TWAS hub - FAIM2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0870	0.0360	6.4e-04	-0.002	0.023	0.023	0.026	0.006	7.2e-01	7.5e-04	7.3e-04	3.7e-04	4.8e-02
2	GTEx	Artery Tibial	0.1662	0.0603	5.3e-03	0.032	NA	0.030	NA	0.029	1.3e-03	NA	1.9e-03	NA	2.1e-03
3	GTEx	Cells Transformed fibroblasts	0.4060	0.0630	4.4e-11	0.180	NA	0.244	NA	0.224	1.7e-13	NA	2.5e-18	NA	9.7e-17
4	GTEx	Testis	0.2720	0.0930	2.6e-03	0.091	NA	0.058	NA	0.063	7.7e-05	NA	1.5e-03	NA	9.3e-04
5	METSIM	Adipose	0.1458	0.0368	8.4e-08	0.071	0.067	0.055	0.071	0.067	7.4e-11	2.5e-10	9.5e-09	8.9e-11	3.1e-10
6	TCGA	Bladder Urothelial Carcinoma	0.1190	0.0430	1.5e-04	0.054	0.039	0.029	NA	0.038	2.3e-05	2.8e-04	1.7e-03	NA	3.6e-04
7	TCGA	Breast Invasive Carcinoma	0.0227	0.0109	2.9e-03	0.000	0.008	0.004	NA	0.002	4.0e-01	8.5e-03	3.8e-02	NA	1.0e-01
8	TCGA	Head and Neck Squamous Cell Carcinoma	0.1026	0.0316	2.3e-08	0.088	0.076	0.099	NA	0.089	4.0e-10	6.8e-09	3.7e-11	NA	3.1e-10
9	TCGA	Kidney Renal Clear Cell Carcinoma	0.1078	0.0340	2.6e-06	0.061	0.053	0.064	NA	0.058	1.8e-07	1.2e-06	9.2e-08	NA	3.9e-07
10	TCGA	Lung Squamous Cell Carcinoma	0.1261	0.0388	3.0e-08	0.084	0.090	0.081	NA	0.082	8.2e-10	1.9e-10	1.6e-09	NA	1.3e-09
11	TCGA	Prostate Adenocarcinoma	0.0661	0.0297	1.9e-03	0.024	0.013	0.009	NA	0.023	1.3e-03	1.4e-02	3.9e-02	NA	1.7e-03
12	TCGA	Thyroid Carcinoma	0.1370	0.0400	4.1e-09	0.043	0.073	0.055	NA	0.051	4.4e-05	1.2e-07	4.3e-06	NA	1.0e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Comparative body size at age 10	15.2	42.0	256.0	8.7	-1.9	-0.5	-16.0	-0.5	0.5	-8.3	3.7	-4.3	4.6	0.5	6.7
Family relationship satisfaction	5.3	6.6	11.0	-2.2	2.4	3.2	1.3	2.4	2.2	3.1	2.9	3.3	2.4	3.1	1.1
Qualifications: NVQ or HND or HNC or equivalent	5.3	6.3	12.4	-0.3	1.7	2.2	-1.7	3.2	3.5	1.7	3.0	2.3	2.9	2.5	3.2
Medication: Lansoprazole	5.0	5.7	11.4	1.3	-2.2	-2.9	1.2	-2.0	-2.8	-2.6	-2.5	-1.6	-2.4	-2.6	-3.4
Happiness	4.6	5.6	10.7	-3.3	0.9	2.8	-0.6	2.6	1.8	2.9	2.5	1.9	1.9	2.9	2.6
Ovarian Cancer	4.4	5.8	10.0	-0.1	-3.0	-3.2	-0.2	-2.9	-2.4	-1.7	-2.7	-2.7	-2.9	-2.7	-2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	4.3	5.0	11.9	1.0	-1.3	-2.6	1.9	-2.3	-2.2	-2.8	-2.5	-1.4	-2.0	-2.4	-3.5
Unable to work because of sickness or disability	4.2	5.4	14.9	1.5	-2.7	-2.9	1.0	-1.5	-2.4	-2.4	-1.5	-1.1	-2.7	-2.6	-3.9
BMI	4.1	23.8	132.2	5.6	-2.7	-1.3	-11.5	-1.3	0.0	-8.3	1.1	-4.7	2.6	-0.9	3.4
Basal cell carcinoma (self-reported)	4.1	4.9	11.6	2.8	-1.4	-2.7	-2.9	-1.5	-1.7	-3.4	-1.6	-2.5	-1.6	-2.3	-0.5
Osteoarthritis (self-reported)	4.0	5.2	11.8	1.8	-3.4	-2.2	-0.9	-2.2	-2.9	-3.0	-1.5	-1.7	-2.0	-2.4	-2.2
Body Mass Index (BMI) (2010)	3.8	5.2	31.4	2.8	0.1	-0.4	-5.6	-0.2	0.8	-3.2	1.2	-1.4	1.6	0.3	2.6
Weight	3.5	17.1	94.1	4.9	-2.2	-0.3	-9.7	-0.7	1.0	-6.4	1.4	-3.3	3.2	0.1	3.9
Arm fat mass (right)	3.5	14.5	79.0	3.5	-2.4	0.5	-8.9	0.0	1.9	-5.6	1.9	-2.5	3.7	0.7	4.2
Arm fat mass (left)	3.5	14.4	78.9	3.6	-2.5	0.1	-8.9	-0.3	1.6	-5.9	1.6	-2.8	3.3	0.4	4.0
Severe depression (siblings)	3.3	3.7	8.6	1.3	-1.4	-2.3	-0.1	-2.2	-2.1	-1.6	-1.5	-2.1	-2.9	-2.2	-1.8
Coronary Artery Disease (CAD)	3.2	3.8	7.3	0.2	-1.9	-2.0	-2.0	-2.1	-2.7	-1.9	-1.9	-2.2	-1.9	-2.2	-1.5
Leg fat-free mass (left)	3.2	17.1	94.9	5.3	-1.8	-0.9	-9.7	-1.6	0.0	-6.5	0.7	-3.9	2.1	-0.7	3.5
Leg predicted mass (left)	3.2	17.1	93.8	5.4	-1.9	-0.9	-9.7	-1.7	-0.1	-6.6	0.6	-4.0	2.0	-0.8	3.3
Exposure to tobacco smoke outside home	3.2	4.2	7.0	1.4	-2.6	-2.6	-0.4	-1.8	-2.5	-1.6	-2.0	-2.5	-1.6	-2.3	-2.1
Commuting to job workplace: Car/motor vehicle	3.2	3.7	7.7	-1.3	1.2	2.3	0.5	2.8	1.6	1.2	2.3	2.6	2.6	2.1	0.8
Leg fat mass (left)	3.2	12.5	63.7	3.5	-2.8	-0.3	-8.0	-0.5	1.1	-6.1	0.9	-3.1	2.5	-0.2	3.3
Trunk fat mass	3.1	13.2	65.9	4.1	-2.1	-0.5	-8.1	-0.7	1.5	-6.0	1.0	-3.1	2.7	-0.1	3.6
Whole body fat mass	3.1	12.9	65.6	3.9	-2.5	-0.3	-8.1	-0.6	1.3	-6.0	1.1	-3.0	2.7	-0.1	3.5
Leg fat-free mass (right)	3.1	16.7	93.7	5.2	-1.7	-0.8	-9.7	-1.7	-0.2	-6.5	0.4	-4.1	1.7	-0.8	3.4
Leg predicted mass (right)	3.1	16.7	94.8	5.1	-1.6	-0.8	-9.7	-1.6	-0.2	-6.4	0.5	-4.1	1.8	-0.7	3.5
Pack years adult smoking proportion	3.0	4.5	13.4	-1.1	-3.7	-1.9	0.3	-1.1	-2.3	-1.7	-2.4	-2.1	-1.9	-2.2	-2.8
Body mass index (BMI)	3.0	13.0	68.8	2.9	-3.2	0.4	-8.3	-0.1	1.1	-6.0	1.6	-2.8	3.1	0.4	3.3
Leg fat mass (right)	3.0	11.6	56.7	3.4	-2.9	-0.5	-7.5	-0.6	1.1	-6.1	0.9	-2.9	2.5	-0.3	2.9
