TWAS
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Usage
Models
Genes
Traits
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Traits
:
Arm fat mass (left)
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chr18:38,837,001-40,365,619
Best TWAS P=7.47e-09 · Best GWAS P=2.02e-09 conditioned to 1
38.8M
39M
39.2M
39.4M
39.6M
39.8M
40M
40.2M
40.4M
0
2
4
6
8
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Testis
PIK3C3
0.10
0.01
enet
24
0.02
4.8e-02
5.0
-5.8
7.5e-09
-0.39
0.15
0.09
TRUE
4
The Cancer Genome Atlas
Colon Adenocarcinoma
PIK3C3
0.09
0.04
lasso
8
0.03
6.0e-03
5.8
-5.4
6.8e-08
-0.98
0.02
0.90
TRUE
1
GTEx
Nerve Tibial
PIK3C3
0.16
0.12
enet
13
0.15
1.2e-10
4.7
-5.6
2.2e-08
-0.60
0.72
0.27
FALSE
3
METSIM
Adipose
PIK3C3
0.10
0.08
enet
28
0.08
1.8e-12
5.5
-5.3
1.4e-07
-0.58
0.28
0.72
FALSE