 -1.2 -0.1 0.6 0.3 1.4 1.6 1.4 1.2 0.9 1.5 0.9 0.4
Type 2 Diabetes (T2D) (2018) 0.3 0.6 4.3 -0.7 -0.5 -0.5 -0.4 -0.3 -0.0 -2.1 -0.0 -0.6 -0.1 -0.5 -0.9
Lung FEV1/FVC ratio 0.3 1.3 6.8 2.5 0.6 -0.0 -1.3 -0.1 -0.4 -2.6 0.6 0.2 -0.2 -0.4 0.0
Lung FVC 0.3 1.5 8.4 2.9 0.2 0.8 -1.6 -1.9 -0.9 -0.1 0.4 0.5 0.9 0.8 0.5
Neuroticism 2.0 4.8 10.8 3.3 -1.0 -2.5 -2.3 -3.0 -1.9 -2.0 -1.1 -2.6 -2.0 -2.3 -1.0
Chronotype (morning person) 0.2 0.4 1.0 0.2 0.2 -0.4 -0.4 -1.0 -0.8 -1.0 -0.7 -0.5 0.3 -0.7 -0.6
Hair Pigment 0.1 1.6 6.4 -2.5 -0.3 1.4 1.1 1.1 0.7 2.2 0.8 0.6 1.0 1.0 -0.2
Tanning 0.2 2.3 4.5 -0.8 -1.5 -1.8 0.5 -1.6 -0.8 -0.8 -2.1 -1.8 -2.0 -2.1 -1.1
Hand grip strength (left) 0.9 2.4 5.7 -0.4 1.8 2.0 -1.2 0.2 0.9 1.3 1.8 0.8 1.9 2.0 2.4
Number of treatments/medications taken 2.1 3.7 12.4 0.9 -2.7 -1.9 -1.5 -1.6 -1.2 -3.5 -1.1 -2.6 -0.8 -1.7 -1.4
Average weekly spirits intake 1.9 2.3 4.1 0.2 -1.7 -1.4 0.8 -2.0 -1.7 -1.7 -1.9 -1.6 -1.2 -1.7 -1.3
Sensitivity / hurt feelings 0.1 0.2 0.9 0.0 0.8 -0.3 0.7 -1.0 -0.0 -0.1 -0.3 -0.1 -0.3 -0.3 0.2
Frequency of depressed mood in last 2 weeks 1.7 2.4 5.5 0.0 -1.4 -2.2 0.4 -1.6 -1.3 -1.0 -1.6 -1.4 -2.3 -2.1 -1.6
Hearing difficulty/problems: Yes 0.6 0.9 3.2 -0.5 -1.1 0.3 1.4 1.4 -0.1 -0.0 1.0 1.8 0.7 0.5 -0.8
Relative age of first facial hair 0.7 1.4 5.1 -2.2 0.9 0.0 2.2 0.0 -0.2 1.9 -0.7 0.9 -0.7 0.2 -0.3
Other serious medical condition/disability diagnosed by doctor 2.8 3.6 9.4 0.1 -2.6 -1.9 1.0 -1.5 -2.2 -1.8 -2.0 -0.7 -2.0 -1.9 -3.1
Ever used hormone-replacement therapy (HRT) 1.9 2.4 7.0 -1.1 -2.1 -1.2 2.3 1.2 -1.2 -1.2 -0.9 0.1 -1.7 -1.1 -2.6
Ever had hysterectomy (womb removed) 1.6 1.8 11.5 -3.4 -0.3 0.8 2.0 1.4 0.7 1.4 0.2 0.4 -0.2 0.4 -0.1
Systolic blood pressure, automated reading 1.3 3.8 19.9 -4.5 -0.9 1.1 2.2 2.0 1.8 2.0 0.6 1.5 1.6 1.3 -0.7
Eye problems/disorders: Diabetes related eye disease 0.7 0.8 1.5 0.5 -1.2 -1.2 -0.6 -0.4 -0.8 -1.2 -0.4 -1.0 -0.7 -1.0 -0.9
Angina 0.3 0.4 1.4 -1.0 -0.6 -0.3 -0.2 1.2 0.3 -1.2 -0.1 0.1 -0.1 -0.3 -0.5
Medication for hormone replacement therapy 1.8 2.0 7.0 -1.6 0.7 1.2 0.6 2.7 1.5 1.2 1.0 1.4 1.8 1.5 0.4
Vitamin and mineral supplements 1.0 1.4 5.3 1.6 -0.4 0.1 -2.3 -1.1 -0.9 -1.2 -0.3 -2.0 -0.0 -0.6 0.7
Supplements: Zinc 0.5 0.5 1.6 1.2 -0.1 0.5 1.1 0.3 -0.3 0.4 0.5 1.3 0.2 0.3 -0.9
Medication: Co-codamol 0.6 0.7 2.1 -1.2 -1.0 -0.9 0.4 -0.5 -0.4 -0.3 -0.5 -0.5 -1.4 -1.0 -1.1
Medication: Metformin 0.5 0.7 1.9 -0.8 -1.2 -0.3 -1.4 -0.6 -0.7 -1.3 0.4 -1.1 0.1 -0.3 -0.6
Diabetes (father) 0.8 0.9 2.2 0.5 0.6 0.9 -0.1 1.0 0.9 1.5 1.5 0.8 1.4 0.9 0.0
Diabetes (mother) 0.5 0.6 2.3 0.5 -1.0 -0.7 -1.2 0.2 -0.0 -1.5 -0.3 -0.7 -0.8 -0.6 0.2
Severe depression (siblings) 3.3 3.7 8.6 1.3 -1.4 -2.3 -0.1 -2.2 -2.1 -1.6 -1.5 -2.1 -2.9 -2.2 -1.8
Pack years adult smoking proportion 3.0 4.5 13.4 -1.1 -3.7 -1.9 0.3 -1.1 -2.3 -1.7 -2.4 -2.1 -1.9 -2.2 -2.8
Impedance of leg (right) 2.4 11.6 66.9 -3.2 2.6 0.1 8.2 1.4 1.4 5.8 -0.3 3.5 -0.7 0.8 -2.1
Leg fat-free mass (left) 3.2 17.1 94.9 5.3 -1.8 -0.9 -9.7 -1.6 0.0 -6.5 0.7 -3.9 2.1 -0.7 3.5
Trunk fat percentage 2.2 8.8 44.0 2.6 -2.0 -0.3 -6.6 -0.3 1.7 -4.9 0.9 -2.6 2.4 0.0 3.2
Hand grip strength (right) 0.4 1.2 2.7 -0.2 1.4 1.1 -1.6 -0.0 0.5 0.6 1.2 0.6 1.2 1.3 1.5
Townsend deprivation index at recruitment 0.5 0.8 5.2 1.1 -0.3 -0.1 -2.3 -0.2 -0.9 -0.1 0.3 -1.0 -0.1 -0.3 0.8
Current tobacco smoking 1.1 1.8 6.9 -2.6 -1.0 -0.8 1.6 -0.8 -1.1 1.0 -1.3 -1.2 -1.3 -1.0 -1.4
Average weekly fortified wine intake 0.2 0.2 0.8 -0.2 0.9 -0.3 0.2 -0.6 0.2 -0.1 -0.9 -0.2 -0.5 -0.3 0.6