Pack years of smoking	3.0	4.4	14.2	-1.1	-3.8	-1.9	0.1	-1.2	-2.2	-1.7	-2.4	-2.1	-1.9	-2.2	-2.4
Arm fat percentage (left)	2.9	11.5	58.4	3.0	-2.8	0.1	-7.6	-0.3	1.6	-5.6	1.4	-2.6	3.0	0.2	3.4
Other serious medical condition/disability diagnosed by doctor	2.8	3.6	9.4	0.1	-2.6	-1.9	1.0	-1.5	-2.2	-1.8	-2.0	-0.7	-2.0	-1.9	-3.1
Arm fat percentage (right)	2.8	11.2	57.4	2.7	-2.8	0.5	-7.6	0.2	1.9	-5.1	1.7	-2.1	3.4	0.6	3.7
Friendships satisfaction	2.8	3.4	8.6	-2.9	1.0	2.3	0.0	2.2	1.4	1.9	1.7	2.0	1.1	2.2	1.5
Age at First Birth	2.7	3.9	8.1	0.7	1.4	2.1	-2.1	0.9	1.8	2.6	2.7	0.9	2.9	2.4	1.7
Basal metabolic rate	2.7	15.2	82.8	5.5	-1.6	-0.6	-9.1	-1.2	0.3	-5.9	1.0	-3.3	2.4	-0.2	3.5
Waist circumference	2.6	9.5	49.8	2.6	-2.8	-0.5	-7.1	-0.2	0.9	-5.4	1.0	-2.4	2.1	-0.2	2.7
Qualifications: None of the above	2.6	5.5	14.2	0.5	-3.6	-2.6	1.9	-0.1	-2.7	-2.6	-1.6	-1.0	-2.1	-2.6	-3.8
Mouth/teeth dental problems: Mouth ulcers	2.6	4.1	6.0	1.6	-2.1	-2.1	-1.0	-2.2	-2.4	-1.6	-2.3	-2.2	-2.3	-2.2	-1.4
Impedance of leg (right)	2.4	11.6	66.9	-3.2	2.6	0.1	8.2	1.4	1.4	5.8	-0.3	3.5	-0.7	0.8	-2.1
Hip circumference	2.4	10.5	59.3	3.6	-1.5	0.1	-7.7	-0.6	0.8	-4.8	1.4	-2.4	3.0	0.3	3.3
Worrier / anxious feelings	2.4	4.5	9.7	3.1	-1.6	-2.5	0.6	-3.0	-1.6	-1.3	-1.3	-2.1	-2.5	-2.4	-1.8
Whole body fat-free mass	2.4	13.7	72.9	5.6	-1.4	-0.7	-8.5	-1.4	-0.1	-5.6	0.8	-3.1	2.0	-0.4	3.1
Mood swings	2.4	4.4	9.7	1.8	-3.1	-2.0	-0.3	-2.2	-1.8	-2.1	-1.6	-2.4	-2.4	-2.4	-1.8
Financial situation satisfaction	2.4	3.0	8.7	-2.7	1.7	2.2	1.0	2.0	0.9	3.0	1.6	1.1	0.8	1.5	0.1
Pain type(s) experienced in last month: Hip pain	2.4	3.0	11.7	-0.0	-3.4	-1.6	0.4	-1.3	-1.9	-1.8	-1.2	-1.4	-1.7	-1.7	-2.1
Whole body water mass	2.3	13.3	71.1	5.5	-1.3	-0.6	-8.4	-1.3	0.0	-5.5	0.9	-3.0	2.1	-0.3	3.1
Trunk fat percentage	2.2	8.8	44.0	2.6	-2.0	-0.3	-6.6	-0.3	1.7	-4.9	0.9	-2.6	2.4	0.0	3.2
Impedance of leg (left)	2.2	10.9	60.4	-3.3	2.9	0.3	7.8	1.6	1.3	5.6	-0.5	3.2	-0.9	0.8	-1.6
Illnesses of mother	2.2	2.7	13.1	3.6	-0.6	-1.1	-0.7	-2.7	-1.9	-1.2	-0.7	-0.9	-1.3	-1.2	-0.4
Medication: Ventolin 100micrograms inhaler	2.2	2.8	6.5	1.9	-1.3	-2.5	0.2	-1.4	-0.9	-1.2	-1.6	-2.1	-1.9	-1.9	-1.9
Body fat percentage	2.2	8.8	43.4	2.6	-2.4	-0.1	-6.6	-0.1	1.6	-5.0	1.1	-2.4	2.5	0.1	3.1
Arm fat-free mass (left)	2.2	11.3	60.7	4.9	-1.4	-0.3	-7.8	-0.6	0.6	-4.9	1.3	-2.5	2.4	0.2	3.3
Arm predicted mass (left)	2.2	11.3	60.1	4.9	-1.5	-0.7	-7.8	-1.0	0.2	-5.1	0.8	-2.8	2.1	-0.2	2.9
Crohns Disease (2012)	2.1	3.4	5.7	-1.3	2.4	2.0	1.1	1.8	2.1	2.2	1.8	2.2	1.5	1.8	1.3
Number of treatments/medications taken	2.1	3.7	12.4	0.9	-2.7	-1.9	-1.5	-1.6	-1.2	-3.5	-1.1	-2.6	-0.8	-1.7	-1.4
Number of live births	2.1	3.0	9.2	0.3	-1.9	-1.1	3.0	-0.2	-1.9	-1.2	-1.2	0.3	-2.1	-1.5	-2.9
Chronic bronchitis/emphysema (mother)	2.1	2.5	8.4	-2.9	1.0	1.3	1.3	2.5	1.5	2.0	0.8	1.6	0.6	1.1	0.2
Arm predicted mass (right)	2.1	10.6	53.9	4.8	-1.3	-0.6	-7.3	-1.1	0.4	-5.1	0.9	-2.8	2.0	-0.2	2.7
Had major operations	2.1	2.4	8.2	-2.9	1.5	1.8	1.0	1.4	1.0	2.4	0.9	1.3	1.1	1.3	0.8
Neuroticism	2.0	4.8	10.8	3.3	-1.0	-2.5	-2.3	-3.0	-1.9	-2.0	-1.1	-2.6	-2.0	-2.3	-1.0
Nervous feelings	2.0	3.7	7.0	0.7	-1.8	-2.6	1.3	-2.0	-1.8	-1.4	-2.2	-1.4	-2.5	-2.5	-2.1
Arm fat-free mass (right)	2.0	10.1	51.7	4.8	-1.1	-0.5	-7.2	-1.0	0.4	-4.9	0.9	-2.8	2.0	-0.1	2.8
Medication: Omeprazole (e.g. Zanprol)	2.0	2.5	6.4	2.3	-2.0	-0.8	-0.2	-1.5	-1.9	-1.9	-0.3	-1.1	-1.0	-1.3	-2.5
Average weekly spirits intake	1.9	2.3	4.1	0.2	-1.7	-1.4	0.8	-2.0	-1.7	-1.7	-1.9	-1.6	-1.2	-1.7	-1.3
Ever used hormone-replacement therapy (HRT)	1.9	2.4	7.0	-1.1	-2.1	-1.2	2.3	1.2	-1.2	-1.2	-0.9	0.1	-1.7	-1.1	-2.6
Chest pain or discomfort	1.9	2.8	5.0	0.2	-1.6	-2.0	1.0	-1.8	-1.9	-1.4	-1.6	-1.5	-2.2	-1.9	-2.2
Leg fat percentage (left)	1.9	6.9	33.1	2.3	-2.5	-0.0	-5.8	0.2	1.1	-4.7	0.9	-1.9	2.1	0.1	2.5
Medication for hormone replacement therapy	1.8	2.0	7.0	-1.6	0.7	1.2	0.6	2.7	1.5	1.2	1.0	1.4	1.8	1.5	0.4
Trunk fat-free mass	1.8	10.5	53.7	5.6	-0.9	-0.5	-7.3	-1.2	-0.1	-4.7	0.9	-2.2	2.0	-0.1	2.5
Noisy workplace	1.8	2.2	6.5	-0.4	-2.5	-1.3	1.4	-0.5	-1.1	-2.0	-1.1	-1.5	-1.3	-1.6	-1.7
Trunk predicted mass	1.8	10.2	52.3	5.5	-0.9	-0.5	-7.2	-1.1	-0.0	-4.6	1.0	-2.1	2.0	-0.1	2.5
Commuting to job workplace: Walk	1.8	2.0	5.2	0.2	-1.3	-1.6	-0.3	-1.4	-2.3	-0.8	-1.4	-1.7	-1.7	-1.6	-1.0
Frequency of depressed mood in last 2 weeks	1.7	2.4	5.5	0.0	-1.4	-2.2	0.4	-1.6	-1.3	-1.0	-1.6	-1.4	-2.3	-2.1	-1.6
