Best TWAS P=1.73e-12 · Best GWAS P=8.32e-12 conditioned to 0.0849
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | REXO1 | 0.07 | 0.01 | bslmm | 391 | 0.01 | 1.7e-02 | -3.6 | 7.1 | 1.7e-12 | -0.51 | 0.11 | 0.63 | TRUE |
| 6 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | ATP8B3 | 0.04 | 0.01 | blup | 49 | 0.02 | 2.2e-03 | -6.8 | -6.5 | 8.8e-11 | 0.84 | 0.00 | 0.76 | TRUE |
| 3 | GTEx | Esophagus Muscularis | CTB-31O20.6 | 0.16 | 0.07 | lasso | 5 | 0.05 | 7.8e-04 | -5.9 | -6.0 | 2.6e-09 | 0.50 | 0.35 | 0.44 | FALSE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | KLF16 | 0.12 | 0.08 | bslmm | 372 | 0.08 | 1.0e-10 | -6.8 | -5.9 | 3.2e-09 | 0.85 | 0.00 | 1.00 | FALSE |
| 5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ATP8B3 | 0.06 | 0.00 | blup | 49 | 0.03 | 2.7e-04 | -1.4 | -5.7 | 1.1e-08 | 0.54 | 0.06 | 0.21 | FALSE |
| 2 | GTEx | Esophagus Muscularis | KLF16 | 0.17 | 0.07 | enet | 9 | 0.09 | 3.7e-06 | -5.9 | -5.6 | 1.8e-08 | 0.50 | 0.34 | 0.55 | FALSE |