Maternal smoking around birth 1.2 1.7 10.5 -3.2 -0.4 -0.5 2.0 1.7 0.6 1.2 0.1 0.9 0.1 0.0 -0.6
Fed-up feelings 1.4 2.6 5.5 -0.2 -1.4 -2.3 -0.0 -1.3 -1.5 -1.4 -1.4 -1.9 -2.2 -2.1 -1.6
Frequency of unenthusiasm / disinterest in last 2 weeks 1.1 1.4 4.2 -0.3 -0.1 -2.0 0.5 -1.6 -0.5 -0.1 -1.4 -1.4 -1.8 -1.5 -0.6
Relative age voice broke 0.8 1.2 2.8 -0.6 0.4 -0.9 1.6 -1.7 -1.2 0.6 -1.3 -0.1 -1.1 -0.9 -1.4
Taking other prescription medications 0.7 1.1 6.5 -0.2 -2.5 -1.3 0.5 -0.5 -0.0 -1.7 -0.3 -0.7 -0.4 -0.7 -0.8
Age when periods started (menarche) 1.4 3.4 21.0 -2.0 1.3 -0.1 4.6 -0.2 -0.0 2.1 -1.4 1.3 -2.0 -0.3 -1.3
Bilateral oophorectomy (both ovaries removed) 1.7 1.9 4.4 -1.6 -0.0 1.7 1.5 2.1 1.6 0.8 1.4 1.6 1.2 1.4 0.3
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.1 5.2 2.0 -0.5 -0.4 -2.3 1.3 -0.1 -0.9 0.4 -0.6 0.7 -0.3 0.3
Tinnitus: Yes, but not now, but have in the past 0.8 0.8 2.9 -0.4 -0.3 0.7 1.7 -0.6 -1.5 1.0 0.0 0.1 0.2 -0.1 -1.6
Qualifications: CSEs or equivalent 0.6 0.7 2.0 -1.3 0.5 -0.5 1.1 1.4 1.4 0.6 0.0 0.9 -0.1 0.4 0.6
Serious illness, injury or assault to yourself 1.3 1.6 3.8 1.5 -0.2 -1.6 -0.4 -0.4 -1.7 -1.3 -0.5 -0.4 -1.9 -1.3 -1.8
High blood pressure 0.3 0.7 3.5 -0.4 -0.7 -0.6 -1.3 0.2 -0.1 -1.9 -0.1 -0.9 0.9 -0.4 -1.0
Hayfever, allergic rhinitis or eczema 0.5 1.2 4.7 -1.4 1.5 0.8 -0.2 -0.7 0.8 2.2 0.0 -0.9 0.6 0.6 1.4
Multivitamins +/- minerals 0.6 0.7 2.5 -1.3 -0.5 -0.1 1.2 1.1 0.5 0.7 0.4 1.6 0.6 0.5 -0.7
Stomach or abdominal pain in last month 1.3 1.6 3.7 -0.0 -0.3 -1.9 0.2 -1.8 -1.6 -0.6 -1.6 -1.3 -1.2 -1.5 -1.2
Supplements: Glucosamine 0.8 1.0 4.6 2.1 -0.2 -1.0 -1.6 -1.3 -0.8 -0.7 -0.1 -0.4 0.0 -0.7 0.2
Diverticular disease/diverticulitis (self-reported) 0.8 1.0 2.3 0.4 -1.3 -1.2 0.2 -1.3 -0.9 -1.5 -0.8 -0.7 -0.6 -0.9 -1.2
Medication: Atenolol 0.2 0.2 0.6 -0.4 -0.0 -0.3 -0.0 -0.5 -0.7 -0.6 -0.3 -0.4 -0.2 -0.5 -0.8
Medication: Levothyroxine sodium 0.7 1.1 3.1 -0.8 0.7 1.2 -1.6 0.3 0.4 -0.3 1.1 0.3 1.6 1.1 1.8
Sitting height 0.2 1.5 5.9 2.4 0.7 -1.3 -1.1 -1.5 -0.4 -1.3 -1.0 -1.4 -0.7 -0.9 0.1
Chronic bronchitis/emphysema (father) 1.1 1.3 6.7 -1.6 -1.1 -0.1 2.6 -0.1 -0.9 0.0 -0.4 0.3 -1.3 -0.8 -1.4
High blood pressure (mother) 0.6 0.9 2.9 -1.7 0.1 0.6 -0.8 1.0 1.0 1.1 0.5 -0.7 1.5 0.7 0.4
Body mass index (BMI) 3.0 13.0 68.8 2.9 -3.2 0.4 -8.3 -0.1 1.1 -6.0 1.6 -2.8 3.1 0.4 3.3
Impedance of leg (left) 2.2 10.9 60.4 -3.3 2.9 0.3 7.8 1.6 1.3 5.6 -0.5 3.2 -0.9 0.8 -1.6
Leg predicted mass (left) 3.2 17.1 93.8 5.4 -1.9 -0.9 -9.7 -1.7 -0.1 -6.6 0.6 -4.0 2.0 -0.8 3.3
Trunk fat mass 3.1 13.2 65.9 4.1 -2.1 -0.5 -8.1 -0.7 1.5 -6.0 1.0 -3.1 2.7 -0.1 3.6
Waist circumference 2.6 9.5 49.8 2.6 -2.8 -0.5 -7.1 -0.2 0.9 -5.4 1.0 -2.4 2.1 -0.2 2.7
Number of incorrect matches in round 0.7 1.1 5.7 1.0 0.1 0.1 -1.8 0.8 1.2 -0.1 0.9 0.7 -0.0 0.8 2.4
Past tobacco smoking 0.6 1.0 3.9 2.0 -0.1 -1.1 -0.9 -0.8 -1.0 -1.0 -0.8 -0.4 -1.0 -1.3 -0.5
Alcohol usually taken with meals 0.6 1.0 7.3 1.6 0.9 -0.2 -2.7 -0.4 -0.6 -0.9 0.5 -0.0 0.4 -0.0 0.5
Nervous feelings 2.0 3.7 7.0 0.7 -1.8 -2.6 1.3 -2.0 -1.8 -1.4 -2.2 -1.4 -2.5 -2.5 -2.1
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.5 6.0 -0.5 -0.3 -1.8 1.0 -0.8 -0.3 -0.3 -1.2 -1.1 -2.4 -1.6 -1.0
Hearing difficulty/problems with background noise 0.6 0.9 2.3 -1.0 0.6 1.0 1.4 0.7 -0.1 0.9 1.1 1.5 0.6 0.9 -0.5
Hair/balding pattern: Pattern 2 0.9 1.2 4.8 -2.2 0.3 0.9 2.1 -0.3 0.0 1.5 -0.1 0.9 0.2 0.7 -0.6
Had menopause 0.2 0.3 0.8 -0.7 -0.7 -0.3 0.9 -0.1 -0.2 0.2 -0.5 0.3 -0.6 -0.3 -0.9
Had other major operations 1.1 1.4 5.6 -0.4 -0.3 -1.1 1.4 -0.1 -1.6 -1.1 -1.1 -0.3 -1.2 -1.0 -2.4