Bilateral oophorectomy (both ovaries removed)	1.7	1.9	4.4	-1.6	-0.0	1.7	1.5	2.1	1.6	0.8	1.4	1.6	1.2	1.4	0.3
Neuroticism score	1.7	3.6	7.5	2.0	-1.4	-2.3	-0.5	-2.7	-1.6	-1.2	-1.5	-2.4	-2.2	-2.2	-1.3
Leg fat percentage (right)	1.7	6.0	26.7	2.2	-2.6	-0.3	-5.2	0.0	1.0	-4.6	0.9	-1.7	2.1	-0.0	1.9
Osteoporosis (self-reported)	1.7	2.1	8.0	-1.7	-1.7	-0.8	2.8	-0.9	-0.6	0.2	-1.6	0.4	-1.1	-0.9	-2.2
HDL Cholesterol	1.6	2.7	6.2	0.3	-1.0	-1.1	1.8	-2.5	-2.0	-0.8	-2.1	-1.1	-1.6	-1.6	-2.2
Ever had hysterectomy (womb removed)	1.6	1.8	11.5	-3.4	-0.3	0.8	2.0	1.4	0.7	1.4	0.2	0.4	-0.2	0.4	-0.1
Falls in the last year	1.6	2.2	5.8	-0.9	-2.4	-1.4	0.4	-1.1	-1.6	-0.7	-1.2	-0.5	-1.9	-1.6	-2.4
Migraine (self-reported)	1.6	2.0	3.7	0.2	-1.8	-1.1	0.6	-1.1	-1.9	-1.5	-1.6	-0.8	-1.9	-1.3	-1.7
Ever taken oral contraceptive pill	1.6	1.8	7.2	-2.7	0.8	0.4	0.8	2.2	1.4	1.6	0.7	0.9	1.0	0.8	0.2
Commuting to job workplace: Public transport	1.6	1.9	7.2	2.7	-1.0	-0.4	-2.1	-1.5	-1.2	-1.4	-0.8	-1.4	-0.7	-0.7	0.8
Fractured/broken bones in last 5 years	1.6	2.0	7.6	-2.8	0.7	1.3	2.4	0.5	1.6	2.0	0.6	1.1	0.0	0.6	0.5
Alzheimer’s Disease (including proxy)	1.5	2.2	3.9	-0.6	1.8	1.8	-0.4	1.4	0.9	0.6	1.5	1.9	2.0	1.8	1.8
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.4	5.9	-1.5	-1.8	-1.6	1.2	-0.5	-0.6	-1.3	-1.3	-1.4	-2.4	-1.9	-1.8
Tense / ‘highly strung’	1.5	2.5	4.9	1.6	-1.6	-1.8	1.3	-1.6	-1.5	-0.6	-1.3	-0.5	-2.2	-1.8	-2.2
Mouth/teeth dental problems: Loose teeth	1.5	1.8	3.6	0.7	1.0	0.8	-1.5	1.4	1.1	1.2	1.7	1.4	1.9	1.4	1.2
Handedness (chirality/laterality): Left-handed	1.5	1.8	7.1	-2.4	0.5	0.4	2.7	0.8	1.5	1.8	-0.4	0.9	0.5	0.4	0.7
Average weekly beer plus cider intake	1.5	2.2	11.0	-2.7	-0.9	0.3	3.3	1.1	0.1	1.8	-0.8	1.0	-0.2	0.2	-0.9
Impedance of whole body	1.5	7.8	43.8	-2.9	2.6	-0.2	6.6	0.9	0.7	4.6	-0.9	2.5	-1.3	0.2	-1.6
Depression (Nagel 2018)	1.4	2.1	5.3	0.5	-1.2	-2.3	-0.3	-1.8	-1.3	-0.5	-1.4	-1.5	-2.0	-1.9	-1.0
Alzheimer’s Disease (in father)	1.4	1.5	3.1	0.0	0.6	1.8	-1.1	1.1	0.0	-0.6	1.8	1.5	1.8	1.7	0.8
Fed-up feelings	1.4	2.6	5.5	-0.2	-1.4	-2.3	-0.0	-1.3	-1.5	-1.4	-1.4	-1.9	-2.2	-2.1	-1.6
Age when periods started (menarche)	1.4	3.4	21.0	-2.0	1.3	-0.1	4.6	-0.2	-0.0	2.1	-1.4	1.3	-2.0	-0.3	-1.3
Neck or shoulder pain in last month	1.4	2.0	4.6	-1.2	-2.1	-1.5	0.7	-1.6	-1.2	-0.7	-1.7	-1.5	-1.0	-1.8	-1.4
Ever had prostate specific antigen (PSA) test	1.4	1.6	6.8	1.6	-1.1	-0.7	-2.6	-1.4	-1.8	-0.7	-0.2	-0.8	-0.9	-0.8	0.1
Alzheimer’s Disease (in mother)	1.3	1.5	3.5	-0.7	1.9	1.0	0.7	1.2	1.2	0.8	0.8	1.6	1.1	1.3	1.6
Neuroticism (2016)	1.3	1.8	5.5	2.2	-0.1	-1.3	0.0	-2.3	-1.0	-1.4	-0.8	-1.4	-1.4	-1.3	-0.8
Triglycerides	1.3	2.1	4.0	-0.8	2.0	1.7	-0.6	1.4	2.0	0.8	1.5	0.9	1.0	1.6	2.0
Systolic blood pressure, automated reading	1.3	3.8	19.9	-4.5	-0.9	1.1	2.2	2.0	1.8	2.0	0.6	1.5	1.6	1.3	-0.7
Serious illness, injury or assault to yourself	1.3	1.6	3.8	1.5	-0.2	-1.6	-0.4	-0.4	-1.7	-1.3	-0.5	-0.4	-1.9	-1.3	-1.8
Stomach or abdominal pain in last month	1.3	1.6	3.7	-0.0	-0.3	-1.9	0.2	-1.8	-1.6	-0.6	-1.6	-1.3	-1.2	-1.5	-1.2
Mouth/teeth dental problems: Dentures	1.3	2.3	7.5	-2.7	-1.4	-1.0	1.9	0.3	-0.9	-0.6	-1.7	-0.8	-2.3	-1.1	-1.3
Lung cancer (father)	1.3	1.5	12.6	-0.5	0.3	-0.2	3.5	0.1	0.0	-0.0	-0.4	1.1	-0.8	-0.4	-1.7
Worry too long after embarrassment	1.3	2.1	12.1	3.5	1.4	0.1	-2.6	-0.9	-0.3	0.2	1.3	-0.5	0.0	0.3	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.7	6.8	-0.2	-2.6	-1.3	1.0	-0.7	-1.1	-1.2	-0.9	-0.4	-1.3	-1.3	-1.7
Age at first live birth	1.3	2.3	7.2	1.4	2.2	1.0	-1.9	-0.7	1.2	1.8	1.0	-0.4	1.1	1.2	2.7
Knee pain experienced in last month	1.3	2.1	4.0	-0.6	-1.7	-1.8	-0.5	-1.6	-0.9	-1.3	-1.7	-2.0	-1.5	-1.8	-0.7
Alcohol drinker status: Never	1.3	1.5	5.7	1.0	-0.8	-0.6	-1.0	-1.9	-2.4	-1.5	-0.8	-1.1	-0.3	-1.0	-1.2
Maternal smoking around birth	1.2	1.7	10.5	-3.2	-0.4	-0.5	2.0	1.7	0.6	1.2	0.1	0.9	0.1	0.0	-0.6
High blood pressure (siblings)	1.2	1.8	5.2	-1.9	0.8	0.3	-1.5	0.5	1.6	1.4	0.4	-0.7	1.8	0.8	2.3
Pulse wave peak to peak time	1.2	1.4	3.0	1.5	-0.8	-1.4	-1.5	-1.1	-0.3	-1.6	-1.2	-1.7	-0.4	-1.0	-0.2
Emphysema/chronic bronchitis	1.2	1.4	3.4	1.0	-1.7	-1.3	-1.8	-1.0	-1.7	-0.7	-0.2	-1.2	-0.7	-0.8	-0.5
Supplements: Fish oil (including cod liver oil)	1.2	1.5	7.7	2.8	-0.1	-1.7	0.5	-1.6	-0.7	-0.7	-0.3	0.1	-0.6	-0.9	-1.6
Irritability	1.2	2.1	6.0	2.4	0.0	-1.0	-1.1	-1.9	-0.8	-2.1	-0.9	-1.8	-0.9	-1.5	-0.8
Heart attack/myocardial infarction (self-reported)	1.2	1.6	5.0	0.7	0.7	0.8	-2.2	1.8	1.3	-0.5	1.4	0.5	1.0	1.0	1.8
Depressed Affect (Nagel 2018)	1.1	2.3	3.9	0.7	-2.0	-2.0	-1.6	-1.1	-1.4	-1.8	-0.6	-1.9	-1.6	-1.8	-0.7
Worry (Nagel 2018)	1.1	2.3	5.9	2.4	-2.1	-1.9	-0.9	-1.7	-1.2	-1.0	-0.7	-1.5	-1.4	-1.6	-0.8
Verbal and Numeric Reasoning (VNR)	1.1	2.6	6.3	2.1	0.2	-1.0	0.6	-1.5	-2.1	-1.1	-1.6	-1.7	-1.9	-1.7	-2.5
Systolic Blood Pressure	1.1	5.4	30.1	-5.5	-0.9	1.2	3.3	1.6	2.1	2.5	0.2	1.2	2.1	1.4	-0.9
Current tobacco smoking	1.1	1.8	6.9	-2.6	-1.0	-0.8	1.6	-0.8	-1.1	1.0	-1.3	-1.2	-1.3	-1.0	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.4	4.2	-0.3	-0.1	-2.0	0.5	-1.6	-0.5	-0.1	-1.4	-1.4	-1.8	-1.5	-0.6
Chronic bronchitis/emphysema (father)	1.1	1.3	6.7	-1.6	-1.1	-0.1	2.6	-0.1	-0.9	0.0	-0.4	0.3	-1.3	-0.8	-1.4
Had other major operations	1.1	1.4	5.6	-0.4	-0.3	-1.1	1.4	-0.1	-1.6	-1.1	-1.1	-0.3	-1.2	-1.0	-2.4
Heart attack	1.1	1.5	6.5	0.9	0.6	0.6	-2.5	1.4	1.2	-0.7	1.1	0.1	0.7	0.8	1.7
Medication: Simvastatin	1.1	1.6	4.9	-0.3	1.1	1.3	-1.1	1.3	1.6	0.2	1.5	0.4	2.2	1.4	1.2
Medication: Cholesterol lowering	1.1	1.8	9.9	-0.1	-0.1	0.9	-3.1	0.7	1.0	-0.7	1.4	-0.2	1.7	1.1	1.5
Length of working week for main job	1.1	1.2	2.0	-0.1	-1.4	-1.0	0.2	-0.5	-1.4	-1.1	-1.4	-0.9	-1.1	-1.3	-1.4
Pulse wave reflection index	1.1	1.4	4.2	-1.4	-0.1	1.4	0.8	0.6	-0.1	2.1	1.2	1.5	1.4	1.2	0.4
Headache pain in last month	1.1	1.9	6.4	0.1	-2.5	-0.9	0.8	-1.6	-1.5	-1.3	-1.0	-0.6	-0.5	-0.9	-2.3
Medication: Omeprazole	1.1	1.3	3.7	1.7	-1.5	-0.5	-0.4	-1.3	-1.2	-1.0	0.2	-1.0	-0.5	-0.8	-1.9
Comparative height size at age 10	1.1	6.3	28.2	5.3	0.4	-1.1	-5.2	-1.0	-0.3	-3.0	1.1	-1.3	1.6	-0.3	1.9
Hearing aid user	1.1	1.3	4.0	-0.6	-2.0	-0.8	1.9	0.1	-1.0	-0.5	-0.8	-0.4	-0.9	-1.0	-1.7
Mother’s age at death	1.1	1.4	3.2	1.1	0.7	0.9	-0.5	1.4	1.2	0.9	1.1	1.2	1.8	1.5	1.3
Medication: Atorvastatin	1.1	1.3	4.0	0.9	-1.1	-0.7	-0.4	-1.2	-1.3	-2.0	-0.6	-1.5	-1.1	-1.1	-1.2
Major Depression (MDD)	1.0	1.2	8.7	3.0	-0.2	-0.9	0.0	-0.4	-0.0	-1.5	-0.1	-0.8	-0.4	-0.7	-0.9
Vitamin and mineral supplements	1.0	1.4	5.3	1.6	-0.4	0.1	-2.3	-1.1	-0.9	-1.2	-0.3	-2.0	-0.0	-0.6	0.7
Pain all over the body in last month	1.0	1.1	2.7	0.8	-1.0	-1.3	0.3	-0.2	-0.6	-1.6	-0.8	-1.3	-1.4	-1.2	-1.1
Hair/balding pattern: Pattern 4	1.0	2.3	7.4	0.4	0.6	1.7	-2.5	1.0	0.3	0.8	2.7	1.3	2.0	1.6	0.6
Alcohol intake frequency.	1.0	2.3	7.3	2.7	-1.3	-0.7	-2.7	-0.9	-0.8	-2.7	0.5	-1.3	0.5	-0.5	-0.4
High cholesterol (Self-reported)	1.0	1.8	4.4	-0.3	1.2	0.8	-2.1	0.4	1.8	-0.1	1.4	-0.0	2.0	1.2	2.0
Pain experienced in last month	1.0	1.7	5.0	0.9	2.2	1.4	-0.1	1.5	1.1	0.6	1.4	1.7	1.1	1.4	1.1
Neuroticism (Nagel 2018)	0.9	2.1	7.3	2.7	-1.3	-1.6	-1.8	-1.4	-1.2	-1.5	0.0	-1.3	-1.1	-1.4	-0.3
Crohns Disease (2017)	0.9	1.9	5.4	0.2	1.5	1.8	-0.0	1.9	1.3	1.1	2.3	1.4	1.1	1.3	1.0
Reaction Time	0.9	1.7	4.8	1.9	-1.7	-1.5	-0.6	-0.5	-1.6	-2.2	-0.5	-0.6	-0.7	-1.0	-1.1
Mean Putamen Volume	0.9	1.1	3.7	0.1	0.4	-1.9	0.6	-1.0	-0.9	0.5	-1.6	-0.9	-0.7	-1.3	-1.0
Heel T-Score	0.9	7.0	18.7	2.1	0.3	1.8	-4.3	3.1	3.1	-0.5	2.4	0.4	3.1	2.0	4.3
Allergy or Eczema	0.9	2.4	7.0	-1.9	1.9	1.6	0.6	0.2	1.9	2.6	0.7	0.3	1.7	1.4	1.6
Hand grip strength (left)	0.9	2.4	5.7	-0.4	1.8	2.0	-1.2	0.2	0.9	1.3	1.8	0.8	1.9	2.0	2.4
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.5	6.0	-0.5	-0.3	-1.8	1.0	-0.8	-0.3	-0.3	-1.2	-1.1	-2.4	-1.6	-1.0
Hair/balding pattern: Pattern 2	0.9	1.2	4.8	-2.2	0.3	0.9	2.1	-0.3	0.0	1.5	-0.1	0.9	0.2	0.7	-0.6
Birth weight of first child	0.9	1.6	3.6	0.8	-0.8	-1.7	-0.0	-0.9	-1.2	-0.6	-1.6	-1.1	-1.8	-1.9	-1.0
Gout (self-reported)	0.9	1.2	3.1	-1.0	-0.6	1.7	0.2	0.9	0.6	1.7	1.4	0.7	1.3	1.1	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	2.9	0.1	-0.2	-1.2	1.7	-0.3	-0.7	-1.4	-1.4	-0.5	-1.1	-1.2	-1.2
Shortness of breath walking on level ground	0.9	1.1	3.1	-0.8	-1.8	-1.0	-0.2	-0.7	-0.6	-0.9	-1.1	-1.8	-0.9	-1.2	-0.5
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	4.0	-0.8	0.9	0.9	-1.6	0.4	0.8	-0.1	0.6	0.9	1.5	0.8	2.0
Smoking status: Previous	0.9	1.3	4.3	-2.1	0.4	1.1	0.8	1.0	1.6	0.9	0.9	0.7	1.1	1.5	0.6
Mineral and other dietary supplements	0.9	1.2	7.5	-2.7	-0.3	1.4	0.0	1.5	0.7	0.6	0.2	-0.3	0.4	0.9	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.8	6.0	2.4	2.4	0.8	-0.7	-0.1	1.0	-0.7	1.1	1.3	1.6	1.0	1.2
Bipolar Disorder (2018)	0.8	1.2	4.0	-1.4	-2.0	-1.0	-0.1	-1.5	-1.3	-0.5	-1.0	-0.9	-0.6	-1.1	-0.4