Forced vital capacity (FVC) 0.5 1.8 9.2 3.0 2.3 0.0 -1.1 -1.1 0.7 0.1 0.5 0.7 1.3 0.7 1.0
Heel bone mineral density (BMD) T-score, automated (right) 0.7 1.6 6.9 2.0 0.0 -0.1 -2.6 1.8 0.5 -0.9 1.0 -0.4 1.6 0.2 0.6
Ever unenthusiastic/disinterested for a whole week 0.7 0.9 1.8 -0.6 -1.1 -0.9 1.3 -0.5 -0.1 -0.7 -1.3 -1.4 -1.0 -0.8 -0.7
Qualifications: None of the above 2.6 5.5 14.2 0.5 -3.6 -2.6 1.9 -0.1 -2.7 -2.6 -1.6 -1.0 -2.1 -2.6 -3.8
Financial difficulties in last 2 years 0.4 0.5 1.8 1.3 0.6 0.2 -0.7 0.2 0.6 1.4 1.0 -0.2 0.7 0.5 0.2
Mouth/teeth dental problems 0.4 0.7 2.4 1.2 0.8 0.8 0.1 -0.1 0.1 0.3 1.5 1.0 1.2 0.8 0.3
Heart attack 1.1 1.5 6.5 0.9 0.6 0.6 -2.5 1.4 1.2 -0.7 1.1 0.1 0.7 0.8 1.7
Allergy 0.3 0.8 3.3 0.8 -0.5 -0.4 0.6 0.2 -0.7 -1.8 -0.4 0.8 -1.2 -0.6 -1.1
Pain all over the body in last month 1.0 1.1 2.7 0.8 -1.0 -1.3 0.3 -0.2 -0.6 -1.6 -0.8 -1.3 -1.4 -1.2 -1.1
Diabetes (self-reported) 0.7 1.1 3.6 -1.5 -1.7 -0.6 -0.7 -0.7 -0.9 -1.9 -0.6 -1.1 -0.3 -0.8 -0.9
Hayfever/allergic rhinitis (self-reported) 0.2 0.3 1.1 -1.0 -0.4 0.6 0.5 -0.5 -0.5 1.0 0.3 0.0 0.2 0.2 -0.6
Medication: Ramipril 0.3 0.4 1.3 -1.1 0.3 0.7 -0.3 0.2 0.8 -0.5 0.4 -0.3 0.6 0.6 0.7
Medication: Simvastatin 1.1 1.6 4.9 -0.3 1.1 1.3 -1.1 1.3 1.6 0.2 1.5 0.4 2.2 1.4 1.2
Fluid intelligence score 0.5 1.1 3.5 1.9 0.5 -0.4 -0.6 -0.7 -1.3 -0.5 -0.8 -1.3 -1.0 -0.8 -1.4
Illnesses of siblings 0.2 0.3 1.3 0.6 1.1 0.4 0.5 0.2 0.1 0.2 0.6 1.1 -0.2 0.6 -0.0
Neuroticism score 1.7 3.6 7.5 2.0 -1.4 -2.3 -0.5 -2.7 -1.6 -1.2 -1.5 -2.4 -2.2 -2.2 -1.3
Weight 3.5 17.1 94.1 4.9 -2.2 -0.3 -9.7 -0.7 1.0 -6.4 1.4 -3.3 3.2 0.1 3.9
Impedance of arm (right) 0.8 3.8 17.6 -2.1 1.8 0.0 4.2 0.8 0.7 3.6 -0.6 2.2 -0.6 0.3 -0.8
Arm fat percentage (right) 2.8 11.2 57.4 2.7 -2.8 0.5 -7.6 0.2 1.9 -5.1 1.7 -2.1 3.4 0.6 3.7
Trunk fat-free mass 1.8 10.5 53.7 5.6 -0.9 -0.5 -7.3 -1.2 -0.1 -4.7 0.9 -2.2 2.0 -0.1 2.5
Hip circumference 2.4 10.5 59.3 3.6 -1.5 0.1 -7.7 -0.6 0.8 -4.8 1.4 -2.4 3.0 0.3 3.3
Time employed in main current job 0.6 0.7 1.6 1.3 0.8 1.2 -1.0 -0.2 0.4 -0.2 1.0 0.6 0.7 1.0 0.9
Alcohol intake versus 10 years previously 0.3 0.5 1.1 1.0 -1.0 -0.5 -0.5 0.7 0.1 -1.0 0.9 0.3 0.8 0.1 0.1
Father’s age at death 0.6 0.8 4.3 0.5 2.1 -0.0 -0.8 1.1 0.2 1.3 -0.2 0.3 -0.0 0.0 1.3
Worrier / anxious feelings 2.4 4.5 9.7 3.1 -1.6 -2.5 0.6 -3.0 -1.6 -1.3 -1.3 -2.1 -2.5 -2.4 -1.8
Frequency of tiredness / lethargy in last 2 weeks 1.5 2.4 5.9 -1.5 -1.8 -1.6 1.2 -0.5 -0.6 -1.3 -1.3 -1.4 -2.4 -1.9 -1.8
Falls in the last year 1.6 2.2 5.8 -0.9 -2.4 -1.4 0.4 -1.1 -1.6 -0.7 -1.2 -0.5 -1.9 -1.6 -2.4
Hair/balding pattern: Pattern 3 0.5 0.7 2.9 -0.8 -0.3 0.3 0.5 0.9 1.4 0.7 0.4 0.4 -0.2 0.8 1.7
Number of live births 2.1 3.0 9.2 0.3 -1.9 -1.1 3.0 -0.2 -1.9 -1.2 -1.2 0.3 -2.1 -1.5 -2.9
Forced expiratory volume in 1-second (FEV1) 0.6 1.9 8.7 3.0 2.0 0.3 -1.3 -0.7 0.8 -0.5 1.1 1.1 1.6 0.9 1.2
Pulse rate 0.3 0.4 1.0 0.1 1.0 -1.0 0.5 -0.8 0.3 -0.3 -1.0 -0.5 -0.6 -0.7 -0.4
Happiness 4.6 5.6 10.7 -3.3 0.9 2.8 -0.6 2.6 1.8 2.9 2.5 1.9 1.9 2.9 2.6
Noisy workplace 1.8 2.2 6.5 -0.4 -2.5 -1.3 1.4 -0.5 -1.1 -2.0 -1.1 -1.5 -1.3 -1.6 -1.7
Qualifications: A levels/AS levels or equivalent 0.4 0.9 2.8 1.6 1.7 0.5 -1.0 -0.2 0.7 1.2 0.6 0.5 0.4 0.6 0.9
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 1.1 -0.2 0.2 0.3 0.0 -0.3 -0.5 1.0 0.0 -0.8 -0.0 0.1 -0.5
Mouth/teeth dental problems: Dentures 1.3 2.3 7.5 -2.7 -1.4 -1.0 1.9 0.3 -0.9 -0.6 -1.7 -0.8 -2.3 -1.1 -1.3
Asthma 0.5 1.0 2.7 -0.2 -0.3 0.4 0.4 1.1 1.5 1.4 1.3 0.8 1.6 1.0 0.3