Bipolar Disorder or Schizophrenia	0.8	1.9	5.4	-0.5	-2.3	-1.7	-0.5	-1.2	-1.9	-1.1	-1.1	-1.2	-0.8	-1.6	-1.3
Diabetes (father)	0.8	0.9	2.2	0.5	0.6	0.9	-0.1	1.0	0.9	1.5	1.5	0.8	1.4	0.9	0.0
Relative age voice broke	0.8	1.2	2.8	-0.6	0.4	-0.9	1.6	-1.7	-1.2	0.6	-1.3	-0.1	-1.1	-0.9	-1.4
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	2.9	-0.4	-0.3	0.7	1.7	-0.6	-1.5	1.0	0.0	0.1	0.2	-0.1	-1.6
Supplements: Glucosamine	0.8	1.0	4.6	2.1	-0.2	-1.0	-1.6	-1.3	-0.8	-0.7	-0.1	-0.4	0.0	-0.7	0.2
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	2.3	0.4	-1.3	-1.2	0.2	-1.3	-0.9	-1.5	-0.8	-0.7	-0.6	-0.9	-1.2
Impedance of arm (right)	0.8	3.8	17.6	-2.1	1.8	0.0	4.2	0.8	0.7	3.6	-0.6	2.2	-0.6	0.3	-0.8
Impedance of arm (left)	0.8	3.5	18.1	-1.8	2.1	-0.3	4.2	0.1	0.4	3.2	-0.8	1.7	-0.9	-0.1	-1.0
Number of full brothers	0.8	1.0	3.3	0.5	-0.7	-1.3	-0.5	-1.2	-0.6	-0.4	-1.1	-1.8	-1.1	-1.2	0.2
Medication: Blood pressure	0.8	1.5	5.7	1.7	-1.3	-0.6	-2.4	-0.3	0.3	-1.9	0.1	-1.3	0.8	-0.0	0.6
Pulse rate, automated reading	0.8	2.6	5.4	0.4	-0.8	-2.1	1.9	-2.2	-0.6	-0.7	-1.8	-1.1	-2.1	-1.6	-2.3
Age at last live birth	0.8	1.1	5.8	2.4	1.4	0.3	-1.3	-1.2	0.2	0.5	0.6	-0.3	0.5	0.4	1.2
Illnesses of siblings: Diabetes	0.8	1.0	2.6	0.9	-1.0	-0.8	-0.3	-0.4	-1.6	-0.9	-1.0	-1.1	-1.1	-1.2	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	2.7	0.9	-1.1	-0.8	0.4	-0.9	-1.5	-1.0	-0.5	-0.1	-0.5	-0.7	-1.6
Medication: Aspirin	0.8	1.0	5.0	0.0	0.1	0.3	-1.8	-0.6	-0.0	-2.2	-0.0	-1.1	1.1	-0.1	0.8
Smoking status: Current	0.8	1.2	4.1	-2.0	-0.8	-0.6	1.2	-0.7	-1.0	1.1	-1.1	-1.1	-1.1	-0.8	-0.8
Number of self-reported non-cancer illnesses	0.8	1.3	4.4	0.2	-2.0	-1.3	-1.0	-0.6	-0.6	-2.1	-0.5	-1.0	0.1	-1.0	-1.3
Average weekly champagne plus white wine intake	0.8	1.0	4.2	2.1	-0.5	-0.4	-1.0	-0.3	-1.4	-1.7	-0.7	-0.5	-0.6	-0.9	-0.4
Supplements: Calcium	0.8	0.9	2.8	0.1	-1.3	-0.7	1.7	-0.3	-0.7	0.2	-0.9	0.7	-0.8	-0.8	-1.5
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	2.7	1.4	-1.6	-0.6	-1.5	-0.5	-1.6	-1.0	0.1	-0.6	-0.2	-0.7	-0.6
Smoking Status	0.7	1.8	15.3	-3.9	-0.5	0.1	1.1	0.7	0.4	1.8	-0.2	-0.4	-0.3	0.5	0.3
Relative age of first facial hair	0.7	1.4	5.1	-2.2	0.9	0.0	2.2	0.0	-0.2	1.9	-0.7	0.9	-0.7	0.2	-0.3
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	1.5	0.5	-1.2	-1.2	-0.6	-0.4	-0.8	-1.2	-0.4	-1.0	-0.7	-1.0	-0.9
Taking other prescription medications	0.7	1.1	6.5	-0.2	-2.5	-1.3	0.5	-0.5	-0.0	-1.7	-0.3	-0.7	-0.4	-0.7	-0.8
Medication: Levothyroxine sodium	0.7	1.1	3.1	-0.8	0.7	1.2	-1.6	0.3	0.4	-0.3	1.1	0.3	1.6	1.1	1.8
Number of incorrect matches in round	0.7	1.1	5.7	1.0	0.1	0.1	-1.8	0.8	1.2	-0.1	0.9	0.7	-0.0	0.8	2.4
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	6.9	2.0	0.0	-0.1	-2.6	1.8	0.5	-0.9	1.0	-0.4	1.6	0.2	0.6
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	1.8	-0.6	-1.1	-0.9	1.3	-0.5	-0.1	-0.7	-1.3	-1.4	-1.0	-0.8	-0.7
Diabetes (self-reported)	0.7	1.1	3.6	-1.5	-1.7	-0.6	-0.7	-0.7	-0.9	-1.9	-0.6	-1.1	-0.3	-0.8	-0.9
Pulse wave Arterial Stiffness index	0.7	0.8	2.1	-0.9	0.8	1.0	1.1	0.9	0.1	1.3	1.1	1.4	0.3	0.7	0.2
Peak expiratory flow (PEF)	0.7	1.7	4.0	0.5	1.7	0.8	-1.4	0.0	1.5	0.6	1.5	1.1	2.0	1.4	1.6
Medication: Paracetamol	0.7	1.1	3.4	1.0	-1.8	-1.3	0.1	-0.6	-0.8	-1.8	-0.3	-0.7	-0.8	-0.6	-1.1
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	7.0	-0.6	0.8	0.3	2.7	0.0	-0.3	1.5	-0.3	1.2	-0.7	-0.2	-1.0
Long-standing illness, disability or infirmity	0.7	1.0	5.6	-0.5	-2.4	-1.0	-1.3	-0.1	-0.3	-1.4	0.2	-0.6	0.1	-0.6	-1.1
Diabetes diagnosed by doctor	0.7	1.2	6.5	-1.2	-1.3	-0.8	-0.8	-0.8	-0.3	-2.6	-0.7	-1.3	-0.1	-0.8	-0.6
Asthma (self-reported)	0.7	1.3	3.9	-0.2	-0.4	0.6	0.2	1.3	1.6	1.4	1.5	1.0	2.0	1.2	0.5
Tinnitus: Yes, now most or all of the time	0.7	0.8	3.1	-0.2	-1.5	0.4	1.8	0.5	-0.6	0.7	0.5	0.4	-0.7	0.1	-1.4
Medication: Lisinopril	0.7	1.0	5.5	0.7	-1.1	-0.3	-0.7	0.0	-0.6	-2.3	-0.7	-0.7	-0.3	-0.9	-1.2
Myopia	0.7	1.0	2.9	-1.5	1.7	0.8	0.0	0.0	1.2	1.0	-0.2	-0.2	0.4	0.8	1.7
Lupus	0.6	0.9	2.0	-0.2	-0.7	-0.1	0.9	-1.4	-1.4	-0.7	-1.0	-0.7	-0.8	-1.0	-1.3
Cardiovascular Disease	0.6	2.0	6.1	-1.7	0.0	0.8	-2.2	1.5	1.5	-1.2	1.1	-0.4	2.5	1.0	0.8
Hearing difficulty/problems: Yes	0.6	0.9	3.2	-0.5	-1.1	0.3	1.4	1.4	-0.1	-0.0	1.0	1.8	0.7	0.5	-0.8
Medication: Co-codamol	0.6	0.7	2.1	-1.2	-1.0	-0.9	0.4	-0.5	-0.4	-0.3	-0.5	-0.5	-1.4	-1.0	-1.1
Qualifications: CSEs or equivalent	0.6	0.7	2.0	-1.3	0.5	-0.5	1.1	1.4	1.4	0.6	0.0	0.9	-0.1	0.4	0.6
Multivitamins +/- minerals	0.6	0.7	2.5	-1.3	-0.5	-0.1	1.2	1.1	0.5	0.7	0.4	1.6	0.6	0.5	-0.7
High blood pressure (mother)	0.6	0.9	2.9	-1.7	0.1	0.6	-0.8	1.0	1.0	1.1	0.5	-0.7	1.5	0.7	0.4
Past tobacco smoking	0.6	1.0	3.9	2.0	-0.1	-1.1	-0.9	-0.8	-1.0	-1.0	-0.8	-0.4	-1.0	-1.3	-0.5
Alcohol usually taken with meals	0.6	1.0	7.3	1.6	0.9	-0.2	-2.7	-0.4	-0.6	-0.9	0.5	-0.0	0.4	-0.0	0.5
Hearing difficulty/problems with background noise	0.6	0.9	2.3	-1.0	0.6	1.0	1.4	0.7	-0.1	0.9	1.1	1.5	0.6	0.9	-0.5
Time employed in main current job	0.6	0.7	1.6	1.3	0.8	1.2	-1.0	-0.2	0.4	-0.2	1.0	0.6	0.7	1.0	0.9
Father’s age at death	0.6	0.8	4.3	0.5	2.1	-0.0	-0.8	1.1	0.2	1.3	-0.2	0.3	-0.0	0.0	1.3
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	8.7	3.0	2.0	0.3	-1.3	-0.7	0.8	-0.5	1.1	1.1	1.6	0.9	1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	2.0	14.7	3.8	1.8	-0.2	-1.3	-0.9	-0.1	-1.0	0.8	0.6	1.1	0.4	0.4
Birth weight	0.6	1.3	3.8	1.3	0.1	-0.5	-1.6	-1.6	-1.5	-0.4	-0.6	-2.0	-0.4	-0.9	0.8
Qualifications: College or University degree	0.6	1.8	6.3	2.5	1.5	-0.4	-2.3	-1.8	-0.5	0.4	-0.2	-1.2	-1.1	-0.4	0.9
Number of full sisters	0.6	0.7	3.6	0.0	-1.9	-0.7	-0.0	-0.7	-0.8	-0.7	-0.6	-1.0	-0.6	-0.6	-0.4
Overall health rating	0.6	1.3	7.0	-1.2	-2.7	-1.3	0.2	0.4	0.1	-1.5	-0.4	-0.7	-0.2	-0.8	-1.3
Medication: Aspirin	0.6	0.9	5.6	0.2	-0.3	0.0	-1.4	-0.6	-0.6	-2.4	-0.0	-1.0	0.9	-0.3	0.1
Loneliness, isolation	0.6	0.8	2.2	0.7	-0.8	-1.5	0.2	-0.3	-0.9	-1.0	-0.2	-0.7	-1.1	-0.8	-1.3
Wears glasses or contact lenses	0.6	0.7	2.5	-1.6	1.2	0.3	0.5	1.2	0.7	0.9	0.0	0.1	-0.7	0.3	0.5
Age started oral contraceptive pill	0.6	0.8	2.0	0.8	0.2	0.8	-0.9	1.2	0.9	-0.3	1.0	1.0	0.8	0.6	1.4
Diastolic blood pressure, automated reading	0.6	2.0	12.5	-3.5	-0.5	0.1	2.0	1.0	1.6	1.4	-0.7	0.2	0.8	0.4	-0.7
Schizophrenia (2018)	0.5	1.0	1.9	0.5	-1.4	-1.3	-0.6	-0.3	-1.3	-0.9	-0.6	-0.8	-0.6	-1.2	-1.3
Irritable Bowel Disease (IBD)	0.5	1.2	4.2	0.3	1.1	1.2	-0.2	1.9	0.8	0.3	2.0	1.2	0.3	0.7	0.6
Primary Biliary Cirrhosis	0.5	0.7	2.0	-0.6	0.6	1.1	-0.6	1.0	0.5	0.1	1.0	0.7	1.4	1.0	0.6
Respiratory disease	0.5	1.1	2.5	-1.2	-0.1	0.6	0.3	1.4	1.6	1.4	1.2	0.9	1.5	0.9	0.4
Supplements: Zinc	0.5	0.5	1.6	1.2	-0.1	0.5	1.1	0.3	-0.3	0.4	0.5	1.3	0.2	0.3	-0.9
Medication: Metformin	0.5	0.7	1.9	-0.8	-1.2	-0.3	-1.4	-0.6	-0.7	-1.3	0.4	-1.1	0.1	-0.3	-0.6
Diabetes (mother)	0.5	0.6	2.3	0.5	-1.0	-0.7	-1.2	0.2	-0.0	-1.5	-0.3	-0.7	-0.8	-0.6	0.2
Townsend deprivation index at recruitment	0.5	0.8	5.2	1.1	-0.3	-0.1	-2.3	-0.2	-0.9	-0.1	0.3	-1.0	-0.1	-0.3	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	5.2	2.0	-0.5	-0.4	-2.3	1.3	-0.1	-0.9	0.4	-0.6	0.7	-0.3	0.3
Hayfever, allergic rhinitis or eczema	0.5	1.2	4.7	-1.4	1.5	0.8	-0.2	-0.7	0.8	2.2	0.0	-0.9	0.6	0.6	1.4
Forced vital capacity (FVC)	0.5	1.8	9.2	3.0	2.3	0.0	-1.1	-1.1	0.7	0.1	0.5	0.7	1.3	0.7	1.0
Fluid intelligence score	0.5	1.1	3.5	1.9	0.5	-0.4	-0.6	-0.7	-1.3	-0.5	-0.8	-1.3	-1.0	-0.8	-1.4
Hair/balding pattern: Pattern 3	0.5	0.7	2.9	-0.8	-0.3	0.3	0.5	0.9	1.4	0.7	0.4	0.4	-0.2	0.8	1.7
Asthma	0.5	1.0	2.7	-0.2	-0.3	0.4	0.4	1.1	1.5	1.4	1.3	0.8	1.6	1.0	0.3
Exposure to tobacco smoke at home	0.5	0.6	2.9	-0.9	-1.4	0.4	-1.7	0.6	0.3	0.4	0.1	-0.0	0.2	0.1	0.7
Loud music exposure frequency	0.5	0.6	2.1	-0.3	-1.0	-0.3	-1.2	-1.0	-0.7	0.2	-0.6	-1.4	-0.3	-0.3	0.1
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	5.6	1.1	2.4	0.5	-0.4	-0.7	0.3	0.6	-0.0	-0.1	0.1	0.6	0.9
Blood clot in the leg (DVT)	0.5	0.6	2.5	1.3	-0.9	-0.1	-1.6	0.0	-1.2	-0.4	0.7	0.1	0.4	-0.1	-0.2
Forced vital capacity (FVC), Best measure	0.5	1.9	13.6	3.7	1.7	-0.4	-1.3	-1.6	-0.4	-0.5	0.4	0.0	1.2	0.2	0.4
Medication for pain relief, constipation, heartburn	0.5	0.9	4.3	-0.7	1.5	0.4	1.0	0.4	0.8	2.1	-0.2	1.0	0.3	0.4	0.6
Medication: Seretide 50 evohaler	0.5	0.5	2.0	-1.4	-0.2	0.2	-0.8	1.0	0.7	0.4	-0.1	-0.6	-0.7	-0.1	1.1
Heart disease (mother)	0.5	0.6	1.6	-1.3	-1.2	-0.8	0.4	0.5	0.5	-0.5	-0.5	-0.6	-0.9	-0.8	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.9	0.5	0.3	0.8	-0.4	1.2	0.9	0.6	1.4	0.3	0.4	0.9	1.0
Leg pain on walking	0.5	0.6	3.0	-1.7	-0.9	1.1	-0.5	0.5	0.4	0.5	0.3	0.5	0.2	0.6	0.5
Breast cancer (self-reported)	0.5	0.6	3.7	1.1	-0.4	0.4	1.0	0.1	-0.7	-0.2	0.4	0.7	0.3	0.1	-1.9
Eye problems/disorders: Glaucoma	0.5	0.6	2.7	-1.6	0.3	1.1	0.4	-0.2	-0.6	1.0	0.1	0.6	0.7	0.5	-0.4