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.2 1.2 -1.1 -0.6 -0.1 0.4 0.4 0.7 0.5 -0.2 -0.1 -0.3 0.1 0.6
Medication: Cholesterol lowering 1.1 1.8 9.9 -0.1 -0.1 0.9 -3.1 0.7 1.0 -0.7 1.4 -0.2 1.7 1.1 1.5
Depression (self-reported) 0.2 0.3 1.3 1.1 -0.9 -0.6 0.2 0.2 0.2 -0.2 0.8 0.1 -0.4 -0.1 -0.1
Medication: Lansoprazole 5.0 5.7 11.4 1.3 -2.2 -2.9 1.2 -2.0 -2.8 -2.6 -2.5 -1.6 -2.4 -2.6 -3.4
Prospective memory result 0.4 0.5 2.1 -0.7 0.4 0.4 1.4 -0.2 -0.0 -0.0 0.4 1.3 -0.4 0.6 0.6
Lung cancer (father) 1.3 1.5 12.6 -0.5 0.3 -0.2 3.5 0.1 0.0 -0.0 -0.4 1.1 -0.8 -0.4 -1.7
Illnesses of mother 2.2 2.7 13.1 3.6 -0.6 -1.1 -0.7 -2.7 -1.9 -1.2 -0.7 -0.9 -1.3 -1.2 -0.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 2.0 14.7 3.8 1.8 -0.2 -1.3 -0.9 -0.1 -1.0 0.8 0.6 1.1 0.4 0.4
Pulse wave Arterial Stiffness index 0.7 0.8 2.1 -0.9 0.8 1.0 1.1 0.9 0.1 1.3 1.1 1.4 0.3 0.7 0.2
Impedance of arm (left) 0.8 3.5 18.1 -1.8 2.1 -0.3 4.2 0.1 0.4 3.2 -0.8 1.7 -0.9 -0.1 -1.0
Arm fat mass (right) 3.5 14.5 79.0 3.5 -2.4 0.5 -8.9 0.0 1.9 -5.6 1.9 -2.5 3.7 0.7 4.2
Trunk predicted mass 1.8 10.2 52.3 5.5 -0.9 -0.5 -7.2 -1.1 -0.0 -4.6 1.0 -2.1 2.0 -0.1 2.5
Standing height 0.4 4.2 23.3 4.8 2.0 -1.6 -3.5 -1.2 -0.2 -1.7 -0.2 -1.1 0.5 -0.6 1.6
Length of working week for main job 1.1 1.2 2.0 -0.1 -1.4 -1.0 0.2 -0.5 -1.4 -1.1 -1.4 -0.9 -1.1 -1.3 -1.4
Exposure to tobacco smoke at home 0.5 0.6 2.9 -0.9 -1.4 0.4 -1.7 0.6 0.3 0.4 0.1 -0.0 0.2 0.1 0.7
Breastfed as a baby 0.4 0.4 2.5 0.0 -0.2 1.2 0.4 0.0 -0.5 1.6 0.4 0.3 -0.0 0.4 -0.6
Tense / ‘highly strung’ 1.5 2.5 4.9 1.6 -1.6 -1.8 1.3 -1.6 -1.5 -0.6 -1.3 -0.5 -2.2 -1.8 -2.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.5 2.5 0.6 -1.6 -0.4 0.4 -0.3 -0.1 -0.3 0.6 0.5 0.0 -0.2 -1.3
Hair/balding pattern: Pattern 4 1.0 2.3 7.4 0.4 0.6 1.7 -2.5 1.0 0.3 0.8 2.7 1.3 2.0 1.6 0.6
Birth weight of first child 0.9 1.6 3.6 0.8 -0.8 -1.7 -0.0 -0.9 -1.2 -0.6 -1.6 -1.1 -1.8 -1.9 -1.0
Peak expiratory flow (PEF) 0.7 1.7 4.0 0.5 1.7 0.8 -1.4 0.0 1.5 0.6 1.5 1.1 2.0 1.4 1.6
Pulse wave reflection index 1.1 1.4 4.2 -1.4 -0.1 1.4 0.8 0.6 -0.1 2.1 1.2 1.5 1.4 1.2 0.4
Ever highly irritable/argumentative for 2 days 0.3 0.3 1.4 0.7 -0.4 -0.2 0.2 -0.9 -0.3 -1.2 -0.3 -0.8 -0.4 -0.3 0.2
Loud music exposure frequency 0.5 0.6 2.1 -0.3 -1.0 -0.3 -1.2 -1.0 -0.7 0.2 -0.6 -1.4 -0.3 -0.3 0.1
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 5.6 1.1 2.4 0.5 -0.4 -0.7 0.3 0.6 -0.0 -0.1 0.1 0.6 0.9
Mouth/teeth dental problems: Bleeding gums 0.1 0.2 0.7 -0.1 0.4 -0.4 -0.0 -0.3 0.3 0.1 -0.9 -0.5 -0.4 -0.5 -0.4
Blood clot in the leg (DVT) 0.5 0.6 2.5 1.3 -0.9 -0.1 -1.6 0.0 -1.2 -0.4 0.7 0.1 0.4 -0.1 -0.2
Medication: Paracetamol 0.7 1.1 3.4 1.0 -1.8 -1.3 0.1 -0.6 -0.8 -1.8 -0.3 -0.7 -0.8 -0.6 -1.1
Headache pain in last month 1.1 1.9 6.4 0.1 -2.5 -0.9 0.8 -1.6 -1.5 -1.3 -1.0 -0.6 -0.5 -0.9 -2.3
Medication for cholesterol, blood pressure or diabetes 0.7 1.1 7.0 -0.6 0.8 0.3 2.7 0.0 -0.3 1.5 -0.3 1.2 -0.7 -0.2 -1.0
Glaucoma (self-reported) 0.3 0.3 1.0 -0.5 -0.0 0.8 -0.3 -0.8 -0.8 1.0 0.1 -0.3 0.4 0.3 -0.1
Gout (self-reported) 0.9 1.2 3.1 -1.0 -0.6 1.7 0.2 0.9 0.6 1.7 1.4 0.7 1.3 1.1 0.5
Hypothyroidism/myxoedema (self-reported) 0.4 0.8 3.3 0.8 -0.2 0.1 -1.8 -0.9 -0.5 -1.4 0.7 -0.3 1.0 0.3 1.0
Medication: Amlodipine 0.2 0.2 0.9 0.5 0.2 -0.7 -0.4 -0.6 0.3 -0.6 0.3 -1.0 0.3 -0.2 0.1
Medication: Ventolin 100micrograms inhaler 2.2 2.8 6.5 1.9 -1.3 -2.5 0.2 -1.4 -0.9 -1.2 -1.6 -2.1 -1.9 -1.9 -1.9
Birth weight 0.6 1.3 3.8 1.3 0.1 -0.5 -1.6 -1.6 -1.5 -0.4 -0.6 -2.0 -0.4 -0.9 0.8
Chronic bronchitis/emphysema (mother) 2.1 2.5 8.4 -2.9 1.0 1.3 1.3 2.5 1.5 2.0 0.8 1.6 0.6 1.1 0.2