Heart disease (siblings)	0.5	0.6	1.7	0.5	-0.1	-0.5	0.3	-0.7	-1.2	-0.4	-0.5	-1.2	-0.9	-0.8	-1.3
Schizophrenia vs Biploar Disorder	0.4	0.5	2.3	0.6	0.3	0.0	0.9	1.5	1.1	-0.3	0.4	0.5	0.6	0.4	-0.1
HbA1C	0.4	0.4	2.4	-0.6	-0.3	-0.1	0.1	0.6	-1.1	0.8	0.2	0.2	0.3	-0.1	-1.5
Rheumatoid Arthritis	0.4	0.6	1.6	-0.5	-0.8	-0.8	-0.1	-0.6	-0.3	-0.3	-1.1	-1.2	-1.0	-1.0	0.2
Type 2 Diabetes (T2D) (2012)	0.4	0.5	2.3	0.4	0.4	0.3	-1.2	-0.1	0.1	-1.5	0.0	-1.0	0.0	-0.4	0.3
Waist Hip Ratio (WHR)	0.4	1.7	4.7	-2.2	-1.1	-1.3	1.8	0.3	-0.1	-0.3	-1.6	0.0	-1.9	-1.2	-1.5
Hand grip strength (right)	0.4	1.2	2.7	-0.2	1.4	1.1	-1.6	-0.0	0.5	0.6	1.2	0.6	1.2	1.3	1.5
Financial difficulties in last 2 years	0.4	0.5	1.8	1.3	0.6	0.2	-0.7	0.2	0.6	1.4	1.0	-0.2	0.7	0.5	0.2
Mouth/teeth dental problems	0.4	0.7	2.4	1.2	0.8	0.8	0.1	-0.1	0.1	0.3	1.5	1.0	1.2	0.8	0.3
Qualifications: A levels/AS levels or equivalent	0.4	0.9	2.8	1.6	1.7	0.5	-1.0	-0.2	0.7	1.2	0.6	0.5	0.4	0.6	0.9
Prospective memory result	0.4	0.5	2.1	-0.7	0.4	0.4	1.4	-0.2	-0.0	-0.0	0.4	1.3	-0.4	0.6	0.6
Standing height	0.4	4.2	23.3	4.8	2.0	-1.6	-3.5	-1.2	-0.2	-1.7	-0.2	-1.1	0.5	-0.6	1.6
Breastfed as a baby	0.4	0.4	2.5	0.0	-0.2	1.2	0.4	0.0	-0.5	1.6	0.4	0.3	-0.0	0.4	-0.6
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	3.3	0.8	-0.2	0.1	-1.8	-0.9	-0.5	-1.4	0.7	-0.3	1.0	0.3	1.0
Number of children fathered	0.4	0.5	1.6	-0.0	0.8	0.3	1.3	0.7	-0.1	0.3	0.9	0.7	0.4	0.4	-1.1
Health satisfaction	0.4	0.5	1.6	-1.3	-0.7	0.9	-0.7	0.8	0.7	-0.6	0.5	-0.4	0.5	0.5	0.7
Medication: Ibuprofen	0.4	0.5	1.4	-1.2	-0.5	0.5	-0.9	0.7	1.0	0.5	0.4	0.0	0.3	0.6	1.1
Medication: Allopurinol	0.4	0.6	2.1	-0.9	-1.4	1.0	0.2	0.7	0.6	0.8	0.8	0.2	0.8	0.3	0.1
Mean time to correctly identify matches	0.4	0.7	2.4	1.1	-1.0	-0.8	0.2	-0.1	-1.4	-1.5	-0.2	-0.1	-0.5	-0.4	-0.9
Illnesses of father: Heart disease	0.4	0.6	2.0	0.5	-1.4	-0.6	-0.9	-0.1	0.1	-1.2	-0.5	-0.7	-0.5	-0.5	-0.6
Qualifications: nursing, teaching	0.4	0.6	3.0	1.0	1.0	-0.6	-0.8	-1.7	-0.2	-0.5	-0.4	-0.5	-0.3	-0.2	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	2.9	-1.7	-0.6	-0.4	-0.0	0.2	-1.0	0.5	-0.5	-0.5	-0.1	-0.2	-0.3
Back pain experienced in last month	0.4	0.5	1.7	-0.2	-0.6	0.6	0.7	0.6	-0.4	0.5	1.1	1.1	0.7	0.4	-1.3
Miserableness	0.4	0.6	1.5	-0.1	-1.2	-1.2	-0.9	-0.8	-0.1	-0.8	-0.1	-0.9	-0.9	-0.7	0.4
Ever smoked	0.4	0.8	2.7	-1.6	0.2	1.0	1.1	0.7	0.8	0.9	0.9	0.2	0.8	1.0	0.5
Number of operations (self-reported)	0.4	0.6	3.4	-1.9	-0.3	-0.1	1.0	0.7	-0.6	0.3	-0.4	0.1	-0.5	-0.3	-1.1
Vascular/heart problems diagnosed by doctor	0.4	1.2	5.6	-0.0	1.2	0.9	1.4	-0.0	0.6	2.4	0.4	1.2	-0.6	0.8	1.3
Intelligence (Savage-Jansen 2018)	0.3	0.9	5.9	2.4	0.9	0.3	0.2	-0.7	-0.6	-0.6	-0.4	-0.2	-0.1	-0.2	-1.4
Schizophrenia (2014)	0.3	0.6	1.5	0.5	-1.2	-1.2	-0.8	-0.4	-0.6	-0.9	-0.2	-0.9	-0.4	-1.0	-0.6
Blood Red Count	0.3	3.0	9.3	3.1	2.4	-0.3	-1.9	1.9	1.4	-0.4	2.1	0.5	2.0	1.2	1.0
Hypothyroidism (self reported)	0.3	0.7	3.1	0.2	-0.1	0.2	-1.8	-1.0	-0.4	-1.0	0.4	-0.4	0.9	0.4	1.2
Type 2 Diabetes (T2D) (2018)	0.3	0.6	4.3	-0.7	-0.5	-0.5	-0.4	-0.3	-0.0	-2.1	-0.0	-0.6	-0.1	-0.5	-0.9
Lung FEV1/FVC ratio	0.3	1.3	6.8	2.5	0.6	-0.0	-1.3	-0.1	-0.4	-2.6	0.6	0.2	-0.2	-0.4	0.0
Lung FVC	0.3	1.5	8.4	2.9	0.2	0.8	-1.6	-1.9	-0.9	-0.1	0.4	0.5	0.9	0.8	0.5
Angina	0.3	0.4	1.4	-1.0	-0.6	-0.3	-0.2	1.2	0.3	-1.2	-0.1	0.1	-0.1	-0.3	-0.5
High blood pressure	0.3	0.7	3.5	-0.4	-0.7	-0.6	-1.3	0.2	-0.1	-1.9	-0.1	-0.9	0.9	-0.4	-1.0
Allergy	0.3	0.8	3.3	0.8	-0.5	-0.4	0.6	0.2	-0.7	-1.8	-0.4	0.8	-1.2	-0.6	-1.1
Medication: Ramipril	0.3	0.4	1.3	-1.1	0.3	0.7	-0.3	0.2	0.8	-0.5	0.4	-0.3	0.6	0.6	0.7
Alcohol intake versus 10 years previously	0.3	0.5	1.1	1.0	-1.0	-0.5	-0.5	0.7	0.1	-1.0	0.9	0.3	0.8	0.1	0.1
Pulse rate	0.3	0.4	1.0	0.1	1.0	-1.0	0.5	-0.8	0.3	-0.3	-1.0	-0.5	-0.6	-0.7	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	2.5	0.6	-1.6	-0.4	0.4	-0.3	-0.1	-0.3	0.6	0.5	0.0	-0.2	-1.3
Ever highly irritable/argumentative for 2 days	0.3	0.3	1.4	0.7	-0.4	-0.2	0.2	-0.9	-0.3	-1.2	-0.3	-0.8	-0.4	-0.3	0.2
Glaucoma (self-reported)	0.3	0.3	1.0	-0.5	-0.0	0.8	-0.3	-0.8	-0.8	1.0	0.1	-0.3	0.4	0.3	-0.1
Wheeze or whistling in the chest in last year	0.3	0.6	1.9	-1.4	-1.2	-0.4	1.3	0.9	0.7	0.5	-0.3	-0.0	0.0	-0.0	-0.4
Eye problems/disorders: None of the above	0.3	0.4	1.7	-0.1	0.9	-0.1	-0.2	0.4	1.3	0.2	0.2	-0.3	0.2	0.3	1.2