High blood pressure (siblings) 1.2 1.8 5.2 -1.9 0.8 0.3 -1.5 0.5 1.6 1.4 0.4 -0.7 1.8 0.8 2.3
Forced vital capacity (FVC), Best measure 0.5 1.9 13.6 3.7 1.7 -0.4 -1.3 -1.6 -0.4 -0.5 0.4 0.0 1.2 0.2 0.4
Body fat percentage 2.2 8.8 43.4 2.6 -2.4 -0.1 -6.6 -0.1 1.6 -5.0 1.1 -2.4 2.5 0.1 3.1
Leg fat percentage (right) 1.7 6.0 26.7 2.2 -2.6 -0.3 -5.2 0.0 1.0 -4.6 0.9 -1.7 2.1 -0.0 1.9
Arm fat-free mass (right) 2.0 10.1 51.7 4.8 -1.1 -0.5 -7.2 -1.0 0.4 -4.9 0.9 -2.8 2.0 -0.1 2.8
Exposure to tobacco smoke outside home 3.2 4.2 7.0 1.4 -2.6 -2.6 -0.4 -1.8 -2.5 -1.6 -2.0 -2.5 -1.6 -2.3 -2.1
Comparative body size at age 10 15.2 42.0 256.0 8.7 -1.9 -0.5 -16.0 -0.5 0.5 -8.3 3.7 -4.3 4.6 0.5 6.7
Number of full brothers 0.8 1.0 3.3 0.5 -0.7 -1.3 -0.5 -1.2 -0.6 -0.4 -1.1 -1.8 -1.1 -1.2 0.2
Worry too long after embarrassment 1.3 2.1 12.1 3.5 1.4 0.1 -2.6 -0.9 -0.3 0.2 1.3 -0.5 0.0 0.3 1.2
Seen a psychiatrist for nerves, anxiety, tension or depression 1.3 1.7 6.8 -0.2 -2.6 -1.3 1.0 -0.7 -1.1 -1.2 -0.9 -0.4 -1.3 -1.3 -1.7
Wheeze or whistling in the chest in last year 0.3 0.6 1.9 -1.4 -1.2 -0.4 1.3 0.9 0.7 0.5 -0.3 -0.0 0.0 -0.0 -0.4
Number of children fathered 0.4 0.5 1.6 -0.0 0.8 0.3 1.3 0.7 -0.1 0.3 0.9 0.7 0.4 0.4 -1.1
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.1 2.9 0.1 -0.2 -1.2 1.7 -0.3 -0.7 -1.4 -1.4 -0.5 -1.1 -1.2 -1.2
Age at first live birth 1.3 2.3 7.2 1.4 2.2 1.0 -1.9 -0.7 1.2 1.8 1.0 -0.4 1.1 1.2 2.7
Pulse wave peak to peak time 1.2 1.4 3.0 1.5 -0.8 -1.4 -1.5 -1.1 -0.3 -1.6 -1.2 -1.7 -0.4 -1.0 -0.2
Health satisfaction 0.4 0.5 1.6 -1.3 -0.7 0.9 -0.7 0.8 0.7 -0.6 0.5 -0.4 0.5 0.5 0.7
Shortness of breath walking on level ground 0.9 1.1 3.1 -0.8 -1.8 -1.0 -0.2 -0.7 -0.6 -0.9 -1.1 -1.8 -0.9 -1.2 -0.5
Qualifications: College or University degree 0.6 1.8 6.3 2.5 1.5 -0.4 -2.3 -1.8 -0.5 0.4 -0.2 -1.2 -1.1 -0.4 0.9
Eye problems/disorders: None of the above 0.3 0.4 1.7 -0.1 0.9 -0.1 -0.2 0.4 1.3 0.2 0.2 -0.3 0.2 0.3 1.2
Mouth/teeth dental problems: Loose teeth 1.5 1.8 3.6 0.7 1.0 0.8 -1.5 1.4 1.1 1.2 1.7 1.4 1.9 1.4 1.2
Emphysema/chronic bronchitis 1.2 1.4 3.4 1.0 -1.7 -1.3 -1.8 -1.0 -1.7 -0.7 -0.2 -1.2 -0.7 -0.8 -0.5
Medication for pain relief, constipation, heartburn 0.5 0.9 4.3 -0.7 1.5 0.4 1.0 0.4 0.8 2.1 -0.2 1.0 0.3 0.4 0.6
Neck or shoulder pain in last month 1.4 2.0 4.6 -1.2 -2.1 -1.5 0.7 -1.6 -1.2 -0.7 -1.7 -1.5 -1.0 -1.8 -1.4
Medication: Blood pressure 0.8 1.5 5.7 1.7 -1.3 -0.6 -2.4 -0.3 0.3 -1.9 0.1 -1.3 0.8 -0.0 0.6
Angina (self-reported) 0.3 0.4 2.1 -0.5 -0.9 -0.5 -0.4 1.0 -0.0 -1.5 -0.1 0.0 -0.2 -0.4 -0.6
Migraine (self-reported) 1.6 2.0 3.7 0.2 -1.8 -1.1 0.6 -1.1 -1.9 -1.5 -1.6 -0.8 -1.9 -1.3 -1.7
Medication: Ibuprofen 0.4 0.5 1.4 -1.2 -0.5 0.5 -0.9 0.7 1.0 0.5 0.4 0.0 0.3 0.6 1.1
Medication: Allopurinol 0.4 0.6 2.1 -0.9 -1.4 1.0 0.2 0.7 0.6 0.8 0.8 0.2 0.8 0.3 0.1
Medication: Omeprazole 1.1 1.3 3.7 1.7 -1.5 -0.5 -0.4 -1.3 -1.2 -1.0 0.2 -1.0 -0.5 -0.8 -1.9
Medication: Seretide 50 evohaler 0.5 0.5 2.0 -1.4 -0.2 0.2 -0.8 1.0 0.7 0.4 -0.1 -0.6 -0.7 -0.1 1.1
Mean time to correctly identify matches 0.4 0.7 2.4 1.1 -1.0 -0.8 0.2 -0.1 -1.4 -1.5 -0.2 -0.1 -0.5 -0.4 -0.9
Heart disease (mother) 0.5 0.6 1.6 -1.3 -1.2 -0.8 0.4 0.5 0.5 -0.5 -0.5 -0.6 -0.9 -0.8 -0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 1.9 0.5 0.3 0.8 -0.4 1.2 0.9 0.6 1.4 0.3 0.4 0.9 1.0
Whole body fat mass 3.1 12.9 65.6 3.9 -2.5 -0.3 -8.1 -0.6 1.3 -6.0 1.1 -3.0 2.7 -0.1 3.5
Leg fat mass (right) 3.0 11.6 56.7 3.4 -2.9 -0.5 -7.5 -0.6 1.1 -6.1 0.9 -2.9 2.5 -0.3 2.9