Angina (self-reported)	0.3	0.4	2.1	-0.5	-0.9	-0.5	-0.4	1.0	-0.0	-1.5	-0.1	0.0	-0.2	-0.4	-0.6
Suffer from ‘nerves’	0.3	0.4	1.1	-0.1	-0.5	0.7	-0.5	0.0	0.5	1.0	1.1	0.5	0.7	0.7	0.7
Supplements: Vitamin C	0.3	0.3	1.7	-0.4	-0.4	-0.4	1.3	0.4	-0.3	-0.2	-0.5	1.0	-0.4	-0.1	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	2.7	1.6	1.1	-0.3	0.0	0.8	0.8	-0.3	0.7	0.4	0.4	0.4	0.0
Average weekly red wine intake	0.3	0.4	1.0	0.9	0.8	-0.7	-1.0	0.1	-0.1	-0.1	-0.4	-0.9	-0.1	-0.7	-0.4
Eye problems/disorders: Cataract	0.3	0.4	1.0	0.8	-1.0	0.5	-0.3	-0.0	-0.8	-0.7	0.3	0.9	0.3	0.3	-0.3
Medication: Gliclazide	0.3	0.4	1.5	-0.6	-0.8	-0.0	-1.0	0.3	-0.7	-1.2	-0.1	-0.4	-0.2	0.1	-0.4
Illnesses of father: None of the above (group 1)	0.3	0.4	1.7	0.6	0.4	-0.1	0.5	-1.3	0.1	0.7	-0.3	-0.5	-0.8	-0.4	0.8
Guilty feelings	0.3	0.5	3.6	1.9	0.5	0.4	-0.4	-0.8	0.2	0.3	0.8	-0.2	-0.6	0.0	0.1
Medication: Paracetamol	0.3	0.4	1.9	0.8	-1.0	-0.8	-0.6	-0.2	0.1	-1.4	0.3	-0.5	-0.4	-0.1	-0.3
Illnesses of father: High blood pressure	0.3	0.4	1.7	0.2	0.6	-0.8	-0.8	0.3	0.9	-1.3	-0.2	-0.5	0.6	-0.3	-0.0
Ever depressed for a whole week	0.3	0.4	2.0	-0.3	-1.4	-0.4	0.8	0.5	0.6	-0.2	-0.1	0.2	-0.7	-0.2	-0.2
Commuting to job workplace: Cycle	0.3	0.4	1.3	0.1	0.8	0.3	-0.5	0.4	1.2	0.5	0.3	-0.1	0.1	0.6	1.1
Cholesterol lowering medication	0.3	0.4	1.1	-1.1	0.6	0.6	1.0	1.0	0.0	0.4	0.3	0.3	0.6	0.4	-0.7
Bipolar Disorder (2011)	0.2	0.2	0.7	-0.6	0.2	0.2	0.0	-0.4	0.1	0.7	0.2	0.2	0.8	0.4	0.2
LDL Cholesterol	0.2	0.3	1.3	-0.5	1.1	0.4	-1.2	0.1	-0.1	0.4	-0.3	-0.8	-0.2	-0.1	0.4
Ulcerative Colitis	0.2	0.3	1.2	0.8	0.9	0.0	0.2	0.2	-0.3	-0.5	0.2	-0.1	-0.4	-0.4	-1.1
Blood White Count	0.2	1.2	8.1	-2.8	-0.2	1.1	0.0	-0.5	0.6	0.6	1.2	0.8	0.6	1.0	-0.7
Height	0.2	4.6	25.4	5.0	1.5	-0.9	-3.7	-0.8	0.5	-0.7	0.7	-1.1	1.7	0.2	2.6
Chronotype (morning person)	0.2	0.4	1.0	0.2	0.2	-0.4	-0.4	-1.0	-0.8	-1.0	-0.7	-0.5	0.3	-0.7	-0.6
Tanning	0.2	2.3	4.5	-0.8	-1.5	-1.8	0.5	-1.6	-0.8	-0.8	-2.1	-1.8	-2.0	-2.1	-1.1
Average weekly fortified wine intake	0.2	0.2	0.8	-0.2	0.9	-0.3	0.2	-0.6	0.2	-0.1	-0.9	-0.2	-0.5	-0.3	0.6
Medication: Atenolol	0.2	0.2	0.6	-0.4	-0.0	-0.3	-0.0	-0.5	-0.7	-0.6	-0.3	-0.4	-0.2	-0.5	-0.8
Sitting height	0.2	1.5	5.9	2.4	0.7	-1.3	-1.1	-1.5	-0.4	-1.3	-1.0	-1.4	-0.7	-0.9	0.1
Had menopause	0.2	0.3	0.8	-0.7	-0.7	-0.3	0.9	-0.1	-0.2	0.2	-0.5	0.3	-0.6	-0.3	-0.9
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	1.1	-1.0	-0.4	0.6	0.5	-0.5	-0.5	1.0	0.3	0.0	0.2	0.2	-0.6
Illnesses of siblings	0.2	0.3	1.3	0.6	1.1	0.4	0.5	0.2	0.1	0.2	0.6	1.1	-0.2	0.6	-0.0
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	1.1	-0.2	0.2	0.3	0.0	-0.3	-0.5	1.0	0.0	-0.8	-0.0	0.1	-0.5
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	1.2	-1.1	-0.6	-0.1	0.4	0.4	0.7	0.5	-0.2	-0.1	-0.3	0.1	0.6
Depression (self-reported)	0.2	0.3	1.3	1.1	-0.9	-0.6	0.2	0.2	0.2	-0.2	0.8	0.1	-0.4	-0.1	-0.1
Medication: Amlodipine	0.2	0.2	0.9	0.5	0.2	-0.7	-0.4	-0.6	0.3	-0.6	0.3	-1.0	0.3	-0.2	0.1
Hypertension (Self-reported)	0.2	0.7	3.2	-0.8	-0.7	-0.4	-1.1	0.2	-0.2	-1.8	-0.2	-0.8	1.0	-0.2	-0.7
Ever had bowel cancer screening	0.2	0.3	1.2	1.1	-0.4	-0.2	-0.0	0.1	-0.8	-0.7	-0.2	-0.2	-0.3	-0.6	-0.5
Medication for cholesterol	0.2	0.3	1.5	0.9	-0.0	-0.1	-0.1	-1.2	-0.3	0.5	-0.2	0.3	-0.8	-0.1	0.6
Medication: Blood pressure	0.2	0.4	1.4	-1.2	-0.5	0.3	0.5	0.8	0.1	-0.7	0.0	-0.2	0.8	0.1	-0.8
Medication: Bendroflumethiazide	0.2	0.3	1.0	-0.6	-0.5	0.3	-0.6	-0.2	1.0	-0.5	0.1	-1.0	0.4	0.1	0.8
Alcohol drinker status: Previous	0.2	0.3	2.3	-0.2	-0.4	-0.4	0.1	-0.1	0.0	-0.4	-0.3	-0.2	0.2	-0.3	-1.5
Ulcerative Colitis (UC)	0.1	0.3	1.0	0.3	0.5	-0.2	-0.1	0.6	-0.4	-0.8	0.2	-0.2	-1.0	-0.7	-0.3
Fasting Glucose	0.1	0.1	0.7	0.3	0.0	0.2	-0.8	0.1	-0.5	-0.1	-0.1	-0.3	-0.3	0.3	-0.3
Blood Eosinophil Count	0.1	0.6	4.7	0.7	0.0	0.2	-2.2	-0.2	-0.5	-0.2	1.1	0.1	0.8	0.5	-0.6
Blood Platelet Count	0.1	0.8	3.1	-1.3	-1.8	0.5	-1.5	-0.6	-0.6	-0.1	0.6	-0.7	-0.8	-0.1	-0.5
Hair Pigment	0.1	1.6	6.4	-2.5	-0.3	1.4	1.1	1.1	0.7	2.2	0.8	0.6	1.0	1.0	-0.2
Sensitivity / hurt feelings	0.1	0.2	0.9	0.0	0.8	-0.3	0.7	-1.0	-0.0	-0.1	-0.3	-0.1	-0.3	-0.3	0.2
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.7	-0.1	0.4	-0.4	-0.0	-0.3	0.3	0.1	-0.9	-0.5	-0.4	-0.5	-0.4
Risk taking	0.1	0.2	0.9	0.0	-0.8	0.6	0.6	0.1	-1.0	-0.0	-0.1	-0.1	0.2	0.2	-0.2
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0

Hub : Genes

FAIM2

Models

Trait associations