Arm predicted mass (right) 2.1 10.6 53.9 4.8 -1.3 -0.6 -7.3 -1.1 0.4 -5.1 0.9 -2.8 2.0 -0.2 2.7
Pulse rate, automated reading 0.8 2.6 5.4 0.4 -0.8 -2.1 1.9 -2.2 -0.6 -0.7 -1.8 -1.1 -2.1 -1.6 -2.3
Alcohol intake frequency. 1.0 2.3 7.3 2.7 -1.3 -0.7 -2.7 -0.9 -0.8 -2.7 0.5 -1.3 0.5 -0.5 -0.4
Comparative height size at age 10 1.1 6.3 28.2 5.3 0.4 -1.1 -5.2 -1.0 -0.3 -3.0 1.1 -1.3 1.6 -0.3 1.9
Number of full sisters 0.6 0.7 3.6 0.0 -1.9 -0.7 -0.0 -0.7 -0.8 -0.7 -0.6 -1.0 -0.6 -0.6 -0.4
Suffer from ‘nerves’ 0.3 0.4 1.1 -0.1 -0.5 0.7 -0.5 0.0 0.5 1.0 1.1 0.5 0.7 0.7 0.7
Overall health rating 0.6 1.3 7.0 -1.2 -2.7 -1.3 0.2 0.4 0.1 -1.5 -0.4 -0.7 -0.2 -0.8 -1.3
Chest pain or discomfort 1.9 2.8 5.0 0.2 -1.6 -2.0 1.0 -1.8 -1.9 -1.4 -1.6 -1.5 -2.2 -1.9 -2.2
Had major operations 2.1 2.4 8.2 -2.9 1.5 1.8 1.0 1.4 1.0 2.4 0.9 1.3 1.1 1.3 0.8
Age at last live birth 0.8 1.1 5.8 2.4 1.4 0.3 -1.3 -1.2 0.2 0.5 0.6 -0.3 0.5 0.4 1.2
Family relationship satisfaction 5.3 6.6 11.0 -2.2 2.4 3.2 1.3 2.4 2.2 3.1 2.9 3.3 2.4 3.1 1.1
Leg pain on walking 0.5 0.6 3.0 -1.7 -0.9 1.1 -0.5 0.5 0.4 0.5 0.3 0.5 0.2 0.6 0.5
Qualifications: NVQ or HND or HNC or equivalent 5.3 6.3 12.4 -0.3 1.7 2.2 -1.7 3.2 3.5 1.7 3.0 2.3 2.9 2.5 3.2
Commuting to job workplace: Car/motor vehicle 3.2 3.7 7.7 -1.3 1.2 2.3 0.5 2.8 1.6 1.2 2.3 2.6 2.6 2.1 0.8
Illness, injury, bereavement, stress in last 2 years 0.9 1.1 4.0 -0.8 0.9 0.9 -1.6 0.4 0.8 -0.1 0.6 0.9 1.5 0.8 2.0
Medication: Aspirin 0.6 0.9 5.6 0.2 -0.3 0.0 -1.4 -0.6 -0.6 -2.4 -0.0 -1.0 0.9 -0.3 0.1
Supplements: Vitamin C 0.3 0.3 1.7 -0.4 -0.4 -0.4 1.3 0.4 -0.3 -0.2 -0.5 1.0 -0.4 -0.1 -0.7
Knee pain experienced in last month 1.3 2.1 4.0 -0.6 -1.7 -1.8 -0.5 -1.6 -0.9 -1.3 -1.7 -2.0 -1.5 -1.8 -0.7
Hypertension (Self-reported) 0.2 0.7 3.2 -0.8 -0.7 -0.4 -1.1 0.2 -0.2 -1.8 -0.2 -0.8 1.0 -0.2 -0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 4.3 5.0 11.9 1.0 -1.3 -2.6 1.9 -2.3 -2.2 -2.8 -2.5 -1.4 -2.0 -2.4 -3.5
Illnesses of father: Heart disease 0.4 0.6 2.0 0.5 -1.4 -0.6 -0.9 -0.1 0.1 -1.2 -0.5 -0.7 -0.5 -0.5 -0.6
Illnesses of siblings: Diabetes 0.8 1.0 2.6 0.9 -1.0 -0.8 -0.3 -0.4 -1.6 -0.9 -1.0 -1.1 -1.1 -1.2 -1.0
Smoking status: Previous 0.9 1.3 4.3 -2.1 0.4 1.1 0.8 1.0 1.6 0.9 0.9 0.7 1.1 1.5 0.6
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.6 2.7 1.6 1.1 -0.3 0.0 0.8 0.8 -0.3 0.7 0.4 0.4 0.4 0.0
Whole body fat-free mass 2.4 13.7 72.9 5.6 -1.4 -0.7 -8.5 -1.4 -0.1 -5.6 0.8 -3.1 2.0 -0.4 3.1
Leg fat-free mass (right) 3.1 16.7 93.7 5.2 -1.7 -0.8 -9.7 -1.7 -0.2 -6.5 0.4 -4.1 1.7 -0.8 3.4
Arm fat percentage (left) 2.9 11.5 58.4 3.0 -2.8 0.1 -7.6 -0.3 1.6 -5.6 1.4 -2.6 3.0 0.2 3.4
Average weekly red wine intake 0.3 0.4 1.0 0.9 0.8 -0.7 -1.0 0.1 -0.1 -0.1 -0.4 -0.9 -0.1 -0.7 -0.4
Handedness (chirality/laterality): Left-handed 1.5 1.8 7.1 -2.4 0.5 0.4 2.7 0.8 1.5 1.8 -0.4 0.9 0.5 0.4 0.7
Mood swings 2.4 4.4 9.7 1.8 -3.1 -2.0 -0.3 -2.2 -1.8 -2.1 -1.6 -2.4 -2.4 -2.4 -1.8
Loneliness, isolation 0.6 0.8 2.2 0.7 -0.8 -1.5 0.2 -0.3 -0.9 -1.0 -0.2 -0.7 -1.1 -0.8 -1.3
Long-standing illness, disability or infirmity 0.7 1.0 5.6 -0.5 -2.4 -1.0 -1.3 -0.1 -0.3 -1.4 0.2 -0.6 0.1 -0.6 -1.1
Ever had bowel cancer screening 0.2 0.3 1.2 1.1 -0.4 -0.2 -0.0 0.1 -0.8 -0.7 -0.2 -0.2 -0.3 -0.6 -0.5
Diabetes diagnosed by doctor 0.7 1.2 6.5 -1.2 -1.3 -0.8 -0.8 -0.8 -0.3 -2.6 -0.7 -1.3 -0.1 -0.8 -0.6
Ever had stillbirth, spontaneous miscarriage or termination 0.8 0.9 2.7 0.9 -1.1 -0.8 0.4 -0.9 -1.5 -1.0 -0.5 -0.1 -0.5 -0.7 -1.6
Friendships satisfaction 2.8 3.4 8.6 -2.9 1.0 2.3 0.0 2.2 1.4 1.9 1.7 2.0 1.1 2.2 1.5
Qualifications: nursing, teaching 0.4 0.6 3.0 1.0 1.0 -0.6 -0.8 -1.7 -0.2 -0.5 -0.4 -0.5 -0.3 -0.2 0.7
Commuting to job workplace: Walk 1.8 2.0 5.2 0.2 -1.3 -1.6 -0.3 -1.4 -2.3 -0.8 -1.4 -1.7 -1.7 -1.6 -1.0
Eye problems/disorders: Cataract 0.3 0.4 1.0 0.8 -1.0 0.5 -0.3 -0.0 -0.8 -0.7 0.3 0.9 0.3 0.3 -0.3
Mouth/teeth dental problems: Mouth ulcers 2.6 4.1 6.0 1.6 -2.1 -2.1 -1.0 -2.2 -2.4 -1.6 -2.3 -2.2 -2.3 -2.2 -1.4
Medication for cholesterol 0.2 0.3 1.5 0.9 -0.0 -0.1 -0.1 -1.2 -0.3 0.5 -0.2 0.3 -0.8 -0.1 0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.5 2.9 -1.7 -0.6 -0.4 -0.0 0.2 -1.0 0.5 -0.5 -0.5 -0.1 -0.2 -0.3
Back pain experienced in last month 0.4 0.5 1.7 -0.2 -0.6 0.6 0.7 0.6 -0.4 0.5 1.1 1.1 0.7 0.4 -1.3
Mineral and other dietary supplements 0.9 1.2 7.5 -2.7 -0.3 1.4 0.0 1.5 0.7 0.6 0.2 -0.3 0.4 0.9 0.8
Breast cancer (self-reported) 0.5 0.6 3.7 1.1 -0.4 0.4 1.0 0.1 -0.7 -0.2 0.4 0.7 0.3 0.1 -1.9
Asthma (self-reported) 0.7 1.3 3.9 -0.2 -0.4 0.6 0.2 1.3 1.6 1.4 1.5 1.0 2.0 1.2 0.5
Osteoporosis (self-reported) 1.7 2.1 8.0 -1.7 -1.7 -0.8 2.8 -0.9 -0.6 0.2 -1.6 0.4 -1.1 -0.9 -2.2
Osteoarthritis (self-reported) 4.0 5.2 11.8 1.8 -3.4 -2.2 -0.9 -2.2 -2.9 -3.0 -1.5 -1.7 -2.0 -2.4 -2.2
Medication: Aspirin 0.8 1.0 5.0 0.0 0.1 0.3 -1.8 -0.6 -0.0 -2.2 -0.0 -1.1 1.1 -0.1 0.8
Medication: Gliclazide 0.3 0.4 1.5 -0.6 -0.8 -0.0 -1.0 0.3 -0.7 -1.2 -0.1 -0.4 -0.2 0.1 -0.4
Illnesses of father: None of the above (group 1) 0.3 0.4 1.7 0.6 0.4 -0.1 0.5 -1.3 0.1 0.7 -0.3 -0.5 -0.8 -0.4 0.8
Smoking status: Current 0.8 1.2 4.1 -2.0 -0.8 -0.6 1.2 -0.7 -1.0 1.1 -1.1 -1.1 -1.1 -0.8 -0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.9 1.8 6.0 2.4 2.4 0.8 -0.7 -0.1 1.0 -0.7 1.1 1.3 1.6 1.0 1.2
Whole body water mass 2.3 13.3 71.1 5.5 -1.3 -0.6 -8.4 -1.3 0.0 -5.5 0.9 -3.0 2.1 -0.3 3.1
Leg predicted mass (right) 3.1 16.7 94.8 5.1 -1.6 -0.8 -9.7 -1.6 -0.2 -6.4 0.5 -4.1 1.8 -0.7 3.5
Arm fat mass (left) 3.5 14.4 78.9 3.6 -2.5 0.1 -8.9 -0.3 1.6 -5.9 1.6 -2.8 3.3 0.4 4.0
Number of self-reported non-cancer illnesses 0.8 1.3 4.4 0.2 -2.0 -1.3 -1.0 -0.6 -0.6 -2.1 -0.5 -1.0 0.1 -1.0 -1.3
Average weekly champagne plus white wine intake 0.8 1.0 4.2 2.1 -0.5 -0.4 -1.0 -0.3 -1.4 -1.7 -0.7 -0.5 -0.6 -0.9 -0.4
Miserableness 0.4 0.6 1.5 -0.1 -1.2 -1.2 -0.9 -0.8 -0.1 -0.8 -0.1 -0.9 -0.9 -0.7 0.4
Guilty feelings 0.3 0.5 3.6 1.9 0.5 0.4 -0.4 -0.8 0.2 0.3 0.8 -0.2 -0.6 0.0 0.1
Wears glasses or contact lenses 0.6 0.7 2.5 -1.6 1.2 0.3 0.5 1.2 0.7 0.9 0.0 0.1 -0.7 0.3 0.5
Ever taken oral contraceptive pill 1.6 1.8 7.2 -2.7 0.8 0.4 0.8 2.2 1.4 1.6 0.7 0.9 1.0 0.8 0.2
Hearing aid user 1.1 1.3 4.0 -0.6 -2.0 -0.8 1.9 0.1 -1.0 -0.5 -0.8 -0.4 -0.9 -1.0 -1.7
Mother’s age at death 1.1 1.4 3.2 1.1 0.7 0.9 -0.5 1.4 1.2 0.9 1.1 1.2 1.8 1.5 1.3
Financial situation satisfaction 2.4 3.0 8.7 -2.7 1.7 2.2 1.0 2.0 0.9 3.0 1.6 1.1 0.8 1.5 0.1
Tinnitus: Yes, now most or all of the time 0.7 0.8 3.1 -0.2 -1.5 0.4 1.8 0.5 -0.6 0.7 0.5 0.4 -0.7 0.1 -1.4
Commuting to job workplace: Public transport 1.6 1.9 7.2 2.7 -1.0 -0.4 -2.1 -1.5 -1.2 -1.4 -0.8 -1.4 -0.7 -0.7 0.8
Eye problems/disorders: Glaucoma 0.5 0.6 2.7 -1.6 0.3 1.1 0.4 -0.2 -0.6 1.0 0.1 0.6 0.7 0.5 -0.4
Medication: Blood pressure 0.2 0.4 1.4 -1.2 -0.5 0.3 0.5 0.8 0.1 -0.7 0.0 -0.2 0.8 0.1 -0.8
Pain type(s) experienced in last month: Hip pain 2.4 3.0 11.7 -0.0 -3.4 -1.6 0.4 -1.3 -1.9 -1.8 -1.2 -1.4 -1.7 -1.7 -2.1
Supplements: Fish oil (including cod liver oil) 1.2 1.5 7.7 2.8 -0.1 -1.7 0.5 -1.6 -0.7 -0.7 -0.3 0.1 -0.6 -0.9 -1.6
High cholesterol (Self-reported) 1.0 1.8 4.4 -0.3 1.2 0.8 -2.1 0.4 1.8 -0.1 1.4 -0.0 2.0 1.2 2.0
Medication: Bendroflumethiazide 0.2 0.3 1.0 -0.6 -0.5 0.3 -0.6 -0.2 1.0 -0.5 0.1 -1.0 0.4 0.1 0.8
Medication: Paracetamol 0.3 0.4 1.9 0.8 -1.0 -0.8 -0.6 -0.2 0.1 -1.4 0.3 -0.5 -0.4 -0.1 -0.3
Medication: Lisinopril 0.7 1.0 5.5 0.7 -1.1 -0.3 -0.7 0.0 -0.6 -2.3 -0.7 -0.7 -0.3 -0.9 -1.2
Medication: Atorvastatin 1.1 1.3 4.0 0.9 -1.1 -0.7 -0.4 -1.2 -1.3 -2.0 -0.6 -1.5 -1.1 -1.1 -1.2
Illnesses of father: High blood pressure 0.3 0.4 1.7 0.2 0.6 -0.8 -0.8 0.3 0.9 -1.3 -0.2 -0.5 0.6 -0.3 -0.0
Alcohol drinker status: Never 1.3 1.5 5.7 1.0 -0.8 -0.6 -1.0 -1.9 -2.4 -1.5 -0.8 -1.1 -0.3 -1.0 -1.2
Ever smoked 0.4 0.8 2.7 -1.6 0.2 1.0 1.1 0.7 0.8 0.9 0.9 0.2 0.8 1.0 0.5
Basal metabolic rate 2.7 15.2 82.8 5.5 -1.6 -0.6 -9.1 -1.2 0.3 -5.9 1.0 -3.3 2.4 -0.2 3.5
Leg fat percentage (left) 1.9 6.9 33.1 2.3 -2.5 -0.0 -5.8 0.2 1.1 -4.7 0.9 -1.9 2.1 0.1 2.5
Arm fat-free mass (left) 2.2 11.3 60.7 4.9 -1.4 -0.3 -7.8 -0.6 0.6 -4.9 1.3 -2.5 2.4 0.2 3.3
Number of operations (self-reported) 0.4 0.6 3.4 -1.9 -0.3 -0.1 1.0 0.7 -0.6 0.3 -0.4 0.1 -0.5 -0.3 -1.1
Average weekly beer plus cider intake 1.5 2.2 11.0 -2.7 -0.9 0.3 3.3 1.1 0.1 1.8 -0.8 1.0 -0.2 0.2 -0.9
Irritability 1.2 2.1 6.0 2.4 0.0 -1.0 -1.1 -1.9 -0.8 -2.1 -0.9 -1.8 -0.9 -1.5 -0.8
Risk taking 0.1 0.2 0.9 0.0 -0.8 0.6 0.6 0.1 -1.0 -0.0 -0.1 -0.1 0.2 0.2 -0.2
Ever had prostate specific antigen (PSA) test 1.4 1.6 6.8 1.6 -1.1 -0.7 -2.6 -1.4 -1.8 -0.7 -0.2 -0.8 -0.9 -0.8 0.1
Fractured/broken bones in last 5 years 1.6 2.0 7.6 -2.8 0.7 1.3 2.4 0.5 1.6 2.0 0.6 1.1 0.0 0.6 0.5
Age started oral contraceptive pill 0.6 0.8 2.0 0.8 0.2 0.8 -0.9 1.2 0.9 -0.3 1.0 1.0 0.8 0.6 1.4
Diastolic blood pressure, automated reading 0.6 2.0 12.5 -3.5 -0.5 0.1 2.0 1.0 1.6 1.4 -0.7 0.2 0.8 0.4 -0.7
Ever depressed for a whole week 0.3 0.4 2.0 -0.3 -1.4 -0.4 0.8 0.5 0.6 -0.2 -0.1 0.2 -0.7 -0.2 -0.2
Unable to work because of sickness or disability 4.2 5.4 14.9 1.5 -2.7 -2.9 1.0 -1.5 -2.4 -2.4 -1.5 -1.1 -2.7 -2.6 -3.9
Commuting to job workplace: Cycle 0.3 0.4 1.3 0.1 0.8 0.3 -0.5 0.4 1.2 0.5 0.3 -0.1 0.1 0.6 1.1
Myopia 0.7 1.0 2.9 -1.5 1.7 0.8 0.0 0.0 1.2 1.0 -0.2 -0.2 0.4 0.8 1.7
Vascular/heart problems diagnosed by doctor 0.4 1.2 5.6 -0.0 1.2 0.9 1.4 -0.0 0.6 2.4 0.4 1.2 -0.6 0.8 1.3
Cholesterol lowering medication 0.3 0.4 1.1 -1.1 0.6 0.6 1.0 1.0 0.0 0.4 0.3 0.3 0.6 0.4 -0.7
Medication: Omeprazole (e.g. Zanprol) 2.0 2.5 6.4 2.3 -2.0 -0.8 -0.2 -1.5 -1.9 -1.9 -0.3 -1.1 -1.0 -1.3 -2.5
Pain experienced in last month 1.0 1.7 5.0 0.9 2.2 1.4 -0.1 1.5 1.1 0.6 1.4 1.7 1.1 1.4 1.1
Supplements: Calcium 0.8 0.9 2.8 0.1 -1.3 -0.7 1.7 -0.3 -0.7 0.2 -0.9 0.7 -0.8 -0.8 -1.5
Basal cell carcinoma (self-reported) 4.1 4.9 11.6 2.8 -1.4 -2.7 -2.9 -1.5 -1.7 -3.4 -1.6 -2.5 -1.6 -2.3 -0.5
Heart attack/myocardial infarction (self-reported) 1.2 1.6 5.0 0.7 0.7 0.8 -2.2 1.8 1.3 -0.5 1.4 0.5 1.0 1.0 1.8
Deep venous thrombosis (DVT) (self-reported) 0.8 1.0 2.7 1.4 -1.6 -0.6 -1.5 -0.5 -1.6 -1.0 0.1 -0.6 -0.2 -0.7 -0.6
Heart disease (siblings) 0.5 0.6 1.7 0.5 -0.1 -0.5 0.3 -0.7 -1.2 -0.4 -0.5 -1.2 -0.9 -0.8 -1.3
Alcohol drinker status: Previous 0.2 0.3 2.3 -0.2 -0.4 -0.4 0.1 -0.1 0.0 -0.4 -0.3 -0.2 0.2 -0.3 -1.5
Pack years of smoking 3.0 4.4 14.2 -1.1 -3.8 -1.9 0.1 -1.2 -2.2 -1.7 -2.4 -2.1 -1.9 -2.2 -2.4
Impedance of whole body 1.5 7.8 43.8 -2.9 2.6 -0.2 6.6 0.9 0.7 4.6 -0.9 2.5 -1.3 0.2 -1.6
Leg fat mass (left) 3.2 12.5 63.7 3.5 -2.8 -0.3 -8.0 -0.5 1.1 -6.1 0.9 -3.1 2.5 -0.2 3.3
Arm predicted mass (left) 2.2 11.3 60.1 4.9 -1.5 -0.7 -7.8 -1.0 0.2 -5.1 0.8 -2.8 2.1 -0.2 2.9